Citations with the tag: VIRUS-induced immunosuppression
Results 1 - 50
- Persistence of Human Immunodeficiency Virus (HIV) Type 1 DNA in Peripheral Blood Despite Prolonged Suppression of Plasma HIV-1 RNA in Children.
Saitoh, Akihiko; Hsia, Karen; Fenton, Terence; Powell, Christine A.; Christopherson, Cindy; Fletcher, Courtney V.; Starr, Stuart E.; Spector, Stephen A. // Journal of Infectious Diseases; 5/15/2002, Vol. 185 Issue 10, p1409
Examines the persistence of HIV type 1 DNA in peripheral blood mononuclear cells in children. Usefulness of HIV-1 DNA as a marker for virus suppression; Effect of antiretroviral therapy on HIV-1 DNA levels; Median half-life of intracellular HIV-1 DNA.
- NNRTIs COMPARED IN SWITCH STUDY.
Saitoh, Akihiko; Hsia, Karen; Fenton, Terence; Powell, Christine A.; Christopherson, Cindy; Fletcher, Courtney V.; Starr, Stuart E.; Spector, Stephen A. // AIDS Patient Care & STDs; Jun2002, Vol. 16 Issue 6, p302
Compares the effect of nevirapine and efavirenz in patients with long-lasting viral suppression. Evaluation of patients following the treatment with the drugs; Changes in cholesterol levels on patients; Improvement or deterioration in body fat redistribution for patients.
- Bug of the Month.
Taylor, Sue // Geographical (Campion Interactive Publishing); Apr99, Vol. 71 Issue 4, p59
Focuses on human immunodeficiency virus (HIV). How the disease is transmitted; Symptoms of HIV.
- South African public sceptical about new AIDS `cure'.
Sidley, Pat // BMJ: British Medical Journal (International Edition); 03/20/99, Vol. 318 Issue 7186, p757
Reports on the development of Inactivan, a drug intended to prolong the lives of people with AIDS as announced by a team of scientists from the Medical University of South Africa (Medunsa). Background information on the development of the drug; Remarks from Wimpie du Plooy, professor of...
- Reversal of Human Immunodeficiency Virus Type 1-Associated Hematosuppression by Effective Antiretroviral Therapy.
Huang, Susan S.; Barbour, Jason D.; Deeks, Steven G.; Huang, Jeannie S.; Grant, Robert M.; Ng, Valerie L.; McCune, Joseph M. // Clinical Infectious Diseases; 3/1/2000, Vol. 30 Issue 3, p504
Examines the reversal of HIV type 1-associated hematosuppression by effective antiretroviral therapy. Effects of durable viral suppression on multilineage hematopoiesis in 66 HIV-1 seropositive patients; Increase in circulating CD4(sup +) T cell counts and circulating levels of other...
- Trial suggests vaccines could aid HIV therapy.
Check, Erika // Nature; 4/17/2003, Vol. 422 Issue 6933, p650
Reports on the therapeutic vaccine that could aid HIV therapy. Benefits of the vaccine; Features of the vaccine.
- HIV-1, NFAT, and Cyclosporin: Immunosuppression for the Immunosuppressed?
Cron, Randy Q. // DNA & Cell Biology; Dec2001, Vol. 20 Issue 12, p761
The human immunodeficiency virus-1 (HIV-1), the cause of AIDS, remains a significant cause of morbidity and mortality throughout the planet. Although reverse transcriptase and protease inhibitors have substantially slowed the virus, viral resistance complicates therapy. Because HIV-1 relies on...
- Targeting Tat and IFNa as a Therapeutic AIDS Vaccine.
Gallo, R.C.; Burny, A.; Zagury, D. // DNA & Cell Biology; Sep2002, Vol. 21 Issue 9, p611
Evolution to AIDS is characterized by a progressive cellular immune suppression. Although there is substantial evidence for several mechanisms involved in disrupting the immune response by induction of apoptosis in responder cells by contact with infected cells, we propose that humoral factors...
- Role of Human �-defensins in HIV Infection.
Weinberg, A.; Qui�ones-Mateu, M. E.; Lederman, M. M. // Advances in Dental Research; Apr2006, Vol. 19 Issue 1, p42
Mechanisms of resistance to HIV-1 infection in the human oral cavity are incompletely understood. While salivary components have been implicated in protection, there is growing evidence that human beta-defensins (hBDs), originating in oral epithelial cells, may be playing an important role in...
- (B2) Periodontal Diseases and Other Bacterial Infections.
Umadevi, M.; Adeyemi, O.; Patel, M.; Reichart, P. A.; Robinson, P. G. // Advances in Dental Research; Apr2006, Vol. 19 Issue 1, p139
The workshop addressed the following questions with respect to periodontal diseases and bacterial infections seen in HIV infection: (1) What is linear gingival erythema? Is it prevalent only in HIV disease? A crude Delphi technique was used to ascertain whether LGE existed, but a consensus could...
- HIV Prevention Interventions in Chennai, India: Are Men Who Have Sex with Men Being Reached?
Thomas, Beena; Mimiaga, Matthew J.; Mayer, Kenneth H.; Johnson, Carey V.; Menon, Sunil; Chandrasekaran, V.; Murugesan, P.; Swaminathan, Soumya; Safren, Steven A. // AIDS Patient Care & STDs; Nov2009, Vol. 23 Issue 11, p981
India has the greatest number of HIV infections in Asia and the third highest total number of infected persons globally. Men who have sex with men (MSM) are considered by the Government of India's National AIDS Control Organization (NACO) a �core risk group� for HIV in need of HIV prevention...
- Dual phasic suppression of viral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers.
Kannagi, Mari; Nakamura, Tahei; Akari, Hirofumi; Kuroda, Marcelo J.; Fujii, Masahiro; Oka, Shinichi; Iwamoto, Aikichi; Kurata, Takeshi; Higashi, Daisuke; Harada, Shinji // Leukemia (08876924); Apr97 Supplement 3, Vol. 11, p545
Replication of human immunodeficiency virus type 1 (HIV-1) is suppressed in asymptomatic HIV-1 carriers (ACs). By using an in vitro experimental system, the mechanism of this suppression was investigated. Following in vitro infection of a laboratory HIV-1 strain, the peripheral blood mononuclear...
- Structure of the HCMV UL16-MICB Complex Elucidates Select Binding of a Viral Immunoevasin to Diverse NKG2D Ligands.
M�ller, Steffen; Zocher, Georg; Steinle, Alexander; Stehle, Thilo // PLoS Pathogens; Jan2010, Vol. 6 Issue 1, p1
The activating immunoreceptor NKG2D promotes elimination of infected or malignant cells by cytotoxic lymphocytes through engagement of stress-induced MHC class I-related ligands. The human cytomegalovirus (HCMV)-encoded immunoevasin UL16 subverts NKG2D-mediated immune responses by retaining a...
- World AIDS Day -- December 1, 2008.
M�ller, Steffen; Zocher, Georg; Steinle, Alexander; Stehle, Thilo // MMWR: Morbidity & Mortality Weekly Report; 11/28/2008, Vol. 57 Issue 47, p1273
The article offers an update on HIV/AIDS epidemic as of November 28, 2008 in celebration of the World AIDS Day on December 1. An estimated 33 million persons worldwide are living with HIV, 2 millions died from AIDS-related causes, and 2.7 million are newly infected in 2007, according to the...
- Learning to understand the viruses with no symptoms.
Lister, Stephen // Poultry World; Dec2008, Vol. 162 Issue 12, p30
The article explains that there is a whole range of viruses capable of impairing bird performance without causing any clinical effects. These so-called immunosuppressive viruses prevent the immune system from fighting off disease or responding to vaccination. The immune system competes with...
- HELLO, My name is.
Chiu, Lorna // Faces (07491387); Mar2007, Vol. 23 Issue 7, p26
The article introduces several patients, who inherited diseases through their parents or otherwise. It reports on a Kibera, Kenya-based 13 years old girl, who got AIDS viruses through her parents, who were also HIV positive. She was put on anti-retroviral treatment. Likewise, another 11 years...
- Guerrilla warfare.
Day, Michael // New Scientist; 11/28/98, Vol. 160 Issue 2162, p42
Focuses on work by Frank Miedema and his team from the University of Amsterdam and others on how HIV causes AIDS. Explanation of Miedema's theory that the virus impairs the body's ability to produce a class of T cells known as CD4 cells instead of killing them; Criticism of Miedema's research;...
- GERMAN AIDS NUMBERS DROP.
Wockner, Rex // Bay Windows; 4/14/1999, pN.PAG
Presents information on the number of AIDS cases in Germany as of April 14, 1999. Decrease in the number of AIDS cases in 1998 compared in 1997; Total number of Germans that developed AIDS.
- Dispatches from the front line.
Wockner, Rex // Nature; 8/1/2002, Vol. 418 Issue 6897, p465
Reports on the lack of political and financial support for the prevention of the spread of HIV virus despite numerous ways and schemes for its prevention. Pledge of the international community in reducing HIV prevalence; Opposition of some economists and politicians to putting available cash...
- T Cell Polarization and the Formation of Immunological Synapses: From Antigen Recognition to Virus Spread.
Pais-Correia, Ana Monica; Thoulouze, Maria Isabel; Alcover, Andr�s // Current Immunology Reviews; 2007, Vol. 3 Issue 3, p170
Soon after antigen recognition, T lymphocytes polarize towards antigen presenting cells (APC) and form immunological synapses. The formation of immunological synapses is a complex process that involves T cell signaling, as well as membrane, cytoskeleton and vesicular trafficking events....
- The Vpu Protein: New Concepts in Virus Release and CD4 Down-Modulation.
Ruiz, Autumn; Guatelli, John C.; Stephens, Edward B. // Current HIV Research; Apr2010, Vol. 8 Issue 3, p240
Human immunodeficiency virus type 1 (HIV-1) and several simian immunodeficiency viruses (SIV) encode for a transmembrane protein known as Vpu (viral protein U). While one of the smallest of the HIV-1 proteins, it has two important functions within virus-infected cells. The first of these...
- NeuroAIDS in West Africa: A Full Circle.
Power, Christopher // Canadian Journal of Neurological Sciences; May2007, Vol. 34 Issue 2, p118
The article provides information about human immunodeficiency virus type 1 (HIV-1), a retrolentivirus that cause immunosuppression which progresses to acquired immunodeficiency syndrome (AIDS) and death. The primary central nervous system manifestations of HIV-1 which is directly caused by the...
- What shapes research impact on policy? Understanding research uptake in sexual and reproductive health policy processes in resource poor contexts.
Sumner, Andy; Crichton, Jo; Theobald, Sally; Zulu, Eliya; Parkhurst, Justin // Health Research Policy & Systems; Jan2011 Supplement 1, Vol. 9, p1
Assessing the impact that research evidence has on policy is complex. It involves consideration of conceptual issues of what determines research impact and policy change. There are also a range of methodological issues relating to the question of attribution and the counter-factual. The dynamics...
- Raltegravir plus optimized background therapy suppressed HIV-1 RNA levels.
Volansky, Rob // Infectious Disease News; Sep2008, Vol. 21 Issue 9, p28
The article highlights the findings published in "The New England Journal of Medicine" which found the effectiveness of combination therapy using raltegravir plus optimized background therapy in providing viral suppression than background therapy alone in people. These findings are said to be...
- Targeting HIV Interventions for Adolescent Girls and Young Women in Southern Africa: Use of the PLACE Methodology in Hwange District, Zimbabwe.
Singh, Kavita; Sambisa, William; Munyati, Shungu; Chandiwana, Brian; Chingono, Alfred; Monash, Roeland; Weir, Sharon // AIDS & Behavior; Feb2010, Vol. 14 Issue 1, p200
This paper addresses the issue of how to target interventions to girls 15�19 and young women 20�24 in a resource poor setting of Hwange District, Zimbabwe. The Priorities for Local AIDS Control efforts methodology was used to understand where these young people socialize and also to...
- A SURFEIT OF AIDS VIRUSES.
Singh, Kavita; Sambisa, William; Munyati, Shungu; Chandiwana, Brian; Chingono, Alfred; Monash, Roeland; Weir, Sharon // AIDS & the Third World; 1989, p15
This article deals with the different forms of acquired immunodeficiency syndrome (AIDS) viruses. One of the viruses was isolated from the blood of healthy Senegalese female prostitutes and hospitalized non-AIDS patients in Dakar and was called HTL-4. Another virus which cause AIDS and was...
- The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site.
Abram, Michael E.; Sarafianos, Stefan G.; Parniak, Michael A. // Retrovirology; 2010, Vol. 7, p1
Background: The p51 subunit of the HIV-1 reverse transcriptase (RT) p66/p51 heterodimer arises from proteolytic cleavage of the RT p66 subunit C-terminal ribonuclease H (RNH) domain during virus maturation. Our previous work showed that mutations in the RT p51?RNH cleavage site resulted in virus...
- Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages.
Sundaravaradan, Vasudha; Das, Suman R.; Ramakrishnan, Rajesh; Sehgal, Shobha; Gopalan, Sarla; Ahmad, Nafees; Jameel, Shahid // Virology Journal; 2007, Vol. 4, p126
Background: Several subtypes of HIV-1 circulate in infected people worldwide, including subtype B in the United States and subtype C in Africa and India. To understand the biological properties of HIV-1 subtype C, including cellular tropism, virus entry, replication efficiency and cytopathic...
- Can Routine Clinical Markers Be Used Longitudinally to Monitor Antiretroviral Therapy Success in Resource-Limited Settings?
Bagchi, Shashwatee; Kempf, Mirjam C.; Westfall, Andrew O.; Maherya, Anastasiya; Willig, James; Saag, Michael S. // Clinical Infectious Diseases; 1/1/2007, Vol. 44 Issue 1, p135
Although routine clinical markers are used routinely to determine the stage of human immunodeficiency virus (HIV) disease, their use in monitoring response to antiretroviral therapy is poorly defined. Selected clinical markers were evaluated for their ability to predict first-line antiretroviral...
- Participation in clinical trials among women living with HIV in Canada.
Hankins, Catherine; Lapointe, Normand; Walmsley, Sharon // CMAJ: Canadian Medical Association Journal; 12/01/98, Vol. 159 Issue 11, p1359
Presents a study that described participation in clinical trials among HIV-positive women in Canada in an effort to assess their level of participation. Methods; Results; Interpretation.
- Recent Evolutionary History of Human Immunodeficiency Virus Type 1 Subtype B�Response.
Smith, Una R.; Kuiken, Carla R.; Korber, Bette T. // Journal of Molecular Evolution; May2003, Vol. 56 Issue 5, p643
The year of origin estimated by Lukashov and Goudsmit for HIV-1 subtype B is 1976 (95% CI, 1974�1977); this is significantly different from our prior estimate, 1967 (95% CI, 1960�1971). We review published evidence, which suggests that their estimate is too late.
- South Africa will not pay for antiretroviral therapy.
Sidley, Pat // BMJ: British Medical Journal (International Edition); 06/16/2001, Vol. 322 Issue 7300, p1441
Reports that the South African government will not pay for antiretroviral therapy. Reasons why Minister of Health Dr. Manto Tshabalala-Msimang believes the government cannot afford the drugs regardless of how low the price goes; Provision of the antiretroviral treatment to pregnant women in...
- Fast Facts.
Sidley, Pat // Medical Economics; 7/23/2004, Vol. 81 Issue 14, p9
Presents statistics on AIDS as of July 2004. Number of Africans needing AIDS treatment; Percentage of Africans receiving treatment; Number of people in Latin America and the Caribbean needing AIDS treatment.
- Understanding the correlations between wealth, poverty and human immunodeficiency virus infection in African countries.
Parkhurst, Justin O. // Bulletin of the World Health Organization; Jul2010, Vol. 88 Issue 7, p519
Objective To investigate the relationships between the prevalence of human immunodeficiency virus (HIV) infection and underlying structural factors of poverty and wealth in several African countries. Methods A retrospective ecological comparison and trend analysis was conducted by reviewing data...
- HIV-Infected and Unaware.
Klitsch, Michael // Family Planning Perspectives; Nov/Dec93, Vol. 25 Issue 6, p243
This article discusses human immunodeficiency virus (HIV) infected people's lack of knowledge about their infection until shortly before developing AIDS. Young people and those who were infected heterosexually with the (HIV) often may not know they are infected until shortly before developing...
- On a Four Stage Model for Development to AIDS.
Aggarwala, B. D. // Engineering Letters; 2006, Vol. 13 Issue 4, p308
We present a model consisting of four first order ODE's to model the progression of HIV from infection to AIDS. The model clarifies the role of protease inhibitors in this progression. We also show that, depending upon the viral activity, the solution may exhibit progression to an endemic state,...
- What is new in the nucleolus?: Workshop on the Nucleolus: New Perspectives.
Matthews, David A.; Olson, Mark O. J. // EMBO Reports; Sep2006, Vol. 7 Issue 9, p870
The article reports on the "EMBO Workshop on the Nucleolus: New Perspectives," held at York, United Kingdom, from March 27-29, 2006. Information on the main focus of the workshop that revealed the involvement of nucleolus in internal functions of cells is presented. An overview of the structure,...
- The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members.
Alm�n, Markus S�llman; Bringeland, Nathalie; Fredriksson, Robert; Schi�th, Helgi B. // PLoS ONE; Feb2012, Vol. 7 Issue 2, p1
The Interferon induced transmembrane proteins (IFITM) are a family of transmembrane proteins that is known to inhibit cell invasion of viruses such as HIV-1 and influenza. We show that the IFITM genes are a subfamily in a larger family of transmembrane (TM) proteins that we call Dispanins, which...
- Evaluation of Cervical Mucosa in Transmission Bottleneck during Acute HIV-1 Infection Using a Cervical Tissue-Based Organ Culture.
Chengli Shen; Ming Ding; Ratner, Deena; Montelaro, Ronald C.; Yue Chen; Gupta, Phalguni // PLoS ONE; Mar2012, Vol. 7 Issue 3, p1
Background: Although there are different strains of HIV-1 in a chronically infected individual, only one or limited virus strains are successfully transmitted to a new individual. The reason for this "transmission bottleneck" is as yet unknown. Methodology/Principal Findings: A human cervical...
- Chitinases in Pneumocystis carinii pneumonia.
Villegas, Leah; Kottom, Theodore; Limper, Andrew // Medical Microbiology & Immunology; Aug2012, Vol. 201 Issue 3, p337
Pneumocystis pneumonia remains an important complication of immune suppression. The cell wall of Pneumocystis has been demonstrated to potently stimulate host inflammatory responses, with most studies focusing on �-glucan components of the Pneumocystis cell wall. In the current study, we have...
- Two consecutive measles outbreaks with genotypes D8 and D4 in two mainly unvaccinated communities in Germany.
Roggendorf, Hedwig; Santibanez, Sabine; Mankertz, Annette; Treeck, Ulrich; Roggendorf, Michael // Medical Microbiology & Immunology; Aug2012, Vol. 201 Issue 3, p349
A measles infection in a 13-year-old student from a free progressive school was the index case for an outbreak in Essen in 2010. In this type of school, mainly unvaccinated and measles-susceptible children accumulate. This observation is confirmed by the fact that some of the recent outbreaks...
- Epidemiology and prognosis of AIDS-associated progressive multifocal leukoencephalopathy in the HAART era.
Antinori, Andrea; Ammassari, Adriana; Giancola, Maria Letizia; Cingolani, Antonella; Grisetti, Susanna; Murri, Rita; Alba, Lucia; Ciancio, Bruno; Soldani, Fabio; Larussa, Dora; Ippolito, Giuseppe; De Luca, Andrea // Journal of NeuroVirology; Aug2001, Vol. 7 Issue 4, p323
Whereas most AIDS-related neurologic disorders have reduced incidence since HAART therapy was introduced, we find that the incidence of progressive multifocal leukoencephalopathy (PML) did not significantly differ between the preHAART and the HAART period (OR 0.78; 95% CI 0.41-1.50). These...
- Treatment of non-AIDS progressive multifocal leukoencephalopathy with cytosine arabinoside.
Aksamit, A.J. // Journal of NeuroVirology; Aug2001, Vol. 7 Issue 4, p386
This open label study determined the outcome of non-AIDS progressive multifocal leukoencephalopathy patients treated with a standard dose of intravenous cytosine arabinoside. Nineteen patients with PML proven by brain biopsy or spinal fluid polymerase chain reaction were treated with intravenous...
- Cidofovir in AIDS-associated progressive multifocal leukoencephalopathy: A monocenter observational study with clinical and JC virus load monitoring.
Gasnault, Jacques; Kousignian, Pascale; Kahraman, Mufide; Rahoiljaon, Josoa; Matheron, Sophie; Delfraissy, Jean-Fran�ois; Taoufik, Yassine // Journal of NeuroVirology; Aug2001, Vol. 7 Issue 4, p375
A monocenter observational study was conducted to determine the clinical and virological effects of cidofovir added to highly active anti-retroviral therapy (HAART) in AIDS-associated progressive multifocal leukoencephalopathy (PML). Exposure to other anti-viral drugs or late initiation of...
- Re-thinking global health sector efforts for HIV and tuberculosis epidemic control: promoting integration of programme activities within a strengthened health system.
Maher, Dermot // BMC Public Health; 2010, Vol. 10, p394
Background: The global financial crisis threatens global health, particularly exacerbating diseases of inequality, e.g. HIV/AIDS, and diseases of poverty, e.g. tuberculosis. The aim of this paper is to reconsider established practices and policies for HIV and tuberculosis epidemic control,...
- Vaccinia virus infection suppresses the cell microRNA machinery.
Grinberg, Moran; Gilad, Shlomit; Meiri, Eti; Levy, Asaf; Isakov, Ofer; Ronen, Roy; Shomron, Noam; Bentwich, Zvi; Shemer-Avni, Yonat // Archives of Virology; Sep2012, Vol. 157 Issue 9, p1719
MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host...
- HIV testing in primary care.
Bryce, Gavin // BMJ: British Medical Journal (Overseas & Retired Doctors Edition; 4/25/2009, Vol. 338 Issue 7701, p966
The author reflects on the benefits of early HIV testing in primary care in Great Britain. He suggests that pilot programs in the country which focus on early diagnosis can be a powerful prevention tool at an individual and community level. He argues that early diagnosis and treatment is cost...
- Viral persistence: IL-10 is the key.
Jones, Susan // Nature Reviews Immunology; Dec2006, Vol. 6 Issue 12, p878
The article reports that two research groups led by scientists Michael Oldstone and Matthias von Herrath have concluded that the immunosuppression that allows viruses to persist unchecked by the immune system is caused by increased interleukin-10 (IL-10). Administering a therapeutic antibody to...
- Control of the medical treatment of AIDS.
Velichenko, V.; Pritykin, D. // Automation & Remote Control; Mar2006, Vol. 67 Issue 3, p493
This work deals with the statement and the solution of problems of optimal control of the human immune system affected by a human immunodeficiency virus (HIV). The solution is performed by the numerical methods of optimal control on the basis of a dynamic model of the development of an infection...
- Zapping worms the organic way.
Velichenko, V.; Pritykin, D. // Health (Time Inc. Health); Nov/Dec95, Vol. 9 Issue 7, p16
Offers information on a virus found in fruits. Target of this virus; Virus discovered by University of California researchers; Development of virus-laden spray for farmers; Spray developed by entomologist Louis Falcon; Approval of pesticide; By Environmental Protection Agency; Reactions of...