Citations with the tag: TUMOR necrosis factor
Results 1 - 50
- The Role of 60-kDA Heat Shock Protein.
// Fertility Weekly; 1/12/2004, p1
Discusses an abstract of the study "Increased Production of Tumor Necrosis Factor-a by Peritoneal Fluid Mononuclear Cells Induced by 60-kDa Heat Shock Protein in Women With Minimal to Mild Endometriosis," by T. Noda and colleagues, published in the November 2003 issue of the "American Journal of...
- Autocrine regulation of matrix metalloproteinase-9 gene expression and secretion by tumor necrosis factor-a (TNF-a) in NB4 leukemic cells: specific involvement of TNF receptor type 1.
Ismair, M G; Ries, C; Lottspeich, F; Zang, C; Kolb, H J; Petrides, P E // Leukemia (08876924); Jul98, Vol. 12 Issue 7, p1136
Matrix metalloproteinases have been reported to be involved in tumor cell invasion and metastasis. Dissemination of malignant cells in acute myeloid leukemia (AML) may be mediated by similar mechanisms. Here, we report, that the t(15/17)[SUP+] acute promyelocytic leukemia (APL) cell line NB4...
- Role of TNFa in bryostatin-induced inhibition of human hematopoiesis.
Dr�ger, A M; van der Hem, K G; Zevenbergen, A; Odding, J H; Huijgens, P C; Schuurhuis, G J // Leukemia (08876924); Jan99, Vol. 13 Issue 1, p62
In previous studies bryostatin has been shown to cause dose-dependent stimulatory or inhibitory effects on colony formation in acute myeloid leukemias. In this study we investigated the inhibitory effect of high dose bryostatin-1 (bryo-1) on normal human bone marrow mononuclear cells (BMNC)...
- Correlation Between Polymorphonuclear Leukocyte Counts and Levels of Tumor Necrosis Factor-a in Pleural Fluid of Patients with Parapneumonic Effusion.
Odeh, M.; Sabo, E.; Srugo, I.; Oliven, A. // Lung; 2002, Vol. 180 Issue 5, p265
High concentrations of tumor necrosis factor-a (TNF), as well as excess of polymorphonuclear leukocytes (PMNs), are present in pleural fluid of patients with complicated parapneumonic effusion (CPPE). Several studies have shown that PMNs are capable of secreting TNF. However, the correlation...
- Transcriptional control of viral gene therapy by cisplatin.
Park, James O.; Lopez, Carlos A.; Gupta, Vinay K.; Brown, Charles K.; Mauceri, Helena J.; Darga, Thomas E.; Manan, Abdullah; Hellman, Samuel; Posner, Mitchell C.; Kufe, Donald W.; Weichselbaum, Ralph R. // Journal of Clinical Investigation; 8/1/2002, Vol. 110 Issue 3, p403
Presents a study that demonstrated induction of tumor necrosis factor (TNF)-a production in tumor cells and xenografts treated with the combination of Ad.Egr.TNF.11D and cisplatin. Induction of Egr1 by cisplatin; Mediation of the induction in part through the CArG elements; Demonstration of an...
Park, James O.; Lopez, Carlos A.; Gupta, Vinay K.; Brown, Charles K.; Mauceri, Helena J.; Darga, Thomas E.; Manan, Abdullah; Hellman, Samuel; Posner, Mitchell C.; Kufe, Donald W.; Weichselbaum, Ralph R. // Journal of Dental Research; Jul2001, Vol. 80 Issue 7, p1684
A correction is presented for the article "Tumor Necrosis Factor-a and its Receptors" which is in volume 80 of this journal.
- Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-a antagonists.
Park, James O.; Lopez, Carlos A.; Gupta, Vinay K.; Brown, Charles K.; Mauceri, Helena J.; Darga, Thomas E.; Manan, Abdullah; Hellman, Samuel; Posner, Mitchell C.; Kufe, Donald W.; Weichselbaum, Ralph R. // Current Medical Literature: Dermatology; 2007, Vol. 12 Issue 3, p73
An abstract of the article "Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-a antagonists," by H. H. Lee, I. H. Song and M. Friedrich is presented.
- Blocking Agents.
Kapes, Beth // Dermatology Times; Oct2003, Vol. 24 Issue 10, p32
Reports on the vitro study on fontolizumab that targets TNF-alpha in addition to IFN-gamma in the U.S. Examination of inflammatory cells; Suggestions of the study; Clinical observations.
- Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.
Olsson, A; Diaz, T; Aguilar-Santelises, M; �sterborg, A; Celsing, F; Jondal, M; Osorio, L M // Leukemia (08876924); Dec2001, Vol. 15 Issue 12, p1868
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent activator of the cell death pathway and exerts tumoricidal activity in vivo with minimal toxicity. In order to investigate the therapeutic potential of TRAIL in B chronic lymphocytic leukemia (B-CLL) we have analyzed the...
- Synergistic effects of mineral fibres and cigarette smoke on the production of tumour necrosis factor by alveolar macropha es of rats
Higashi, Toshiaki; Kido, Masamitsu; Tanaka, Isamu; Fujino, Akihiro; Yokosaki, Yasuyuki; Morimoto, Yasuo // British Journal of Industrial Medicine; Oct1993, Vol. 50 Issue 10, p955
No abstract available.
- Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-?B.
Wang, Cun-Yu; Cusack, James C.; Liu, Rong; Baldwin, Albert S. // Nature Medicine; Apr99, Vol. 5 Issue 4, p412
Programmed cell death (apoptosis) seems to be the principal mechanism whereby anti-oncogenic therapies such as chemotherapy and radiation effect their responses. Resistance to apoptosis, therefore, is probably a principal mechanism whereby tumors are able to overcome these cancer therapies. The...
- T cells require TRAIL for optimal graft-versus-tumor activity.
Schmaltz, Cornelius; Alpdogan, Onder; Kappel, Barry J.; Muriglan, Stephanie J.; Rotolo, Jimmy A.; Ongchin, Jennifer; Willis, Lucy M.; Greenberg, Andrew S.; Eng, Jeffrey M.; Crawford, James M.; Murphy, George F.; Yagita, Hideo; Walczak, Henning; Peschon, Jacques J.; van den Brink, Marcel R.M. // Nature Medicine; Dec2002, Vol. 8 Issue 12, p1433
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that exhibits specific tumoricidal activity against a variety of tumors. It is expressed on different cells of the immune system and plays a role in natural killer cell�mediated tumor...
- Correction regarding Adalimumab Labelling.
Spencer-Green, George // Clinical Infectious Diseases; 10/15/2004, Vol. 39 Issue 8, p1257
Presents a correction to the article "Granulomatous Infections Due to Tumor Necrosis Factor Blockade."
- Distinct molecular mechanism for initiating TRAF6 signalling.
Hong Ye; Arron, Joseph R.; Lamothe, Betty; Cirilli, Maurizio; Kobayashi, Takashi; Shevde, Nirupama K.; Segal, Deena; Dzivenu, Oki K.; Vologodskaia, MAsha; Mijung Yim; Khoi Du; Sujay Singh; Pike, J. Wesley; Darnay, Bryant G.; Yongwon Choi; Hao Wu // Nature; 7/25/2002, Vol. 418 Issue 6896, p443
Presents a study that reported crystal structures of tumor-necrosis factor receptor-associated factor 6 (TRAF6) to gain insight into the mechanism by which TRAF6 mediates several signalling cascades. Description and importance of TRAF6; Reason for the expected low affinity between TRAF6 and...
- Tumour necrosis factor.
Malik, Saleem; Balkwill, Frances R. // British Medical Journal (Clinical Research Edition); 4/30/1988, Vol. 296 Issue 6631, p1214
Details the production and mechanism of tumor necrosis factor. Role as mediators of immunity and inflammation; Result of high levels of biologically active tumor necrosis factors; Exploration on potential role in treating cancer.
- The death of a T-cell: expression of the CD95 ligand.
Li-Weber, M.; Krammer, P.H. // Cell Death & Differentiation; Feb2002, Vol. 9 Issue 2, p101
Discusses the molecular mechanisms of CD95L activation, a member of the tumor necrosis factor (TNF) receptor. Activation of CD95L through the calcineurin signaling pathway; T-cell receptor (TCR)-mediated expression of CD95L; Role of constitutive transcription factor SP-1.
- C-FLIP efficiently rescues TRAF-2?/? cells from TNF-induced apoptosis.
Guiet, C.; Silvestri, E.; De Smaele, E.; Franzoso, G.; Vito, P. // Cell Death & Differentiation; Feb2002, Vol. 9 Issue 2, p138
For the past 20 years, it has been known that preparations of Tumor Necrosis Factor a (TNF) fail to induce apoptosis due to cytoprotective responses that render cells resistant to its cytotoxic activity. Here we show that TRAF-2[sup -/-] embryonic fibroblasts express reduced levels of the...
Publishers // Current Medicinal Chemistry; 2007, Vol. 14 Issue 8, p953
Current Medicinal Chemistry, 2005, 12 (25), 2923-2924. Contents Tumour Necrosis Factor Alpha Converting Enzyme Guest Editor : David Fairlie This should read Current Medicinal Chemistry, 2005, 12 (25), 2923-2924. Contents Latest Developments in the Treatment of Inflammatory Disease Guest Editor :...
- The incidence and management of infusion reactions to infliximab: a large center experience.
Cheifetz, Adam; Smedley, Michelle; Martin, Sara; Reiter, Monica; Leone, Grace; Mayer, Lloyd; Plevy, Scott // American Journal of Gastroenterology; Jun2003, Vol. 98 Issue 6, p1315
: ObjectiveTo assess the incidence and management of infusion reactions to infliximab, a chimeric monoclonal antibody that targets human tumor necrosis factor-a, in patients with Crohn�s disease treated at a large infusion center.: MethodsA total of 165 consecutive patients who received 479...
- Regulation by Granulocyte-Macrophage Colony-Stimulating Factor and/or Steroids Given In Vivo of Proinflammatory Cytokine and Chemokine Production by Bronchoalveolar Macrophages in Response to Aspergillus Conidia.
Brummer, Elmer; Kamberi, Marika; Stevens, David A. // Journal of Infectious Diseases; 2/15/2003, Vol. 187 Issue 4, p705
Production of the proinflammatory cytokines interleukin(IL) -- 1a and tumor necrosis factor (TNF) -- a and of the chemotactic chemokine macrophage inflammatory protein (MIP) -- 1a by bronchoalveolar macrophages (BAMs) from mice in response to Aspergillus conidia was tested after in vivo...
- Antisense targets Fas.
Jamison, Judy // Nature Biotechnology; Aug2000, Vol. 18 Issue 8, p814
Discusses that Fas is a member of the tumor necrosis family of proteins and has been implicated in an array of human diseases.
Jamison, Judy // Encyclopedic Reference of Molecular Pharmacology; 2004, p911
An encyclopedia entry for "TNS" is presented, which refers to tumor necrosis factor.
- Death and decoy receptors and p53-mediated apoptosis.
Sheikh, M S; Fornace, A J // Leukemia (08876924); Aug2000, Vol. 14 Issue 8, p1509
Recently, several tumor necrosis factor receptor 1 (TNF-R1) and Fas-related death receptors have been discovered and include DR3, DR4, DR5 and DR6. These receptors contain an extracellular region containing varying numbers of cysteine-rich domains and an intracellular region that contains the...
- Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFa gene.
Smith, Robert M.; Suleman, Naushaad; McCarthy, Joy; Sack, Michael N. // Cardiovascular Research; Aug2002, Vol. 55 Issue 3, p553
Objective: Tumor necrosis factor alpha (TNFa) is known to mimic ischemic preconditioning (IP). However, it is not known whether TNFa-preconditioning is mediated by �established� preconditioning signaling or via novel signaling cascades. Moreover, whether TNFa is required to induce the...
- Asbestos fibres and man-made mineral fibres: induction and release of tumour necrosis factor-a from rat alveolar macrophages
Tagesson, C.; Ljungman, A. G.; Lindahl, M. // Occupational & Environmental Medicine; Nov1994, Vol. 51 Issue 11, p777
No abstract available.
- Microbiologic Findings and Correlations with Serum Tumor Necrosis Factor-alpha in Patients with Severe Sepsis and Septic Shock.
Cohen, Jonathan; Abraham, Edward // Journal of Infectious Diseases; 7/1/99, Vol. 180 Issue 1, p116
Analyzes the microbiology of sepsis and its relationship with tumor necrosis factor (TNF)-alpha. Isolates commonly derived from sepsis; Anaerobes isolated in pure culture; TNF-alpha levels in patients with pure gram-negative infection and those with pure gram-positive or mixed infection.
- Silicone Granuloma Management.
Guttman, Cheryl // Dermatology Times; May2003, Vol. 24 Issue 5, p75
Focuses on the use of tumor necrosis factor inhibitors in silicone granuloma management. T-cell activation; Infectious processes and elevated levels of tumor necrosis factor-alpha.
- TNF AND MURINE CEREBRAL MALARIA.
Clark, I. A.; Rockett, K. A.; Cowden, W. B. // Immunology & Cell Biology; Dec1990 Supplement 1, Vol. 68, p3
Presents an abstract of the article "TNF and Murine Cerebral Malaria," by I. A. Clark, published in the December 2, 1990 issue of the journal “Immunology & Cell Biology.”
- Transgenic TNF-α Causes Apoptosis in Epidermal Keratinocytes After Subcutaneous Injection of TNF-α DNA Plasmid.
Xianmin Meng; Sawamura, Daisuke; Baba, Takako; Ina, Shinsuke; Itai, Koji; Tamai, Katsuto; Hanada, Katsumi; Hashimoto, Isao // Journal of Investigative Dermatology; Nov99, Vol. 113 Issue 5, p0
Examines the biologic effect of transgenic tumor necrosis factor(TNF)-alpha in epidermal keratinocytes. Construction of human TNF-alpha expression plasmid; Injection of phTNF-alpha.
- Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing.
Mohler, Kendall M.; Sleath, Paul R. // Nature; 7/21/1994, Vol. 370 Issue 6486, p218
Describes a potent inhibitor of tumor necrosis factor processing and analyzes its ability to protect mice from a lethal dose of endotoxin. Biological activities of forms of tumor necrosis factor and lymphotoxin-alpha; Determination of tumor necrosis factor's mechanistic class; Metalloprotease...
- Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
Moss, Marcia L.; Jin, S.-L. Catherine // Nature; 2/20/1997, Vol. 385 Issue 6618, p733
Reports the purification of a tumor-necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE) and the cloning of its complementary DNA. The status of TACE as a membrane-bound disintegrin metalloproteinase; The results of structural comparisons with other disintegrin-containing enzymes.
- Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF...
Erickson, Sharon L.; de Sauvage, Frederic J. // Nature; 12/8/1994, Vol. 372 Issue 6506, p560
Clarifies the physiological role of tumor necrosis factor cell surface receptor TNF-R2 in mice. Review of related literature; Use of gene targetting; Defects in the immune response.
- A death-domain-containing receptor that mediates apoptosis.
Kitson, Jeremy; Raven, Thomas // Nature; 11/28/1996, Vol. 384 Issue 6607, p372
Reports on the isolation of a 54K receptor that is a new member of the TNFR superfamily. The use of the death domain of TNFR1 in a yeast two-hybrid system; The similarity of the protein WSL-1 to TNFR1; The role of TNFR1 as a cell-surface receptor; The differences with Fas and TNFR1.
Kitson, Jeremy; Raven, Thomas // Taber's Cyclopedic Medical Dictionary (2009); 2009, Issue 21, p2328
A definition of the acronym "TNF," which refers to tumor necrosis factor, is presented.
- Pleiotropy of tumor necrosis factor-a in C2C12 myotubes: in vitro studies on genes, networks and pathways involved in TNF-a induced skeletal muscle atrophy.
Kitson, Jeremy; Raven, Thomas // BMC Bioinformatics; 2010 Supplement 4, Vol. 11, p1
An abstract of the article "Pleiotropy of tumor necrosis factor-a in C2C12 myotubes: in vitro studies on genes, networks and pathways involved in TNF-a induced skeletal muscle atrophy," by Shepali Bhatnagar, Siva K. Panguluri, and Robert F. Lundy is presented.
- The neutrophil migration induced by tumour necrosis factor alpha in mice is unaffected by glucocorticoids.
Cecilio, C. A.; Costa, E. H.; Ucelli, P.; Chaves, C. A. A.; Toffoli, M. C.; Flores, C. A.; Cunha, F. Q.; Ferreira, S. H.; Tamashiro, W. M. S. C. // Mediators of Inflammation; Feb97, Vol. 6 Issue 1, p46
MACROPHAGES harvested from the peritoneal cavities of rats release a neutrophil chemotactic factor (MNCF) in response to stimulation with Gram-negative bacterial lipopolysaccharide (LPS). MNCF has been shown to be active in rats treated with dexamethasone, a glucocorticoid that usually inhibits...
- Effects of acanthoic acid on TNF- alpha gene expression and haptoglobin synthesis.
Kang, H-S.; Song, H. K.; Lee, J-J.; Pyun, K-H.; Choi, I. // Mediators of Inflammation; Aug98, Vol. 7 Issue 4, p257
TUMOUR necrosis factor- alpha (TNF- alpha ) is a major proinflammatory cytokine inducing the synthesis and release of many inflammatory mediators. It is involved in immune regulation, autoim mune diseases, and inflammation. Our previous study demonstrated that acanthoic acid, (-)-pimara-9(11),...
- Serum IL-1� , sIL-2R, IL-6, IL-8 and TNF-a in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment.
Erbagcica, Aysc�e Binnur; Herken, Hasan; K�yl�oglu, Oya; Yilmaz, Necat; Tarak�ioglu, Mehmet // Mediators of Inflammation; Jun2001, Vol. 10 Issue 3, p109
Activation of the inflammatory response system and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. Psychopharmacologic agents can differentially effect cytokine production, which suggests that therapeutic function of neuroleptics may involve...
- Clinical research helps elucidate the role of tumor necrosis factor-a in the pathogenesis of T[sub 1]-mediated immune disorders: use of targeted immunotherapeutics as pathogenic probes.
Gottlieb, A B // Lupus; 2003, Vol. 12 Issue 3, p190
Psoriasis is a life-disabling disorder in which 8-10% of patients aged 18-54 actively contemplate suicide because of their disease. Owing to the toxicity and/or inconvenience of current, FDAapproved treatments far moderate-to-severe psoriasis, they are generally used intermittently so that...
- The Effects of Intrapleural Polyclonal Anti-Tumor Necrosis Factor alpha (TNFa) Fab Fragments on Pleurodesis in Rabbits.
Cheng, D.-S.; Rogers, J.; Wheeler, A.; Parker, R.; Teixeira, L.; Light, R. W. // Lung; 2000, Vol. 178 Issue 1, p19
Abstract. The mechanism by which various agents produce a pleurodesis is unknown. The purpose of this project was to determine whether the pleurodesis that results from the intrapleural administration of talc or doxycycline depends on tumor necrosis factor alpha (TNF alpha. In a randomized,...
- Synthesis of mini-proinsulin precursors using N-termini of human TNF a as fusion partners in recombinant Escherichia coli.
Shin, C S; Hong, M S; Kim, D Y; Lee, J; Park, Y-H // Journal of Industrial Microbiology & Biotechnology; Mar99, Vol. 22 Issue 3, p176
Synthesis of human mini-proinsulin precursors was investigated in controlled fed-batch cultures at high cell concentrations of recombinant Escherichia coil Transcription of the recombinant gene was controlled by a T7 promoter system. The human mini-proinsulin was prepared by substituting a...
- The Role of TNF and Its Family Members in Inflammation and Cancer: Lessons from Gene Deletion.
B. B. Aggarwal; S. Shishodia; K. Ashikawa; Alok C. Bharti // Current Drug Targets - Inflammation & Allergy; Dec2002, Vol. 1 Issue 4, p327
Almost two decades ago, tumor necrosis factor (TNF) was identified as a protein produced by the immune system that played a major role in suppression of tumor cell proliferation. Extensive research since then has revealed that TNF is a major mediator of inflammation, viral replication, tumor...
- Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway.
Gommerman, Jennifer L.; Mackay, Fabienne; Donskoy, Elina; Meier, Werner; Martin, Pauline; Browning, Jeffrey L. // Journal of Clinical Investigation; 11/1/2002, Vol. 110 Issue 9, p1359
Reports on a study performed on cynomolgus monkeys to test the effects of lymphotoxin-� receptor-immunoglobulin treatment. Methods; Results; Discussion.
- Defective TNF-a-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice.
Garcia-Ruiz, Carmen; Colell, Anna; Mari, Montserrat; Morales, Albert; Calvo, Maria; Enrich, Carlos; Fernandez-Checa, Jose C. // Journal of Clinical Investigation; 1/15/2003, Vol. 111 Issue 2, p197
Presents a study which addressed the contribution of acidic sphingomyelinase in tumor necrosis factor (TNF)-a-mediated hepatocellular apoptosis. Background on TNF-a; Methodology; Results of the study.
- Regarding "Diagnosis of Deep Venous Thrombosis by Use of Soluble Necrosis Factor Receptor"
Hirose, Hitoshi // Angiology; Jan1999, Vol. 50 Issue 1, p85
Presents a letter to the editor about the study of tumor necrosis factor in patients with deep vein thrombosis.
- Regarding "Diagnosis of Deep Venous Thrombosis by Use of Soluble Necrosis Factor Receptor"
Taheri, Syde A. // Angiology; Jan1999, Vol. 50 Issue 1, p85
Presents a letter to the editor in response to the article "Diagnosis of deep venous thrombosis by use of soluble tumor necrosis factor receptor" that was publishes in the January 1999 issue of "Angiology."
- Tumor Necrosis Factor (TNF)-alpha-Induced Interleukin-8 in Human Blood Cultures Discriminates Neutralization by the p55 and p75 TNF Soluble Receptors.
Frishman, Jordan I.; Edwards III, Carl K.; Sonnenberg, Michael G.; Kohno, Tadahiko; Cohen, Arthur M.; Dinarello, Charles A. // Journal of Infectious Diseases; 12/1/2000, Vol. 182 Issue 6
The dose-dependent increase in mortality in patients with sepsis who are treated with tumor necrosis factor (TNF) p75 soluble receptor Fc conjugate (p75-Fc) remains unexplained. In this study, neutralization of TNF-alpha-induced interleukin (IL)-8 by p75-Fc in whole human blood exhibited a...
- Plasma Levels of Soluble CD14 and Tumor Necrosis Factor-alpha Type II Receptor Correlate with Cognitive Dysfunction during Human Immunodeficiency Virus Type 1 Infection.
Ryan, Lisa A.; Zheng, Jialin; Brester, Michelle; Bohac, Daryl; Hahn, Francis; Anderson, James; Ratanasuwan, Winal; Gendelman, Howard E.; Swindells, Susan // Journal of Infectious Diseases; 9/15/2001, Vol. 184 Issue 6, p699
The relationship between monocyte immune responses and cognitive impairment during progressive human immunodeficiency virus type 1 (HIV-1) infection was investigated in 28 subjects receiving highly active antiretroviral therapy. The mean � SEM CD4[sup +] T lymphocyte count and virus load for...
- The Role of Endogenous Interleukin (IL)--18, IL-12, IL-1b,andTumor Necrosis Factor--a in the Production of Interferon-g Induced by Candida albicans in Human Whole-Blood Cultures.
Netea, Mihai G.; Stuyt, Rogier J.L.; Soo-Hyun Kim; Van der Meer, Jos W.M.; Kullberg, Bart Jan; Dinarello, Charles A. // Journal of Infectious Diseases; 4/1/2002, Vol. 185 Issue 7, p963
Despite the importance of interferon (IFN)--g, tumor necrosis factor (TNF), and interleukin (IL)--18 for host defense against candidiasis, the pathways leading to their stimulation by Candi-da albicans are unclear. In a whole-blood model, IL-18 neutralization by IL-18 binding protein ...
- Delayed Clearance of Intraabdominal Abscesses Caused by Candida albicans in Tumor Necrosis Factor-a-and Lymphotoxin-a-Deficient Mice.
Vonk, Alieke G.; Netea, Mihai G.; van Krieken, Johan H.; van der Meer, Jos W.M.; Kullberg, Bart Jan // Journal of Infectious Diseases; 12/15/2002, Vol. 186 Issue 12, p1815
The role of endogenous tumor necrosis factor-a (TNF) and lymphotoxin-a (LT) in a model of intraabdominal Candida sepsis and abscess formation was investigated. Significantly more abscesses were observed in TNF/LT double knockout (TNF[sup -/-]LT[sup -/-]) mice, compared with that in wild-type...