Citations with the tag: RECTUM -- Cancer -- Treatment

Results 1 - 44

  • A quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis of adjuvant radiation...
    Gelber, Richard D.; Goldhirsch, Aron // JNCI: Journal of the National Cancer Institute; 08/07/96, Vol. 88 Issue 15, p1039 

    Focuses on the improvement of survival rates for rectal cancer patients receiving adjuvant radiation therapy and chemotherapy following surgery. Assessment of toxic effects of cancer treatment; Analysis standards used to determine treatment success.

  • Preoperative Chemoradiation and Coloanal J Pouch Reconstruction for Low Rectal Cancer.
    Chaudhry, Vivek; Nittala, Murali; Prasad, Madhava L. // American Surgeon; Apr2000, Vol. 66 Issue 4, p387 

    Our objective was to determine clinical outcomes of treatment of low rectal adenocarcinoma with neoadjuvant chemoradiation, rectal excision, and coloanal J pouch reconstruction. A retrospective review of 69 patients with stage B2 or higher lesions was performed. Preoperative chemoradiation was...

  • Calcium supplementation and rectal mucosal proliferation: A randomized controlled trial.
    Baron, John A.; Tosteson, Tor D. // JNCI: Journal of the National Cancer Institute; 9/6/95, Vol. 87 Issue 17, p1303 

    Examines the effect of calcium supplementation on rectal mucosal proliferation in humans. Absence of effect of calcium supplementation on rectal mucosal proliferation; Insufficiency of evidence for the anticarcinogenic effect of calcium.

  • Colorectal carcinoma in patients 30 years of age and younger.
    McGahren III, Eugene D.; Mills, Stacey E. // American Surgeon; Jan1995, Vol. 61 Issue 1, p78 

    Studies the treatment of colorectal cancer in patients aged 30 years or younger at the University of Virginia Health Sciences Center. Physical findings; Onset of symptoms; Precancerous conditions; Surgical interventions.

  • Optimising Treatment for Resectable Rectal Cancer: Is Preoperative Therapy Beneficial?
    Ngan, S.Y.K. // Drugs & Aging; 2001, Vol. 18 Issue 2, p79 

    Preoperative radiotherapy is becoming the standard of care for resectable locally advanced adenocarcinoma of the rectum. Its practice is no longer limited to a few specialised cancer centres. Adjuvant preoperative radiotherapy can reduce the risk of local recurrence by 50% compared with surgery...

  • Radiation therapy plus surgery extended OS in metastatic rectal cancer.
    Ngan, S.Y.K. // Hem/Onc Today; 1/10/2014, Vol. 15 Issue 1, p8 

    The article discusses the study that found longer survival in patients with primary rectal or rectosigmoid tumors, who were treated with pelvic radiation therapy and surgery compared to those treated with surgery alone, a treatment commonly used in patients with rectosigmoid tumors.

  • Accelerated hyperfractionation field-involved re-irradiation combined with concurrent capecitabine chemotherapy for locally recurrent and irresectable rectal cancer.
    Sun, D.-S.; Zhang, J.-D.; Li, L.; Y. Dai; Yu, J.-M.; Shao, Z.-Y. // British Journal of Radiology; Mar2012, Vol. 85 Issue 1011, p259 

    Objectives: To evaluate the efficacy and treatment-related toxicity of accelerated hyperfractionation field-involved re-irradiation combined with concurrent capecitabine chemotherapy for locally recurrent and irresectable rectal cancer (LRIRC). Methods: 72 patients with LRIRC who underwent the...

  • Evaluation of the learning curve in laparoscopic low anterior resection for rectal cancer.
    Kayano, Hajime; Okuda, Junji; Tanaka, Keitaro; Kondo, Keisaku; Tanigawa, Nobuhiko // Surgical Endoscopy; Sep2011, Vol. 25 Issue 9, p2972 

    Background: Laparoscopic low anterior resection for rectal cancer is considered to be more technically demanding than laparoscopic colectomy. This study aimed to analyze the learning curve for laparoscopic low anterior resection and to identify the factors that influence this learning curve....

  • Lokale Diagnostik beim Rektumkarzinom.
    Ptok, H.; Gastinger, I.; Lippert, H. // Der Chirurg; May2012, Vol. 83 Issue 5, p448 

    Accurate pretherapeutic staging of rectal cancer is crucial for further therapeutic management and important for prognosis. The most accurate diagnostic tools in the assessment of T and N categories of rectal cancer are endorectal ultrasound (EUS) and magnetic resonance imaging (MRI)....

  • Pathologisches Staging und Response-Evaluation beim Rektumkarzinom.
    Wittekind, C.; Oberschmid, B // Der Chirurg; May2012, Vol. 83 Issue 5, p423 

    The application of so-called neoadjuvant therapy may induce changes in tumor tissues that have to be determined concerning the degree of severity (regression grading) and which also influence pathological staging. The extent of morphological changes (response) to be evaluated ranges from...

  • Valor pronóstico de la respuesta patológica a la radioquimioterapia preoperatoria en el cáncer de recto bajo localmente avanzado.
    BANNURA C., GUILLERMO; VARGAS N., CLAUDIO; BARRERA E., ALEJANDRO; MELO L., CARLOS; ILLANES F., FELIPE // Revista Chilena de Cirugia; jun2013, Vol. 65 Issue 3, p236 

    Background: Preoperative chemo radiotherapy improves the prognosis of locally advanced low rectal cancer and induces a pathological response in the tumor, which may have prognostic value. Aim: To assess the results of rectal cancer treatment according to the degree of pathological response of...

  • A deterministic model for estimating the reduction in colorectal cancer incidence due to endoscopic surveillance.
    Cafferty, Fay H.; Sasieni, Peter D.; Duffy, Stephen W. // Statistical Methods in Medical Research; Apr2009, Vol. 18 Issue 2, p163 

    There is evidence that the removal of adenomas, by endoscopy, from the large bowel can prevent the occurrence of colorectal cancer (CRC). However, the reduction in cancer incidence due to endoscopic surveillance is difficult to estimate. Studies of cohorts of adenoma patients typically rely on...

  • Rectal Cancer Treatment and Survival -Comparison of Two 5 - Year Time Intervals.
    Krebs, Bojan; Koželj, Miran; Potrč, Stojan // Collegium Antropologicum; Jun2012, Vol. 36 Issue 2, p419 

    In last two decades there was a huge step forward concerning rectal cancer treatment. The aim of our study was comparison of two time intervals regarding the methods of treatment and results of radical rectal cancer surgery. 407 patients operated on for rectal cancer were included in study....

  • Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization.
    Choi, So-young; Jang, Jun; Kim, Kyung // Clinical & Experimental Medicine; Dec2011, Vol. 11 Issue 4, p219 

    The existence and treatment of rectal cancer are important for the function of defecation and the quality of life. However, the precise mechanisms of rectal carcinogenesis remain unclear. To screen the overexpressed gene in rectal carcinoma, we performed suppressive subtractive hybridization...

  • Laparoscopic total mesorectal excision.
    Khanna, A. // Techniques in Coloproctology; Feb2013 Supplement, Vol. 17, p41 

    This article describes the operative technique that my colleagues and I apply to total mesorectal excision in patients with rectal cancer. A body of data support improvement of short-term outcomes over open resection. Although long-term data remain scarce, several ongoing trials may clarify this...

  • Robotic total mesorectal excision: operative technique and review of the literature.
    Kim, S.; Kwak, J. // Techniques in Coloproctology; Feb2013 Supplement, Vol. 17, p47 

    In recent years, an increasing number of reports have been published on robotic colorectal surgery; this modality has also garnered an increasing amount of attention from the colorectal society. Most of the interest has been in robotic total mesorectal excision (TME) for rectal cancer. The...

  • A phase II study of oxaliplatin with 5-FU/folinic acid and concomitant radiotherapy as a preoperative treatment in patients with locally advanced rectal cancer.
    Chitapanarux, I.; Chitapanarux, T.; Tharavichitkul, E.; Mayurasakorn, S.; Siriwittayakorn, P.; Yamada, S.; Lorvidhaya, V. // Biomedical Imaging & Intervention Journal; Oct-Dec2011, Vol. 7 Issue 4, p1 

    Objective: To evaluate the activity and safety of adding oxaliplatin to a standard chemoradiotherapy schema, including 5-fluorouracil (5-FU)/folinic acid (FA), in locally-advanced rectal cancer (LARC). Methods: Two cycles of oxaliplatin 130 mg/m2 plus FA 20 mg/m2 bolus for 5 days and 5-FU 350...

  • Prognostic Significance of the Lymph Node Ratio Regarding Recurrence and Survival in Rectal Cancer Patients Treated with Postoperative Chemoradiotherapy.
    Ji-Yoon Kim; Su-Mi Chung; Byung-Ock Choi; In-Kyu Lee; Chang-Hyeok An; Jong-Man Won; Mi-Ryeong Ryu // Gut & Liver; Apr2012, Vol. 6 Issue 2, p203 

    Background/Aims: To evaluate the prognostic impact of the lymph node ratio (LNR: the ratio of positive lymph nodes to the total number of lymph nodes examined) on disease recurrence and survival among rectal cancer patients who received curative surgery and postoperative chemoradiotherapy (CRT)....

  • Neo adjuvant chemo-radiotherapy and rectal cancer: Can India follow the West?
    Bansal, Vivek; Bhutani, Ritu; Doval, Dinesh; Kumar, Kapil; Pande, Pankaj; Kumar, Gaurav // Journal of Cancer Research & Therapeutics; Apr-Jun2012, Vol. 8 Issue 2, p209 

    Aims: The management of locally advanced rectal cancer has changed over the years with an emphasis on neoadjuvant chemo radiation therapy (CT-RT) followed by surgery. This study is undertaken to evaluate the efficacy of this treatment in our set of patients with a special focus on the outcome in...

  • TREATMENT OF RECTAL CARSINOID TUMOR BY ENDOSCOPIC SUBMUCOZAL RESECTION WITH A LIGATION DEVICE; A CASE REPORT.
    Demir, Mehmet; Gokturk, Huseyin Savas; Ozturk, Nevin Akcaer; Akkaya, Didem; Serin, Ender; Yilmaz, Ugur // Anatolian Journal of Clinical Investigation; 2010, Vol. 4 Issue 1, p44 

    Rectal carcinoid tumors smaller than 1 cm in diameter can be successfully treated by local excision, such as that using endoscop, because they infrequently metastasize. We report on a patient with rectal carcinoid tumour, who was treated successfully by endoscopic submucosal resection with a...

  • Bedeutung der Schnittbildverfahren für das Staging des Rektumkarzinoms.
    Schäfer, A.O.; Langer, M.; Baumann, T. // Der Chirurg; May2012, Vol. 83 Issue 5, p439 

    The ongoing diversification of treatment strategies for rectal cancer justifies the demand for highly specialized radiological imaging. Currently, numerous studies have underlined the ability of magnetic resonance imaging (MRI) to determine those parameters that are critical for therapeutic...

  • Radiological imaging of rectal cancer.
    Lincender-Cvijetić, Lidija; Banjin-Čardžić, Maja; Vegar-Zubović, Sandra; Vrcić, Dunja // Acta Medica Academica; 2012, Vol. 41 Issue 2, p199 

    This article discusses the possibilities of diagnosing abdominal imaging in patients with rectal cancer, detecting lesions and assessing the stage of the lesions, in order to select the appropriate therapy. Before the introduction of imaging technologies, the diagnosis of colorectal pathology...

  • Perineal Rectosigmoidectomy for Rectal Prolapse Secondary to Rectal Cancer: A Case Report and Literature Review.
    Rawin Ingsirorat // Thai Journal of Surgery; Oct-Dec2012, Vol. 33 Issue 4, p142 

    We report here an 83-year-old woman presented with severe degree of rectal prolapse secondary to rectal cancer. She underwent perineal rectosigmoidectomy to correct rectal prolapse and also to treat rectal cancer. The result was good with free surgical margins and good sphincter function. This...

  • Preoperative Concurrent Chemoradiotherapy for Locally Advanced Rectal Cancer: Treatment Outcomes and Analysis of Prognostic Factors.
    Moonkyoo Kong; Seong Eon Hong; Woo Suk Choi; Si-Young Kim; Jinhyun Choi // Cancer Research & Treatment; Jun2012, Vol. 44 Issue 2, p104 

    Purpose This study was designed to investigate the long-term oncologic outcomes for locally advanced rectal cancer patients after treatment with preoperative concurrent chemoradiotherapy followed by total mesorectal excision, and to identify prognostic factors that affect survival and pathologic...

  • Interval between Surgery and Radiation Therapy Is an Important Prognostic Factor in Treatment of Rectal Cancer.
    Jin Hee Kim; Sang Jun Byun; Seung Gyu Park; Young Kee Oh; Seong Kyu Baek // Cancer Research & Treatment; Sep2012, Vol. 44 Issue 3, p187 

    Purpose The purpose of this study is to evaluate survival and prognostic factors for rectal cancer, including interval between surgery and radiation therapy after surgery, radiation therapy, and chemotherapy. Materials and Methods We conducted a retrospective study of 153 patients with rectal...

  • Dosimetric impact of inter-observer variability for 3D conformal radiotherapy and volumetric modulated arc therapy: the rectal tumor target definition case.
    Lobefalo, Francesca; Bignardi, Mario; Reggiori, Giacomo; Tozzi, Angelo; Tomatis, Stefano; Alongi, Filippo; Fogliata, Antonella; Gaudino, Anna; Navarria, Piera; Cozzi, Luca; Scorsetti, Marta; Mancosu, Pietro // Radiation Oncology; 2013, Vol. 8 Issue 1, p1 

    Background: To assess the dosimetric effect induced by inter-observer variability in target definition for 3D-conformal RT (3DCRT) and volumetric modulated arc therapy by RapidArc (RA) techniques for rectal cancer treatment. Methods: Ten patients with rectal cancer subjected to neo-adjuvant RT...

  • EVALUAREA RÄ‚SPUNSULUI LA TRATAMENTUL NEOADJUVANT ÃŽN CANCERUL DE RECT JOS SITUAT, LOCAL AVANSAT. EXPERIENÅ¢A UNEI SINGURE ECHIPE CHIRURGICALE.
    Aniței, Maria-Gabriela; Scripcariu, V. // Jurnalul de Chirurgie; 2013, Vol. 9 Issue 1, p35 

    BACKGROUND: The gold standard in low rectal cancer today is a multimodal approach, tailored for each patient. AIM: The aim of this study was to evaluate the histopathological tumor response after long term neoadjuvant chemoradiation in locally advanced rectal cancer and the possibilities of...

  • Laparoscopic rectal surgery in the elderly: clinical outcomes compared to open surgery.
    Amato, Bruno; Compagna, Rita; Coretti, Guido; Vigliotti, Gabriele; Rocca, Aldo; Fappiano, Francesca; Rossi, Roberto; Amato, Maurizio; Serra, Raffaele; Aprea, Giovanni // BMC Surgery; 2013, Vol. 13 Issue Suppl 1, p1 

    An abstract of the article "Laparoscopic rectal surgery in the elderly: clinical outcomes compared to open surgery" by Bruno Amato, Rita Compagna, Guido Coretti, Gabriele Vigliotti, Aldo Rocca, Francesca Fappiano, Roberto Rossi, Maurizio Amato, Rafael Serra, and Giovanni Aprea is presented.

  • Drug shortage broaches ethics of buying in excess.
    Thompson, Cheryl A.. // American Journal of Health-System Pharmacy; 4/1/2009, Vol. 66 Issue 7, p610 

    The article focuses on the effect of leucovorin calcium injection shortage in the health care industry. It states that the shortage affect the treatment for colon and rectal cancer for both diseases require the use of leucovorin. It also notes that the shortage result for the rise of quality and...

  • Respuesta patológica completa en pacientes sometidos a neoadyuvancia en cáncer de recto.
    DANIELLA ESPÍNOLA, M.; MARÍA E. MOLINA, P.; FELIPE BELLOLIO, R.; JOSÉ GELLONA, V.; MARIZA BUSTOS, C.; ÁLVARO ZÚÑIGA, D. // Revista Chilena de Cirugia; Aug2013, Vol. 65 Issue 4, p333 

    Background: The standard treatment of locally advanced rectal cancer (RC) of the middle and lower third of the rectum is neoadjuvant chemoradiotherapy (XRQT) follow by oncologic resection. After this treatment in 15-25% of the cases, the pathologist reports complete pathological response (pCR)....

  • Complete Response of Para-Aortic and Lateral Pelvic Lymph Node Recurrence of Rectal Cancer Treated to S-1 Monotherapy.
    Miyazawa, Tomonori; Koide, Norihiko; Fujita, Nobuhiro // World Journal of Oncology; 2013, Vol. 4 Issue 1, p46 

    This report presents a case of para-aortic and lateral pelvic lymph node recurrence of rectal cancer that showed complete response to S-1 monotherapy. A 69-year-old man underwent low anterior resection for rectal cancer in 2007. Para-aortic lymph and right lateral pelvic lymph node recurrence...

  • Individualisierung von Leitlinien.
    Eismann, N.; Emmermann, A.; Zornig, C. // Der Chirurg; Feb2014, Vol. 85 Issue 2, p125 

    Background: The German guidelines for the therapy of rectal carcinoma in Union Internationale Contre le Cancer (UICC) stages II and III raise questions of overtherapy. This is why we have individualized the therapy in suitable isolated cases (localization in the upper third of the rectum and...

  • Oncologic superiority of extralevator abdominoperineal excision for low rectal cancer.
    Lukić, Dejan; Radovanović, Zoran; Petrović, Tomislav; Breberina, Milan; Golubović, Andrija; Škoric-Jokić, Svetlana // Archive of Oncology; 2013, Vol. 21 Issue 1, p11 

    Background: Rectal cancer treatment has been dramatically improved during the last two decades in terms of a lower local recurrence rate and prolonged survival. This improvement was achieved mainly due to a better surgical technique (implementation of a total mesorectal excision-TME) and...

  • Primary Rectal Malignant Melanoma-Case Report.
    Gavriilidis, P.; Moula, E.; Nikolaidou, A. // Hippokratia; 2013, Vol. 17 Issue 4, p380 

    Introduction: Primary malignant melanoma that arises from the true anatomic rectal mucosa is extremely rare. Case report: An endoscopic investigation of a 79-year-old woman with long history of tenesmus and rectal bleeding revealed posterior fleshy mass 4.5 cm from the anal verge. Biopsies...

  • Microarray-based Classification of Histopathologic Responses of Locally Advanced Rectal Carcinomas to Neoadjuvant Radiochemotherapy Treatment.
    YAHYA, Waheed Babatunde; ROSENBERG, Robert; ULM, Kurt // Turkiye Klinikleri Journal of Biostatistics; 2014, Vol. 6 Issue 1, p8 

    Objective: This paper aims to present preoperative prediction of responses of locally advanced rectal cancer (LARC) patients to neoadjuvant radiochemotherapy (NRC) treatments using their gene expression profiles. Materials and Methods: Expression profiles of 24,026 genes were generated on 43...

  • Current status of intensified neo-adjuvant systemic therapy in locally advanced rectal cancer.
    Engels, Benedikt; Gevaert, Thierry; Sermeus, Alexandra; De Ridder, Mark // Frontiers in Oncology; May2012, Vol. 2, p1 

    The addition of 5-fluorouracil (5-FU) or its prodrug capecitabine to radiotherapy (RT) is a standard approach in the neo-adjuvant treatment of patients with rectal tumors extending beyond the muscularis propria (stage II) and/or with clinical evidence of regional lymph node metastases (stage...

  • Retrospective Study on the Effect of Preoperative Versus Postoperative Chemoradiation for Rectal Carcinoma.
    Sirikurnpiboon, Siripong; Surabenjawong, Supakade; Laosunthornsiri, Viroj; Awapittaya, Burin // Thai Journal of Surgery; Apr-Jun2012, Vol. 33 Issue 2, p47 

    Background: In the present, there are two types of giving radiotherapy together with chemotherapy for treatment of rectal carcinoma: neoadjuvant chemoradiation (CRT) and adjuvant CRT. A study conducted overseas has found that patients given neoadjuvant CRT had better disease-free survival rate...

  • A phase II study of neoadjuvant bevacizumab plus capecitabine and concomitant radiotherapy in patients with locally advanced rectal cancer.
    Gasparini, Giampietro; Torino, Francesco; Ueno, Takayuki; Cascinu, Stefano; Troiani, Teresa; Ballestrero, Alberto; Berardi, Rossana; Shishido, Junichi; Yoshizawa, Akihiko; Mori, Yukiko; Nagayama, Satoshi; Morosini, Paola; Toi, Masakazu // Angiogenesis; Mar2012, Vol. 15 Issue 1, p141 

    Purpose: To assess safety and activity of neoadjuvant bevacizumab, capecitabine and standard radiotherapy in locally advanced rectal cancer as well as potential predictive biomarkers. Patients and methods: The multicentric phase II study enrolled 43 patients who received bevacizumab infusion (5...

  • RECURENÅ¢A LOCALÄ‚ DUPÄ‚ EXICIZIA TOTALÄ‚ DE MEZORECT -- O PROBLEMÄ‚ DE ACTUALITATE.
    Lozneanu, Lili-Gabriela; Dimofte, G.; Nicolescu, Simona; Boboc, V.; Tarcoveanu, E. // Jurnalul de Chirurgie; 2011, Vol. 7 Issue 3, p359 

    Background: Despite the major improvements that have been made in both surgical technique and adjuvant radio(chemo)-therapy, local recurrence still remains a challenge and is difficult to treat. The introduction of total mesorectal excision (TME) has increased the patient's outcome. Methods: By...

  • CTC AND MRI ASSESSMENT OF LOCAL TUMOUR STAGING OF THE RECTAL CARCINOMA.
    Sofić, Amela; Bešlić, Šerif; Husić-Selimović, Azra; Đuran, Aleksandra; Eminagić, Đenana; Gogov, Bisera; Banjin, Maja // Medical Journal; jul-sep2013, Vol. 19 Issue 3, p212 

    TNM staging was introduced in 1987 by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (IUCC) and is based on the following criteria: depth of a primary local tumour invasion (T), presence of nodal metastases (N), and existence of distant metastases. The...

  • Is adjuvant radiotherapy warranted in resected pT1-2 node-positive rectal cancer?
    Junjie Peng; Xinxiang Li; Ying Ding; Debing Shi; Hongbin Wu; Sanjun Cai // Radiation Oncology; 2013, Vol. 8 Issue 1, p1 

    Background Stage T1-2 rectal cancers are unlikely to have lymph node metastases and neoadjuvant therapy is not routinely administered. Postoperative management is controversial if lymph node metastases are detected in the resected specimen. We studied the outcomes of patients with pT1-2...

  • Patterns of Pelvic Radiotherapy in Patients with Stage II/III Rectal Cancer.
    Fitzgerald, Timothy L.; Zervos, Emmanuel; Wong, Jan H. // Journal of Cancer Epidemiology; 2013, p1 

    High-level evidence supports adjuvant radiotherapy for rectal cancer. We examined the influence of sociodemographic factors on patterns of adjuvant radiotherapy for resected Stage II/III rectal cancer. Methods. Patients undergoing surgical resection for stage II/III rectal cancer were identified...

  • A predictive genetic signature for response to fluoropyrimidine-based neoadjuvant chemoradiation in clinical Stage II and III rectal cancer.
    Chan, Jason; Kinsella, Michael T.; Willis, Joseph E.; Hu, Huankai; Reynolds Jr, Harry; Delaney, Conor; McCulla, Andrea; Deharo, Steve; Ahdesmäki, Miika; Allen, Wendy Louise; Johnston, Patrick G.; Kinsella, Timothy J. // Frontiers in Oncology; Nov2013, Vol. 3, p1 

    Purpose: Pre-operative chemoradiation (CRT) is currently the standard of care for patients with clinical stage II and III rectal cancer but only about 45% of patients achieve tumor downstaging and <20% of patients achieve a pathologic complete response. Better methods to stratify patients...

  • Predicting the pathologic response of locally advanced rectal cancer to neoadjuvant concurrent chemoradiation using enzyme-linked immunosorbent assays (ELISAs) for biomarkers.
    Yoon, Hong; Koom, Woong; Kim, Yong; Min, Byung; Lee, Kang; Kim, Nam; Shin, Sang; Ahn, Joong; Keum, Ki // Journal of Cancer Research & Clinical Oncology; Mar2014, Vol. 140 Issue 3, p399 

    Purpose: To investigate the role of biomarkers including serum tissue inhibitor of metalloproteinases-1 (TIMP-1), urokinase plasminogen activator receptor, vascular endothelial growth factor, and epidermal growth factor receptor in predicting pathologic response to neoadjuvant chemoradiation...

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