Citations with the tag: PEPTIDES

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• New whey peptides boost muscle growth!
  Nettl, Francis // Joe Weider's Muscle & Fitness; Jul96, Vol. 57 Issue 7, p154 

  Reports on scientific changes in enzymes technologies to theoretically boost metabolic response to protein structure into peptides. Why peptides are the preferred methodology for human metabolism.

• Selectivity of MHC-encoded peptide transporters from human, mouse and rat.
  Momburg, Frank; Roelse, Joost // Nature; 2/17/1994, Vol. 367 Issue 6464, p648 

  Studies the selectivity of major histocompatibility complex-encoded peptide transporters from human, mouse and rat. Translocation of the peptides in an adenosine triphosphate- (ATP) dependent fashion; Members of a family of proteins containing an ATP-binding cassette; Substitution of the amino-...

• Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains.
  Lim, Wendell A.; Richards, Frederic M. // Nature; 11/24/1994, Vol. 372 Issue 6504, p375 

  Reports on the crystal structure of peptide-binding and the sequence of specificity in SH3 domains. Effect of peptide residues in asymmetric interactions; Role of peptide-recognition proteins; Cause of reversal in specificity; Factors affecting polarity and speficity of peptide binding.

• RETICULOSE AND HPV STUDIES.
  Lim, Wendell A.; Richards, Frederic M. // AIDS Patient Care & STDs; Jul98, Vol. 12 Issue 7, p579 

  Reports on the investigation being carried on the drug Reticulose, which is part of a class of drugs called peptide nucleic acids (PNA). Information on Reticulose; How PNAs works; Identification of the developer of the drug.

• Corrigendum: Amyloid peptide inhibits ATP release from human erythrocytes.
  Misiti, Francesco; Orsini, Federica; Clementi, M. Elisabetta; Masala, Daniele; Tellone, Ester; Galtieri, Antonio; Giardina, Bruno // Biochemistry & Cell Biology; Apr2009, Vol. 87 Issue 2, p467 

  A correction to the article "Amyloid Peptide Inhibits ATP Release From Human Erythrocytes" that was published in the journal "Biochemitsry & Cell Biology" in 2009 is presented.

• BACTERICIDAL AND LPS-NEUTRALIZING ACTIVITIES OF A HUMAN ANTIMICROBIAL CATHELICIDIN PEPTIDE CAP18/LL-37.
  Nagaoka, Isao; Tamura, Hiroshi; Hirata, Michimasa // Mediators of Inflammation; 2007, Vol. 2007 Issue 2, Special section p10 

  An abstract of the article "Bactericidal and LPS-Neutralizing Activities of a Human Antimicrobial Cathelicidin Peptide CAP18/LL-37," by Isao Nagaoka, Hiroshi Tamura, and Michimasa Hirata is presented.

• A DESIGN FOR PEPTIDATION IN THE CRYSTAL LATTICE[sup#].
  Ranganathan, Subramania; Singh, Girupal // Research on Chemical Intermediates; 1999, Vol. 25 Issue 6, p551 

  Presents a study on the peptide bond formation of crystal composites. Related studies on the X-ray structures of amino acids; Arrangement of spartic acid; Results and discussion.

• Tetrahymena termophila as a Source of the Opioid Receptors for Testing of Opioid Peptides.
  Kostyra, E.; Kostyra, H.; Jarmolowska, B.; Krawczuk, S. // Polish Journal of Environmental Studies; 2002, Vol. 11 Issue 6, p707 

  Provides information on a study which used Tetrahymena termophila for testing the opioid activity of peptide, Beta-casomorphin-7, isolated from cheese. Experimental procedure; Results and discussion.

• Conformer Profiles and Biological Activities of Peptides.
  J.W. Payne; N.J. Marshall; B.M. Grail; S. Gupta // Current Organic Chemistry; Dec2002, Vol. 6 Issue 14, p1221 

  Small, zwitterionic peptides (2-6 residues) are flexible molecules that occur in solution as an ensemble of conformational forms in dynamic equilibrium. They occur widely in Nature as components of the peptide pool produced by protein hydrolysis. Molecular modelling provides information on the...

• Measuring brain natriuretic peptide in suspected left ventricular systolic dysfunction in general practice: cross-sectional study.
  Landray, Martin J.; Lehman, Richard; Arnold, Ian // BMJ: British Medical Journal (International Edition); 04/08/2000, Vol. 320 Issue 7240, p985 

  Provides information on a study which reported the results of a study designed to investigate the effectiveness of measuring brain natriuretic peptide to diagnose left ventricular systolic dysfunction. Participants, methods and results; Comment on the study.

• The Role of Formyl Peptide Receptors in Microbial Infection and Inflammation.
  Yingying Le; Ronghua Sun, Tarek; Guoguan Ying, Tarek; Iribarren, Pablo; Ji Ming Wang // Current Medicinal Chemistry - Anti-Infective Agents; Mar2003, Vol. 2 Issue 1, p83 

  Although cell surface receptors are not usually considered to be anti-infective agents, they must be included when they serve as extremely sensitive detectors of bacterial invaders that alert and mobilize the innate immune host defense as is the case for the family of formyl peptide receptors....

• Inhibition of Pneumococcal Carriage in Mice by Subcutaneous Immunization with Peptides from the Common Surface Protein Pneumococcal Surface Adhesin A.
  Johnson, Scott E.; Dykes, Janet K.; Jue, Danny L.; Sampson, Jaquelyn S.; Carlone, George M. // Journal of Infectious Diseases; 2/15/2002, Vol. 185 Issue 4, p489 

  Pneumococcal surface adhesin A (PsaA), a common protein expressed on all 90 pneumococcal serotypes, is a vaccine candidate. Three anti-PsaA monoclonal antibody phage display-expressed monopeptides (15 mers), in various formulations as lipidated or nonlipidated multiantigenic peptides or as bi-...

• Mammalian Genome: Vol. 14, No. 5, May 2003, pp. 341�349 (DOI: 10.1007/s00335-002-3061-y).
  Johnson, Scott E.; Dykes, Janet K.; Jue, Danny L.; Sampson, Jaquelyn S.; Carlone, George M. // Mammalian Genome; Aug2003, Vol. 14 Issue 8, p580 

  Presents a correction to the article about C14TKL-1 peptide previously published in the journal "Mammalian Genome."

• Dynamics and orientation of amphipathic peptides in solution and bound to membranes: a steady-state and time-resolved fluorescence study of staphylococcal d-toxin and its synthetic analogues.
  Talbot, Jean-Claude; Thiaudi�re, Eric; Vincent, Michel; Gallay, Jacques; Siffert, Odile; Dufourcq, Jean // European Biophysics Journal; 2001, Vol. 30 Issue 2, p147 

  Abstract The environment of both the hydrophilic and hydrophobic sides of alpha-helical delta-toxin are probed by tryptophanyl (Trp) fluorescence, when self-association occurs in solution and on binding to membranes. The fluorescence parameters of staphylococcal delta-toxin (Trp15 on the polar...

• Time-resolved two-dimensional vibrational spectroscopy of a short a-helix in water.
  Woutersen, Sander; Hamm, Peter // Journal of Chemical Physics; 10/22/2001, Vol. 115 Issue 16, p7737 

  Nonlinear two-dimensional (2D) vibrational spectroscopy has been used to investigate the amide I band of an alanine-based 21-residue a-helical peptide in aqueous solution. Whereas the linear absorption spectrum consists of a single, broad amide I band, the 2D vibrational spectrum clearly reveals...

• Dynamics of hierarchical folding on energy landscapes of hexapeptides.
  Levy, Yaakov; Jortner, Joshua; Becker, Oren M. // Journal of Chemical Physics; 12/8/2001, Vol. 115 Issue 22, p10533 

  In this paper we apply the master equation approach to study the effects of the energy landscape topology and topography on the kinetics of folding, and on kinetic transitions of three alanine-hexapeptides analogs which involve polypeptides with neutral and charged groups and a cyclized...

• Interaction of grammistins with lipids and their antibacterial activity.
  Yokota, Hiroshi; Nagashima, Yuji; Shiomi, Kazuo // Fisheries Science; Oct2001, Vol. 67 Issue 5, p928 

  Grammistins are hemolytic and ichthyotoxic peptides in the skin secretion of soapfishes and are structurally characterized by their abundance in amphiphilic a-helicity. In the present study, their interaction with lipids and lipid vesicles as well as antibacterial activity were examined using...

• PR39, a peptide regulator of angiogenesis.
  Li, Jian; Post, Mark; Volk, Rudiger; Gao, Youhe; Li, Min; Metais, Caroline; Sato, Kaori; Tsai, Jo; Aird, William; Rosenberg, Robert D.; Hampton, Thomas G.; Li, Jianyi; Sellke, Frank; Carmeliet, Peter; Simons, Michael // Nature Medicine; Jan2000, Vol. 6 Issue 1, p49 

  Although tissue injury and inflammation are considered essential for the induction of angiogenesis, the molecular controls of this cascade are mostly unknown. Here we show that a macrophagederived peptide, PR39, inhibited the ubiquitin-proteasome-dependent degradation of hypoxia-inducible...

• Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.
  Sawada, Motoshi; Hayes, Paulette; Matsuyama, Shigemi // Nature Cell Biology; Apr2003, Vol. 5 Issue 4, p352 

  Bax is a pro-apoptotic member of Bcl-2 family proteins and is central to mitochondria-dependent apoptosis. Bax resides in the cytosol as a quiescent protein and translocates into mitochondria after apoptotic stimuli. Ku70 is a 70K subunit of the Ku complex, which has an important role in DNA...

• Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology.
  Hayman, Wendy A; Toth, Istvan; Flinn, Nicholas; Scanlon, Martin; Good, Michael F // Immunology & Cell Biology; Apr2002, Vol. 80 Issue 2, p178 

  Summary A conserved helical peptide vaccine candidate from the M protein of group A streptococci, p145, has been described. Minimal epitopes within p145 have been defined and an epitope recognized by protective antibodies, but not by autoreactive T cells, has been identified. When administered...

• A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding.
  Yigong Shi // Cell Death & Differentiation; Feb2002, Vol. 9 Issue 2, p93 

  Discusses the potentiating apoptosis through inhibitors of apoptosis proteins (IAP). Diseases cause by alterations in apoptotic pathways; Potential use of Smac N-terminal peptide for drug design; Elevated levels of IAP expressed by cancer cells.

• Dominant effector genetics in mammalian cells.
  Xu, Xiang; Leo, Cindy; Jang, Yngju; Chan, Eva; Padilla, David; Huang, Betty C.B.; Lin, Tong; Gururaja, Tarikere; Hitoshi, Yasumichi; Lorens, James B.; Anderson, David C.; Sikic, Branimir; Luo, Ying; Payan, Donald G.; Nolan, Garry P. // Nature Genetics; Jan2001, Vol. 27 Issue 1, p23 

  We have expressed libraries of peptides in mammalian cells to select for trans-dominant effects on intracellular signaling systems. As an example?and to reveal pharmacologically relevant points in pathways that lead to Taxol resistance?we selected for peptide motifs that confer resistance to...

• A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis.
  Smith, Tom; Betten, �sa; Bylund, Johan; Christophe, Thierry; Boulay, Fran�ois; Romero, Ana; Hellstrand, Kristoffer; Dahlgren, Claes // Journal of Clinical Investigation; May2006, Vol. 116 Issue 5, p1457 

  A correction to the article "A Proinflammatory Peptide from Helicobacter Pylori Activates Monocytes to Induce Lymphocyte Dysfunction and Apoptosis."

• Humanin peptide suppresses apoptosis by interfering with Bax activation.
  Guo, Bin; Zhai, Dayong; Cabezas, Edelmira; Welsh, Kate; Nouraini, Shahrzad; Satterthwait, Arnold C.; Reed, John C. // Nature; 5/22/2003, Vol. 423 Issue 6938, p456 

  Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. Bax resides in an inactive state in the cytosol of many cells. In response to death stimuli, Bax protein undergoes conformational changes that...

• Peptides on the growth path.
  WILHELM, CAROLYN // Chemical Market Reporter; 01/18/99, Vol. 255 Issue 3, Focus 99 p9 

  Reports on the growth in peptide market. Improvements in peptide synthesis; Global bulk peptide market in 1998; Drawbacks to using peptides.

• Conformer Profiles and Biological Activities of Peptides.
  J.W. Payne; N.J. Marshall; B.M. Grail; S. Gupta // Current Organic Chemistry; Dec2002, Vol. 6 Issue 14, p1221 

  Small, zwitterionic peptides (2-6 residues) are flexible molecules that occur in solution as an ensemble of conformational forms in dynamic equilibrium. They occur widely in Nature as components of the peptide pool produced by protein hydrolysis. Molecular modelling provides information on the...

• Editorial.
  Vynios, Demitrios H. // Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry; Dec2008, Vol. 7 Issue 4, p239 

  The article discusses various reports published within the issue including articles about Mimetic peptides in allergy and inflammation treatment.

• Nonribosomal Peptides from Marine Sponges.
  S. Matsunaga; N. Fusetani // Current Organic Chemistry; Jul2003, Vol. 7 Issue 10, p945 

  Marine sponges are shown to be abundant sources of bioactive peptides. Structurally they include linear peptides, peptide lactones, cyclic peptides, and depsipeptides, with number of residues ranging from two to 48. Some of them have highly modified structural features with nonproteinogenic...

• Recognition of Peptides by Antibodies and Investigations of Affinity Using Biosensor Technology.
  Van Regenmortel, M.H.V.; Choulier, L. // Combinatorial Chemistry & High Throughput Screening; Aug2001, Vol. 4 Issue 5, p385 

  The study of peptide-antibody interactions has many applications in biology and medicine. Synthetic peptides corresponding to single protein epitopes are used instead of intact proteins as reagents for the diagnosis of viral and autoimmune diseases. Furthermore, antibodies raised against...

• Predicting In Vivo Protein-Peptide Interactions with Random Phage Display.
  Smothers, James F.; Henikoff, Steven // Combinatorial Chemistry & High Throughput Screening; Nov2001, Vol. 4 Issue 7, p585 

  Binding sites in protein complexes occasionally map to small peptides within one or more proteins. Random peptide display methods simulate binding interactions by providing all possible peptide combinations with an equal opportunity to bind a protein of interest. The natural substrates for the...

• Preface.
  Tuncel, Nes'e // Current Pharmaceutical Design; Jan2001, Vol. 7 Issue 2, p1l 

  Introduces articles about peptides, published in the journal 'Current Pharmaceutical Design'. 'Immunology of VIP: A review and therapeutically perspectives,' by R.P. Gomariz, C. Martinez, C. Abad, J. Leceta and M. Delgado; 'Nerve growth factor in neurological and non neurological diseases:...

• Bisphosphonates as a Foundation of Drug Delivery to Bone.
  Uludag, Hasan // Current Pharmaceutical Design; Sep2002, Vol. 8 Issue 21, p1929 

  Bisphosphonates are organic analogues of pyrophosphate that are resistant to hydrolysis. Bisphosphonates exhibit an exceptional affinity to bone, which led to exploration of their utility for targeting pharmacological agents to bone. Among the pharmacological agents explored for bone delivery...

• Designing Decoys for Chemokine-Chemokine Receptor Interaction.
  Rajarathnam, Krishna // Current Pharmaceutical Design; Nov2002, Vol. 8 Issue 24, p2159 

  Aberrant expression of chemokines and their receptors play causative roles in the pathophysiology of numerous autoimmune and inflammatory disease processes. Moreover, an integral step in HIV infection involves binding to chemokine receptors, and hence chemokines are intimately linked to...

• Bombesin-like Peptides: Candidates as Diagnostic and Therapeutic Tools.
  Yegen, B.C. // Current Pharmaceutical Design; May2003, Vol. 9 Issue 12, p1013 

  Bombesin (BBS) is proved to have a wide variety of the pharmacologic effects, including effects on the release of gastrointestinal hormones and control of gastrointestinal motility. More recently, the role of BBS in tumor growth, cellular proliferation and inflammation has attracted attention....

• Design of �-turn Based Therapeutic Agents.
  K. Suat; S.D.S. Jois // Current Pharmaceutical Design; Jun2003, Vol. 9 Issue 15, p1209 

  Peptides and proteins are essential to many biological processes. The interaction between the peptide ligands and their receptor targets commonly involves �-turn structures. Yet poor bioavailability and unfavorable pharmacokinetics significantly compromise the use of peptides as drugs. Thus,...

• Crystallization And Preliminary X-Ray Studies Of L-(+)-2,3-Butanediol Dehydrogenase From Brevibacterium Saccharolyticum C-1012.
  Otagiri, Masato; Kurisu, Genji; Ui, Sadaharu; Ohkuma, Moriya; Kudo, Toshiaki; Kusunoki, Masami // Protein & Peptide Letters; Feb2001, Vol. 8 Issue 1, p57 

  L(+)-2,3 -Butanediol dehydrogenase (L-BDH) from Brevibacterium saccharolyticum C-1012 has been crystallized by the hanging drop vapor diffusion method with polyethylene glycol 4000 as the precipitant. Crystals of L-BDH belong to the triclinic system, space group P1 with cell dimensions a = 60.8...

• Cd Conformational And Modeling Studies Of A Synthetic Peptide Vpdlladllk In Different Media.
  Shobini, J.; Mishra, A.K.; Chandra, Nagasuma // Protein & Peptide Letters; Feb2001, Vol. 8 Issue 1, p49 

  CD spectral studies of VPDLLADLK, a synthetic peptide shows that it undergoes a conformational transition from an unordered structure to a more ordered structure from a polar to a non-polar homogeneous medium. In microheterogeneous media like SDS, CTAB micelles and DMPC lipid bilayer, the...

• Presence of Distinct Virtual Backbone Torsion angles in Dipeptide Conformers.
  Gupta, S.; Grail, B.M.; Payne, J.W. // Protein & Peptide Letters; Apr2002, Vol. 9 Issue 2, p133 

  Zwitterionic dipeptides have recently been shown to exist in water mainly as nine conformational forms with specific combinations of backbone ?, ? and f torsions, which allows conformer-specific molecular recognition of peptide ligands by proteins. Here, we show that pairs of virtual backbone...

• Antibiotic Activity of Reversed Peptides of a- Helical Antimicrobial Peptide, P18.
  Si-Hyung Lee, M.; Dong Gun Lee; Sung-Tae Yang, M.; Yangmee Kim, M.; Jae Il Kim; Kyung-Soo Hahm; Song Yub Shin // Protein & Peptide Letters; Oct2002, Vol. 9 Issue 5, p395 

  P18 (KWKLFKKIPKFLHLAKKF-NH2), an a-helical antimicrobial peptide designed from cecropin Amagainin 2 hybrid, was known to have potent antimicrobial activity against bacteria as well as fungi without hemolytic activity. To find the peptides comparable or superior to the antimicrobial activity of...

• Binding Potency of Peptide Fragments of Type 1 Collagen Cross-Linked N Telopeptide Measured by an Enzyme-Linked Immunosorbant Assay.
  Lung, Feng-Di T.; Chiu-Heng Chen, Feng-Di T.; Heuy-Yi Chen, Feng-Di T.; Chien-Chung Liou, Feng-Di T.; Yen-Meng Liou, Feng-Di T. // Protein & Peptide Letters; Oct2002, Vol. 9 Issue 5, p451 

  Osteoporosis represents a major healthcare problem affecting elderly person. Urinary level of the crosslinked N-telopeptide of type I collagen is a sensitive marker of bone resorption. Ten overlapping peptides covering the N-telopeptide of alpha-2 type I collagen were synthesized, purified, and...

• Antibiotic Properties of Novel Synthetic Temporin A Analogs and a Cecropin A-Temporin A Hybrid Peptide.
  Wade, David; Flock, Jan-Ingmar; Edlund, Charlotta; Lofving-Arvholm, Ingegerd; Sallberg, Matti; Bergman, Tomas; Silveira, Angela; Unson, Cecille; Rollins-Smith, Louise; Silberring, Jerzy; Richardson, Malcolm; Kuusela, Pentti; Lankinen, Hilkka // Protein & Peptide Letters; Dec2002, Vol. 9 Issue 6, p533 

  Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays.Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead...

• Characterization of Rhodamine Conjugated Agiotensin II Peptide: Synthesis, Analysis and Receptor Binding and Internalization.
  Yadav, Satya P.; Karnick, Sadashiv; Wei-Zhen Shen, Sadashiv; Jingli Zhang // Protein & Peptide Letters; Dec2002, Vol. 9 Issue 6, p465 

  The results in this study show that the rhodamine fluorophore can be specifically conjugated to Angiotensin II at Lys3 residue (substituted for a Val) without altering the biological activity of the parent compound. The conjugated peptide was characterized using HPLC, mass spectrometry, and...

• ph-Induced Conformational Change in An A- Helical Coiled-Coil is Controlled by His Residues in the Hydrophobic Core.
  Wada, Kiyoko; Mizuno, Toshihisa; Oku, Jun-ichi; Tanaka, Toshiki // Protein & Peptide Letters; Feb2003, Vol. 10 Issue 1, p27 

  An a-helical coiled-coil structure is one of the basic structural units in proteins. Hydrophilic residues at the hydrophobic positions in the coiled-coil structure play important roles in structures and functions of natural proteins. We reported here a peptide that formed a triple stranded...

• Editorial.
  Dunn, Ben M. // Protein & Peptide Letters; Sep2008, Vol. 15 Issue 9, p866 

  The article discusses various reports published within the issue including one by Vladimir Uversky et al on the use of a new prediction tool for measuring the propensity for intrinsic disorder in proteins or peptides and another by Willy Taylor et al on the use of protein fragments in protein...

• Protein Reconstitution and 3D Domain Swapping.
  Maria Hakansson; Sara Linse // Current Protein & Peptide Science; Dec2002, Vol. 3 Issue 6, p629 

  The native structures of proteins are governed by a large number of non-covalent interactions yielding a high specificity for the native packing of structural elements. This allows for the reconstitution of proteins from disconnected polypeptide fragments. The specificity for the native...

• Phosphinic Acid Compounds in Biochemistry, Biology and Medicine.
  Collinsova, M.; Jiracek, J. // Current Medicinal Chemistry; Jun2000, Vol. 7 Issue 6, p629 

  This review summarizes our knowledge of biochemical, biological and medical applications and properties of phosphinic acid compounds. Phosphinic acid compounds (phosphinates) are derivatives of phosphinic acid H 2 P(O)(OH). The major attention of this article is focused on applications of...

• Endothelin Receptor Antagonists: Structures, Synthesis, Selectivity and Therapeutic Applications.
  Boss, C.; Bolli, M.; Weller, T. // Current Medicinal Chemistry; Feb2002, Vol. 9 Issue 3, p349 

  Endothelin (ET) was discovered in 1988 and is the most potent vasoconstrictive peptide known to date. It exists in three isoforms (ET-1 to ET-3) and acts on two endothelin receptor subtypes, the endothelin-A (ETA)-receptor and the endothelin-B (ETB)-receptor. Endothelin receptor antagonists are...

• Peptidomimetics and Angiogenesis.
  Mazitschek, Ralph; Baumhof, Patrick; Giannis, Athanassios // Mini Reviews in Medicinal Chemistry; Oct2002, Vol. 2 Issue 5, p491 

  Angiogenesis is the sprouting of new blood capillaries from surrounding preexisting blood vessels. This process is fundamental for embryonic development, wound healing and inflammation. In healthy adults angiogenesis is of minor importance. However, aberrant angiogenesis is essentially involved...

• Peptidomimetics and Peptide Backbone Modifications.
  Jung-Mo Ahn; Boyle, Nicholas A.; MacDonald, Mary T.; Janda, Kim D. // Mini Reviews in Medicinal Chemistry; Oct2002, Vol. 2 Issue 5, p463 

  The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review.

• Design, Synthesis, and Application of Peptide Secondary Structure Mimetics.
  Eguchi, Masakatsu; Kahn, Michael // Mini Reviews in Medicinal Chemistry; Oct2002, Vol. 2 Issue 5, p447 

  The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years is reviewed along with the recent...

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