Citations with the tag: NEURAL stem cells
Results 1 - 50
- Correction: Distinct Mammalian Precursors Are Committed to Generate Neurons with Defined Dendritic Projection Patterns.
Kelsch, Wolfgang; Mosley, Colleen P.; Chia-Wei Lin; Lois, Carlos // PLoS Biology; Apr2008, Vol. 6 Issue 4, pe91
- Genetically engineered human neural stem cells for brain repair in neurological diseases.
Kelsch, Wolfgang; Mosley, Colleen P.; Chia-Wei Lin; Lois, Carlos // Current Medical Literature: Lysosomal Storage Disease; 2007, Vol. 7 Issue 1, p30
An abstract of the article "Genetically engineered human neural stem cells for brain repair in neurological diseases," by S. U. Kim is presented.
- Neural stem cells, acetylcholine and Alzheimer's disease.
Fullwood, Nigel J. // Nature Chemical Biology; Aug2007, Vol. 3 Issue 8, p435
A letter to the editor is presented in response to the article that discussed the results of the screening of molecules that affect neurotransmission pathways in a neural stem cell model published in the May 2007 issue.
- Dedifferentiation in glioma.
Feliciano, Pamela // Nature Genetics; Dec2012, Vol. 44 Issue 12, p1293
The article offers information on a research that shows dedifferentiation of neurons and astrocytes into neural stem cells (NSCs) that can induce gliomas in a mouse model.
- Great balls of fire: newborn nerve cells navigate their universe.
Bradford, Dana // Chemistry in Australia; Jul2011, Vol. 78 Issue 6, p13
An image of a neurosphere taken by Dana Bradford, one of the top 25 images in the 2010 New Scientist Eureka Prize for Science Photography, is presented.
Bradford, Dana // Encyclopedic Reference of Cancer; 2001, p619
The article presents an encyclopedia entry for the term "NEDD2," which stands for neural precursor cell expressed, developmentally down-regulated 2.
- Lhx2 and Lhx9 Determine Neuronal Differentiation and Compartition in the Caudal Forebrain by Regulating Wnt Signaling.
Peukert, Daniela; Weber, Sabrina; Lumsden, Andrew; Scholpp, Steffen // PLoS Biology; Dec2011, Vol. 9 Issue 12, p1
Initial axial patterning of the neural tube into forebrain, midbrain, and hindbrain primordia occurs during gastrulation. After this patterning phase, further diversification within the brain is thought to proceed largely independently in the different primordia. However, mechanisms that...
- 692. Bone Marrow Derived Neural Stem-Like Cells Expressing IL-27 Exhibit Antitumor Activity in Intracranial Gliomas.
Yuan, Xiangpeng; Hu, Jinwei; Yoshimoto, Takayuki; Black, Keith L.; Yu, John S. // Molecular Therapy; Jun2005, Vol. 11, p268
An abstract of the article "Bone Marrow Derived Neural Stem-Like Cells Expressing IL-27 Exhibit Antitumor Activity in Intracranial Gliomas," by Xiangpeng Yuan, Jinwei Hu, Takayuki Yoshimoto, Keith L. Black and John S. Yu is presented.
- mGluR5 regulated proliferation of neural stem cells after hypoxia with activation of MAPK signaling pathway.
Lingyu Zhao; Qian Jiao; Xinlin Chen; Pengbo Yang; Bingqiao Zhao; Ping Zheng; Yong Liu // Molecular Neurodegeneration; 2012 Supplement, Vol. 7, p1
An abstract of the article "mGluR5 Regulated Proliferation of Neural Stem Cells After Hypoxia With Activation of MAPK Signaling Pathway," by Lingyu Zhao, Qian Jiao, Xinlin Chen, Pengbo Yang, Bingqiao Zhao, Ping Zheng and Yong Liu is presented.
- FRONTIERS OF SCIENCE.
Radin, Dean // Shift: At the Frontiers of Consciousness; Mar-May2006, Issue 10, p36
The article discusses about the implications of bioentanglement on the nature of psychic phenomena. An experiment was conducted to prove the existence of bioentanglement. It involved the study of cultures of human neurons from neural stem cells. There were indications of the presence of...
- Focus on neuro-immune interactions.
Radin, Dean // Nature Neuroscience; Aug2012, Vol. 15 Issue 8, p1055
An introduction is presented in which the editor discusses various reports within the issue on topics including interaction between neural stem and immune cells, role of prostaglandins in the association between systemic infection and sickness syndrome and effect of the immune system of neural...
- Novel bioreactors for the culture and expansion of aggregative neural stem cells.
Yuen Ng; Howard Chase // Bioprocess & Biosystems Engineering; Aug2008, Vol. 31 Issue 5, p393
Abstract��Neural stem cells have been cultured as three-dimensional aggregates in a number of different types of bioreactors. The design and configuration of the bioreactor are shown to be crucial factors for the successful propagation of the cells. A novel bioreactor with liquid...
- Research highlights.
Yuen Ng; Howard Chase // Nature; 7/28/2005, Vol. 436 Issue 7050, p444
Presents several research in the U.S. Analysis on the behavior of male lobsters; Examination of the cycle of neural stem cells in the embryonic mammalian brain divide; Investigation on the utility of laser pulses in writing patterns into transparent objects.
- Transplantation: Bridging the gap.
Lewis, Sian // Nature Reviews Neuroscience; Nov2012, Vol. 13 Issue 11, p740
The article offers information on the study related to the ability of neural stem cells (NSCs) to repair the spinal cord following injury.
- Stem cells: Sending cells back in time.
Lewis, Sian // Nature Reviews Neuroscience; Feb2013, Vol. 14 Issue 2, p78
The article presents a research on neural stem cells (NSCs) and reprogramming of human urine cells or epithelial-like cells into expandable population of neural progenitors.
- Neural stem cell transplant may tackle diabetes.
Lewis, Sian // Biomedical Market Newsletter; 10/10/2011, Vol. 21, p171
The article focuses on the study by researchers in Japan which found that a patient's neural stem cells can serve as an alternative source of beta cells for a regenerative treatment of diabetes.
- Neural stem cells and the regulation of adult neurogenesis.
Lennington, Jessica B.; Zhengang Yang; Conover, Joanne C. // Reproductive Biology & Endocrinology; 2003, Vol. 1, p99
Presumably, the 'hard-wired' neuronal circuitry of the adult brain dissuades addition of new neurons, which could potentially disrupt existing circuits. This is borne out by the fact that, in general, new neurons are not produced in the mature brain. However, recent studies have established that...
- Multicystic Mesothelioma: Case Reports.
Chen, Karl T. K. // International Journal of Surgical Pathology; Jan1998, Vol. 6 Issue 1, p43
The immunohistochemical and histochemical findings of five multicystic mesotheliomas, including a unique case of inguinal soft tissue location, are reported. The results of this study indicate that the histochemical and immunohistochemical profiles of multicystic mesothelioma parallel those of...
- Neural Synchronization at Tonic-to-Bursting Transitions.
Postnova, Svetlana; Voigt, Karlheinz; Braun, Hans // Journal of Biological Physics; Apr2007, Vol. 33 Issue 2, p129
We studied the synchronous behavior of two electrically-coupled model neurons as a function of the coupling strength when the individual neurons are tuned to different activity patterns that ranged from tonic firing via chaotic activity to burst discharges. We observe asynchronous and various...
- Brain stem cells are limited.
Postnova, Svetlana; Voigt, Karlheinz; Braun, Hans // Reproductive BioMedicine Online; Apr2004, Vol. 8 Issue 4, p482
Discusses the limitations in the use of brain stem cells as therapies. Restrictions to the therapeutic nature of brain stem cells; Response of human neural stem cells to in vitro culture; Problem with the sources of neural stem cells.
- DHEA Shown to Boost Brain Cell Growth.
Rosick, Edward R. // Life Extension; Jul2004, Vol. 10 Issue 7, p22
Provides evidence on the effects of dehydroepiandrosterone (DHEA) in enhancing brain cell growth. Control of the deleterious effects of aging such as decreased libido, muscle mass and brain function; Direct effects on neural stem cell growth and neuron formation.
- Specificity and Plasticity of Thalamocortical Connections in Sema6A Mutant Mice.
Little, Graham E.; L�pez-Bendito, Guillermina; R�nker, Annette E.; Garc�a, Noelia; Pi�on, Maria C.; Ch�dotal, Alain; Moln�r, Zolt�n; Mitchell, Kevin J. // PLoS Biology; Apr2009, Vol. 7 Issue 4, p0756
The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model...
- Calcium-independent phospholipase A2 mediates store-operated calcium entry in rat cerebellar granule cells.
Singaravelu, Karthika; Lohr, Christian; Deitmer, Joachim W. // Cerebellum; Sep2008, Vol. 7 Issue 3, p467
Store-operated Ca2+ entry (SOCE) has been extensively studied in non-neuronal cells, such as glial cells and smooth muscle cells, in which Ca2+-independent phospholipase A2 (iPLA2) has been shown to play a key role in the regulation of SOCE channels. In the present study, we have investigated...
- Specific Contributions of Ventromedial, Anterior Cingulate, and Lateral Prefrontal Cortex for Attentional Selection and Stimulus Valuation.
Kaping, Daniel; Vinck, Martin; Hutchison, R. Matthew; Everling, Stefan; Thilo Womelsdorf // PLoS Biology; Dec2011, Vol. 9 Issue 12, p1
Attentional control ensures that neuronal processes prioritize the most relevant stimulus in a given environment. Controlling which stimulus is attended thus originates from neurons encoding the relevance of stimuli, i.e. their expected value, in hand with neurons encoding contextual information...
- 183. Development of Ex-Vivo Gene Therapy Procedures for Central Nervous System Diseases, Based on Homologous Recombination in Human Neural Stem Cells.
Lopez, Carlos A. Bueno; Serrano, Alberto Martinez // Molecular Therapy; Jun2005, Vol. 11, p71
An abstract of the article "Development of Ex-Vivo Gene Therapy Procedures for Central Nervous System Diseases, Based on Homologous Recombination in Human Neural Stem Cells," by Carlos A. Bueno Lopez and Alberto Martinez Serrano is presented.
- 649. Effects of GIT1on Human Neuronal (NT2N) Cells.
Lieu, Ann-Shung; Zhong Li, Jin; Webb, Donna J.; Hankins, Gerald R.; Helm, Gregory A. // Molecular Therapy; Jun2005, Vol. 11, p251
An abstract of the article "Effects of GIT1on Human Neuronal (NT2N) Cells," by Ann-Shung Lieu, Jin Zhong Li, Donna J. Webb, Gerald R. Hankins, and Gregory A. Helm is presented.
- New growth-stimulating cue identified for nerve cells.
Lieu, Ann-Shung; Zhong Li, Jin; Webb, Donna J.; Hankins, Gerald R.; Helm, Gregory A. // PharmaWatch: CNS; September 2003, Vol. 2 Issue 9, p8
Presents a study of a team of researchers from John Hopkins University identifying family of proteins best known for repelling axons. Identification of semaphorin-7a interactions with different proteins; Role of semaphorin in the growth of axons; Effect of semaphorins on nerve development.
- Notch signaling in the mammalian central nervous system: insights from mouse mutants.
Keejung Yoon; Gaiano, Nicholas // Nature Neuroscience; Jun2005, Vol. 8 Issue 6, p709
The Notch pathway, although originally identified in fruit flies, is now among the most heavily studied in mammalian biology. In mice, loss-of-function and gain-of-function work has demonstrated that Notch signaling is essential both during development and in the adult in a multitude of tissues....
- PEDF: bridging neurovascular interactions in the stem cell niche.
Pumiglia, Kevin; Temple, Sally // Nature Neuroscience; Mar2006, Vol. 9 Issue 3, p299
The article discusses the results of a study on pigment epithelium-derived factor (PEDF). PEDF was not expressed by cells in the neural stem cell lineage which is composed of Type B astrocyte-like stem cells that produce Type C transit amplifying cells and Type A neuroblasts. This conclusion was...
- Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation.
Shi, J.; Parada, L. F.; Kernie, S. G.; Lipton, S. // Cell Death & Differentiation; Dec2005, Vol. 12 Issue 12, p1601
Neural stem cells in the mammalian brain persist and are functional well into adulthood. There is, however, little insight into mechanisms that control adult neural stem cell survival. Mice deficient in the proapoptotic molecule Bax exhibit increased numbers of multipotent progenitor cells in...
- Neural stem cell migration toward gliomas in vitro.
Heese, Oliver; Disko, Andreas; Zirkel, Dorothea; Westphal, Manfred; Lamszus, Katrin // Neuro-Oncology; Oct2005, Vol. 7 Issue 4, p476
Various in vivo studies demonstrated a migration tendency of neural stem cells (NSCs) toward gliomas, making these cells a potential carrier for delivery of therapeutic genes to disseminated glioma cells. We analyzed which factors determine NSC migration and invasion in vitro. Conditioned media...
- Targeting of melanoma brain metastases using engineered neural stem/progenitor cells.
Aboody, Karen S.; Najbauer, Joseph; Schmidt, Nils Ole; Yang, Wendy; Julian K. Wu; Yuzheng Zhuge; Przylecki, Wojciech; Carroll, Rona; Black, Peter M.; Perides, George // Neuro-Oncology; Apr2006, Vol. 8 Issue 2, p119
Brain metastases are an increasingly frequent and serious clinical problem for cancer patients, especially those with advanced melanoma. Given the extensive tropism of neural stem/progenitor cells (NSPCs) for pathological areas in the central nervous system, we expanded investigations to...
- Microenvironmental Determinants of Adult Neural Stem Cell Proliferation and Lineage Commitment in the Healthy and Injured Central Nervous System.
Moyse, Emmanuel; Segura, St�phanie; Liard, Oliver; Mahaut, St�phanie; Mechawar, Naguib // Current Stem Cell Research & Therapy; Sep2008, Vol. 3 Issue 3, p163
The discovery of neural stem cells (NSC) which ensure continuous neurogenesis in the adult mammalian brain, has led to a conceptual revolution in basic neuroscience and to high hopes for clinical nervous tissue repair. However, several research issues remain to address before neural stem cells...
- Using the Neurosphere Assay to Quantify Neural Stem Cells In Vivo.
Marshall, Gregory P.; Reynolds, Brent A.; Laywell, Eric D. // Current Pharmaceutical Biotechnology; Jun2007, Vol. 8 Issue 3, p141
Since their initial description in 1992, neurospheres have appeared in some aspect of more than a thousand published studies. Despite their ubiquitous presence in the scientific literature, there is little consensus regarding the fundamental defining characteristics of neurospheres; thus, there...
- Fluorescence Activated Cell Sorting: A Window on the Stem Cell.
Johnson, K. W.; Dooner, M.; Quesenberry, P. J. // Current Pharmaceutical Biotechnology; Jun2007, Vol. 8 Issue 3, p133
Fluorescence activated cell sorting (FACS) in the field of stem cell biology has become an indispensable tool for defining and separating rare cell populations with a high degree of purity. Steady progress has been made in this regard, but the intrinsic lability of the stem cell phenotype...
- Using Endogenous Neural Stem Cells to Enhance Recovery from Ischemic Brain Injury.
Leker, Ronen R.; McKay, R. D. G. // Current Neurovascular Research; Dec2004, Vol. 1 Issue 5, p421
The use of cell-based therapy may be a valid therapeutic approach to ischemic brain injury. Stem cells have been proposed as a new form of cell based therapy in a variety of disorders, including acute and degenerative brain diseases. Up to date most efforts have concentrated on transplantation...
- Signalling: An oncogene becomes RESTless.
Alderton, Gemma K. // Nature Reviews Cancer; May2008, Vol. 8 Issue 5, p327
The article discusses the repressor-element-1 silencing transcription factor (REST) as an oncogene in neuronal stem cells in epithelial tissues. REST is a transcriptional repressor that is associated with the maintenance of neuron stem cell self-renewal. A report published in "Nature" revealed...
- Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation.
Wexler, E. M.; Geschwind, D. H.; Palmer, T. D. // Molecular Psychiatry; Mar2008, Vol. 13 Issue 3, p285
Neural stem cells give rise to new hippocampal neurons throughout adulthood, and defects in neurogenesis may predispose an individual to mood disorders, such as major depression. Our understanding of the signals controlling this process is limited, so we explored potential pathways regulating...
- Directed differentiation of hippocampal stem/progenitor cells in the adult brain.
Jessberger, Sebastian; Toni, Nicolas; Clemenson Jr., Gregory D.; Ray, Jasodhara; Gage, Fred H. // Nature Neuroscience; Aug2008, Vol. 11 Issue 8, p888
Adult neurogenesis is a lifelong feature of brain plasticity; however, the potency of adult neural stem/progenitor cells in vivo remains unclear. We found that retrovirus-mediated overexpression of a single gene, the bHLH transcription factor Ascl1, redirected the fate of the proliferating adult...
- Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons.
Mann, Edward O.; Mody, Istvan // Nature Neuroscience; Feb2010, Vol. 13 Issue 2, p205
Gamma-frequency oscillations depend on phasic synaptic GABAA receptor (GABAAR)-mediated inhibition to synchronize spike timing. The spillover of synaptically released GABA can also activate extrasynaptic GABAARs, and such tonic inhibition may also contribute to modulating network dynamics. In...
- The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
Silver, Debra L.; Watkins-Chow, Dawn E.; Schreck, Karisa C.; Pierfelice, Tarran J.; Larson, Denise M.; Burnetti, Anthony J.; Hung-Jiun Liaw; Kyungjae Myung; Walsh, Christopher A.; Gaiano, Nicholas; Pavan, William J. // Nature Neuroscience; May2010, Vol. 13 Issue 5, p551
Brain structure and size require precise division of neural stem cells (NSCs), which self-renew and generate intermediate neural progenitors (INPs) and neurons. The factors that regulate NSCs remain poorly understood, and mechanistic explanations of how aberrant NSC division causes the reduced...
- Successful elimination of non-neural cells and unachievable elimination of glial cells by means of commonly used cell culture manipulations during differentiation of GFAP and SOX2 positive neural progenitors (NHA) to neuronal cells.
Witusik, Monika; Piaskowski, Sylwester; Hulas-Bigoszewska, Krystyna; Zakrzewska, Magdalena; Gresner, Sylwia M.; Azizi, S. Ausim; Krynska, Barbara; Liberski, Pawel P.; Rieske, Piotr // BMC Biotechnology; 2008, Vol. 8, Special section p1
Background: Although extensive research has been performed to control differentiation of neural stem cells -- still, the response of those cells to diverse cell culture conditions often appears to be random and difficult to predict. To this end, we strived to obtain stabilized protocol of NHA...
- 'Three-Dimensional Regulation of Radial Glial Functions by Lis1-Nde1 and Dystrophin Glycoprotein Complexes.
Pawlisz, Ashley S.; Feng, Yuanyi // PLoS Biology; Oct2011, Vol. 9 Issue 10, p1
Radial glial cells (RGCs) are distinctive neural stem cells with an extraordinary slender bipolar morphology and dual functions as precursors and migration scaffolds for cortical neurons. Here we show a novel mechanism by which the Lis1- Nde1 complex maintains RGC functions through stabilizing...
- Stem Cells and Metastatic Cancer: Fatal Attraction?
Fodde, Riccardo // PLoS Medicine; Dec2006, Vol. 3 Issue 12, p2182
The article discusses the research on the pathotropism characteristic of neural stem cells (NSCs) and its role in the treatment of metastatic cancer. According to the author, NSCs are candidates to replace damaged tissue in degenerative pathologies and to deliver therapeutic molecules in...
- Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.
Jingxian Yang; Zhilong Jiang; Fitzgerald, Denise C.; Cungen Ma; Shuo Yu; Hongmei Li; Zhao Zhao; Yonghai Li; Ciric, Bogoljub; Curtis, Mark; Rostami, Abdolmohamad; Guang-Xian Zhang // Journal of Clinical Investigation; Dec2009, Vol. 119 Issue 12, p3678
Adult neural stem cells (aNSCs) derived from the subventricular zone of the brain show therapeutic effects in EAE, an animal model of the chronic inflammatory neurodegenerative disease MS; however, the beneficial effects are modest. One critical weakness of aNSC therapy may be an insufficient...
Jingxian Yang; Zhilong Jiang; Fitzgerald, Denise C.; Cungen Ma; Shuo Yu; Hongmei Li; Zhao Zhao; Yonghai Li; Ciric, Bogoljub; Curtis, Mark; Rostami, Abdolmohamad; Guang-Xian Zhang // Orange County Business Journal; 12/13/2010, Vol. 33 Issue 50, p6
The article reports that the regulators in Switzerland had approved the trial treatments for spinal cord injuries with neural stem cells being developed by the researchers of University of California, Irvine.
- Intensity-modulated radiation to spare neural stem cells in brain tumors: A computational platform for evaluation of physical and biological dose metrics.
Jaganathan, Arun; Tiwari, Meena; Phansekar, Rahul; Panta, Rajkumar; Huilgol, Nagraj // Journal of Cancer Research & Therapeutics; Jan-Mar2011, Vol. 7 Issue 1, p58
Background: Neurocognitive effects following whole-brain and partial-brain irradiation can cause considerable morbidity. Sparing of neural stem cells (NSCs) is proposed as an avenue for reducing the long-term radiation-induced defects in learning, memory, and intelligence. We performed an...
- Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
Lim, Daniel A.; Huang, Yin-Cheng; Swigut, Tomek; Mirick, Anika L.; Garcia-Verdugo, Jose Manuel; Wysocka, Joanna; Ernst, Patricia; Alvarez-Buylla, Arturo // Nature; 3/26/2009, Vol. 458 Issue 7237, p529
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood. Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an evolutionarily conserved chromatin remodelling system that activate or silence gene expression, respectively. Although PcG...
- Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration.
Sanai, Nader; Tramontin, Anthony D.; Qui�ones-Hinojosa, Alfredo; Barbaro, Nicholas M.; Gupta, Nalin; Kunwar, Sandeep; Lawton, Michael T.; McDermott, Michael W.; Parse, Andrew T.; Verdugo, Jos� Manuel-Garcia; Berger, Mitchel S.; Alvarez-Buylla, Arturo // Nature; 2/19/2004, Vol. 427 Issue 6976, p740
The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain, generating thousands of olfactory bulb neurons every day. If the adult human brain contains a comparable germinal region, this could have considerable implications for future neuroregenerative...
- Cell fusion-independent differentiation of neural stem cells to the endothelial lineage.
Wurmser, Andrew E.; Nakashima, Kinichi; Summers, Robert G.; Toni, Nicolas; D'Amour, Kevin A.; Lie, Dieter C.; Gage, Fred H. // Nature; 7/15/2004, Vol. 430 Issue 6997, p350
Somatic stem cells have been claimed to possess an unexpectedly broad differentiation potential (referred to here as plasticity) that could be induced by exposing stem cells to the extracellular developmental signals of other lineages in mixed-cell cultures. Recently, this and other experimental...