Citations with the tag: LEISHMANIASIS -- Treatment
Results 1 - 50
- Treatment of post-kala-azar dermal leishmaniasis with sodium stibogluconate.
Thakur, C.P.; Kumar, K.; Sinha, P.K.; Mishra, B.N.; Pandey, A.K. // British Medical Journal (Clinical Research Edition); 10/10/1987, Vol. 295 Issue 6603, p886
Focuses on the treatment of post-kala-azar dermal leishmaniasis with sodium stibogluconate. Comparison between the cure rate of 20mg regimen and 10mg and 15mg regimens; Percentage relapse rate after the fourth course of treatment; Patients with nodular and erythematous disease and hypopigmented...
- American Cutaneous Leishmaniasis in U.S. Travelers.
Herwaldt, Barbara L.; Stokes, Susan L.; Juranek, Dennis D. // Annals of Internal Medicine; 5/15/93, Vol. 118 Issue 10, p779
Presents a study which characterized the exposures and practices of U.S. travelers who acquired cutaneous leishmaniasis in the Americas and highlighted problems they encountered in seeking medical care from U.S. physicians. Method of the study; Results and discussion; Conclusion.
Chance, M.L. // British Medical Journal (Clinical Research Edition); 11/7/1981, Vol. 283 Issue 6301, p1245
Focuses on the treatment and control of Leishmaniasis. Increase in the use of liposomes to encapsulate antileishmanial drugs; Availability of improved methods of isolation from animal tissue; Application of the techniques of biochemical taxonomy.
- Epidemic visceral leishmaniasis in southern Sudan...
Seaman, Jill; Mercer, Alec J. // Annals of Internal Medicine; 4/01/96, Vol. 124 Issue 7, p664
Focuses on epidemic, visceral leishmaniasis which is being experienced in southern Sudan. How visceral leishmaniasis syndrome is recognized; Number of countries reporting similar cases; What the disease is associated with; Study carried out on persons with the disease; Analysis of the findings;...
- Combination therapy improves the treatment of visceral leishmaniasis.
Seaman, Jill; Mercer, Alec J. // Clinical Infectious Diseases; 10/15/2008, Vol. 47 Issue 8, pi
The article discusses the study on combination therapy for treatment of visceral leishmaniasis within the issue.
- Short-course multidrug treatment for visceral leishmaniasis in India.
Seaman, Jill; Mercer, Alec J. // Africa Health; May2011, Vol. 33 Issue 4, p64
The article reports on the randomized clinical trial which assesses the effectiveness of using the short-course multidrug treatment for visceral leishmaniasis in Bihar, India.
Seaman, Jill; Mercer, Alec J. // Africa Health; May2013, Vol. 35 Issue 4, p58
The article focuses on a study conducted on 375 patients suffering from Leishmaniasis which stated that topical treatment with paromomycin cream is effective.
- Efficacy of miltefosine declined for visceral leishmaniasis in India.
Seaman, Jill; Mercer, Alec J. // Infectious Disease News; Sep2012, Vol. 25 Issue 9, p34
The article reports on the increase in the failure rate of miltefosine for the treatment of visceral leishmaniasis in India.
- Meglumine antimonate/miltefosine.
Seaman, Jill; Mercer, Alec J. // Reactions Weekly; 6/9/2012, Issue 1405, p24
The article describes the case of a 64-year-old woman who developed hypokalaemia and other toxicities while receiving meglumine antimonate, and subsequently miltefosine, for mucosal leishmaniasis, published in the March-April 2012 issue of the "Journal of Travel Medicine."
- Reply to Monge-Maillo et al.
Soto, Jaime; Berman, Jonathan // Clinical Infectious Diseases; Nov2013, Vol. 57 Issue 10, p1503
A response to the letter to the editor by the authors about their article "Concerns about topical treatment for New World cutaneous leishmaniasis" in the 2013 issue is presented.
- Correction: Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia.
Soto, Jaime; Berman, Jonathan // PLoS Neglected Tropical Diseases; Jun2014, Vol. 8 Issue 6, p1
A correction to the article "Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia" that was published in the 2014 issue is presented.
- Cutaneous leishmaniasis.
Marsden, P.D. // BMJ: British Medical Journal (International Edition); 6/30/90, Vol. 300 Issue 6741, p1716
Focuses on the treatment of leishmaniasis in Europe. Symptomatology of the disease; Recommendation of pentavalent antimonial drugs for the treatment of the disease; Disease diagnosis.
- Meglumine antimonate.
Marsden, P.D. // Reactions Weekly; Nov2014, Vol. 1524 Issue 1, p132
The article presents a cast study of a 42-year-old woman, who developed acute eczema during treatment with meglumine antimonate.
- Treatment of American Cutaneous Leishmaniasis with Miltefosine, an Oral Agent.
Soto, J.; Toledo, J.; Gutierrez, P.; Nicholls, R. S.; Padilla, J.; Engel, J.; Fischer, C.; Voss, A.; Berman, J. // Clinical Infectious Diseases; 10/1/2001, Vol. 33 Issue 7, pe57
There is no recognized oral treatment for American cutaneous leishmaniasis. A rising-dose, open-label phase I/II trial of the oral agent miltefosine against Colombian cutaneous leishmaniasis was conducted. Seventy-two male Colombian soldiers (mean weight, 67 kg) received miltefosine at 50--100...
- Successful Treatment of Drug-Resistant Cutaneous Leishmaniasis in Humans by Use of Imiquimod, an Immunomodulator.
Arevalo, Iracema; Ward, Brian; Miller, Richard; Meng, Tze-Chiang; Najar, Enrique; Alvarez, Eugenia; Matlashewski, Greg; Llamos-Cuentas, Alejandro // Clinical Infectious Diseases; 12/1/2001, Vol. 33 Issue 11, p2847
Treatment failures for leishmaniasis with pentavalent antimonials, including meglumine antimonate, are in-creasingly common in many endemic areas. Imiquimod (Aldara; 3M Pharmaceuticals) is a novel immune response--activating compound, approved by the United States Food and Drug Administration,...
- Variation of Proteinuria in Dogs with Leishmaniasis Treated with Meglumine Antimoniate and Allopurinol: A Retrospective Study.
Pierantozzi, Marco; Roura, Xavier; Paltrinieri, Saverio; Poggi, Marco; Zatelli, Andrea // Journal of the American Animal Hospital Association; Jul/Aug2013, Vol. 49 Issue 4, p231
The article discusses a study which determined how meglumine antimoniate and allopurinol treatments affect proteinuria levels in dogs diagnosed with leishmaniasis. Proteinuria for 53 dogs was evaluated through the urine protein/creatinine (UP/C) ratio. The experiment confirmed that after 4 to 8...
- Leishmaniasis: will new technology provide a breakthrough?
Pierantozzi, Marco; Roura, Xavier; Paltrinieri, Saverio; Poggi, Marco; Zatelli, Andrea // WHO Drug Information; 1999, Vol. 13 Issue 3, p150
Reports on developments concerning leishmaniasis treatment as of August 1999. Drug treatment; Vaccine development; World Health Organization's research on the analysis and mapping of genomes of five tropical parasites; Underestimation of the prevalence and impact of leishmaniasis.
- Comparetaive Study on Glucantime and Oral Terbinafine along with Systemic Glucantime on Cutaneous Leishmaniasis.
Ebrahimian, Saba; Asilian, Ali; Faghihi, Gita // Journal of Isfahan Medical School; 2/14/2011, Vol. 28 Issue 118, p1
Background: Cutaneous leishmaniasis is the endemic type of leishmaniasis in Iran especially Isfahan province. Pentavalent antimonials are the first line treatment in all kind of leismaniasis; but their high cost side effect and also injection from, shows the necessity of finding new ways of...
- Leishmaniasis treatmentâ€”a challenge that remains: a review.
Dilvani Santos; Carlos Coutinho; Maria Madeira; Carolina Bottino; Rodrigo Vieira; Samara Nascimento; Alice Bernardino; Saulo Bourguignon; Suzana Corte-Real; Rosa Pinho; Carlos Rodrigues; Helena Castro // Parasitology Research; Jun2008, Vol. 103 Issue 1, p1
AbstractÂ Â Leishmaniasis is a disease caused by flagellate protozoan Leishmania spp. and represents an emergent illness with high morbidity and mortality in the tropics and subtropics. Since the discovery of the first drugs for Leishmaniasis treatment (i.e., pentavalent antimonials), until...
- Treatment of Experimental Leishmaniasis with the Immunomodulators Imiquimod and S-28436: Efficacy...
Buates, Sureemas; Matlashewski, Greg // Journal of Infectious Diseases; 6/1/99, Vol. 179 Issue 6, p1485
Studies the efficacy of the immunomodulators imiquimod and S-28463 in the treatment of experimental leishmaniasis. Measurement of nitric oxide (NO) production and inhibition of NO synthesis with N[sup G]-monomeethyl-L-arginine; Analysis of activated signal transducer and activator of...
Krause, Gérard; Kroeger, Axel; Soto, J.; Berman, J.; Pillay, Thillagavathie; Adhikari, Miriam; Lee, Lucia H.; Graman, Paul S.; Michaels, Stephanie H.; Clark, Rebecca; Kissinger, Patricia // Clinical Infectious Diseases; 8/1/1999, Vol. 29 Issue 2, p466
Presents several letters regarding infectious diseases. Topical paromomycin/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment of American cutaneous leishmaniasis; Congenital tuberculosis in a neonatal intensive care unit; Incidence and spectrum of AIDS-defining...
- Combined Interleukin-12 and Topical Chemotherapy for Established Leishmaniasis Drastically Reduces Tissue Parasitism and Relapses in Susceptible Mice.
Fernandes, Ana Paula; Ferreira, Lucas A. M.; Castro, Gisele A.; Carvalho, Fernando A. A.; Tavares, Carlos Alberto P.; Santiago, Helton C.; Tafuri, Wagner Luiz; Gazzinelli, Ricardo T. // Journal of Infectious Diseases; 6/1/2001, Vol. 183 Issue 11, p1646
Presents information on a study which examined the effectiveness of paramomycin sulfate with recombinant interleukin-12 in treating Leishmaniasis. Details on leishmaniasis; Methodology; Results and discussion.
- Treatment failure may be result of Leishmania parasites' greater infectivity.
Oldt, Amanda; Shafer, Emily; Volansky, Rob // Infectious Disease News; Nov2013, Vol. 26 Issue 11, p18
The article discusses research being done on relapses after treatment for Leishmania infection, which references a study by K. Rai published in a 2013 issue of "mBio."
- AstraZeneca and DNDi to collaborate on drug screening for neglected tropical diseases.
Oldt, Amanda; Shafer, Emily; Volansky, Rob // Biomedical Market Newsletter; 4/14/2012, Vol. 21, p1
The article informs that AstraZeneca PLC and the organization Drugs for Neglected Diseases initiative (DNDi) have announced to collaborate on drug-compound screening for leishmaniasis, Chagas disease, and sleeping sickness.
- Infectious disease: Combating visceral leishmaniasis.
Harrison, Charlotte // Nature Reviews Drug Discovery; Nov2013, Vol. 12 Issue 11, p828
The article discusses a research on the treatment of visceral leishmaniasis which references the study "Vaccination with Leishmania hemoglobin receptor-encoding DNA protects against visceral leishmanias," by R. Guha and colleagues in the 2013 issue of "Science Translational Medicine"
- New therapy for visceral leishmaniasis.
Harrison, Charlotte // Weekly Epidemiological Record; 6/21/2002, Vol. 77 Issue 25, p210
Reports on the use of miltefosine, manufactured by German pharmaceutical company Zentaris, as a chemotherapeutic agent for oral administration against the parasitic disease leishmaniasis. Transmission of leishmaniasis through the bite of the sandfly; Clinical trials conforming to international...
- Visceral leishmaniasis in Afghanistan.
Leslie, Toby; Saleheen, Sarah; Sami, Mohammad; Mayan, Ismail; Mahboob, Najibullah; Fiekert, Kathy; Lenglet, Annick; Ord, Rosalynn; Reithinger, Richard // CMAJ: Canadian Medical Association Journal; 8/1/2006, Vol. 175 Issue 3, p245
Presents information on visceral leishmaniasis in Afghanistan after the fall of the Taliban in 2002. Epidemiology; Information on various clinical management, such as pentavalent antimony therapy and therapeutic approaches that include miltefosine; Strategies to prevent and control visceral...
Bryceson, Anthony; Lawson, Nigel; Taylor, Andrew; Fleiss, Paul M.; Fisher, R.F.; Sawyer, C.N.; Cleary, John; Gabriel, Roger; Baron, D.N.; Hoskins, Percy; Jackson, Doris; Hastings, Adrian; Redstone, I. // British Medical Journal (Clinical Research Edition); 11/19/1983, Vol. 287 Issue 6404, p1555
Presents the views of several physicians on medical issues in Great Britain. Effectivity of curettage in the treatment of cutaneous leishmaniasis; Correlation of serum parathyroid hormone measurements and hyperparathyroidism diagnosis; Information on toxic properties of the drug zimelidine.
- Antileishmanial Patents Antileishmanial Current Drugs and Relevant Patents.
Monzote, Lianet // Recent Patents on Anti-Infective Drug Discovery; Jan2011, Vol. 6 Issue 1, p1
The World Health Organization has classified the leishmaniasis as a major tropical disease. An effective vaccine is not available and the chemotherapy is the only effective way to treat all forms of disease. Currently, the therapy is toxic, expensive and the resistance has emerged as a serious...
Monzote, Lianet // WHO Technical Report Series; 2005, Issue 933, p35
The article reports on the submission of an application for the inclusion of miltefosine in the World Health Organization's Model List of Essential Medicines for treatment of leishmaniasis. The Committee has rejected the application, noting that any future application should include data...
- Use of meglumine antimoniate in canine leishmaniasis.
Lamothe, Jacques // Veterinary Record: Journal of the British Veterinary Association; 3/20/2004, Vol. 154 Issue 12, p378
Presents a letter to the editor about the use of meglumine antimoniate in canine leishmaniasis.
- Leishmania amazonensis Growth Inhibitors: Biological and Theoretical Features of Sulfonamide 4-Methoxychalcone Derivatives.
Souza, Alessandra M. T.; Castro, Helena C.; Brito, Monique A.; Andrighetti-Fröhner, Carla R.; Magalhães, Uiaran; Oliveira, Kely N.; Gaspar-Silva, Daniela; Pacheco, Letícia; Joussef, Antônio C.; Steindel, Mário; Simões, Cláudia M. O.; Santos, Dilvani O.; Albuquerque, Magaly G.; Rodrigues, Carlos R.; Nunes, Ricardo J. // Current Microbiology; Oct2009, Vol. 59 Issue 4, p374
Current drugs for treating leishmaniasis are still associated with significant toxicity and failure rates. Thus, new effective and less toxic antileishmanial agents are still in need. Herein, we tested a series of sulfonamide 4-methoxychalcone derivatives against L. amazonensis promastigote and...
- Liposomal Amphotericin B in the Treatment of Fungal Infections.
Lopez-Berestein, Gabriel // Annals of Internal Medicine; Jul86, Vol. 105 Issue 1, p130
Editorial. Discusses the use of amphotericin B, a polyene antibiotic, in the treatment of systemic fungal infections. Effectiveness of the agent for the treatment of leishmaniasis; Mechanism of action of amphotericin B; Definition of the term liposomes; Therapeutic use of liposomal amphotericin B.
- Evaluation of Leishmanicidal Activity of Oxypeucedanin and Isoimperatorin on Leishmania major Promastigotes.
Sajjadi, Seyed Ebrahim; Eskandarian, Abbas-Ali; Yousefi, Hossein-Ali; Mansourian, Marjan; Taheri, Mohammad // Journal of Isfahan Medical School; Jul2013, Vol. 31 Issue 235, p581
Background: Leishmaniasis has a wide range of clinical symptoms including cutaneous, mucocutaneous, and visceral leishmaniasis. Recently, advances have been observed in the field of using herbal medicines for the treatment of leishmaniasis. The study aimed to determine the in-vitro effect of two...
- Cheminformatic models based on machine learning for pyruvate kinase inhibitors of Leishmania mexicana.
Jamal, Salma; Scaria, Vinod // BMC Bioinformatics; 2013, Vol. 14 Issue 1, p1
Background Leishmaniasis is a neglected tropical disease which affects approx. 12 million individuals worldwide and caused by parasite Leishmania. The current drugs used in the treatment of Leishmaniasis are highly toxic and has seen widespread emergence of drug resistant strains which...
- Control of visceral leishmaniasis in Brazil:recommendations from Brasileish.
Ribeiro, Vitor Márcio; da Silva, Sydnei Magno; Menz, Ingrid; Tabanez, Paulo; Santos Nogueira, Fábio dos; Werkhaüser, Manfredo; da Fonseca, André Luis S.; Dantas-Torres, Filipe // Parasites & Vectors; 2013, Vol. 6 Issue 1, p1
On 26 October 2012, veterinary medicine clinicians and researchers, members of Brasileish - Study Group about Animal Leishmaniasis - met at the Regional Council of Veterinary Medicine of Minas Gerais, in the city Belo Horizonte, in order to discuss many aspects of the situation of canine...
- Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and Leishmania chagasi infections.
Danilo C. Miguel; Rogéria C. Zauli-Nascimento; Jenicer K. U. Yokoyama-Yasunaka; Simone Katz; Clara L. Barbiéri; Silvia R. B. Uliana // Journal of Antimicrobial Chemotherapy (JAC); Feb2009, Vol. 63 Issue 2, p365
: Objectives The aim of this study was to evaluate the efficacy of tamoxifen in vivo in experimental models of cutaneous (CL) and visceral leishmaniasis (VL) caused by Leishmania braziliensis and Leishmania chagasi, respectively. : Methods Drug activity was assessed against intracellular...
- Induction of Apoptosis by Miltefosine in Iranian Strain Leishmania infantum Promastigotes.
Khademvatan, S.; Gharavi, M. J.; Akhlaghi, L.; Samadikuchaksaraei, A.; Oormazdi, H.; Mousavizadeh, K.; Hadighi, R.; Saki, J. // Iranian Journal of Parasitology; 2009, Vol. 4 Issue 2, p23
Background: Miltefosine is a new drug of choice for the treatment of visceral leishmaniasis. Numerous experimental studies have shown miltefosine is effective on Leishmania donovani, however, effectiveness of miltefosine in treatment of L. infantum is not fully understood. The aims of the...
- U.S. Food and Drug Administration Approval of AmBisome (Liposomal Amphotericin B) for Treatment of Visceral Leishmaniasis.
Meyerhoff, Andera // Clinical Infectious Diseases; 1/1/1999, Vol. 28 Issue 1, p42
Reports on the United States Food and Drug Administration's approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. Access to drugs for the treatment of the infection; Use of historical control and data studies for the approval of the drug.
- Editorial Response: U.S. Food and Drug Administration Approval of AmBisome (Liposomal Amphotericin B) for Treatment of Visceral Leishmaniasis.
Berman, Jonathan D. // Clinical Infectious Diseases; 1/1/1999, Vol. 28 Issue 1, p49
Focuses on the United States Food and Drug Administration's approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. Standard treatment of visceral leishmaniasis; Pros and cons of amphotericin B therapy.
- A Randomized, Double-Blind Study of the Efficacy of a 10- or 20-Day Course of Sodium Stibogluconate for Treatment of Cutaneous Leishmaniasis in United States Military Personnel.
Wortmann, Glenn; Miller, R. Scott; Oster, Charles; Jackson, Joan; Aronson, Naomi // Clinical Infectious Diseases; 8/1/2002, Vol. 35 Issue 3, p261
The recommended treatment for cutaneous leishmaniasis is pentavalent antimony at a dosage of 20 mg/kg/ day for 20 days. Some studies conducted in locales in which Leishmania is endemic have suggested that shorter courses of treatment may be as efficacious. We conducted a randomized,...
- Topical Fluconazole Combined with Local Glucantime Injection Compared with Local Glucantime Injections in Treatment of Leishmaniasis.
Nilforooshzadeh, Mohammad Ali; Hejazi, Seyed Hossein; Nabipour, Reza // Journal of Isfahan Medical School; 2/14/2011, Vol. 28 Issue 118, p1
Background: Leishmaniasis is one of the 6th important infectious diseases in the world that has been certificated as an endemic disease in Iran. The aim of this study was comparison of two methods of treatment included flouconazole with glucantime and glucantime alone in treatment of...
- Absence of Leishmania infantum in cave bats in an endemic area in Spain.
Millán, Javier; López-Roig, Marc; Cabezón, Oscar; Serra-Cobo, Jordi // Parasitology Research; May2014, Vol. 113 Issue 5, p1993
Though dogs have been historically considered the main reservoir of Leishmania infantum, the role of wildlife in its epidemiology is attracting increasing attention. Rodents, wild carnivores and, recently, hares ( Lepus spp.) have been proposed as sylvatic reservoirs for this parasite. Bats have...
- Imiquimod benefits.
Melville, Nancy A. // Dermatology Times; May2008, Vol. 29 Issue 5, p62
The article reports on the result of the research for treating Bowen's disease. It indicates that topical imiquimod has potential for treating the disease to leishmaniasis. A problem is that imiquimod may not cure things over the long haul. Meanwhile, problems with inflammation and recurrences...
- In vitro leishmanicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against Leishmania infantum and Leishmania braziliensis species.
Sánchez-Moreno, Manuel; Gómez-Contreras, Fernando; Navarro, Pilar; Marín, Clotilde; Ramírez-Macías, Inmaculada; Olmo, Francisco; Sanz, Ana María; Campayo, Lucrecia; Cano, Carmen; Yunta, María J. R. // Journal of Antimicrobial Chemotherapy (JAC); Feb2012, Vol. 67 Issue 2, p387
Objectives To evaluate the in vitro leishmanicidal activity of imidazole-based (1â€“4) and pyrazole-based (5â€“6) benzo[g]phthalazine derivatives against Leishmania infantum and Leishmania braziliensis. Methods The in vitro activity of compounds 1â€“6 was assayed on extracellular...
- Kala-Azar Elimination in Bihar: Adoption of Newer Evidence-based Strategies Required for Elimination.
Soni, Prashant; Mishra, Ragini; Kumar, Ganga; Pandey, Prabhat; Kumar, Prashant // Middle East Journal of Scientific Research; 2013, Vol. 17 Issue 9, p1220
Kala-azar i.e, Visceral Leishmaniasis (VL) is a menace to Bihar, affecting large number of population. As per WHO, one-third cases of Kala-azar are reported from Bihar itself. Diagnosis and case detection is done by rk39. Miltefosine has been rolled out in 16 highly endemic districts of Bihar;...
- FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE.
VALETE-ROSALINO, Claudia Maria; ARAUJO-MELO, Maria Helena; de Oliveira BEZERRA, Débora Cristina; de BARCELOS, Renata Oliveira; de MELO-FERREIRA, Vanessa; de Sousa TORRACA, Tania Salgado; da Costa MARTINS, Ana Cristina; MOREIRA, Joäo Soares; VARGAS, Mirian Catherine Melgares; BRAGA, Frederico Pereira Bom; de Matos SALGUEIRO, Mariza; SAHEKI, Mauricio Naoto; SCHUBACH, Armando Oliveira // Revista do Instituto de Medicina Tropical de Sao Paulo; Sep/Oct2014, Vol. 56 Issue 5, p439
Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary...
- Antileishmanial Agents: An Updated Review.
Pathak, Devender; Yadav, Mithlesh; Siddiqui, Nadeem; Kushawah, Sapana // Der Pharma Chemica; 2011, Vol. 3 Issue 1, p239
Antileishmanial activity is associated with diverse heterocyclic nucleus such as piperazine, pyrimidine, quinoline, azoles (imidazole, 1, 2, 4 triazole, isoxazole, pyrazole, thiazole, thiadiazole), quinazoline, acridine and indole. This review article covers different heterocyclic nucleus with...
- Antiprotozoal Activity of Quinonemethide Triterpenes from Maytenus ilicifolia (Celastraceae).
Dos Santos, Vania A. F. F. M.; Leite, Karoline M.; da Costa Siqueira, Mariana; Regasini, Luis O.; Martinez, Isabel; Nogueira, Camila T.; Galuppo, Mariana Kolos; Stolf, Beatriz S.; Pereira, Ana Maria Soares; Cicarelli, Regina M. B.; Furlan, Maysa; Graminha, Marcia A. S. // Molecules; Jan2013, Vol. 18 Issue 1, p1054
The present study describes the leishmanicidal and trypanocidal activities of two quinonemethide triterpenes, maytenin (1) and pristimerin (2), isolated from Maytenus ilicifolia root barks (Celastraceae). The compounds were effective against the Trypanosomatidae Leishmania amazonensis and...
- Homology Modeling and Molecular Dynamics Study of Serine Hydroxyl Methyl Transferase Enzyme from Leishmania donovani.
Sethi, Ashish; Sharma, Rakesh Kumar; Bharti, Sanjay K. // Journal of Pharmacy Research; Jul2011, Vol. 4 Issue 7, p2269
Leishmaniasis is a major public health problem in many developing countries. Current drug therapy which inculdes many anti cancer drugs can reduce the severity of the disease but leads to many undesirable side effects. However, owing to the increased resistance to most of the widely used drugs,...