Citations with the tag: HOST-parasite relationships -- Immunological aspects

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  • Parasites and the immune system.
    Wakelin, Derek // BioScience; Jan1997, Vol. 47 Issue 1, p32 

    Examines the capacity of humans to respond immunologically to parasites. The question of the relationship of the immune system to the control of parasitic infections; Examination of what is understood about the role of the immune system in regulating the interactions between hosts and...

  • Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus.
    Kash, John C.; Tumpey, Terrence M.; Proll, Sean C.; Carter, Victoria; Perwitasari, Olivia; Thomas, Matthew J.; Basler, Christopher F.; Palese, Peter; Taubenberger, Jeffery K.; García-Sastre, Adolfo; Swayne, David E.; Katze, Michael G. // Nature; 10/5/2006, Vol. 443 Issue 7111, p578 

    The influenza pandemic of 1918–19 was responsible for about 50 million deaths worldwide. Modern histopathological analysis of autopsy samples from human influenza cases from 1918 revealed significant damage to the lungs with acute, focal bronchitis and alveolitis associated with massive...

  • A new specific gene for wasp cellular immune resistance in Drosophila.
    BENASSI,; FREY // Heredity; Mar1998, Vol. 80 Issue 3, p347 

    Larvae of Drosophila melanogaster produce a haemocytic reaction against eggs of the parasitoid, Asobara tabida, which leads to the formation of a multicellular capsule surrounding the foreign object. The same phenomenon was observed with the parasitoid, Leptopilina boulardi. Concerning the...

  • Modulation of the Host Immune System by Ectoparasitic Arthropods.
    Wikel, Stephen K. // BioScience; Apr99, Vol. 49 Issue 4, p311 

    Discusses the immunological interactions between ectoparasitic arthropods and their hosts. Contents of the saliva of blood-feeding arthropods; How arthropods evade the effects of host grooming; Transmission of disease; Development of different host responses; Complexity of host immune responses...

  • Role of innate cytokines in mycobacterial infection.
    Cooper, A. M.; Mayer-Barber, K. D.; Sher, A. // Mucosal Immunology (1933-0219); May2011, Vol. 4 Issue 3, p252 

    Cells of the innate immune system produce cytokines and lipid mediators that strongly influence the outcome of mycobacterial infection. In the case of Mycobacterium tuberculosis, the lung is a critical site for this interaction. Here, we review current information on the role of the major innate...

  • Environmental Constraints Guide Migration of Malaria Parasites during Transmission.
    Hellmann, Janina Kristin; Münter, Sylvia; Kudryashev, Mikhail; Schulz, Simon; Heiss, Kirsten; Matuschewski, Ann-Kristin Müller Kai; Spatz, Joachim P.; Schwarz, Ulrich S.; Frischknecht, Friedrich // PLoS Pathogens; Jun2011, Vol. 7 Issue 6, Special section p1 

    Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue. During transmission of malaria, parasite motility in the skin is important for Plasmodium sporozoites to reach the blood circulation. Here we show that sporozoite...

  • Variation of parasite load and immune parameters in two species of New Zealand shore crabs.
    Dittmer, Jessica; Koehler, Anson V.; Richard, Freddie-Jeanne; Poulin, Robert; Sicard, Mathieu // Parasitology Research; Sep2011, Vol. 109 Issue 3, p759 

    While parasites are likely to encounter several potential intermediate hosts in natural communities, a parasite's actual range of compatible hosts is limited by numerous biological factors ranging from behaviour to immunology. In crustaceans, two major components of immunity are haemocytes and...

  • How Does the Dinoflagellate Parasite Hematodinium Outsmart the Immune System of Its Crustacean Hosts?
    Rowley, Andrew F.; Smith, Amanda L.; Davies, Charlotte E. // PLoS Pathogens; May2015, Vol. 11 Issue 5, p1 

    The article discusses the relationship of species of marine crustaceans as hosts to dinoflagellates of the genus Hematodinium. Topics discussed include the impact of Hematodinium parasitism on crustacean fisheries and aquaculture, the pathology of Hematodinium infection in crustacean hosts, and...

  • Tying the conductor's arms.
    Good, Michael F. // Nature; 7/1/1999, Vol. 400 Issue 6739, p25 

    Discusses research by Urban et al which described a way in which Plasmodium falciparum inhibits the immune response of its host. Immune response in people with malaria; The antigen-presenting dendritic cells; How P. falciparum prevents the maturation of dendritic cells; Role of the PfEMP1...

  • Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells.
    Urban, Britta C.; Ferguson, David J.P.; Pain, Arnab; Willcox, Nick; Plebanski, Magdalena; Austyn, Jonathan M.; Roberts, David J. // Nature; 7/1/1999, Vol. 400 Issue 6739, p73 

    Presents research which showed the effects of malaria-infected erythrocytes' adherence to dendritic cells. Virulence factors of the malaria parasite Plasmodium falciparum; Inhibition of the maturation of dendritic cells and their capacity to stimulate T cells; Induction of immune dysregulation.

  • Oral Pathogens, Immunity, and Periodontal Diseases.
    Mesa, Francisco; Liebana, Jose; Galindo-Moreno, Pablo; O'Valle, Francisco J. // Current Immunology Reviews; Feb2011, Vol. 7 Issue 1, p83 

    The pathogenesis of periodontal disease is not fully understood. Subgingival bacterial pathogens are essential for the initiation and development of the disease, but it is the resulting host reaction that primarily mediates tissue damage. Complex inflammatory and immune responses are involved in...

  • A new malaria antigen produces partial protection against Plasmodium yoelii challenge.
    Zhang, Yanhui; Qi, Yanwei; Li, Jian; Liu, Shengfa; Hong, Lingxian; Lin, Tianlong; Long, Carole; Su, Xin-zhuan // Parasitology Research; Apr2012, Vol. 110 Issue 4, p1337 

    Of all the parasitic diseases, malaria is the number one killer. Despite tremendous efforts in disease control and research, nearly a million people, primarily children, still die from the disease each year, partly due to drug resistance and the lack of an effective vaccine. Many parasite...

  • Functional Analysis of Host Factors that Mediate the Intracellular Lifestyle of Cryptococcus neoformans.
    Qing-Ming Qin; Jijing Luo; Lin, Xiaorong; Pei, Jianwu; Lei Li; Ficht, Thomas A.; de Figueiredo, Paul // PLoS Pathogens; Jun2011, Vol. 7 Issue 6, Special section p1 

    Cryptococcus neoformans (Cn), the major causative agent of human fungal meningoencephalitis, replicates within phagolysosomes of infected host cells. Despite more than a half-century of investigation into host-Cn interactions, host factors that mediate infection by this fungal pathogen remain...

  • New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection.
    Lawrence, B.; Vorderstrasse, Beth // Seminars in Immunopathology; Nov2013, Vol. 35 Issue 6, p615 

    The host response to infection is known to be influenced by many factors, including genetics, nutritional status, age, as well as drug and chemical exposures. Recent advances reveal that the aryl hydrocarbon receptor (AhR) modulates aspects of the innate and adaptive immune response to viral,...

  • Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population.
    Hanel, Susanne; TP, Velavan; Kremsner, Peter; Kun, Jürgen // Immunogenetics; Jul2011, Vol. 63 Issue 7, p409 

    Parasites exert a selection pressure on their hosts and are accountable for driving diversity within gene families and immune gene polymorphisms in a host population. The overwhelming response of regulatory T cells during infectious challenges directs the host immune system to lose the ability...

  • Intravascular immunity: the host–pathogen encounter in blood vessels.
    Hickey, Michael J.; Kubes, Paul // Nature Reviews Immunology; May2009, Vol. 9 Issue 5, p364 

    The immune system provides an essential defence against invading pathogens. However, bacteria have evolved numerous strategies to overcome this defence, many of which facilitate systemic dissemination of the pathogen. Nevertheless, the host has evolved many mechanisms to detect and protect...

  • Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection.
    Rodrigues, Claudiney Melqu�ades; Valadares, Helder Magno Silva; Francisco, Amanda Fortes; Arantes, Jerusa Marilda; Campos, Camila Fran�a; Teixeira-Carvalho, Andr�a; Martins-Filho, Olindo Assis; Araujo, M�rcio Sobreira Silva; Arantes, Rosa Maria Esteves; Chiari, Egler; Franco, Gl�ria Regina; Machado, Carlos Renato; Pena, S�rgio Danilo Junho; Faria, Ana Maria Caetano; Macedo, Andr�a Mara // PLoS Neglected Tropical Diseases; Oct2010, Vol. 4 Issue 10, p1 

    A century after the discovery of Trypanosoma cruzi in a child living in Lassance, Minas Gerais, Brazil in 1909, many uncertainties remain with respect to factors determining the pathogenesis of Chagas disease (CD). Herein, we simultaneously investigate the contribution of both host and parasite...

  • A Major Genetic Locus in Trypanosoma brucei Is a Determinant of Host Pathology.
    Morrison, Liam J.; Tait, Andy; McLellan, Sarah; Sweeney, Lindsay; C. Michael R. Turner; MacLeod, Annette // PLoS Neglected Tropical Diseases; Dec2009, Vol. 3 Issue 12, p1 

    The progression and variation of pathology during infections can be due to components from both host or pathogen, and/ or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has been well studied in recent years, but the...


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