Citations with the tag: GENOMICS
Results 1 - 50
- Genome project faces scientific, business hurdles.
Chase, Victor // R&D Magazine; Nov95, Vol. 37 Issue 12, p24Focuses on the obstacles facing the human genome project, an international program dedicated to sequencing the DNA on all 23 pairs of human chromosomes. Institute for Genomic Research's opening of its data banks to university and government scientists; `Bioinformatics research'; Intellectual...
- Mane Event.
Chase, Victor // Current Events; 3/1/2010, Vol. 109 Issue 18, p6The article offers information on the hair sample found in Greenland to decode the first full genetic blueprint or genome of an ancient human.
- Human genome project.
Chase, Victor // Congressional Digest; Feb98, Vol. 77 Issue 2, p39Focuses on the Human Genome Project which is aimed at understanding the hereditary instructions that make each human unique. Background information on the project; How genetic alterations increase a person's risk of developing diseases; Information of tools and techniques designed to find genes...
- Whole-Genome Microarrays Redefined.
Chase, Victor // R&D Magazine; Mar2001, Vol. 43 Issue 3, p22Reports that in the future technology may allow scientists to examine whole genomes with a single-chip experiment. Details of the benefits of such technology.
- Genomics forges ahead in East Asia.
Triendl, Robert // Nature Biotechnology; Mar2000, Vol. 18 Issue 3, p278Discusses the emergence of genomic research in East Asia. Genome research centers set up in China; Efforts made by the Chinese government to protect the country's genetic resources; Goal of Japan's genomic research-oriented Millennium Project; Prospects of genomic research in East Asia.
- Genomic Medicine Program Advisory Committee; Notice of Meeting.
Drake, Vivian // Federal Register; 10/21/2011, Vol. 76 Issue 204, p65563The article announces that a notice of meeting of the Geomic Medicine Program Advisory Committee on November 2, 2011 in Washington D.C. has been given by the Department of Veterans Affairs (VA).
- Corn genome next in line?
Drake, Vivian // R&D Magazine; Oct97, Vol. 39 Issue 11, p12States that the United States Congress may fund research to sequence the three billion base pairs in corn as the next genome project. Arguments made regarding the crop chosen for the project.
- Anticipating the impact of genomics.
Campalani, Sally // Cancer Nursing Practice; Mar2012, Vol. 11 Issue 2, p8The author highlights the importance of understanding and anticipating the impact of genomics by cancer nurses for better understanding of targeted therapies explaining their benefits to patients and their families.
- Sacrifice for the greater good?
Campalani, Sally // Nature; 2/27/2003, Vol. 421 Issue 6926, p875Examines the implications of the plans of U.S. and British genomics researchers to extend their principles of open access throughout the world of biology. Concern on the need to protect the originators' rights to publish; Implications of deposition of data on an open-access website; Principles...
- CLEAN: CLustering Enrichment ANalysis.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p234Background: Integration of biological knowledge encoded in various lists of functionally related genes has become one of the most important aspects of analyzing genome-wide functional genomics data. In the context of cluster analysis, functional coherence of clusters established through such...
- An XML transfer schema for exchange of genomic and genetic mapping data: implementation as a web service in a Taverna workflow.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p252Background: Genomic analysis, particularly for less well-characterized organisms, is greatly assisted by performing comparative analyses between different types of genome maps and across species boundaries. Various providers publish a plethora of on-line resources collating genome mapping data...
- CASSIOPE: An expert system for conserved regions searches.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p284Background: Understanding genome evolution provides insight into biological mechanisms. For many years comparative genomics and analysis of conserved chromosomal regions have helped to unravel the mechanisms involved in genome evolution and their implications for the study of biological systems....
- Deep proteogenomics; high throughput gene validation by multidimensional liquid chromatography and mass spectrometry of proteins from the fungal wheat pathogen Stagonospora nodorum.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p301Background: Stagonospora nodorum, a fungal ascomycete in the class dothideomycetes, is a damaging pathogen of wheat. It is a model for necrotrophic fungi that cause necrotic symptoms via the interaction of multiple effector proteins with cultivar-specific receptors. A draft genome sequence and...
- Detection of recurrent copy number alterations in the genome: taking among-subject heterogeneity seriously.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p308Background: Alterations in the number of copies of genomic DNA that are common or recurrent among diseased individuals are likely to contain disease-critical genes. Unfortunately, defining common or recurrent copy number alteration (CNA) regions remains a challenge. Moreover, the heterogeneous...
- Unsupervised statistical clustering of environmental shotgun sequences.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p316Background: The development of effective environmental shotgun sequence binning methods remains an ongoing challenge in algorithmic analysis of metagenomic data. While previous methods have focused primarily on supervised learning involving extrinsic data, a first-principles statistical model...
- ConservedPrimers 2.0: A high-throughput pipeline for comparative genome referenced intron-flanking PCR primer design and its application in wheat SNP discovery.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p331Background: In some genomic applications it is necessary to design large numbers of PCR primers in exons flanking one or several introns on the basis of orthologous gene sequences in related species. The primer pairs designed by this target gene approach are called "intron-flanking primers" or...
- Integrating functional genomics data using maximum likelihood based simultaneous component analysis.
Campalani, Sally // BMC Bioinformatics; 2009, Vol. 10, p340Background: In contemporary biology, complex biological processes are increasingly studied by collecting and analyzing measurements of the same entities that are collected with different analytical platforms. Such data comprise a number of data blocks that are coupled via a common mode. The goal...
- Taking life to bits.
Wells, William // New Scientist; 08/16/97, Vol. 155 Issue 2095, p30Discusses the work of several researchers that attempt to work out the minimum genome, the smallest group of genes capable of sustaining independent life. Genetic dismantling of Mycoplasma genitalium; Use of computers to model the minimum number of biochemical pathways and the minimum number of...
- French genomics setup questioned.
Lou�t, Sabine // Nature Biotechnology; Apr2000, Vol. 18 Issue 4, p375Questions development of functional genomics project GenHomme launched by France's Education, Science and Technology and Industry Ministries. Criticism related to the program; Budgetary details of the program; Importance of GenHomme for the genomics research in France.
- Parallel genome analysis by two-dimensional DNA typing.
Mullaart, E.; de Vos, G.J. // Nature; 9/30/1993, Vol. 365 Issue 6445, p469Presents a system for large-scale comparative analysis of complex genomes. Background information; Protocol for 2-D DNA typing; Prototype from Instrumek B.V. Schiedam, the Netherlands; Automated electrophoresis unit and image evaluation software.
- MITI turns up heat on research into thermophile genes.
Barker, Stephen // Nature; 6/6/1996, Vol. 381 Issue 6582, p455Reports on Japan's increased support for a genome-related research. Construction of a research annex at its Institute for Bioscience and Human Technology in Tokyo, Japan; Development of technological support for the analyses of proteins from the sequenced genes of a deep-sea-vent bacterium.
- The current trend of genomics research for human diseases.
Zhang, Ke K.; Arabnia, Hamid R.; Yunliang Wang; Youping Deng // BMC Medical Genomics; 2013, Vol. 6 Issue Suppl 1, p1This is an introduction to the supplement to BMC Medical Genomics that includes16 papers selected from the 2011 World Congress in Computer Science, Computer Engineering, Applied Computing as well as other sources with a focus on genomics studies with a focus on human diseases.
- Cytosine Methylation Is Not the Major Factor Inducing CpG Dinucleotide Deficiency in Bacterial Genomes.
Yong Wang; Eduardo P.C. Rocha; Frederick C.C. Leung; Antoine Danchin // Journal of Molecular Evolution; Jun2004, Vol. 58 Issue 6, p692CpG dinucleotide deficiency has been found in viruses, mitochondria, prokaryotes, and eukaryotes. The consensual explanation is that it is due to deamination of methylated cytosines, as established for vertebrate and plants. However, we still do not know whether C5 cytosine methylation is also...
- Mammals' Genomes Getting Smaller.
Yong Wang; Eduardo P.C. Rocha; Frederick C.C. Leung; Antoine Danchin // USA Today Magazine; Jun2010, Vol. 138 Issue 2781, p9The article reveals chromosomal evidence found by scientists from Indiana University, Bloomington, Indiana which showed that genomes of mammals have continued to shrink since the extinction of the dinosaurs and continue to shrink as a result of natural selection and the occurrence of long...
- Private sector moves to exploit complementary DNA molecules.
Yong Wang; Eduardo P.C. Rocha; Frederick C.C. Leung; Antoine Danchin // Japanese Biotechnology & Medical Technology; Feb/Mar2001, Vol. 1 Issue 1, p10Provides information on the international human genome project in Japan. Focus of the project; Amount of investment made by the New Energy & Industrial Technology Centre to the project; Private firms and institutes involved in the project.
- Editorial.
Brown, Steve D.; Nadeau, Joe; Bucan, Maja // Mammalian Genome; Jan2008, Vol. 19 Issue 1, p1An introduction to the January 2008 issue of "Mammalian Genome" is presented.
- Group starts sequence map of the cattle genome.
Brown, Steve D.; Nadeau, Joe; Bucan, Maja // R&D Magazine; Apr2002, Vol. 44 Issue 4, p10No abstract available.
- Tonga joins list of laboratory communities.
Rouse, Rada // Nature Medicine; Jan2001, Vol. 7 Issue 1, p8Reports that Melbourne, Australia-based genomic company Autogen has secured the rights to access DNA from the people of Tonga, a group of islands with a population of 108,000 people of Polynesian descent, east of Fiji. Other genetically isolated communities; Benefits to the island from the...
- Statistical Genetics: False discovery or missed discovery?
Devlin, B.; Roeder, K.; Wasserman, L. // Heredity; Dec2003, Vol. 91 Issue 6, p537Discusses an approach to multiple genome testing based on controlling the false discovery rate (FDR). Hypothesis testing; Role of the Human Genome Project in human genetics; Benjamin-Hochberg method for controlling FDR.
- Large Scale Sequencing and Analysis of AT Rich Eukaryote Genomes.
Glockner, Gernot // Current Genomics; Nov2000, Vol. 1 Issue 3, p289Environmental pressures can direct genomes from a normal to a more or less pronounced imbalance in the base composition. These pressures seem to occur relatively often since genomes with a deviation from a normal base composition are widespread throughout lower eukaryotes. These genomes show...
- Gene Ontology-Facilitated Genome Analysis.
Hanqing Xie, N. // Current Genomics; Oct2003, Vol. 4 Issue 7, p569Gene Ontology facilitates biomedical knowledge representation and efficient information management. The systematic representation and hierarchical structure of Gene Ontology bring forth great potential to examine data and information across the broad spectrum of biology. This article briefly...
- Finding the Needle in the Haystack: Computational Strategies for Discovering Regulatory Sequences in Genomes.
Ovcharenko, Ivan; Loots, Gabriela G. // Current Genomics; Oct2003, Vol. 4 Issue 7, p557Annotating the noncoding portion of the human genome and identifying functional regulatory elements embedded in its sequence creates a continuing challenge. Historically, the functional characterization of regulatory elements has been slow, labor-intensive and inadequate to keep up with the...
- Scientists unravel secrets of the camel.
Ovcharenko, Ivan; Loots, Gabriela G. // Filipino Post; 6/17/2010, p9The article reports that the decoding of the entire genome of Arabian camels by a group of international scientist may lead to the discovery of remedies for cancer and acquired immunodeficiency syndrome (AIDS).
- It's Official: The 'Rough Draft' is Complete.
Bramwell, Michael // Scientific Computing & Instrumentation; Jul2000, Vol. 17 Issue 8, p6Comments on the completion of the rough draft of the human genome by scientists at the Human Genome Project and Celera Genomics. Background on the project to decode the human genome.
- Search for Primitive Methanopyrus Based on Genetic Distance Between Val- and Ile-tRNA Synthetases.
Zhiliang Yu; Takai, Ken; Slesarev, Alexei; Hong Xue; Wong, J. Tze-Fei // Journal of Molecular Evolution; Oct2009, Vol. 69 Issue 4, p386Since evidence indicates that the Last Universal Common Ancestor (LUCA) was phylogenetically closest to Methanopyrus kandleri among living organisms with elucidated genomes, this study has been directed to a search for the most primitive Methanopyrus lineage. For this purpose, the divergence of...
- Capsid.
Zhiliang Yu; Takai, Ken; Slesarev, Alexei; Hong Xue; Wong, J. Tze-Fei // Encyclopedic Reference of Molecular Pharmacology; 2004, p218The article presents an encyclopedia entry for capsid, which is a proteinaceous shell encasing the viral genome.
- The use of a non-LTR element to date the formation of the Sdic gene cluster.
Rita Ponce // Genetica; Nov2007, Vol. 131 Issue 3, p315Abstract Transposable elements comprise a considerable part of eukaryotic genomes, and there is increasing evidence for their role in the evolution of genomes. The number of active transposable elements present in the host genome at any given time is probably small relative to the number of...
- Sequence-specific reconstruction from fragmentary databases using seed sequences: implementation and validation on SAGE, proteome and generic sequencing data.
Tiago J. P. Sobreira; Arthur Gruber // Bioinformatics; Aug2008, Vol. 24 Issue 15, p1676Motivation: DNA assembly programs classically perform an all-against-all comparison of reads to identify overlaps, followed by a multiple sequence alignment and generation of a consensus sequence. If the aim is to assemble a particular segment, instead of a whole genome or transcriptome, a...
- Genome Canada update.
Carty, Arthur; Tsui, Lap-Chee // Nature Biotechnology; Feb2000, Vol. 18 Issue 2, p129Presents facts related to the organization called Genome Canada. Modifications undergone by the organization's proposal entitled 'Genome Canada 1998 Blueprint and Principles'; Work of the organization's interim board of directors to elicit support for a Genome Canada research initiative.
- Genomic Vision wins patent for GMC in several countries.
Carty, Arthur; Tsui, Lap-Chee // Medical Device Daily; 7/5/2012, Vol. 16 Issue 129, p3The article reports the patent awarded to Genomic Vision in several countries for its Genomic Morse Code (GMC), a method for structural and visual analysis of the genome.
- Talking genomic.
Carty, Arthur; Tsui, Lap-Chee // Minnesota Medicine; Oct2012, Vol. 95 Issue 10, p6The article describes three most commonly used terms in genomics including next-generation sequencing, whole-genome sequencing and whole-exome sequencing.
- Sequencing: Dark matter translation.
Carty, Arthur; Tsui, Lap-Chee // Nature Methods; Jan2012, Vol. 9 Issue 1, p17The article offers information on a study conducted by Ingolia and colleagues which focuses on the use of established methods such as RNA sequencing to study the dynamics and complexity of mammalian proteomes.
- Genome Size.
Greilhuber, Johann; Dole�el, Jaroslav; Leitch, Ilia J.; Loureiro, Jo�o; Suda, Jan // Journal of Botany; 2010, p1An introduction is presented in which the editors discuss various reports within the issue on topics including the genome size diversification and physical genomic characters of monocot orders, the effect of growth form in the evolution of genome size among angiosperms, and the relationship...
- Mutations in RLBP1 associated with fundus albipunctatus in consanguineous Pakistani families.
Shagufta Naz // British Journal of Ophthalmology; Jul2011, Vol. 95 Issue 7, p1019OBJECTIVE: To identify disease-causing mutations in two consanguineous Pakistani families with fundus albipunctatus. METHODS: Affected individuals in both families underwent a thorough clinical examination including funduscopy and electroretinography. Blood samples were collected from all...
- Efficient replication, and evolution of Sindbis virus genomes with non-canonical 3â²A/U-rich elements (NC3ARE) in neonatal mice.
Frederick James; Katie Hietala; Dganit Eldar; Tiffany Guess; Cecil Cone; Nathan Mundall; Joey Barnett; Ramaswamy Raju // Virus Genes; Dec2007, Vol. 35 Issue 3, p651Abstract  Sindbis virus (SIN) is a mosquito-transmitted animal RNA virus. We previously reported that SIN genomes lacking a canonical 19 nt 3â²CSE undergo novel repair processes in BHK cells to generate a library of stable atypical SIN genomes with non-canonical 3â²A/U-rich...
- Genome-wide prediction of splice-modifying SNPs in human genes using a new analysis pipeline called AASsites.
Faber, Kirsten; Glatting, Karl-Heinz; Mueller, Phillip J.; Risch, Angela; Hotz-Wagenblatt, Agnes // BMC Bioinformatics; Jan2011 Supplement 4, Vol. 12, p1Background: Some single nucleotide polymorphisms (SNPs) are known to modify the risk of developing certain diseases or the reaction to drugs. Due to next generation sequencing methods the number of known human SNPs has grown. Not all SNPs lead to a modified protein, which may be the origin of a...
- Functional Coverage of the Human Genome by Existing Structures, Structural Genomics Targets, and Homology Models.
Lei Xie; Bourne, Philip E.; Thornton, Janet // PLoS Computational Biology; Aug2005, Vol. 1 Issue 3, p222The bias in protein structure and function space resulting from experimental limitations and targeting of particular functional classes of proteins by structural biologists has long been recognized, but never continuously quantified. Using the Enzyme Commission and the Gene Ontology...
- GENOME NEWS.
Lei Xie; Bourne, Philip E.; Thornton, Janet // Body Bulletin; Sep2003, Vol. 4 Issue 9, p6In 1953, scientists James Watson and Francis Crick made history by describing the double helix shape of DNA, the building blocks of all life. Coinciding with the 50th anniversary of their discovery, the Human Genome Project was completed in April 2003, more than 2 years ahead of schedule, with...
- Determination of complete nucleotide sequence of the genome of hyperthermophilic microorganism.
Skryabin, K. G.; Mardanov, A. V.; Kublanov, I. V.; Bonch-Osmolovskaya, E. A.; Ravin, N. V. // Doklady Biochemistry & Biophysics; Jul2008, Vol. 421 Issue 1, p204The article discusses decoding of microorganism genomes and its uses. Decoding of microorganism genomes is a basis for research into the microbiology and essential for medicine and biotechnology. For example, the sequencing of genomes of microorganisms makes it possible to identify important...
- The Genomic Palimpsest: Genomics in Evolution and Ecology.
Delwiche, Charles F. // BioScience; Nov2004, Vol. 54 Issue 11, p991Genomics is the discipline that has grown up around the sequencing and analysis of complete genomes. It has typically emphasized questions that involve the biological function of individual organisms, and has been somewhat isolated from the fields of evolutionary biology and ecology. However,...
