Citations with the tag: GENES
Results 1 - 50
- Regulation and patterns of endogenous and exogenous gene expression during differentiation of embryonal carcinoma cells
Abarzua, P.; Astigiano, S.; Sherman, M. I. // Environmental Health Perspectives; Mar1989, Vol. 80, p25
No abstract available.
- The use of transgenic mice for environmental health research
Eddy, Mitch // Environmental Health Perspectives; Sep1993, Vol. 101 Issue 4, p298
No abstract available.
- The facts--genes.
Eddy, Mitch // New Internationalist; Aug97, Issue 293, p18
Presents information on genes. Growth of biotechnology, the techniques of molecular biology; Monetary value of genes. INSET: How does your garden grow?..
- Allozyme variation of Fagus crenata in northeastern Japan
Tsumura, Yoshihiko; Uchida, Koji; Nakamura, Tohru; Takahashi, Makoto; Ohba, Kihachiro // Canadian Journal of Forest Research; May1994, Vol. 24 Issue 5, p1071
No abstract available.
- Saving Central America's disappearing conifers
Kaufman, Wallace // American Forests; Mar/Apr1989, Vol. 95 Issue 3/4, p26
No abstract available.
- Lean genes more weighty than fat genes.
McBride, Judy // Agricultural Research; Dec95, Vol. 43 Issue 12, p20
Reports that in research to determine the degree to which inheritance and lifestyle figured into bone density, lean genes were found to be more weighty than fat genes. Use of dual energy x-ray absorptiometry; Study by Elizabeth Krall and Bess Dawson-Hughes.
- Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer
Karjalainen, A.; Vainio, H.; Hirvonen, A.; Husgafvel-Pursiainen, K.; Anttila, S. // Environmental Health Perspectives Supplements; 1993 Supplement 3, Vol. 101, p109
No abstract available.
- Not physically fit? Blame your parents.
Karjalainen, A.; Vainio, H.; Hirvonen, A.; Husgafvel-Pursiainen, K.; Anttila, S. // USA Today Magazine; May96, Vol. 124 Issue 2612, p9
Focuses on the influence of genes on fitness abilities. Physical traits.
- Future possibilities.
Karjalainen, A.; Vainio, H.; Hirvonen, A.; Husgafvel-Pursiainen, K.; Anttila, S. // Mayo Clinic Health Letter; Feb1996, Vol. 14 Issue 2, p6
Reports on the discovery of a gene associated with airway inflammation and constriction.
- What is a cellular gene?
Andrade, Evan T.; R.M.D. // Cortlandt Forum; 3/25/95, Vol. 8 Issue 3, p62
Provides a definition for the term, cellular genes, used in descriptions of prion disease propagation.
- Incorporating rich background knowledge for gene named entity classification and recognition.
Andrade, Evan T.; R.M.D. // BMC Bioinformatics; 2009, Vol. 10, p223
Background: Gene named entity classification and recognition are crucial preliminary steps of text mining in biomedical literature. Machine learning based methods have been used in this area with great success. In most state-of-the-art systems, elaborately designed lexical features, such as...
- Sparse canonical correlation analysis for identifying, connecting and completing gene-expression networks.
Andrade, Evan T.; R.M.D. // BMC Bioinformatics; 2009, Vol. 10, p315
Background: We generalized penalized canonical correlation analysis for analyzing microarray gene-expression measurements for checking completeness of known metabolic pathways and identifying candidate genes for incorporation in the pathway. We used Wold's method for calculation of the canonical...
- GIFtS: annotation landscape analysis with GeneCards.
Andrade, Evan T.; R.M.D. // BMC Bioinformatics; 2009, Vol. 10, p348
Background: Gene annotation is a pivotal component in computational genomics, encompassing prediction of gene function, expression analysis, and sequence scrutiny. Hence, quantitative measures of the annotation landscape constitute a pertinent bioinformatics tool. GeneCards® is a gene-centric...
- Scream gene.
Knight, Jonathan, // New Scientist; 11/22/97, Vol. 156 Issue 2109, p6
Reports on the discovery of a gene in mice that helps them recall terrifying experiences. Protein in the gene called Ras-GRF; Plans to determine the biochemical function of Ras-GRF.
- Variation of dominance of newly arisen adaptive genes.
Bourguet, Denis; Lenormand, Thomas // Genetics; Nov97, Vol. 147 Issue 3, p1225
Discusses how the dominance of arisen adaptive gene alleles vary, such as insecticide resistance genes. Information on the dominance levels of insecticide resistance; How were dominance levels found; Why was the variation not explained.
- Comparable rates of gene loss and functional divergence after genome duplications early in...
Nadeau, Joseph H.; Sankoff, David // Genetics; Nov97, Vol. 147 Issue 3, p1259
Presents information pertaining to gene duplication. Importance of duplicated genes; Information on gene family; Reference to chromosome location.
- Average dominance for polygenes: Drawbacks of regression estimates.
Caballero, Armando; Keightley, Peter D. // Genetics; Nov97, Vol. 147 Issue 3, p1487
Presents information pertaining to the dominance of genes. Consideration of mutation-selection balance; Estimation of average dominance in drosophila; Applications of corrections.
- A tale of too witty? Using whimsy to name fringe genes.
Kuska, Bob // JNCI: Journal of the National Cancer Institute; 10/01/97, Vol. 89 Issue 19, p1396
Part II. Examines the dilemma faced by scientists in naming genes. Preference of scientists in using conservative names reflecting the function of a gene's protein product; Benefits of using witty or whimsical names; Practicality of whimsical names; Importance of the formation of a systematic...
- Dispatches from patched.
Shilo, Ben-Zion // Nature; 7/11/1996, Vol. 382 Issue 6587, p115
Reports that human patched genes plays many roles in development and is making an entry as a tumor suppressor. Identification; Protein as a key element in the `Hedgehog' signalling pathway; Involvement of the Hedgehog/Patched pathway in a variety of processes.
- Integration of positional signals and regulation of wing formation and identity by Drosophila...
Kim, Jaeseob; Sebring, Angela // Nature; 7/11/1996, Vol. 382 Issue 6587, p133
Reports that appendage formation is organized by signals from discrete sources that act upon downstream genes to control growth and patterning. Use of the Drosophila vestigial gene for wing-cell proliferation; Availability of different signals to activate separate enhancers; Signal integration...
- Activation of `C.elegans' cell death protein CED-9 by an amino-acid substitution in a domain...
Hengartner, Michael O.; Horvitz, H. Robert // Nature; 5/26/1994, Vol. 369 Issue 6478, p318
Reports on the `Caenaorhabditis elegans' gene `ced-9' and the human proto-oncogene `bcl-2' as genes that protect cells from programmed cell death. Comparisons of the two genes; Functions of the genes.
- Interactions among dosage-dependent trans-acting modifers of gene expression and position-effect...
Bhadra, Utpal; Bhadra, Manika Pal; Birchler, James A. // Genetics; Sep98, Vol. 150 Issue 1, p251
Presents a study which attempts to gain information on the interaction properties of the combinations of dosage-dependent modifiers of the white eye color gene. Information on position-effect variegation; What developmental transitions from larvae to pupae to adults act as; Method used for the...
- Fat: It's in our genes.
Bhadra, Utpal; Bhadra, Manika Pal; Birchler, James A. // Newsweek; 12/25/1995, Vol. 126/127 Issue 26/1, following p10
Mentions that Amgen Inc., the biotech company, outbid others for rights to products derived from `the fat gene.' Testing plans for the protein made by the gene that turns fat rats slim; Findings on breast-cancer gene called BRCA1.
- The map of life.
chang, maria I. // Science World; 03/22/99, Vol. 55 Issue 12, p8
Provides information on human genes, a hereditary material that is embedded in every cell of the body. Components; Role of genes in the body make-up; Efforts to map the human genome.
- MDM2 and p53: A question of balance.
Meltzer, Paul S. // JNCI: Journal of the National Cancer Institute; 9/7/94, Vol. 86 Issue 17, p1265
Editorial. Discusses matters pertinent to the murine double minute-2 (MDM2) gene and the p53 oncogene. Mutations in p53; Interaction between p53 and MDM2; Amplification and overexpression of MDM2 in human sarcomas and glial tumors; Genetic complexity of the amplification; Importance of a...
- Mapping the Way to Bovine Bounty.
Suszkiw, Jan // Agricultural Research; Jul2000, Vol. 48 Issue 7, p10
Discusses the use of mapping systems to examine the different DNA markers from the semen of stud bulls. Tools in searching for important genes; Loses suffered by dairy producers annually due to mastitis; Determination of traits expressed by genes.
- A problem with synthetic maps.
Sokal, Robert R.; Oden, Neal L. // Human Biology; Feb99, Vol. 71 Issue 1, p1
Shows from first principles and by analyses of real and simulated data that synthetic maps are subject to large errors and that apparent geographic trends may be detected in spatially random data. Uses of the synthetic maps of human gene frequencies; Role played by statistical artifacts in...
- A problem with synthetic maps: Reply to Sokal et al.
Rendine, Sabina; Piazza, Alberto // Human Biology; Feb99, Vol. 71 Issue 1, p15
Presents a reply to the article `A problem with synthetic maps,' by Robert R. Sokal, Neal L. Oden et al. Validity of synthetic maps of gene frequencies calculated from principal component scores; Purpose of synthetic maps; Proposed method for generating a complete data matrix for using...
- Fusions of Existing Targets May Give Options.
Breindl, Anette // BioWorld Today; 2/21/2012, Vol. 23 Issue 34, Special section p1
The article reports on the findings that fusions of known cancer genes in cancer patients could make their carriers sensitive to existing targeted agents, but they will not be detected by existing diagnostic sequencing methods.
- Shrinking genes for therapy.
Bonetta, Laura // Nature Medicine; Mar2002, Vol. 8 Issue 3, p222
Focuses on the use of reduced versions of large genes for gene therapy to treat genetic diseases. Use of micro-dystrophin constructs to correct Duchenne muscular dystrophy phenotype in a mouse model; Speculation that gene therapy using micro-dystrophins might be effective in preventing muscle...
- Early specification of limb muscle precursor cells by the homeobox gene Lbx1h.
Sch�fer, Konstanze; Braun, Thomas // Nature Genetics; Oct99, Vol. 23 Issue 2, p213
During vertebrate embryogenesis, myogenic precursor cells of limb muscles delaminate from the ventro-lateral edge of the somitic dermomyotome and migrate to the limb buds, where they congregate into dorsal and ventral muscle masses. It has been proposed that the surrounding connective tissue...
- Noninvasive, Repetitive, Quantitative Measurement of Gene Expression from a Bicistronic Message by Positron Emission Tomography, Following Gene Transfer with Adenovirus.
Liang, Qianwa; Gotts, Jeff; Satyamurthy, Nagichettiar; Barrio, Jorge; Phelps, Michael E.; Gambhir, Sanjiv S.; Herschman, Harvey R. // Molecular Therapy; Jul2002, Vol. 6 Issue 1, p73
Gene therapy protocols are hampered by the inability to monitor the location, magnitude, and duration of ectopic gene expression following DNA delivery. Consequently, it is difficult to establish quantitative correlations and/or causal relationships between therapeutic gene expression and...
- RAGE and PRAY.
Smith, D. J. // Pharmacogenomics Journal; 2001, Vol. 1 Issue 2, p90
Presents information on the random activation of gene expression (RAGE). Details on the detection of genes activated by RAGE; Factors to consider regarding RAGE; Application of RAGE in pharmacogenomics.
- Maintenance of functional equivalence during paralogous Hox gene evolution.
Greer, Joy M.; Puetz, John // Nature; 2/10/2000, Vol. 403 Issue 6770, p661
Deals with an analysis of functional relationships between paralogous Hox genes. Evolution of the mammalian Hox gene complex; Divergence in either regulatory or protein-coding sequences; Differences in biological functions for even closely related genes; Quantitative modulations in gene expression.
- Target practice.
Laber, Emily // Sciences; Jan/Feb2000, Vol. 40 Issue 1, p8
Discusses obstacles to gene therapy that prevent it from making significant progress. Guidance of replacement genes; Experimentation with adenoviruses; Amount of space available inside a virus; Injection of adenoviruses into the bloodstream.
- Chromosome targeting.
Dove, Alan // Nature Biotechnology; Oct2000, Vol. 18 Issue 10, p1025
Cites a study by the scientists at the University of California in Irvine and the University of California in San Diego stating the inactivation of targeted genes in cultured cells. Usage of two-photon scanning laser microscope in silencing the genes.
- A novel non-overlapping bi-clustering algorithm for network generation using living cell array data.
E. Yang; P.T. Foteinou; K.R. King; M.L. Yarmush; I.P. Androulakis // Bioinformatics; Sep2007, Vol. 23 Issue 17, p2306
Motivation: The living cell array quantifies the contribution of activated transcription factors upon the expression levels of their target genes. The direct manipulation of the regulatory mechanisms offers enormous possibilities for deciphering the machinery that activates and controls gene...
- Annotation-based distance measures for patient subgroup discovery in clinical microarray studies.
Claudio Lottaz; Joern Toedling; Rainer Spang // Bioinformatics; Sep2007, Vol. 23 Issue 17, p2256
Motivation: Clustering algorithms are widely used in the analysis of microarray data. In clinical studies, they are often applied to find groups of co-regulated genes. Clustering, however, can also stratify patients by similarity of their gene expression profiles, thereby defining novel disease...
- A chromosome-based model for estimating the number of conserved segments between pairs of...
Waddington, David; Springbett, Anthea J. // Genetics; Jan2000, Vol. 154 Issue 1, p323
Examines the number of conserved genes between pairs of species from comparative genetic maps. Insights into the rearrangements of their genomes since divergence from a common ancestor; Proposed model for the distribution of the lengths of unobserved segments on each chromosome; Two comparative...
- Creation of genome-wide protein expression libraries using random activation of gene expression.
Harrington, John J.; Sherf, Bruce; Rundlett, Stephen; Jackson, P. David; Perry, Rob; Cain, Scott; Leventhal, Christina; Thornton, Mark; Ramachandran, Rakesh; Whittington, Jessica; Lerner, Laura; Costanzo, Dana; McElligott, Karen; Boozer, Sherry; Mays, Robert; Smith, Emery; Veloso, Neil; Klika, Alison; Hess, Jennifer // Nature Biotechnology; May2001, Vol. 19 Issue 5, p440
Here we report the use of random activation of gene expression (RAGE) to create genome-wide protein expression libraries. RAGE libraries containing only 5 × 10[SUP6] individual clones were found to express every gene tested, including genes that are normally silent in the parent cell line....
- In utero gene therapy: The case against.
Billings, Paul R. // Nature Medicine; Mar1999, Vol. 5 Issue 3, p255
The prospect of in utero gene therapy presents both tremendous opportunities and real concerns. With the possibility of first clinical trials as little as two years away, now is the time to discuss the merits of this new technology. In this spirit, we present arguments for and against the...
- Safer lentiviral vectors.
Kreisberg, Jason // Nature Biotechnology; Jun2012, Vol. 30 Issue 6, p508
The article presents information on the development of safer lentiviral vectors for gene therapy by reducing splice sites and reducing interference with the host genes by silencing cryptic splice sites.
- Genetic Mapping of the Thymoma Susceptible Locus, Tsr1, in BUF/Mna Rats.
Oyabu, Atsushi; Higo, Kyoko; Ye, Chunlin; Amo, Hiroyuki; Saito, Mitsuhiro; Yagyu, Shigeru; Morita, Hiroyuki; Maeda, Kenji; Serikawa, Tadao; Takahashi, Masahide; Matsuyama, Mutsushi // JNCI: Journal of the National Cancer Institute; 02/03/99, Vol. 91 Issue 3, p279
Determines the location of Tsr1 autosomal dominant gene using microsatellite markers and backcross of rats between the thymoma-susceptible BUF strain and thymoma nonsusceptible ACI/NM (ACI) strain. Maintenance of highly inbred rat strain, BUF; Length poplymorphisms between BUF and ACI rats;...
- homeotic gene(s):.
Schlegel, Rolf H. J. // Encyclopedic Dictionary of Plant Breeding & Related Subjects; 2003, p211
A definition of the term "homeotic genes" is presented, which refers to a class of genes that determines the identity of an organ, segment, or other structural unit during development.
- Evidence for intron length conservation in a set of mammalian genes associated with embryonic development.
Seoighe, Cathal; Korir, Paul K. // BMC Bioinformatics; 2011 Supplement 9, Vol. 12 Issue Suppl 9, p1
Background: We carried out an analysis of intron length conservation across a diverse group of nineteen mammalian species. Motivated by recent research suggesting a role for time delays associated with intron transcription in gene expression oscillations required for early embryonic patterning,...
- Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study.
Wei Sun; Shinsheng Yuan; Ker-Chau Li // BMC Genomics; 2008, Vol. 9, Special section p1
Background: Many studies have shown that the abundance level of gene expression is heritable. Analogous to the traditional genetic study, most researchers treat the expression of one gene as a quantitative trait and map it to expression quantitative trait loci (eQTL). This is 1D-trait mapping....
- DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing.
Saveliev, Alexander; Everett, Christopher; Sharpe, Tammy; Webster, Zoe; Festenstein, Richard // Nature; 4/24/2003, Vol. 422 Issue 6934, p909
Gene repression is crucial to the maintenance of differentiated cell types in multicellular organisms, whereas aberrant silencing can lead to disease. The organization of DNA into chromatin and heterochromatin is implicated in gene silencing. In chromatin, DNA wraps around histones, creating...
- ConceptGen: a gene set enrichment and gene set relation mapping tool.
Sartor, Maureen A.; Mahavisno, Vasudeva; Keshamouni, Venkateshwar G.; Cavalcoli, James; Wright, Zachary; Karnovsky, Alla; Kuick, Rork; Jagadish, H. V.; Mirel, Barbara; Weymouth, Terry; Athey, Brian; Omenn, Gilbert S. // Bioinformatics; Feb2010, Vol. 26 Issue 4, p456
Motivation: The elucidation of biological concepts enriched with differentially expressed genes has become an integral part of the analysis and interpretation of genomic data. Of additional importance is the ability to explore networks of relationships among previously defined biological...
- EVI2B, a Gene Lying in an Intron of the Neurofibromatosis Type 1 (NF1) Gene, Is As the NF1 Gene Involved in Differentiation of Melanocytes and Keratinocytes and Is Overexpressed in Cells Derived from NF1 Neurofibromas.
Kaufmann, Dieter; Gruener, Susanne; Braun, Friederike; Stark, Markus; Griesser, Johann; Hoffmeyer, Sven; Bartelt, Britta // DNA & Cell Biology; May99, Vol. 18 Issue 5, p345
The EVI2B gene is one of three genes embedded in intron 27b of the neurofibromatosis type 1 (NF1; M. Recklinghausen) gene, which are transcribed in the direction opposite that of the NF1 gene. The function of EVI2B and its relation to NF1 symptoms is unknown. Here, the amounts of NF1 and EVI2B...
- A His2AvDGFP Fusion Gene Complements a Lethal His2AvD Mutant Allele and Provides an in Vivo Marker for Drosophila Chromosome Behavior.
Clarkson, Michael; Saint, Robert // DNA & Cell Biology; Jun99, Vol. 18 Issue 6, p457
We have generated Drosophila melanogaster lines carrying a modified genomic fragment which encodes the D. melanogaster variant H2A.F/Z class histone, His2AvD, fused to the green fluorescent protein (GFP) of the jellyfish Aequorea victoria. We show here that the fusion protein consists of...