Citations with the tag: EUKARYOTIC cells -- Research

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  • Eukaryotic Organisms in Extreme Acidic Environments, the Río Tinto Case.
    Aguilera, Angeles // Life (2075-1729); Sep2013, Vol. 3 Issue 3, p363 

    A major issue in microbial ecology is to identify the limits of life for growth and survival, and to understand the molecular mechanisms that define these limits. Thus, interest in the biodiversity and ecology of extreme environments has grown in recent years for several reasons. Some are basic...

  • Exocytosis: A sortilin for secretory granules.
    Schuldt, Alison // Nature Reviews Molecular Cell Biology; Dec2013, Vol. 14 Issue 12, p751 

    The article discusses research being done on condensed cargo of eukaryotic cells which references the study "Lysosomal sorting receptors are essential for secretory granule biogenesis in Tetrahymena," by J. S. Briguglio, S. Kumar and A. P. Turkewitz.

  • Marine ecology: Ocean survey finds huge diversity.
    Schuldt, Alison // Nature; 5/28/2015, Vol. 521 Issue 7553, p396 

    The article discusses research on new eukaryotic organisms found in some ocean samples collected by scientists aboard the research schooner Tara, referencing a study by Eric Karsenti at the European Molecular Biology Laboratory in Heidelberg, Germany published in "Science" in 2015.

  • Yes, Size Matters But Not In The Way You Might Think.
    Schuldt, Alison // Electronic Ardell Wellness Report (E-AWR); 3/4/2010, Issue 524, p1 

    The article presents a study about telomeres, the essential functional elements of eukaryotic chromosomes conducted by the researchers of King's College in London, England. It highlights the contribution of regular exercise and attending high fitness programs to slow aging process and the...

  • A Single, Recent Origin of the Accessory B Chromosome of the Grasshopper Eyprepocnemis plorans.
    Muñoz-Pajares, A. Jesüs; Martínez-Rodríguez, Laura; Teruel, María; Cabrero, Josefa; Camacho, Juan Pedro M.; Perfectti, Francisco // Genetics; Mar2011, Vol. 187 Issue 3, p853 

    B chromosomes are dispensable chromosomes found in >2000 eukaryotic species, usually behaving as genomic parasites. Most B chromosomes seem to be made up of the same kind of DNA sequences present in the A chromosomes. This sequence similarity makes it difficult to obtain specific molecular...

  • Surveillance pathways rescuing eukaryotic ribosomes lost in translation.
    Graille, Marc; Séraphin, Bertrand // Nature Reviews Molecular Cell Biology; Nov2012, Vol. 13 Issue 11, p727 

    Living cells require the continuous production of proteins by the ribosomes. Any problem enforcing these protein factories to stall during mRNA translation may then have deleterious cellular effects. To minimize these defects, eukaryotic cells have evolved dedicated surveillance pathways:...

  • Designing customized cell signalling circuits.
    Lim, Wendell A. // Nature Reviews Molecular Cell Biology; Jun2010, Vol. 11 Issue 6, p393 

    Living cells have evolved a broad array of complex signalling responses, which enables them to survive diverse environmental challenges and execute specific physiological functions. Our increasingly sophisticated understanding of the molecular mechanisms of cell signalling networks in eukaryotes...

  • Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration.
    Zhang, Dong; Grode, Kyle D.; Stewman, Shannon F.; Diaz-Valencia, Juan Daniel; Liebling, Emily; Rath, Uttama; Riera, Tania; Currie, Joshua D.; Buster, Daniel W.; Asenjo, Ana B.; Sosa, Hernando J.; Ross, Jennifer L.; Ma, Ao; Rogers, Stephen L.; Sharp, David J. // Nature Cell Biology; Apr2011, Vol. 13 Issue 4, p361 

    Regulation of microtubule dynamics at the cell cortex is important for cell motility, morphogenesis and division. Here we show that the Drosophila katanin Dm-Kat60 functions to generate a dynamic cortical-microtubule interface in interphase cells. Dm-Kat60 concentrates at the cell cortex of S2...

  • Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast.
    He Gong; Romanova, Nina V.; Allen, Kim D.; Chandramowlishwaran, Pavithra; Gokhale, Kavita; Newnam, Gary P.; Mieczkowski, Piotr; Sherman, Michael Y.; Chernoff, Yury O. // PLoS Genetics; Apr2012, Vol. 8 Issue 4, Special section p1 

    Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing endogenous QN-rich proteins in the aggregated...

  • Protein's "Part-Time Job" Reveals New Facet of Signaling Pathway.
    Inman, Mason // PLoS Biology; Nov2010, Vol. 8 Issue 11, p1 

    The article presents a study which examines the crucial role played by eukaryotic translation initiation factor 3 subunit f (eIF3f) in the Notch signaling pathway. The study shows that eIF3f related with Notch when it is in the cell membrane, channeling a single ubiquitin protein. The study...

  • Analysis of Rare Genomic Changes Does Not Support the Unikont—Bikont Phylogeny and Suggests Cyanobacterial Symbiosis as the Point of Primary Radiation of Eukaryotes.
    Rogozin, Igor B.; Basu, Malay Kumar; Csürós, Miklós; Koonin, Eugene V. // Genome Biology & Evolution; Jan2009, Vol. 2009, p99 

    The deep phylogeny of eukaryotes is an important but extremely difficult problem of evolutionary biology. Five eukaryotic supergroups are relatively well established but the relationship between these supergroups remains elusive, and their divergence seems to best fit a “Big Bang”...

  • A Universal Nonmonotonic Relationship between Gene Compactness and Expression Levels in Multicellular Eukaryotes.
    Carmel, Liran; Koonin, Eugene V. // Genome Biology & Evolution; Jan2009, Vol. 2009, p382 

    Analysis of gene architecture and expression levels of four organisms, Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana, reveals a surprising, nonmonotonic, universal relationship between expression level and gene compactness. With increasing expression...

  • AMERICAN MUSEUM'S YOUNGEST SCIENTIST.
    Carmel, Liran; Koonin, Eugene V. // Ebony; Oct1969, Vol. 24 Issue 12, p86 

    The article reports on the investigations on one-celled animals done by a twelve year old scientist Jeffrey Hurtt and his investigations at the American Museum of Natural History in New York City. According to the chairman of the museum's Department of Education Richard Casebeer, Jeffrey was a...

  • Comparative Genomic Evidence for a Complete Nuclear Pore Complex in the Last Eukaryotic Common Ancestor.
    Neumann, Nadja; Lundin, Daniel; Poole, Anthony M. // PLoS ONE; 2010, Vol. 5 Issue 10, p1 

    Background: The Nuclear Pore Complex (NPC) facilitates molecular trafficking between nucleus and cytoplasm and is an integral feature of the eukaryote cell. It exhibits eight-fold rotational symmetry and is comprised of approximately 30 nucleoporins (Nups) in different stoichiometries. Nups are...

  • A late origin of the extant eukaryotic diversity: divergence time estimates using rare genomic changes.
    Neumann, Nadja; Lundin, Daniel; Poole, Anthony M. // Biology Direct; 2011, Vol. 6 Issue 1, p26 

    The article offers information on the estimation of extant eukaryotic diversity. It mentions a study conducted by researchers using genome-wide analysis to determine divergence of the major lineages of eukaryotes with calibration intervals for living beings like insects, land plants and vertebrates.

  • Chromatin features of plant telomeric sequences at terminal vs. internal positions.
    Majerová, Eva; Mandáková, Terezie; Vu, Giang T. H.; Fajkus, Jiří; Lysak, Martin A.; Fojtová, Miloslava // Frontiers in Plant Science; Nov2014, Vol. 5, p1 

    Epigenetic mechanisms are involved in regulation of crucial cellular processes in eukaryotic organisms. Data on the epigenetic features of plant telomeres and their epigenetic regulation were published mostly for Arabidopsis thaliana, in which the presence of interstitial telomeric repeats...

  • Complex archaea that bridge the gap between prokaryotes and eukaryotes.
    Spang, Anja; Saw, Jimmy H.; Jørgensen, Steffen L.; Zaremba-Niedzwiedzka, Katarzyna; Martijn, Joran; Lind, Anders E.; van Eijk, Roel; Schleper, Christa; Guy, Lionel; Ettema, Thijs J. G. // Nature; 5/14/2015, Vol. 521 Issue 7551, p173 

    The origin of the eukaryotic cell remains one of the most contentious puzzles in modern biology. Recent studies have provided support for the emergence of the eukaryotic host cell from within the archaeal domain of life, but the identity and nature of the putative archaeal ancestor remain a...

  • Evolution: Steps on the road to eukaryotes.
    Embley, T. Martin; Williams, Tom A. // Nature; 5/14/2015, Vol. 521 Issue 7551, p169 

    The article discusses research on archaeal phylum titled Lokiarchaeota considered the closest known relatives of eukaryotes, a term for all organisms with nucleated cells. It examines how these findings could affect future understanding of eukaryotic origins and evolution as well as the history...

  • Sequencing: RNA caps in bacteria stabilize transcripts.
    Embley, T. Martin; Williams, Tom A. // Nature Methods; Feb2015, Vol. 12 Issue 2, p105 

    The article focuses on a study by H. Cahová and colleagues that appeared in an issue of "Nature," which revealed that nicotinamide adenine dinucleotide (NAD) can stabilize transcripts to the 5' cap structure in eukaryotic cells.

  • A paneukaryotic genomic analysis of the small GTPase RABL2 underscores the significance of recurrent gene loss in eukaryote evolution.
    Eliáš, Marek; Klimeš, Vladimír; Derelle, Romain; Petrželková, Romana; Tachezy, Jan // Biology Direct; 2/2/2016, Vol. 11, p1 

    Background: The cilium (flagellum) is a complex cellular structure inherited from the last eukaryotic common ancestor (LECA). A large number of ciliary proteins have been characterized in a few model organisms, but their evolutionary history often remains unexplored. One such protein is the...

  • Plant organellar calcium signalling: an emerging field.
    Stael, Simon; Wurzinger, Bernhard; Mair, Andrea; Mehlmer, Norbert; Vothknecht, Ute C.; Teige, Markus // Journal of Experimental Botany; Apr2012, Vol. 63 Issue 4, p1525 

    This review provides a comprehensive overview of the established and emerging roles that organelles play in calcium signalling. The function of calcium as a secondary messenger in signal transduction networks is well documented in all eukaryotic organisms, but so far existing reviews have hardly...

  • Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase.
    Maeshima, Kazuhiro; Iino, Haruki; Hihara, Saera; Funakoshi, Tomoko; Watanabe, Ai; Nishimura, Masaomi; Nakatomi, Reiko; Yahata, Kazuhide; Imamoto, Fumio; Hashikawa, Tsutomu; Yokota, Hideo; Imamoto, Naoko // Nature Structural & Molecular Biology; Sep2010, Vol. 17 Issue 9, p1065 

    Nuclear volume and the number of nuclear pore complexes (NPCs) on the nucleus almost double during interphase in dividing cells. How these events are coordinated with the cell cycle is poorly understood, particularly in mammalian cells. We report here, based on newly developed techniques for...

  • Adenosine Triphosphate (ATP) Is a Candidate Signaling Molecule in the Mitochondria-to-Nucleus Retrograde Response Pathway.
    Zhang, Feng; Pracheil, Tammy; Thornton, Janet; Liu, Zhengchang // Genes; Mar2013, Vol. 4 Issue 1, p86 

    Intracellular communication from the mitochondria to the nucleus is achieved via the retrograde response. In budding yeast, the retrograde response, also known as the RTG pathway, is regulated positively by Rtg1, Rtg2, Rtg3 and Grr1 and negatively by Mks1, Lst8 and two 14-3-3 proteins, Bmh1/2....

  • Discovering non-random segregation of sister chromatids: the naïve treatment of a premature discovery.
    Lark, Karl G.; Rando, Thomas; Hubbard, Karen; Quesenberry, Peter J. // Frontiers in Oncology; Feb2013, Vol. 3, Special section p1 

    The discovery of non-random chromosome segregation (Figure 1) is discussed from the perspective of what was known in 1965 and 1966. The distinction between daughter, parent, or grandparent strands of DNA was developed in a bacterial system and led to the discovery that multiple copies of DNA...

  • HOW p-BENZOQUINONE INHIBITS GROWTH OF VARIOUS FRESHWATER PHOTOTROPHS: DIFFERENT SUSCEPTIBILITY AND MODES OF ACTIONS?
    Bährs, Hanno; Heinze, Tobias; Gilbert, Matthias; Wilhelm, Christian; Steinberg, Christian E. W. // Annals of Environmental Science; 2013, Vol. 7, p1 

    Interactions of polyphenols with freshwater phototrophs have been the focus of many studies, since polyphenols of various classes and their oxidation products (quinones) belong to natural organic matter in any freshwater body. Most of these studies lack information regarding the possible...

  • Periodicities designed in the tropomyosin sequence and structure define its functions.
    Barua, Bipasha // BioArchitecture; May/Jun2013, Vol. 3 Issue 3, p51 

    Tropomyosin is an actin binding protein that regulates actin filament dynamics and its interactions with actin binding proteins such as myosin, tropomodulin, formin, Arp2/3 and ADF-cofilin in most eukaryotic cells. Tropomyosin is the prototypical two-chained, α-helical coiled coil protein...

  • Mechanism of Chromosomal Boundary Action: Roadblock, Sink, or Loop?
    Gohl, Daryl; Aoki, Tsutomu; Blanton, Jason; Shanower, Greg; Kappes, Gretchen; Schedl, Paul // Genetics; Mar2011, Vol. 187 Issue 3, p731 

    Boundary elements or insulators subdivide eukaryotic chromosomes into a series of structurally and functionally autonomous domains. They ensure that the action of enhancers and silencers is restricted to the domain in which these regulatory elements reside. Three models, the roadblock,...

  • Constant Splice-Isoform Ratios in Human Lymphoblastoid Cells Support the Concept of a Splico-Stat.
    Kramer, Marcel; Huse, Klaus; Menzel, Uwe; Backhaus, Oliver; Rosenstiel, Philip; Schreiber, Stefan; Hampe, Jochen; Platzer, Matthias // Genetics; Mar2011, Vol. 187 Issue 3, p761 

    Splicing generates mature transcripts from genes in pieces in eukaryotic cells. Overwhelming evidence has accumulated that alternative routes in splicing are possible for most human and mammalian genes, thereby allowing formation of different transcripts from one gene. No function has been...

  • Role of Heat Shock Proteins in the initiation, elaboration and therapy of infectious diseases.
    Gilea, Beatrice; Lazar, Veronica // Biointerface Research in Applied Chemistry; 2013, Vol. 3 Issue 5, p636 

    The prokaryotic and eukaryotic cells respond to different types of lethal assaults by the synthesis of heat shock proteins (HSP), in order to protect themselves. HSPs are also synthesized constitutively and exhibit important housekeeping functions essential for cellular survival, by their...

  • Proving Lipid Rafts Exist: Membrane Domains in the Prokaryote Borrelia burgdorferi Have the Same Properties as Eukaryotic Lipid Rafts
    LaRocca, Timothy J.; Pathak, Priyadarshini; Chiantia, Salvatore; Toledo, Alvaro; Silvius, John R.; Benach, Jorge L.; London, Erwin // PLoS Pathogens; May2013, Vol. 9 Issue 5, p1 

    Lipid rafts in eukaryotic cells are sphingolipid and cholesterol-rich, ordered membrane regions that have been postulated to play roles in many membrane functions, including infection. We previously demonstrated the existence of cholesterol-lipid-rich domains in membranes of the prokaryote, B....

  • Insights into Chromatin Structure and Dynamics in Plants.
    Rosa, Stefanie; Shaw, Peter // Biology (2079-7737); Dec2013, Vol. 2 Issue 4, p1378 

    The packaging of chromatin into the nucleus of a eukaryotic cell requires an extraordinary degree of compaction and physical organization. In recent years, it has been shown that this organization is dynamically orchestrated to regulate responses to exogenous stimuli as well as to guide complex...

  • Growth control of the eukaryote cell: a systems biology study in yeast.
    Castrillo, Juan I.; Zeef, Leo A.; Hoyle, David C.; Zhang, Nianshu; Hayes, Andrew; Gardner, David C. J.; Cornell, Michael J.; Petty, June; Hakes, Luke; Wardleworth, Leanne; Rash, Bharat; Brown, Marie; Dunn, Warwick B.; Broadhurst, David; O'Donoghue, Kerry; Hester, Svenja S.; Dunkley, Tom P. J.; Hart, Sarah R.; Swainston, Neil; Li, Peter // Journal of Biology; 2007, Vol. 6, p4.1 

    Background: Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried out on cell-growth regulation. Comprehensive studies at the transcriptional, proteomic and metabolic levels under defined controlled conditions are currently...

  • Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress.
    Ralser, Markus; Wamelink, Mirjam M.; Kowald, Axel; Birgit Gerisch; Heeren, Gino; Struys, Eduard A.; Klipp, Edda; Jakobs, Cornelis; Breitenbach, Michael; Lehrach, Hans; Krobitsch, Sylvia // Journal of Biology; 2007, Vol. 6, p10.1 

    Background: Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role. Results: We recently discovered that yeast cells with reduced activity of the key...

  • Pleiotropic Effects of a Mitochondrial-Nuclear Incompatibility Depend upon the Accelerating Effect of Temperature in Drosophila.
    Hoekstra, Luke A.; Siddiq, Mohammad A.; Montooth, Kristi L. // Genetics; Nov2013, Vol. 195 Issue 3, p1129 

    Interactions between mitochondrial and nuclear gene products that underlie eukaryotic energy metabolism can cause the fitness effects of mutations in one genome to be conditional on variation in the other genome. In ectotherms, the effects of these interactions are likely to depend upon the...

  • Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans.
    Xufei Zhou; Fei Xu; Hui Mao; Jiaojiao Ji; Meng Yin; Xuezhu Feng; Shouhong Guang // Genetics; May2014, Vol. 197 Issue 1, p121 

    Small RNAs recognize, bind, and regulate other complementary cellular RNAs. The introduction of small RNAs to eukaryotic cells frequently results in unintended silencing of related, but not identical, RNAs: a process termed off-target gene silencing. Off-target gene silencing is one of the major...

  • How do trypanosomes change gene expression in response to the environment?
    Schwede, Angela; Kramer, Susanne; Carrington, Mark // Protoplasma; Apr2012, Vol. 249 Issue 2, p223 

    All organisms are able to modulate gene expression in response to internal and external stimuli. Trypanosomes represent a group that diverged early during the radiation of eukaryotes and do not utilise regulated initiation of transcription by RNA polymerase II. Here, the mechanisms present in...

  • DNA topology and transcription.
    Kouzine, Fedor; Levens, David; Baranello, Laura // Nucleus (1949-1034); May/Jun2014, Vol. 5 Issue 3, p1 

    The article presents evidence-based approaches to understanding the role of DNA topology in genetic transcriptional regulations and eukaryotic cell dynamics. Topics discussed include topological domains of DNA during cellular processes, the disruption of a repressive chromatin and initiation by...

  • RNA Polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation.
    Bowman, Elizabeth A.; Kelly, William G. // Nucleus (1949-1034); May/Jun2014, Vol. 5 Issue 3, p1 

    The transition between initiation and productive elongation during rNa Polymerase II (Pol II) transcription is a well-appreciated point of regulation across many eukaryotes. elongating Pol II is modified by phosphorylation of serine 2 (Ser2) on its carboxy terminal domain (CTD) by two kinases,...

  • Fission Yeast Cells Undergo Nuclear Division in the Absence of Spindle Microtubules.
    Castagnetti, Stefania; Oliferenko, Snezhana; Nurse, Paul // PLoS Biology; Oct2010, Vol. 8 Issue 10, p1 

    Mitosis in eukaryotic cells employs spindle microtubules to drive accurate chromosome segregation at cell division. Cells lacking spindle microtubules arrest in mitosis due to a spindle checkpoint that delays mitotic progression until all chromosomes have achieved stable bipolar attachment to...

  • The effects of heavy meteorite bombardment on the early evolution - The emergence of the three Domains of life.
    Gogarten-Boekels, Maria; Hilario, Elena; Gogarten, J. // Origins of Life & Evolution of the Biosphere; 1995, Vol. 25 Issue 1-3, p251 

    A characteristic of many molecular phylogenies is that the three domains of life (Bacteria, Archaea, Eucarya) are clearly separated from each other. The analyses of ancient duplicated genes suggest that the last common ancestor of all presently known life forms already had been a sophisticated...

  • Lysosome positioning coordinates mTORC1 activity and autophagy.
    Poüs, Christian; Codogno, Patrice // Nature Cell Biology; Apr2011, Vol. 13 Issue 4, p342 

    Under nutrient-rich conditions, the nutrient-sensitive kinase mTOR (mammalian target of rapamycin) is recruited to the surface of lysosomes where it becomes activated and can promote cell growth and inhibit autophagy. In contrast, mTOR is inhibited in nutrient-poor conditions, leading to the...

  • Context-Dependent Dual Role of SKI8 Homologs in mRNA Synthesis and Turnover.
    Dorcey, Eavan; Rodriguez-Villalon, Antia; Salinas, Paula; Santuari, Luca; Pradervand, Sylvain; Harshman, Keith; Hardtke, Christian S. // PLoS Genetics; Apr2012, Vol. 8 Issue 4, Special section p1 

    Eukaryotic mRNA transcription and turnover is controlled by an enzymatic machinery that includes RNA polymerase II and the 3' to 5' exosome. The activity of these protein complexes is modulated by additional factors, such as the nuclear RNA polymerase II-associated factor 1 (Paf1c) and the...

  • A Coordinated Interdependent Protein Circuitry Stabilizes the Kinetochore Ensemble to Protect CENP-A in the Human Pathogenic Yeast Candida albicans.
    Thakur, Jitendra; Sanyal, Kaustuv // PLoS Genetics; Apr2012, Vol. 8 Issue 4, Special section p1 

    Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle. Kinetochore assembly on point centromeres of S. cerevisiae is considered to be a...

  • Glutaredoxin GRXS13 plays a key role in protection against photooxidative stress in Arabidopsis.
    Laporte, Daniel; Olate, Ema; Salinas, Paula; Salazar, Marcela; Jordana, Xavier; Holuigue, Loreto // Journal of Experimental Botany; Jan2012, Vol. 63 Issue 1, p503 

    Glutaredoxins (GRXs) belong to the antioxidant and signalling network involved in the cellular response to oxidative stress in bacterial and eukaryotic cells. In spite of the high number of GRX genes in plant genomes, the biological functions and physiological roles of most of them remain...

  • Tropomodulins and tropomyosins: working as a team.
    Colpan, Mert; Moroz, Natalia A.; Kostyukova, Alla S. // Journal of Muscle Research & Cell Motility; Aug2013, Vol. 34 Issue 3/4, p247 

    Actin filaments are major components of the cytoskeleton in eukaryotic cells and are involved in vital cellular functions such as cell motility and muscle contraction. Tmod and TM are crucial constituents of the actin filament network, making their presence indispensable in living cells....

  • Metakaryotic stem cell nuclei use pangenomic dsRNA/DNA intermediates in genome replication and segregation.
    Thilly, William G.; Gostjeva, Elena V.; Koledova, Vera V.; Zukerberg, Lawrence R.; Daniel Chung; Fomina, Janna N.; Darroudi, Firouz; Stollar, B. David // Organogenesis; Jan-Mar2014, Vol. 10 Issue 1, p1 

    Bell shaped nuclei of metakaryotic cells double their DNA content during and after symmetric and asymmetric amitotic fissions rather than in the separate, pre-mitotic S-phase of eukaryotic cells. A parsimonious hypothesis was tested that the two anti-parallel strands of each chromatid DNA helix...

  • Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells.
    Wang, Yongming; Wang, Jichang; Devaraj, Anatharam; Singh, Manvendra; Jimenez Orgaz, Ana; Chen, Jia-Xuan; Selbach, Matthias; Ivics, Zoltán; Izsvák, Zsuzsanna // PLoS Genetics; Mar2014, Vol. 10 Issue 3, p1 

    Transposons are discrete segments of DNA that have the distinctive ability to move and replicate within genomes across the tree of life. ‘Cut and paste’ DNA transposition involves excision from a donor locus and reintegration into a new locus in the genome. We studied molecular...

  • Hierarchical multiscale model for biomechanics analysis of microfilament networks.
    Li, Tong; Gu, Y. T.; Feng, Xi-Qiao; Yarlagadda, Prasad K. D. V.; Oloyede, Adekunle // Journal of Applied Physics; May2013, Vol. 113 Issue 19, p194701 

    The mechanisms of force generation and transference via microfilament networks are crucial to the understandings of mechanobiology of cellular processes in living cells. However, there exists an enormous challenge for all-atom physics simulation of real size microfilament networks due to scale...

  • The RNA Helicases AtMTR4 and HEN2 Target Specific Subsets of Nuclear Transcripts for Degradation by the Nuclear Exosome in Arabidopsis thaliana.
    Lange, Heike; Zuber, Hélène; Sement, François M.; Chicher, Johana; Kuhn, Lauriane; Hammann, Philippe; Brunaud, Véronique; Bérard, Caroline; Bouteiller, Nathalie; Balzergue, Sandrine; Aubourg, Sébastien; Martin-Magniette, Marie-Laure; Vaucheret, Hervé; Gagliardi, Dominique // PLoS Genetics; Aug2014, Vol. 10 Issue 8, p1 

    The RNA exosome is the major 3′-5′ RNA degradation machine of eukaryotic cells and participates in processing, surveillance and turnover of both nuclear and cytoplasmic RNA. In both yeast and human, all nuclear functions of the exosome require the RNA helicase MTR4. We show that the...

  • The Movement of Goods Around the Cell.
    Bassereau, Patricia; Goud, Bruno // Scientist; Apr2011, Vol. 25 Issue 4, p44 

    The article reports on a collaboration combining biophysics, cell biology, and theoretical physics to study membrane traffic on eukaryotic cells. The authors use giant unilamellar vesicles (GUVs) as cell membrane lipid bilayer model and cholesterol, sphingomyelin, and dioleoylphosphatidylcholine...

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