Citations with the tag: DRUG targeting
Results 1 - 50
- Preface.
McDonald, Ian A. // Current Drug Targets - CNS & Neurological Disorders; Feb2002, Vol. 1 Issue 1, p1Introduces the articles published in the February 2002 issue of the periodical 'Current Drug Targets--CNS and Neurological Disorders.' Topics of the articles; Authors who contributed to the issue.
- Preface.
Tamminga, C.A.; Coyle, Joseph T. // Current Drug Targets - CNS & Neurological Disorders; Apr2002, Vol. 1 Issue 2, p1Introduces the articles published in the April 2002 issue of the periodical 'Current Drug Targets--CNS and Neurological Disorders.' Topics of the articles; Authors who contributed to the issue.
- Editorial [Hot Topic: Neuron-Glia Interaction (Guest Editor: Joao O. Malva)].
Malva, João O. // Current Drug Targets - CNS & Neurological Disorders; Aug2005, Vol. 4 Issue 4, p317In the past ten years, the neuron-glia interaction has been one of the most fast-growing and sustained research themes in neuroscience. The functional cross-talk between neurons, astrocytes and microglia in normal brain function, in brain diseases and age-related disorders has been a central...
- Preface.
Quon, Michael J.; Jirillo, Emilio // Current Drug Targets - Immune, Endocrine & Metabolic Disorders; May2001, Vol. 1 Issue 1, p1Introduces the articles published in the May 2001 issue of the periodical 'Current Drug Targets--Immune, Endocrine and Metabolic Disorders.' Topics of the articles; Authors who contributed to the issue.
- subject Index To Volume 1.
Bentham, S. // Current Drug Targets - Immune, Endocrine & Metabolic Disorders; Apr2002, Vol. 2 Issue 1, p105Presents the subject index for the April 2002, volume 1 issue of the periodical 'Current Drug Targets--Immune, Endocrine and Metabolic Disorders.'
- Immune Response to Parasitic Infections - An Introduction.
Brandonisio, O.; Spinelli, R. // Current Drug Targets - Immune, Endocrine & Metabolic Disorders; Oct2002, Vol. 2 Issue 3, p193Many parasitic diseases are an important cause of mortality and morbidity in humans. The resurgence of malaria and trypanosomiasis in countries where these diseases have been effectively controlled and the global increase of several other parasitic diseases, such as cryptosporidiosis and...
- subject Index To Volume 2.
Bentham, S. // Current Drug Targets - Immune, Endocrine & Metabolic Disorders; Mar2003, Vol. 3 Issue 1, p95Presents the subject index to the March 2003, volume 2 issue of the periodical 'Current Drug Targets--Immune, Endocrine and Metabolic Disorders.'
- Subject Index to Volume 4.
Bentham Science Publishers // Current Drug Targets - Immune, Endocrine & Metabolic Disorders; Mar2005, Vol. 5 Issue 1, p121Presents the subject index to volume 4 of the periodical "Current Drug Targets - Immune, Endocrine and Metabolic Disorders."
- Preface.
Goldman, Robert C. // Current Drug Targets - Infectious Disorders; May2001, Vol. 1 Issue 1, p1lIntroduces the articles published in the May 2001 issue of the periodical 'Current Drug Targets--Infectious Disorders.' Topics of the articles; Authors who contributed to the issue.
- Antibiotics Targeting Ribosomes: Crystallographic Studies.
Auerbach, Tamar; Bashan, Anat; Harms, Joerg; Schluenzen, Frank; Zavarich, Raz; Bartels, Heike; Agmon, Ilana; Kessler, Maggie; Pioletti, Marta; Franceschi, Francois; Yonath, Ada // Current Drug Targets - Infectious Disorders; Jun2002, Vol. 2 Issue 2, p169Resistance to antibiotics is a major problem in modern therapeutics. Ribosomes, the cellular organelle catalyzing the translation of the genetic code into proteins, are targets for several clinically relevant antibiotics. The ribosomes from eubacteria are excellent pathogen models. High...
- Inhibitor at the Gates, Inhibitor in the Chamber: Allosteric and Competitive Inhibitors of the Proteasome as Prospective Drugs.
M. Gaczynska; P. A. Osmulski // Current Medicinal Chemistry - Immunology, Endocrine & Metabolic ; Dec2002, Vol. 2 Issue 4, p279In the pursuit of new drug targets and novel drugs, finding a promising remedy for an incurable disease is an unusual feat. This exactly happened recently with the proteasome and its inhibitor, PS-341, which emerged in initial clinical trials as a prospective drug against multiple myeloma. The...
- Call for research on vaccination delivery sites.
Foxhall, Kathryn // Drug Topics; Mar2010, Vol. 154 Issue 3, p17The article reports on the call for more research to examine the differences of different sites for vaccination because nontraditional sites for vaccinations are increasing in the U.S.
- Drug target validation and identification of secondary drug target effects using DNA microarrays.
Marton, Matthew J.; DeRisi, Joseph L.; Bennett, Holly A.; Iyer, Vishwanath R.; Meyer, Michael R.; Roberts, Christopher J.; Stoughton, Roland; Burchard, Julja; Slade, David; Dai, Hongyue; Bassett, Douglas E.; Hartwell, Leland H.; Brown, Patrick O.; Friend, Stephen H. // Nature Medicine; Nov98, Vol. 4 Issue 11, p1293We describe here a method for drug target validation and identification of secondary drug target effects based on genome-wide gene expression patterns. The method is demonstrated by several experiments, including treatment of yeast mutant strains defective in calcineurin, immunophilins or other...
- Mutant yeast on drugs.
Lockhart, David J. // Nature Medicine; Nov98, Vol. 4 Issue 11, p1235Analyzing drug-treated and mutant yeast cells with the new tools of genomics enables the identification of drug targets and should improve the odds of developing useful therapeutics (pages 1293?1301).
- The master mammal.
Sands, Arthur T. // Nature Biotechnology; Jan2003, Vol. 21 Issue 1, p31Reports that availability of the mouse draft genome sequence will facilitate experimental manipulation of novel drug targets and accelerate drug discovery. First full-public description of the draft genomic sequence of the mouse genome; Primary interest of the biomedical researchers; Sequence...
- New Strategies and Tools to Identify Drug Targets on Infectious Disorders.
Garcia-Sanz, Jose A. // Infectious Disorders - Drug Targets; Dec2008, Vol. 8 Issue 4, p206The article discusses various reports published within the issue, including one by R. Vernal and J. A. Garcia-Sanz on two new T lymphocyte subpopulations, namely Th17 cells and regulatory T cells, and their role in different infections, and another by F. Erard and B. Ryffel on the potential of...
- Editorial.
Sabatier, Jean-Marc // Infectious Disorders - Drug Targets; Apr2009, Vol. 9 Issue 2, p100The article introduces a series of articles on viral infections including one on the types of pathogenic viruses, current antiviral agents and the use of molecular targets in antiviral development.
- Rational Drug Design and High-Throughput Techniques for RNA Targets.
Hermann, Thomas; Westhof, Eric // Combinatorial Chemistry & High Throughput Screening; Jun2000, Vol. 3 Issue 3, p219RNA molecules are the only known molecules which possess the double property of being depository of genetic information, like DNA, and of displaying catalytic activities, like protein enzymes. RNA molecules intervene in all steps of gene expression and in many other biological activities. Like...
- Drug-Targeting Strategies for Prostate Cancer.
Ast, Gil // Current Pharmaceutical Design; Feb2003, Vol. 9 Issue 6, p455Prostate cancer is the most frequently diagnosed cancer in North American men and accounts for 10% of cancer-related deaths in men. Despite advances in early detection and aggressive treatment of early disease, the overall mortality rate has not appear to have fallen, indicating that the current...
- Subject Index To Volume 6.
Publishers // Current Cancer Drug Targets; Feb2007, Vol. 7 Issue 1, p4A subject index for the February 2007 issue of the "Current Cancer Drug Targets" is presented.
- Author Index To Volume 6.
Publishers // Current Cancer Drug Targets; Feb2007, Vol. 7 Issue 1, p1An author index for the February 2007 issue of the "Current Cancer Drug Targets" is presented.
- ERRATUM.
Publishers // Current Cancer Drug Targets; Jun2008, Vol. 8 Issue 4, p341A correction to the article "Targeting MDM2 and MDMX in Retinoblastoma," by Nikia A. Laurie, Chie-Schin Shih and Michael A. Dyer that was published in the November 2007 issue of "Current Cancer Drug Targets" is presented.
- The Next Generation of Drug Delivery Systems and Diagnostics Based on Micro-Electro-Mechanical-Systems (MEMS) and Nanotechnology.
Elman, Noel M. // Current Pharmaceutical Biotechnology; Jun2010, Vol. 11 Issue 4, p318The article discusses various reports published within the issue including one by A. Alexander-Katz et al. on microdimensional targeting (MDT) in the field of drug delivery, one by F. Alexis et al. on a nanoparticle based delivery system and another one by M. Ferrari et al. on nanofluidic devices.
- Leucine Aminopeptidase as a Target for Inhibitor Design.
Grembecka, J.; Kafarski, P. // Mini Reviews in Medicinal Chemistry; Jul2001, Vol. 1 Issue 2, p133In this review we focus on the most effective and the most promising inhibitors of leucine aminopeptidase. Their binding modes to the enzyme, the attempt to explain the origin of the inhibitory activity, as well as the structure - activity relationship for some of these compounds are discussed....
- Liposomes for Intravenous Drug Targeting: Design and Applications.
J.M. Metselaar; E. Mastrobattista; G. Storm // Mini Reviews in Medicinal Chemistry; Aug2002, Vol. 2 Issue 4, p319Drug targeting with liposomes has been studied for over 25 years and has demonstrated its value in clinical practice. This mini review offers an overview of the design and application of liposomes for i.v. drug targeting. Two approaches are outlined: passive and active targeting. The former...
- Aiming at New Targets for the Treatment of Affective Disorders.
Dremencov, Eliyahu // Current Drug Targets; Nov2009, Vol. 10 Issue 11, p1049The author discusses the aim of this special theme issue entitled "Aiming at New Targets for the Treatment of Affective Disorders," and mentions the people who contributed to the publication of this issue.
- Aiming at New Targets for the Treatment of Affective Disorders: An Introduction.
Dremencov, Eliyahu // Current Drug Targets; Nov2009, Vol. 10 Issue 11, p1050An introduction to this special theme issue of "Current Drug Targets" entitled "Aiming at New Targets for the Treatment of Affective Disorders," is presented.
- Preface.
Szyf, Moshe // Current Drug Targets; Jul2000, Vol. 1 Issue 1, p1lIntroduces the articles in the inaugural 2000 issue of the periodical, 'Current Drug Targets,'. Genome as a drug target; Review of the selective minor groove binding ligands as inhibitors.
- The Genome as a Drug Target Sequence Specific Minor Groove Binding Ligands.
Turner, P.R.; Denny, W.A. // Current Drug Targets; Jul2000, Vol. 1 Issue 1, p1The ability to target defined sequences on the DNA molecule would be of enormous benefit to the treatment of human disease. Towards this goal much research has been invested in examining the DNA binding and biological mechanisms of action of sequence selective minor groove binding ligands. These...
- Ornithine Aminotransferase, A Potential Target for the Treatment of Hyperammonemias.
Seiler, Nikolaus // Current Drug Targets; Sep2000, Vol. 1 Issue 2, p119Ornithine delta aminotransferase (OAT) (EC 2.6.1.13) is a pyridoxal-5 phosphate dependent mitochondrial matrix enzyme. It controls the L-ornithine (Orn) level in tissues by catalysing the transfer of the delta amino group of Orn to 2-oxoglutarate. The products of this reaction are L-glutamate...
- Preface.
Szyf, Moshe // Current Drug Targets; Mar2001, Vol. 2 Issue 1, p1lIntroduces articles in the first issue of the second volume of the periodical, 'Current Drug Targets,'. Potential physiological role of nonjunctional K+ channels in concert with gap junctions in controlling smooth muscle tone; Class of new anticancer agents.
- Subject Index to Volume 1.
Bentham, P.S. // Current Drug Targets; Mar2001, Vol. 2 Issue 1, p111Presents an index of subjects in articles published in the volume one of the periodical, 'Current Drug Targets,'. Blood-brain barrier; DNA demethylases; Candida albicans.
- Update on Antifolate Drugs Targets.
Costi, M.P.; Ferrari, S. // Current Drug Targets; Jun2001, Vol. 2 Issue 2, p135Antifolate drugs are molecules directed to interfere with the folate metabolic pathway at some level. They can be recognized among the first rationally designed compounds applying the principle of structural analogy with the substrate developing the antimetabolite strategy. This strategy has...
- Tuberculosis Drug Targets.
Ying Zhang; Amzel, L. Mario // Current Drug Targets; Apr2002, Vol. 3 Issue 2, p131Despite the availability of the BCG vaccine and chemotherapy, tuberculosis (TB) remains a leading infectious killer worldwide. The recent rise of TB and especially the alarming increase of drug-resistant TB call for urgent need to develop new anti-TB drugs. Lengthy chemotherapy and increasing...
- Preface.
Sharma, Ram P. // Current Drug Targets; Apr2002, Vol. 3 Issue 2, p1Introduces the articles published in the April 2002 issue of the periodical 'Current Drug Targets.' Topics of the articles; Authors of the articles.
- Catalytic DNA: A Novel Tool for Gene Suppression.
Cairns, M.J.; Saravolac, E.G.; Sun, L.Q. // Current Drug Targets; Jun2002, Vol. 3 Issue 3, p269RNA, as an intermediate in the production of every gene encoded protein and the genetic material of many pathogenic viruses, presents an attractive target for both biological and therapeutic manipulation. Despite its extensive involvement in living systems, its chemical diversity based on four...
- The Therapeutic Potential of Host-Defense Antimicrobial Peptides.
Sitaram, N.; Nagaraj, R. // Current Drug Targets; Jun2002, Vol. 3 Issue 3, p259Species across the evolutionary scale from insects to mammals deploy peptides to counter microbial invaders. Although, there are considerable differences in the primary and secondary structures of these peptides, they exert their antimicrobial activity by common mechanisms ie. by membrane...
- The Effects of Drugs Used in Anaesthesia on Platelet Membrane Receptors and on Platelet Function.
Kozek-Langenecker, Sibylle A. // Current Drug Targets; Jun2002, Vol. 3 Issue 3, p247Platelet dysfunctions are known origins of perioperative bleeding disorders which are a major concern in the management of surgical patients. Among multiple factors, interactions of drugs used in anaesthesia with platelets have been implicated to aggravate the risk of haemorrhagic complications....
- Purine Signaling and Potential New Therapeutic Approach: Possible Outcomes of NTPDase Inhibition.
Gendron, F.P.; Benrezzak, O.; Krugh, B.W.; Kong, Q.; Weisman, G.A.; Beaudoin, A.R. // Current Drug Targets; Jun2002, Vol. 3 Issue 3, p229Interest for extracellular nucleotides has increased since the pioneer work of Burnstock in the early seventies. Research on cellular functions modulated by purines and pyrimidines has led to the identification and characterization of the different components of purine signaling, namely...
- Novel Molecular Targets for Systemic Lupus Erythematosus.
Marino, Maria; Rossi, Maria; Ruvo, Menotti; Fassina, Giorgio // Current Drug Targets; Jun2002, Vol. 3 Issue 3, p223For a long time the complement cascade has been believed to be the predominant pathway to inflammation and tissue destruction in autoimmune diseases such as systemic lupus erythematosus. Recently, new evidences show that FcRs may share the primacy with complement cascade, playing an equal or...
- Multiple Drug Targets in the Management of Type 2 Diabetes.
Moneva, M.H.; Dagogo-Jack, S. // Current Drug Targets; Jun2002, Vol. 3 Issue 3, p203Diabetes mellitus (DM) is being diagnosed at an alarming rate around the world. More than 90% of the estimated 200 million affected persons with diabetes worldwide have type 2 DM, an often clinically silent disorder. In the United States, nearly half of the estimated 16 million persons with...
- Furosemide Protective Effect Against Airway Obstruction.
Cavaliere, Franco; Masieri, Simonetta // Current Drug Targets; Jun2002, Vol. 3 Issue 3, p197Furosemide (frusemide) is mainly employed as a powerful diuretic that inhibits Na and K reabsorption in renal tubules. However other valuable pharmacological effects have been discovered that include a protective action from bronchospasm. The effects of furosemide on airways have been recognized...
- Preface.
Christ, George J. // Current Drug Targets; Dec2002, Vol. 3 Issue 6, p1Introduces the articles published in the December 2002 issue of the periodical 'Current Drug Targets.' Topics of the articles; Authors of the articles.
- Targeting DNA with Triplexes.
Fox, Keith R. // Current Medicinal Chemistry; Jan2000, Vol. 7 Issue 1, p17The formation of intermolecular DNA triple helices offers the possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. In these structures a third strand oligonucleotide binds in the DNA major groove,...
- Potential Drug Targets and Progress Towards Pharmacologic Inhibition of Hepatic Glucose Production.
Kurukulasuriya, R.; Link, J.T.; Madar, D.J.; Pei, Z.; Richards, S.J.; Rohde, J.J.; Souers, A.J.; Szczepankiewicz, B.G. // Current Medicinal Chemistry; Jan2003, Vol. 10 Issue 2, p123A number of therapeutic targets are currently under investigation for inhibition of hepatic glucose production with small molecules. Antagonists of the glucagon receptor, glycogen phosphorylase, 11-�- hydroxysteroid dehydrogenase-1 and fructose 1,6-bisphosphatase are, or have been, under...
- Folate and Homocysteine Metabolism: Therapeutic Targets in Cardiovascular and Neurodegenerative Disorders.
Mattson, Mark P.; Haberman, Frank // Current Medicinal Chemistry; Oct2003, Vol. 10 Issue 19, p1923Individuals with elevated homocysteine levels are at increased risk for cardiovascular disease and stroke, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases Homocysteine is a modified form of the amino acid methionine that is tightly regulated by enzymes requiring...
- Combichem's Desert Hideaway.
Koppal, Tanuja // Drug Discovery & Development; Jul2003, Vol. 6 Issue 7, p30Features the Tucson, Arizona-based Aventis Combinatorial Technologies Center, which hosts a group of researchers who collaborate with therapeutic teams to develop chemical leads for challenging drug targets. Complementary role of the center in developing chemical libraries alongside classical...
- subject Index To Volume 2.
Bentham, S. // Current Drug Targets - Infectious Disorders; Mar2003, Vol. 3 Issue 1, p95Presents the subject index of the March 2003 issue of the periodical 'Current Drug Targets - Infectious Disorders.'
- Author Index TO Volume 3.
Bentham Science Publishers // Current Drug Targets - Infectious Disorders; Mar2004, Vol. 4 Issue 1, p87Presents an index of the authors contributed to the 2004 issue of the journal "Current Drug Targets -- Infectious Disorders."
- Subject Index to Volume 3.
Bentham Science Publishers // Current Drug Targets - Infectious Disorders; Mar2004, Vol. 4 Issue 1, p89Presents an index of the subjects of articles published in the 2004 issue of the journal "Current Drug Targets -- Infectious Disorders."
