Citations with the tag: CHALCONES

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  • Synthesis of Chalcones with Anticancer Activities.
    Syam, Suvitha; Abdelwahab, Siddig Ibrahim; Al-Mamary, Mohammed Ali; Mohan, Syam // Molecules; Jun2012, Vol. 17 Issue 6, p6179 

    Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, human adenocarcinoma cell line HT-29 (colorectal cancer) and...

  • A new alternative to methyl bromide.
    WILBANKS, JOHNATHAN // California Farmer; Dec2012, Vol. 295 Issue 12, p10 

    The article reports on chalcones, an organic compound that could be an alternative pesticide for methyl bromide developed by Dr. Saeed Attar and professor Alejandro Calderón-Urrea. INSET: Key Points.

  • Reduções estereosseletivas de chalconas utilizando biocatalisador – Daucus carota.
    Silva, Wender A.; Melo, Lennine R.; Pedreira, Júlia G. B.; Oliveira, Guilherme R. // Orbital: The Electronic Journal of Chemistry; Apr2012 Supplement, Vol. 4, p76 

    No abstract available.

  • Structure-Activity Association of Flavonoids in Lung Diseases.
    Lago, João Henrique G.; Toledo-Arruda, Alessandra C.; Mernak, Márcia; Barrosa, Kaidu H.; Martins, Milton A.; Tibério, Iolanda F. L. C.; Prado, Carla M. // Molecules; Mar2014, Vol. 19 Issue 3, p3570 

    Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. They are abundantly found in Nature and over 8,000 flavonoids have from different sources, mainly plant materials,...

  • Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines.
    Sridhar, S.; Prasad, Y. Rajendra; Dinda, S. C. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 3, p1130 

    In the present study, 3-acetyl-2,5-dimethylfuran on condensation with various aromatic and heterocyclic aldehydes in ethanolic KOH solution yielded the corresponding chalcones (3a-n). These chalcones were reacted with guanidine hydrochloride in presence of potassium hydroxide and ethanol to give...

  • Synthesis of ferrocenyl chalcones of the abietane series.
    Glushkov, V.; Anikina, L.; Maiorova, O.; Nedugov, A.; Slepukhin, P. // Russian Journal of Organic Chemistry; Jun2012, Vol. 48 Issue 6, p836 

    Two isomeric ferrocenyl chalcones having an abietane fragment were synthesized.

  • Synthesis of some novel Isoxazole, Cyanopyridine and Pyrimidinthione derivatives.
    Solankee, N.; Patel, K. P.; Patel, R. B. // Journal of Chemical & Pharmaceutical Research; 2012, Vol. 4 Issue 8, p3778 

    A new series of isoxazoles (7a-d), cyanopyridines (8a-d) and pyrimidinthiones (9a-d) have been prepared from chalcones (6a-d) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium...

    Ameta, K. L.; Rathore, Nitu S.; Kumar, Biresh // Analele Universitatii Bucuresti: Chimie; 2011, Vol. 20 Issue 1, p15 

    A facile synthesis of some novel chalcones (3a-3k) by the condensation of variously substituted aromatic aldehydes and 2,4-dihydroxyacetophenone and their subsequent rapid one pot transformations to 2-aminobenzene-1,3-dicarbonitriles (5a-5k) with malononitrile and morpholine has been described....

  • Chalcones: compounds possessing a diversity in applications.
    Urmila Berar // Orbital: The Electronic Journal of Chemistry; Jul-Sep2012, Vol. 4 Issue 3, p209 

    Chalcones are a class of α,β-unsaturated carbonyl compounds that form the central core for a variety of naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. Besides their various pharmacological activities, chalcones have...

  • A mutation in the rice chalcone isomerase gene causes the golden hull and internode 1 phenotype.
    Hong, Lilan; Qian, Qian; Tang, Ding; Wang, Kejian; Li, Ming; Cheng, Zhukuan // Planta; Jul2012, Vol. 236 Issue 1, p141 

    The biosynthesis of flavonoids, important secondary plant metabolites, has been investigated extensively, but few mutants of genes in this pathway have been identified in rice ( Oryza sativa). The rice gold hull and internode ( gh) mutants exhibit a reddish-brown pigmentation in the hull and...

  • Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.
    Padhye, Subhash; Ahmad, Aamir; Oswal, Nikhil; Sarkar, Fazlul H. // Journal of Hematology & Oncology; 2009, Vol. 2, p1 

    Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have been used to...

  • Synthesis of Side Chain Chalcone Polymers and Their Photoalignment Capability for Film Patterned Retarder.
    Ju Hui Kang; Seung Yong Jeong; Sangkug Lee; Kyung Ho Choi; Gyo jic Shin // International Proceedings of Chemical, Biological & Environmenta; 2012, Vol. 43, p67 

    We synthesized two kinds of photocrosslinkable side chain photopolymer with a chalcone group in the side chain. Two photopolymers have the different alkyl spacer length introduced between main chain and chalconyl moiety. The thermal stability of these photopolymer measured by differential...

  • Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids.
    Selepe, Mamoalosi A.; Van Heerden, Fanie R. // Molecules; Apr2013, Vol. 18 Issue 4, p4739 

    The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the...

  • Synthesis and pharmacological screening of some novel chloro chalconesemicarbazone derivatives.
    Singh, Hemendra Pratap; Chauhan, C. S.; Pandeya, S. N.; Sharma, C. S.; Srivastava, B.; Singhal, Manmohan // Der Pharma Chemica; 2010, Vol. 2 Issue 3, p343 

    A series of chalconyl derivatives of chloro phenyl semicarbazide (CA1-CA5) was synthesized. All the synthesized compounds were screened for their pharmacological action in protection of seizures, behavioral study, anti-inflammatory and analgesic activity. After intraperitoneal injection to mice...

  • Multicomponent reaction for the synthesis of pyridine derivatives based on triphenylamine.
    Geng, Li-Jun; Feng, Guo-Liang; Yu, Jiu-Gao; Zhang, Hong-Li // Journal of Chemical Research; 2011, Vol. 35 Issue 2, p74 

    A facile preparation of pyridine derivatives based on triphenylamine through a multicomponent reaction from 3-cyanoacetylindoles, ammonium acetate and a 1,3-diarylpropenone either by conventional heating or microwave irradiation is described. The three-component reaction afforded good yields and...

  • Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives.
    Hassan, Seham Y. // Molecules; Mar2013, Vol. 18 Issue 3, p2683 

    A series of 2-pyrazolines 5-9 have been synthesized from α,β-unsaturated ketones 2-4. New 2-pyrazoline derivatives 13-15 bearing benzenesulfonamide moieties were then synthesized by condensing the appropriate chalcones 2-4 with 4-hydrazinyl benzenesulfonamide hydrochloride. Ethyl [1,2,4]...

  • Microwave Assisted Synthesis, Spectral Studies and Antibacterial Activity of 1, 5-benzodiazepines Derivatives on a Solid Surface.
    DEVPURA, ANJU; SINGH, JAYANT P.; JAITAWAT, NEETU; RATHORE, RENU; KUMAWAT, MONIKA; DULAWAT, SHIV S. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 12, p5914 

    Chalcones are well known intermediates for synthesizing various heterocyclic compounds. They have been utilized for the synthesis of various substituted benzodiazepines by the reaction of o-phenylenediamine. In present investigation we have carried out the reaction under both conventional method...

  • Synthesis and Antibacterial Studies of Chloro-Substituted 1,3-Thiazines.
    RAJPUT, P. R.; GAJBHIYE, A. V.; BHADE, M. W. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 12, p5699 

    Thiazines are very useful units in the fields of medicinal and pharmaceutical chemistry and have been reported to exhibit a variety of biological activities. This has directed us to synthesize chloro-substituted thiazines from 2'-hydroxy-3',5'-dichloro-4-4'-chlorophenyl chalcone with thiourea,...

  • Microwave Assisted Synthesis and Antibacterial Activity of Chalcone Derivatives.
    YADAV, KHUSHBU; SHARMA, ABHA; SRIVASTAVA, J. N. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 12, p5779 

    Chalcone derivatives have been synthesized by equimolar reactions between substituted aldehydes and substituted acetophenones in basic medium by using conventional and microwave assisted technique. These compounds are characterized by FTIR and ¹H NMR spectra. Before characterization purity of...

  • Synthesis and Antioxidant Activity of Some Chalcones and Flavanoids.
    Yogesh Murti; Ashish Goswami; Pradeep Mishra // International Journal of PharmTech Research; Apr-Jun2013, Vol. 5 Issue 2, p811 

    In the present work we report the reaction of 2,4-dihydroxy acetophenone with different substituted aromatic aldehyde to form 2,4-dihydroxy chalcones. Various analogues of 7-hydroxy flavanoids were reported by oxidative cyclization of 2,4-dihydroxy chalcones. The structure of the newly...

  • Topological Investingation and Modeling of Antimalarial Activity of Chalcone.
    Dwivedi, Sudhanshu Dhar; Bharadwaj, Arpan; Ghuraiya, Anis; Shrivastava, Amit // International Journal of ChemTech Research; Apr-Jun2012, Vol. 4 Issue 2, p662 

    A set of chalcone derivatives were tested for their antimalarial activities¹. Quantitative structure activity relationship (QSAR) analysis was applied to forty-two of the abovementioned derivatives using a combination of various topological descriptors. A multiple linear regression (MLR)...

  • Synthesis and Biological Activity of Heterocycles from Chalcone.
    Al-Ghulikah, H. A. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 4, p1631 

    The reaction between aromatic or heteroaromatic ortho-diamines and chalcone 1a,b is a convenient and versatile method for the preparation of condensed 1,4-diazepines 2a,b and 4a,b. 2,4-Diaryl-2,3-dihydro[1,5]benzothiazepines 5a,b were obtained from the condensation of chalcone 1a,b with...

  • Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model.
    Yau-Hung Chen; Wei-Hua Wang; Yun-Hsin Wang; Zi-Yu Lin; Chi-Chung Wen; Ching-Yuh Chern // Molecules; Feb2013, Vol. 18 Issue 2, p2052 

    The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(mpx:gfp)" to visualize the effect of neutrophil recruitment...

  • Antimicrobial activities of synthesized and characterized 5-acetyl pyrimidine-2, 4, 6-(1H, 3H, 5H)-trione based chalcones.
    Dhorajiya, Bhavesh D.; Malani, Mahesh H.; Patel, Jigar R.; Dholakiya, Bharat Z. // Der Pharma Chemica; 2012, Vol. 4 Issue 1, p141 

    A series of eleven 5-((E)-3-phenylacryloyl) pyrimidine-2, 4, 6-(1H, 3H, 5H)-triones (5-acetyl pyrimidine 2, 4, 6-(1H, 3H, 5H) trione based chalcone) were synthesized using diethylmalonate, urea, acetic anhydride and various aryl aldehydes under basic conditions afforded the 5-acetyl...

  • Evaluation of Silica-H2SO4 as an Efficient Heterogeneous Catalyst for the Synthesis of Chalcones.
    Sultan, Aeysha; Raza, Abdul Rauf; Abbas, Muhammad; Khan, Khalid Mohammed; Tahir, Muhammad Nawaz; Saari, Nazamid // Molecules; Aug2013, Vol. 18 Issue 8, p10081 

    We report an efficient silica-H2SO4 mediated synthesis of a variety of chalcones that afforded the targeted compounds in very good yield compared to base catalyzed solvent free conditions as well as acid or base catalyzed refluxing conditions.

  • Formation of 3,4,5,6-tetrahydroquinazolin-2(1 H)-one derivatives in reaction of 4-aryl-6-methyl-3,4-dihydro-pyrimidin-2(1 H)-ones with chalcones.
    Kolosov, M.; Kulyk, O.; Starchenko, O.; Orlov, V. // Chemistry of Heterocyclic Compounds; Nov2013, Vol. 49 Issue 8, p1166 

    A procedure for the preparation of 6-methyl-3,4-dihydropyrimidin-2(1 H)-ones involving deacylation of 5-acetyl-6-methyl-3,4-dihydropyrimidin-2(1 H)-ones in MeOH-KOH medium is developed. We have shown that the obtained compounds readily undergo reaction with chalcones in MeOH-MeONa with the...

  • Xanthohumol reduces transcription of pro-inflammatory markers TNF-α, IL-1β, NFκB2, and HO1 in the lung of senescence-accelerated prone mice (SAMP8).
    Paredes, S.; Carrasco, A.; Rancan, L.; Kireev, R.; Vara, E.; Tresguerres, J. F. // Proceedings of the Physiological Society; 2013, p237P 

    Lungs are highly vascularised organs directly exposed to atmospheric oxygen. Consequently, they are an important source of reactive species that seem to be involved in local defense against pathogens. With age, increased production of free radicals, together with a reduced antioxidant defense...

  • Synthesis And Biological Evaluation of Different Thiazine Derivatives.
    Keerthi kumar, B.; Varalakshmi Devi, K.; Ramesh gupta, P.; Kranthi, G.; Ramakrishna, C.; Sankaraiah, P.; Kumar, Chitta Suresh // Journal of Pharmacy Research; Jan2011, Vol. 4 Issue 1, p274 

    A series of novel chalcones were prepared by the reaction of different benzaldehydes with various Acetophenones and subsequent treatment with thiourea resulted in the formation of corresponding thiazines in good yields. All the new compounds have been characterized by IR, ¹H NMR, MS and...

  • Synthesis and antibacterial activity of some new thiazine derivatives.
    Deepika, G.; Gopinath, P.; Kranthi, G.; Nagamani, C.; Jayasree Yadav, V.; Naidu, N.V.; Enaganti, Sreenivas // Journal of Pharmacy Research; 2012, Vol. 5 Issue 2, p1105 

    A series of novel chalcones were prepared by the reaction of different benzalaldehyde with various propiophenone and subsequent treatment with thiourea resulted in the formation of corresponding thiazines in good yields. All the new compounds have been characterized by IR and 1H-NMR spectral...

  • Synthesis, Characterization and Biological Evaluation of Functionalized Derivatives of Versatile Synthon 4,4'-Difluoro chalcone.
    Samshuddin, Seranthimata; Narayana, Badiadka; Sarojini, Balladka Kunhanna; Yathirajan, Hemmige S.; Raghavendra, Ramappa // Der Pharma Chemica; 2012, Vol. 4 Issue 4, p1445 

    Some functionalized fluorinated derivatives are prepared by condensing 4,4'-difluoro chalcone with hydrazine derivatives, o-phenylenediamine, ammonium acetate/acetic acid, ethyl cyanoacetate, malononitrile, acetylacetone, esters of acetoacetic acid, acetoacetanilde, aminoguanidine hydrochloride,...

  • Synthesis of a series of highly substituted cyclohexanols via Michael addition in an aqueous medium.
    Lu, Guo-Ping; Cai, Chun // Journal of Chemical Research; 2011, Vol. 35 Issue 3, p147 

    The Michael addition of active methylene compounds or nitromethane to chalcones in an aqueous medium and catalysed by tetrabutyl ammonium hydroxide (TBAOH) to afford highly substituted cyclohexanols is described. The protocol provides an efficient route for the synthesis of highly substituted...

  • Facile synthesis of some novel 2-substituted-4,6- diarylpyrimidines using 4'-hydroxy-3',5'-dinitrochalcones and Sbenzylthiouronium chloride.
    Ameta, K. L.; Kumar, Biresh; Rathore, Nitu S.; Verma, B. L. // Organic Communications; Jan-Mar2012, Vol. 5 Issue 1, p1 

    Various 4'-hydroxy-3',5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6-diaryl-2-(4-morpholinyl / 1- pyrrolidinyl /1-piperidinyl)- pyrimidines 4, 5 and 6 in a facile one-pot conversion....

  • Iodine-catalyzed addition of 2-mercaptoethanol to chalcone derivatives: Synthesis of the novel �-mercapto carbonyl compounds.
    Yerli, G�rkan; Gezegen, Hayreddin; Ceylan, Mustafa // Organic Communications; Apr-Jun2012, Vol. 5 Issue 2, p70 

    In this study, a series of novel �-mercapto carbonyl derivatives (3-(2-hydroxyethylthio)-1,3- diarylpropan-1-one) (5a-i) were prepared by addition of 2-mercaptoethanol (4) to chalcones (3a-i) in the presence of catalytic amount of iodine (10 mol %) in CH2Cl2.

  • Synthesis of Amino Chalcones in Presence of Ionic Liquid as Soluble Support.
    Xianhua Pan; Fengping Yi; Xuan Zhang; Shihong Chen // Asian Journal of Chemistry; Sep2012, Vol. 24 Issue 9, p3809 

    A microwave-assisted liquid phase synthesis of aminochalcones was developed by using aldehyde-functionalized ionic liquid as soluble support. Ionic liquid bound aminoacetophenone was treated with aromatic aldehyde to give supported chalcone derivatives. After cleavage, the target compounds were...

  • Synthesis and Antimicrobial Activity of Some New 2, 4, 6 -Trisubstituted Pyrimidines.
    Srinath, N.; Rajendra^Prasad, Y.; Mukkanti, K.; Agarwal, N. K. // Asian Journal of Research in Chemistry; Feb2011, Vol. 4 Issue 2, p329 

    A variety of 2-amino-4-(3'-methyl-4'-hydroxyphenyl)-6-(substituted) pyrimidines were synthesized by reacting various chalcones with guanidine hydrochloride. The required chalcones were prepared by condensation of 3'-methyl-4'- hydroxyacetophenone with various substituted aromatic /...

    Srinath, N.; Rajendra^Prasad, Y.; Mukkanti, K.; Agarwal, N. K. // Asian Journal of Research in Chemistry; Feb2011, Vol. 4 Issue 2, p3 

    The article presents abstracts on medical topics including latest strategy of medicinal chemistry implements, synthesis and anti-microbial evaluation of chalcone derivatives and synthesis of Copper (II) complexes of Tetradentate Binucleating Schiff Base Ligands.

  • Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho [2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives.
    Gaikwad, Sanjeevan S.; Suryawanshi, Venkat S.; Lohar, Kishan S.; Jadhav, Dhanaji V.; Shinde, Narayan D. // E-Journal of Chemistry; 2012, Vol. 9 Issue 1, p175 

    A series of new oxopyrimidine were prepared by cyclocondensation route with various substituted chalcones in presence of alcoholic solution of potassium hydroxide at reflux temperature. The synthesized oxopyrimidine derivatives were characterized by means of their IR, 1H NMR, mass spectral data...

  • New option to methyl bromide.
    WILBANKS, JOHNATHAN // California Farmer; Jan2013, Vol. 296 Issue 1, p5 

    The article discusses a project by biology professor at California State University Alejandro Calder�n-Urrea aimed at testing specifically engineered chemicals as an alternative to the pesticide methly bromide. Organic chalcones derivatives were used due to their targeted effect on...

  • Synthesis and Antibacterial Activity of Some Heterocyclic Chalcone Analogues Alone and in Combination with Antibiotics.
    Thanh-Dao Tran; Thi-Thao-Nhu Nguyen; Tuong-Ha Do; Thi-Ngoc-Phuong Huynh; Cat-Dong Tran; Khac-Minh Thai // Molecules; Jun2012, Vol. 17 Issue 6, p6684 

    A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The structures of the synthesized chalcones were established by IR...

  • Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives.
    Rani, Mamta; Yusuf, Mohamad // European Journal of Chemistry; Dec2012, Vol. 3 Issue 4, p406 

    Five new compounds, bis-pyrazoline derivatives (2a-e) with antibacterial properties, built around the alkyl chains of varying lengths were prepared via reaction of various 1-ω-alkoxybis- chalcones with N-substituted thiosemicarbazide in ethanolic NaOH solution. The antibacterial activity of...

  • Experimental and quantum chemical studies of a novel synthetic prenylated chalcone.
    Espinoza-Hicks, José C.; Camacho-Dávila, Alejandro A.; Flores-Holguín, Norma R.; Guadalupe V Nevárez-Moorillón1,; Glossman-Mitnik, Daniel; Rodríguez-Valdez, Luz M. // Chemistry Central Journal; 2013, Vol. 7 Issue 1, p1 

    Background: Chalcones are ubiquitous natural compounds with a wide variety of reported biological activities, including antitumoral, antiviral and antimicrobial effects. Furthermore, chalcones are being studied for its potential use in organic electroluminescent devices; therefore the...

  • An efficient and facile ring closure of 2'-hydroxychalcones under irradiation of tungsten light.
    Zangade, Sainath; Shinde, Avinash; Patil, Arvind; Vibhute, Yeshwant // European Journal of Chemistry; Jun2012, Vol. 3 Issue 2, p208 

    An efficient, green and facile reaction has been reported between 2'-hydroxychalcones and hydrazine hydrate in 2-methoxyethanol in presence of catalytic amount of acetic acid under irradiation of tungsten light to afford 2-pyrazolines. Present methodology presents several advantages including...

  • A facile synthesis of 1,2,3-triazolyl indole hybrids via SbCl-catalysed Michael addition of indoles to 1,2,3-triazolyl chalcones.

    An efficient, facile and environmentally benign synthesis of a library of 1,2,3-triazolyl chalcone hybrids (3a-u) has been accomplished by grinding the reactants at room temperature in excellent yields in very short reaction time. Subsequently, SbCl catalysed Michael addition of indoles to the...

  • Efficient solvent-free microwave assisted organic synthesis of 1-{2,4-dihydroxy-5-[3-imidazol-1-yl-3-aryl-propionyl]}-3-aryl-propenone and their antibacterial activity.
    Aravind, K.; Ganesh, Arram; Ashok, D. // Journal of Chemical & Pharmaceutical Research; 2013, Vol. 5 Issue 6, p34 

    A solvent-free synthesis of 1-{2,4-dihydroxy-5-[3-imidazol-1-yl-3-aryl-propionyl]-3-aryl-propenones under microwave irradiation using Micheal addition of chalcones with imidazoles in the presence of glacial acetic acid as catalyst. All title compounds were screened their antibacterial activity...

  • Evaluation of Anti-nociceptive and Anti-inflammatory Activities of Novel Chalcone Derivatives.
    Razmi, Ali; Zarghi, Afshin; Arfaee, Sara; Naderi, Nima; Faizi, Mehrdad // Iranian Journal of Pharmaceutical Research;  

    Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw...

  • An efficient and facile synthesis of flavanones catalyzed by N-methylimidazole.
    PENG WANG; JIABIN YANG; JIN CAI; CHUNLONG SUN; LUSHEN LI; MIN JI // Journal of the Serbian Chemical Society;  

    The use of N-methylimidazole as an efficient catalyst for the cyclization of 2'-hydroxychalcones to the corresponding flavanones in DMSO was investigated. The scope of this process was studied and various flavanones were obtained exclusively in good yields.

  • 2-Methoxyethanol as an alternative reaction solvent for the synthesis of 1,5-benzodiazepines under microwave irradiation.
    Zangade, Sainath; Mokle, Shyam; Chavan, Shivaji; Vibhute, Yeshwant // Orbital: The Electronic Journal of Chemistry; Jul-Sep2011, Vol. 3 Issue 3, p144 

    An improved condensation reaction between substituted 2′-hydroxychalcones and o-phenylenediamine using piperidine in 2-methoxyetahnol as an efficient and alternative reaction medium. The clean reaction conditions, easy work up, time saving and higher yields are notable advantages of...

  • Synthesis, characterization and biological activities of novel chalcone derivatives, containing 4,7-ethanoisoindole-1,3-dione units.
    Ceylan, Mustafa; Karaman, İsa; Keçeci Sarıkaya, Meryem // Organic Communications; Jul-Sep2013, Vol. 6 Issue 3, p102 

    Novel chalcone derivatives, containing 4,7-ethanoisoindole-1,3-dione units were synthesized starting from 1,3-cyclohexadine (4) and maleic anhydride (5). Addition of maleic anhydride (5) to 1,3-cyclehexadine (4) gave an ewcfo-adduct, 3a,4,7,7a-tetrahydro-4,7-ethano-2-benzofuran-l,3-dione (6), in...

  • Silica sulfuric acid-catalyzed Claisen-Schmidt condensation of 1,3,4 trisubstituted pyrrole 2,5 dione to chalcones.
    Patel, J.; Malani, M.; Dholakiya, B. // Research on Chemical Intermediates; Nov2012, Vol. 38 Issue 9, p2371 

    A series of 11 chalcones was synthesized from 1-(4-acetylphenyl)-3,4-dibromo-1 H-pyrrole-2,5-dione with various substituted benzaldehyde under solvent-free conditions using silica-sulphuric acid as a catalyst. The yields of chalcones are more than 90 %. All the compounds were characterized by...

  • Synthesis and application of chalcones to the preparation of heterocyclic structures.
    Velikorodov, A. V.; Ionova, V. A.; Temirbulatova, S. I.; Titova, O. L.; Stepkina, N. N. // Russian Journal of Organic Chemistry; Nov2013, Vol. 49 Issue 11, p1610 

    Condensation of methyl N-(4-acetylphenyl)carbamate with aromatic aldehydes in basic and acid environment, and also with hetarylaldehydes in the presence of bases afforded chalcones with the carbamate function. Under the conditions of basic catalysis a nucleophilic substitution was observed of a...

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