Citations with the tag: CHALCONES

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  • Synthesis of Chalcones with Anticancer Activities.
    Syam, Suvitha; Abdelwahab, Siddig Ibrahim; Al-Mamary, Mohammed Ali; Mohan, Syam // Molecules; Jun2012, Vol. 17 Issue 6, p6179 

    Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, human adenocarcinoma cell line HT-29 (colorectal cancer) and...

  • A new alternative to methyl bromide.
    WILBANKS, JOHNATHAN // California Farmer; Dec2012, Vol. 295 Issue 12, p10 

    The article reports on chalcones, an organic compound that could be an alternative pesticide for methyl bromide developed by Dr. Saeed Attar and professor Alejandro Calderón-Urrea. INSET: Key Points.

  • Reduções estereosseletivas de chalconas utilizando biocatalisador – Daucus carota.
    Silva, Wender A.; Melo, Lennine R.; Pedreira, Júlia G. B.; Oliveira, Guilherme R. // Orbital: The Electronic Journal of Chemistry; Apr2012 Supplement, Vol. 4, p76 

    No abstract available.

  • Structure-Activity Association of Flavonoids in Lung Diseases.
    Lago, João Henrique G.; Toledo-Arruda, Alessandra C.; Mernak, Márcia; Barrosa, Kaidu H.; Martins, Milton A.; Tibério, Iolanda F. L. C.; Prado, Carla M. // Molecules; Mar2014, Vol. 19 Issue 3, p3570 

    Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. They are abundantly found in Nature and over 8,000 flavonoids have from different sources, mainly plant materials,...

  • A New Chalcone Glycoside from Combretum griffithii.
    Wang, Liqin; Wu, Mingmei; Wang, Jihua; Jiang, Jinhe; Chen, Yegao; Li, Ting // Chemistry of Natural Compounds; May2014, Vol. 50 Issue 2, p258 

    A new chalcone glycoside, 2′,4,4′,6′-tetrahydroxydihydrochalcone 2′-O-α-L-rhamnopyranosyl-(1 → 6)-β-Dglucopyranoside ( 1), was isolated from Combretum griffithii Huerck et M.-A. along with the known compounds (-)-epigallocatechin ( 2),...

  • SYNTHESIS OF SOME NOVEL CHALCONES AND THEIR FACILE ONE-POT CONVERSION TO 2-AMINOBENZENE-1, 3-DICARBONITRILES USING MALONONITRILE.
    Ameta, K. L.; Rathore, Nitu S.; Kumar, Biresh // Analele Universitatii Bucuresti: Chimie; 2011, Vol. 20 Issue 1, p15 

    A facile synthesis of some novel chalcones (3a-3k) by the condensation of variously substituted aromatic aldehydes and 2,4-dihydroxyacetophenone and their subsequent rapid one pot transformations to 2-aminobenzene-1,3-dicarbonitriles (5a-5k) with malononitrile and morpholine has been described....

  • Multicomponent reaction for the synthesis of pyridine derivatives based on triphenylamine.
    Geng, Li-Jun; Feng, Guo-Liang; Yu, Jiu-Gao; Zhang, Hong-Li // Journal of Chemical Research; 2011, Vol. 35 Issue 2, p74 

    A facile preparation of pyridine derivatives based on triphenylamine through a multicomponent reaction from 3-cyanoacetylindoles, ammonium acetate and a 1,3-diarylpropenone either by conventional heating or microwave irradiation is described. The three-component reaction afforded good yields and...

  • Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines.
    Sridhar, S.; Prasad, Y. Rajendra; Dinda, S. C. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 3, p1130 

    In the present study, 3-acetyl-2,5-dimethylfuran on condensation with various aromatic and heterocyclic aldehydes in ethanolic KOH solution yielded the corresponding chalcones (3a-n). These chalcones were reacted with guanidine hydrochloride in presence of potassium hydroxide and ethanol to give...

  • Synthesis of ferrocenyl chalcones of the abietane series.
    Glushkov, V.; Anikina, L.; Maiorova, O.; Nedugov, A.; Slepukhin, P. // Russian Journal of Organic Chemistry; Jun2012, Vol. 48 Issue 6, p836 

    Two isomeric ferrocenyl chalcones having an abietane fragment were synthesized.

  • Topological Investingation and Modeling of Antimalarial Activity of Chalcone.
    Dwivedi, Sudhanshu Dhar; Bharadwaj, Arpan; Ghuraiya, Anis; Shrivastava, Amit // International Journal of ChemTech Research; Apr-Jun2012, Vol. 4 Issue 2, p662 

    A set of chalcone derivatives were tested for their antimalarial activities¹. Quantitative structure activity relationship (QSAR) analysis was applied to forty-two of the abovementioned derivatives using a combination of various topological descriptors. A multiple linear regression (MLR)...

  • A mutation in the rice chalcone isomerase gene causes the golden hull and internode 1 phenotype.
    Hong, Lilan; Qian, Qian; Tang, Ding; Wang, Kejian; Li, Ming; Cheng, Zhukuan // Planta; Jul2012, Vol. 236 Issue 1, p141 

    The biosynthesis of flavonoids, important secondary plant metabolites, has been investigated extensively, but few mutants of genes in this pathway have been identified in rice ( Oryza sativa). The rice gold hull and internode ( gh) mutants exhibit a reddish-brown pigmentation in the hull and...

  • Synthesis of Side Chain Chalcone Polymers and Their Photoalignment Capability for Film Patterned Retarder.
    Ju Hui Kang; Seung Yong Jeong; Sangkug Lee; Kyung Ho Choi; Gyo jic Shin // International Proceedings of Chemical, Biological & Environmenta; 2012, Vol. 43, p67 

    We synthesized two kinds of photocrosslinkable side chain photopolymer with a chalcone group in the side chain. Two photopolymers have the different alkyl spacer length introduced between main chain and chalconyl moiety. The thermal stability of these photopolymer measured by differential...

  • Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids.
    Selepe, Mamoalosi A.; Van Heerden, Fanie R. // Molecules; Apr2013, Vol. 18 Issue 4, p4739 

    The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the...

  • Synthesis and antibacterial activity of some new thiazine derivatives.
    Deepika, G.; Gopinath, P.; Kranthi, G.; Nagamani, C.; Jayasree Yadav, V.; Naidu, N.V.; Enaganti, Sreenivas // Journal of Pharmacy Research; 2012, Vol. 5 Issue 2, p1105 

    A series of novel chalcones were prepared by the reaction of different benzalaldehyde with various propiophenone and subsequent treatment with thiourea resulted in the formation of corresponding thiazines in good yields. All the new compounds have been characterized by IR and 1H-NMR spectral...

  • Synthesis of some novel Isoxazole, Cyanopyridine and Pyrimidinthione derivatives.
    Solankee, N.; Patel, K. P.; Patel, R. B. // Journal of Chemical & Pharmaceutical Research; 2012, Vol. 4 Issue 8, p3778 

    A new series of isoxazoles (7a-d), cyanopyridines (8a-d) and pyrimidinthiones (9a-d) have been prepared from chalcones (6a-d) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium...

  • Antimicrobial activities of synthesized and characterized 5-acetyl pyrimidine-2, 4, 6-(1H, 3H, 5H)-trione based chalcones.
    Dhorajiya, Bhavesh D.; Malani, Mahesh H.; Patel, Jigar R.; Dholakiya, Bharat Z. // Der Pharma Chemica; 2012, Vol. 4 Issue 1, p141 

    A series of eleven 5-((E)-3-phenylacryloyl) pyrimidine-2, 4, 6-(1H, 3H, 5H)-triones (5-acetyl pyrimidine 2, 4, 6-(1H, 3H, 5H) trione based chalcone) were synthesized using diethylmalonate, urea, acetic anhydride and various aryl aldehydes under basic conditions afforded the 5-acetyl...

  • Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.
    Padhye, Subhash; Ahmad, Aamir; Oswal, Nikhil; Sarkar, Fazlul H. // Journal of Hematology & Oncology; 2009, Vol. 2, p1 

    Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have been used to...

  • Evaluation of Silica-H2SO4 as an Efficient Heterogeneous Catalyst for the Synthesis of Chalcones.
    Sultan, Aeysha; Raza, Abdul Rauf; Abbas, Muhammad; Khan, Khalid Mohammed; Tahir, Muhammad Nawaz; Saari, Nazamid // Molecules; Aug2013, Vol. 18 Issue 8, p10081 

    We report an efficient silica-H2SO4 mediated synthesis of a variety of chalcones that afforded the targeted compounds in very good yield compared to base catalyzed solvent free conditions as well as acid or base catalyzed refluxing conditions.

  • Synthesis and Antioxidant Activity of Some Chalcones and Flavanoids.
    Yogesh Murti; Ashish Goswami; Pradeep Mishra // International Journal of PharmTech Research; Apr-Jun2013, Vol. 5 Issue 2, p811 

    In the present work we report the reaction of 2,4-dihydroxy acetophenone with different substituted aromatic aldehyde to form 2,4-dihydroxy chalcones. Various analogues of 7-hydroxy flavanoids were reported by oxidative cyclization of 2,4-dihydroxy chalcones. The structure of the newly...

  • Chalcones: compounds possessing a diversity in applications.
    Urmila Berar // Orbital: The Electronic Journal of Chemistry; Jul-Sep2012, Vol. 4 Issue 3, p209 

    Chalcones are a class of α,β-unsaturated carbonyl compounds that form the central core for a variety of naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. Besides their various pharmacological activities, chalcones have...

  • Formation of 3,4,5,6-tetrahydroquinazolin-2(1 H)-one derivatives in reaction of 4-aryl-6-methyl-3,4-dihydro-pyrimidin-2(1 H)-ones with chalcones.
    Kolosov, M.; Kulyk, O.; Starchenko, O.; Orlov, V. // Chemistry of Heterocyclic Compounds; Nov2013, Vol. 49 Issue 8, p1166 

    A procedure for the preparation of 6-methyl-3,4-dihydropyrimidin-2(1 H)-ones involving deacylation of 5-acetyl-6-methyl-3,4-dihydropyrimidin-2(1 H)-ones in MeOH-KOH medium is developed. We have shown that the obtained compounds readily undergo reaction with chalcones in MeOH-MeONa with the...

  • Improved microwave-induced synthesis of indolyl chalcones.
    Pal, Rammohan; Sarkar, Taradas; Sarkar, Tapas // Archives of Applied Science Research; 2014, Vol. 6 Issue 3, p138 

    Various indolyl chalcones have been synthesized in unsealed vessels in a domestic microwave oven. Considerable increase in the reaction rate has been observed with better yields.

  • Microwave assisted synthesis of novel methylenebis{2-[(1-benzyl/cyclohexyl-1 H-1,2,3-triazol-4-yl)methoxy]chalcones} and their antibacterial activity.
    Ramesh, S.; Ashok, D.; Linga Goud, G.; Prabhakar Reddy, V. // Russian Journal of General Chemistry; Aug2014, Vol. 84 Issue 8, p1608 

    A series of novel methylenebis{2-[(1-benzyl/cyclohexyl-1 H-1,2,3-triazol-4-yl)methoxy]chalcones} ( IVa-IVn) have been synthesized by the Click reaction and Claisen-Schmidt condensation of 5,5′-methylenebis[2-(prop-2-yn-1-yloxy)benzaldehyde] under microwave irradiation with high yields. All...

  • ABSTRACT.
    Ramesh, S.; Ashok, D.; Linga Goud, G.; Prabhakar Reddy, V. // Asian Journal of Research in Chemistry; Feb2011, Vol. 4 Issue 2, p3 

    The article presents abstracts on medical topics including latest strategy of medicinal chemistry implements, synthesis and anti-microbial evaluation of chalcone derivatives and synthesis of Copper (II) complexes of Tetradentate Binucleating Schiff Base Ligands.

  • Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model.
    Yau-Hung Chen; Wei-Hua Wang; Yun-Hsin Wang; Zi-Yu Lin; Chi-Chung Wen; Ching-Yuh Chern // Molecules; Feb2013, Vol. 18 Issue 2, p2052 

    The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(mpx:gfp)" to visualize the effect of neutrophil recruitment...

  • Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives.
    Hassan, Seham Y. // Molecules; Mar2013, Vol. 18 Issue 3, p2683 

    A series of 2-pyrazolines 5-9 have been synthesized from α,β-unsaturated ketones 2-4. New 2-pyrazoline derivatives 13-15 bearing benzenesulfonamide moieties were then synthesized by condensing the appropriate chalcones 2-4 with 4-hydrazinyl benzenesulfonamide hydrochloride. Ethyl [1,2,4]...

  • Synthesis And Biological Evaluation of Different Thiazine Derivatives.
    Keerthi kumar, B.; Varalakshmi Devi, K.; Ramesh gupta, P.; Kranthi, G.; Ramakrishna, C.; Sankaraiah, P.; Kumar, Chitta Suresh // Journal of Pharmacy Research; Jan2011, Vol. 4 Issue 1, p274 

    A series of novel chalcones were prepared by the reaction of different benzaldehydes with various Acetophenones and subsequent treatment with thiourea resulted in the formation of corresponding thiazines in good yields. All the new compounds have been characterized by IR, ¹H NMR, MS and...

  • Synthesis and Biological Activity of Heterocycles from Chalcone.
    Al-Ghulikah, H. A. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 4, p1631 

    The reaction between aromatic or heteroaromatic ortho-diamines and chalcone 1a,b is a convenient and versatile method for the preparation of condensed 1,4-diazepines 2a,b and 4a,b. 2,4-Diaryl-2,3-dihydro[1,5]benzothiazepines 5a,b were obtained from the condensation of chalcone 1a,b with...

  • Microwave Assisted Synthesis, Spectral Studies and Antibacterial Activity of 1, 5-benzodiazepines Derivatives on a Solid Surface.
    DEVPURA, ANJU; SINGH, JAYANT P.; JAITAWAT, NEETU; RATHORE, RENU; KUMAWAT, MONIKA; DULAWAT, SHIV S. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 12, p5914 

    Chalcones are well known intermediates for synthesizing various heterocyclic compounds. They have been utilized for the synthesis of various substituted benzodiazepines by the reaction of o-phenylenediamine. In present investigation we have carried out the reaction under both conventional method...

  • Synthesis and Antibacterial Studies of Chloro-Substituted 1,3-Thiazines.
    RAJPUT, P. R.; GAJBHIYE, A. V.; BHADE, M. W. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 12, p5699 

    Thiazines are very useful units in the fields of medicinal and pharmaceutical chemistry and have been reported to exhibit a variety of biological activities. This has directed us to synthesize chloro-substituted thiazines from 2'-hydroxy-3',5'-dichloro-4-4'-chlorophenyl chalcone with thiourea,...

  • Microwave Assisted Synthesis and Antibacterial Activity of Chalcone Derivatives.
    YADAV, KHUSHBU; SHARMA, ABHA; SRIVASTAVA, J. N. // Asian Journal of Chemistry; 2012, Vol. 24 Issue 12, p5779 

    Chalcone derivatives have been synthesized by equimolar reactions between substituted aldehydes and substituted acetophenones in basic medium by using conventional and microwave assisted technique. These compounds are characterized by FTIR and ¹H NMR spectra. Before characterization purity of...

  • Xanthohumol reduces transcription of pro-inflammatory markers TNF-α, IL-1β, NFκB2, and HO1 in the lung of senescence-accelerated prone mice (SAMP8).
    Paredes, S.; Carrasco, A.; Rancan, L.; Kireev, R.; Vara, E.; Tresguerres, J. F. // Proceedings of the Physiological Society; 2013, p237P 

    Lungs are highly vascularised organs directly exposed to atmospheric oxygen. Consequently, they are an important source of reactive species that seem to be involved in local defense against pathogens. With age, increased production of free radicals, together with a reduced antioxidant defense...

  • Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids.
    Otero, Elver; Vergara, Sebastián; Robledo, Sara M.; Cardona, Wilson; Carda, Miguel; Vélez, Ivan D.; Rojas, Carlos; Otálvaro, Felipe // Molecules; Sep2014, Vol. 19 Issue 9, p13251 

    Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds...

  • Synthesis and pharmacological screening of some novel chloro chalconesemicarbazone derivatives.
    Singh, Hemendra Pratap; Chauhan, C. S.; Pandeya, S. N.; Sharma, C. S.; Srivastava, B.; Singhal, Manmohan // Der Pharma Chemica; 2010, Vol. 2 Issue 3, p343 

    A series of chalconyl derivatives of chloro phenyl semicarbazide (CA1-CA5) was synthesized. All the synthesized compounds were screened for their pharmacological action in protection of seizures, behavioral study, anti-inflammatory and analgesic activity. After intraperitoneal injection to mice...

  • Synthesis, Characterization and Biological Evaluation of Functionalized Derivatives of Versatile Synthon 4,4'-Difluoro chalcone.
    Samshuddin, Seranthimata; Narayana, Badiadka; Sarojini, Balladka Kunhanna; Yathirajan, Hemmige S.; Raghavendra, Ramappa // Der Pharma Chemica; 2012, Vol. 4 Issue 4, p1445 

    Some functionalized fluorinated derivatives are prepared by condensing 4,4'-difluoro chalcone with hydrazine derivatives, o-phenylenediamine, ammonium acetate/acetic acid, ethyl cyanoacetate, malononitrile, acetylacetone, esters of acetoacetic acid, acetoacetanilde, aminoguanidine hydrochloride,...

  • Synthesis of benzoazepino incorporated analogues of 1, 5-benzodiazepine of medicinal interest.
    Pareek, Aastha; Rani, Priyanka; Agarwal, Anshu; Shekhawat, Shashi; Kishore, D. // International Journal of Chemical & Pharmaceutical Sciences; Jun2013, Vol. 4 Issue 2, p44 

    Exceedingly facile single step expedient protocols based on the versatility and reactivity of corresponding: (dimethylaminomethylene) ketone (6) and chalcone (7) derivatives, have been developed to provide an easy incorporation of the benzoazepine based privileged templates, on to the (1,5)-...

  • Synthesis and antimicrobial screening of some novel substituted 4'-amino-1,3-diaryl-2-propen-1-one.
    Chavan, Shivaji B.; Vibhute, Archana Y.; Sundge, Shivshankar G.; Zangade, Sainath B. // Journal of Pharmacy Research; Jul2013, Vol. 6 Issue 7, p739 

    Claisen-schmidt base catalyzed condensation reaction of 4'-amino acetophenone with different substituted benzaldehyde afford some substituted 4'-amino chalcones. The newly synthesized chalcones screened for antimicrobial activity. Most of these compounds showed potent activity.

  • Synthesis, characterization and evaluation of antimicrobial activities of new α, β-unsaturated ketone derivatives.
    Moger, Manjunath; Darshan Raj, Chenna Govindaraju; Hindupura, Rama Mohan; Pati, Hari N. // Journal of Pharmacy Research; 2013, Vol. 6 Issue 9, p865 

    A new series of α, β-unsaturated ketones were synthesized by the reaction of different substituted aromatic aldehydes with 3-(2-oxo-propyl)- chromen-2-one. The newly synthesized coumarin based chalcone derivatives 5a-j was characterized by 1H NMR, 13C NMR, IR and mass spectral data, and...

  • Production of kaempferol 3- O-rhamnoside from glucose using engineered Escherichia coli.
    Yang, So-Mi; Han, So; Kim, Bong-Gyu; Ahn, Joong-Hoon // Journal of Industrial Microbiology & Biotechnology; Aug2014, Vol. 41 Issue 8, p1311 

    Flavonoids are ubiquitous phenolic compounds and at least 9,000 have been isolated from plants. Most flavonoids have been isolated and assessed in terms of their biological activities. Microorganisms such as Escherichia coli and Saccharomyces cerevisiae are efficient systems for the synthesis of...

  • Design synthesis and biological evaluation of 2-methylphenyl semicarbazone derivatives.
    Singhal, Manmohan; Paul, Arindam; Singh, Hemendra Pratap // Bangladesh Journal of Pharmacology; Jun2011, Vol. 6 Issue 1, p1 

    We have used pharmacaphore hybridization technique of drug design and designed a pharmacophore model 2-methyphenysemicarbazone which is having hydrogent acceptor site, hydrogen donor site, lipophilic site etc using ligandscout-2.02 software. A series of 2-methylphenyl-semicarbazone was...

  • Seasonal Pattern of Flavonoid Content and Related Enzyme Activities in Leaves of Ginkgo biloba L.
    Shuiyuan Cheng; Feng Xu; Linling Li; Hua Cheng; Weiwei Zhang // Notulae Botanicae Horti Agrobotanici Cluj-Napoca; 2012, Vol. 40 Issue 1, p98 

    The contents of flavonoids and other related components, in addition to the activities of related enzymes, such as phenylalanine ammonia- lyase (PAL), peroxidase (POD), chalcone synthase (CHS), and UDP-glucose:flavonoid 3-O- glucosyltransferase (UFGT), were determined in Ginkgo biloba L. leaves...

  • Methylation effect on chalcone synthase gene expression determines anthocyanin pigmentation in floral tissues of two Oncidium orchid cultivars.
    Liu, Xiao-Jing; Chuang, Yao-Nung; Chiou, Chung-Yi; Chin, Dan-Chu; Shen, Fu-Quan; Yeh, Kai-Wun // Planta; Aug2012, Vol. 236 Issue 2, p401 

    The anthocyanin-biosynthetic pathway was studied in flowers of Oncidium Gower Ramsey with yellow floral color and mosaic red anthocyanin in lip crests, sepals and petals, and compared with the anthocyanin biosynthesis in flowers of Oncidium Honey Dollp, a natural somatoclone derived from tissue...

  • SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CHROMONES BEARING 1, 5-BENZO THIAZEPINYL MOIETY.
    Dengle, R. V.; Deshmukh, R. N. // International Journal of Pharmaceutical Sciences & Research; Apr2013, Vol. 4 Issue 4, p1495 

    1, 5-Benzothazepinyl chromones were synthesized starting from 2, 4-diacyl phenol. The 2, 4-diacyl phenol was condensed with aryl aldehydes to obtain bis-chalcones1a-d. The bis-chalcones on cyclocondensation with equimolar amount of 2-aminothiophenol gave 1, 5-benzothiazepinyl chalcones2a-d. The...

  • SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF FEW CHALCONES.
    PRASADARAO, K.; LUSIRANI SUSUMA, A. J.; MOHAN, S. // International Journal of Pharma & Bio Sciences; Oct-Dec2012, Vol. 3 Issue 4, p781 

    In an effort to develop anti-bacterial agents, a series of Chalcones were synthesized by condensing 4-chloro, 2-hydroxyacetophenone with aldehyde derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to claisen-schmidt condensation. The synthesized compounds...

  • Comparative analysis of the inverted repeat of a chalcone synthase pseudogene between yellow soybean and seed coat pigmented mutants.
    Senda, Mineo; Nishimura, Satsuki; Kasai, Atsushi; Yumoto, Setsuzo; Takada, Yoshitake; Tanaka, Yoshinori; Ohnishi, Shizen; Kuroda, Tomohisa // Breeding Science; Dec2013, Vol. 63 Issue 4, p384 

    In soybean, the I gene inhibits pigmentation over the entire seed coat, resulting in yellow seeds. It is thought that this suppression of seed coat pigmentation is due to naturally occurring RNA silencing of chalcone synthase genes (CHS silencing). Fully pigmented seeds can be found among...

  • Synthesis, characterization and pharmacological evaluation of some novel quinoxaline derived chalcones.
    Kotra, Vijay; Pradeep, Karakavalasa; Vasanthi, R. // Der Pharma Chemica; 2013, Vol. 5 Issue 4, p301 

    Quinoxalines derivatives were reported with wide range of biological activities. Hence it was planned to synthesize some novel series of quinoxalines derivatives. Orthopheneylene diamine was reacted with oxalic acid to form quinoxaline 2, 3 Dione. Quinoxaline-2, 3 (1H, 4H)-dione was chlorinated...

  • Two efficient methods for the synthesis of novel indole-based chalcone derivatives.
    Gao, Wentao; Liu, Rui; Li, Yang; Cui, Peng // Research on Chemical Intermediates; Oct2014, Vol. 40 Issue 8, p3021 

    Two powerful methods for the synthesis of indole-based chalcone derivatives, namely ( E)-1-(2-chloro-1-(4-chlorobenzyl)-1 H-indol-3-yl)-3-aryl(hetaryl)prop-2-en-1-ones ( 3a- l), are described, involving the ultrasound-assisted or solvent-free Claisen-Schmidt condensation reaction of...

  • Synthesis, characterization and biological screening of novel substituted chalcones.
    Konda, Ravi Kumar; Nuthakki, Vijay Kumar; P., Mahesh Babu // Der Pharma Chemica; 2014, Vol. 6 Issue 4, p1 

    Present work deals with synthesizing novel Chalcones using acetophenone with different types of benzaldehyde derivatives using Claisen-Schmidt reaction. A mixture of acetophenone and aryl aldehydes were dissolved in methanol and to it 40%KOH was added. The mixture was kept for 24hours and it was...

  • Ethyl 4,4''-Difluoro-5'-hydroxy-1,1':3',1''-terphenyl-4'- carboxylate.
    Samshuddin, Seranthimata; Narayana, Badiadka; Kunhanna Sarojini, Balladka // Molbank; Dec2011, Vol. 11 Issue 4, Special section p1 

    A simple and novel route for the synthesis of new terphenyl derivative as well as oxidative aromatization of α,β-unsaturated cyclohexenone to the corresponding phenol derivative is developed. The present work involves the condensation of ethylacetoacetate with 4,4'-difluoro chalcone...

  • SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES.
    KOÇYİĞİT-KAYMAKÇIOĞLU, Bedia; ORUÇ-EMRE, Elçin E.; BEYHAN, Nagihan; TOKLU, Hale Z.; GÜMRÜ, Salih; ARICIOGLU, Feyza // Anadolu University of Sciences & Technology - C: Life Sciences &; Aug2011, Vol. 1 Issue 2, p137 

    In the present study, a series of chalcones were prepared by Claisen Schmidt condensation as starting compounds and 2-pyrazoline derivatives have been synthesized by the reaction of chalcones with thiosemicarbazide. Their structures have been confirmed by IR, ¹H-NMR, mass spectral data and...

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