Citations with the tag: BIOMOLECULES
Results 1 - 50
- Origins of homochirality.
Bada, Jeffrey L. // Nature; 4/13/1995, Vol. 374 Issue 6523, p594
Reports on various studies on the origins of biomolecular homochirality. Homochirality as a consequence of universal fundamental physical processes; Necessity of a pure chiral medium for the origin of life; Homochirality as a consequence of life; Physical mechanisms for the generation of...
- Correction: Characterisation of RT1-E2, a multigenic family of highly conserved rat non-classical MHC class I molecules initially identified in cells from immunoprivileged sites.
Bada, Jeffrey L. // BMC Immunology; 2004, Vol. 5, p4
A correction to the article "Characterisation of RT1-E2, a Multigenic Family of Highly Conserved Rat Non-Classical MHC Class I Molecules Initially Identified in Cells From Immunoprivileged Sites.
- Massively parallel adhesion and reactivity measurements using simple and inexpensive magnetic tweezers.
Assi, Fabiano; Jenks, Robert; Yang, Jerry; Love, Christopher; Prentiss, Mara // Journal of Applied Physics; 11/1/2002, Vol. 92 Issue 9, p5584
Single molecule techniques to measure biological molecules and reactions have provided an alternative way to probe and visualize bond characteristics and reaction dynamics. However, these techniques, such as atomic force microscopy, optical tweezers, and micropipettes often require expensive and...
- Biomolecules: Where the physics of complexity and simplicity meet.
Frauenfelder, Hans; Wolynes, Peter G. // Physics Today; Feb94, Vol. 47 Issue 2, p58
Discusses how the study of protein dynamics and biomolecular physics reveal some of the principles of the physics of complexity. Important features of the physics of biomolecules; Approaches in discovering physical laws of complex systems; Description of the energy landscape for simple systems...
- Potentials of mean force for biomolecular simulations: Theory and test on alanine dipeptide.
Pellegrini, Matteo; Gro\nbech-Jensen, Niels; Doniach, Sebastian // Journal of Chemical Physics; 6/1/96, Vol. 104 Issue 21, p8639
We describe a technique for generating potentials of mean force (PMF) between solutes in an aqueous solution. We first generate solute�solvent correlation functions (CF) using Monte Carlo (MC) simulations in which we place a single atom solute in a periodic boundary box containing a few...
- Geometry optimization of large biomolecules in redundant internal coordinates.
Paizs, B�la; Baker, Jon; Suhai, Sandor; Pulay, Peter // Journal of Chemical Physics; 10/22/2000, Vol. 113 Issue 16
We present an improved version of our recent algorithm [B. Paizs, G. Fogarasi, and P. Pulay, J. Chem. Phys. 109, 6571 (1998)] for optimizing the geometries of large molecules. The approximate Cholesky factorization technique has been generalized to the case of redundant coordinates, and an...
- Hotwiring biosensors.
Klemic, James F.; Stern, Eric; Reed, Mark A. // Nature Biotechnology; Oct2001, Vol. 19 Issue 10, p924
Studies the conductance behavior of nanofabricated doped silicon wires functionalized with organic molecules and biomolecules. Basic structure of the biosensor; Ways to demonstrate four different prototype sensors; Developments in nanofabrication techniques.
Eckhardt, S. // Anti-Cancer Agents in Medicinal Chemistry; 2008, Vol. 8 Issue 5, p461
The article discusses various reports published within the issue, including one by J. Tim�r and B. D�me on complex mechanisms between the metastasis development and the TKI-s and another by S. I. Moulder, B. S. Craft and G. N. Hortobagyi on new molecular targeted agents which may enhance...
- Editorial: Thrombospondins.
Lawler, Jack // Current Drug Targets; Oct2008, Vol. 9 Issue 10, p820
The article discusses various reports published within the issue, including one on the effect of thrombospondin-1 (TSP-1) on von Willebrand factor function and another on the molecular mechanisms that involve in the inhibition of angiogenesis by TSP-1.
- Multiplexing Breathes New Life Into Old Techniques.
Masi, C.G. // Drug Discovery & Development; Apr2003, Vol. 6 Issue 4, p67
Discusses the use of multiple fluorophores for detecting and analyzing target biomolecules. Fluorescence phenomenon; Confocal optical system; Fluorescence detection technology. INSET: Quantum Dots as Advanced Fluorophores.
Saida, Fakhri // Protein & Peptide Letters; Aug2008, Vol. 15 Issue 8, p756
The article discusses various reports published within the issue, including one by B. Prieto-Simon et al. on the main biomolecules immobilization strategies and another by D. Zhang et al. on the design of protein-based voltammetric biosensors fabricated with nanomaterials.
- Light-directed, programmable microarray synthesis.
Zhou, Xiaochuan; Gao, Xiaolian; LeProust, Eric; Peppllois, Jean Philippe; Yu, Peilin; Zhang, Hua; Gulari, Erdogan; Srivannavit, Onnop; Gulari, Ning // Nature Genetics; Nov99 Supplement, Vol. 23, p84
Presents an abstract for the article on light-directed programmable biomolecular microarray synthesis.
- Distribution of lipids in nonlamellar phases of their mixtures.
Li, Xiao-jun; Xiao-jun Li; Schick, M. // Journal of Chemical Physics; 4/1/2000, Vol. 112 Issue 13
We consider a model of lipids in which a head group, characterized by its volume, is attached to two flexible tails of equal length. The phase diagram of the anhydrous lipid is obtained within self-consistent field theory, and displays, as a function of lipid architecture, a progression of...
- The Ecomechanics of Mussel Attachment: From Molecules to Ecosystems.
Carrington, Emily // Integrative & Comparative Biology; Aug2002, Vol. 42 Issue 4, p846
Focuses on the ecomechanics of mussel attachment, which contributes to the competitive dominance of mussels on many waveswept shores. Discussion on the molecules of mussel byssus; Interspecies variation at all levels of the mechanical design of mussel byssus; Conclusion.
- Enantiospecific electrodeposition of a chiral catalyst.
Switzer, Jay A.; Kothari, Hiten M.; Poizot, Philippe; Nakanishi, Shuji; Bohannan, Eric W. // Nature; 10/2/2003, Vol. 425 Issue 6957, p490
Many biomolecules are chiral-they can exist in one of two enantiomeric forms that only differ in that their structures are mirror images of each other. Because only one enantiomer tends to be physiologically active while the other is inactive or even toxic, drug compounds are increasingly...
- Editorial: Computing with biomolecules.
Csuhaj-Varj�, Erzs�bet; Salomaa, Kai // Natural Computing; Jun2011, Vol. 10 Issue 2, p775
An introduction is presented in which the editor discusses various reports within the issue on topics including a class of membrane systems (P systems), formal-language-theoretic models for transposable genetic elements, and a novel DNA recombination mechanism called XPCR.
Schlegel, Rolf H. J. // Encyclopedic Dictionary of Plant Breeding & Related Subjects; 2003, p339
The article presents a definition of the term "prototroph," which refers to a strain of organisms capable of growth on a defined minimal medium from which they can synthesize all of the more complex biological molecules they require.
- Journal club.
Bagshaw, Clive R. // Nature; 11/15/2007, Vol. 450 Issue 7168, p323
A personal narrative is presented which explores the experience of the authors on investigating the dynamic properties of proteins at the level of a single molecule.
- One small step for myosin...
Block, Steven M. // Nature; 11/9/1995, Vol. 378 Issue 6553, p132
Focuses on studies which examine the behavior of individual biomolecules. Measurement of nanometre-sized steps and piconewton-sized forces produced by motor proteins such as myosin; Recordings of displacements produced by heavy meromyosin.
- Mind-Blowing Mirror Molecules.
Cox, Mary Bah // Odyssey; Mar2011, Vol. 20 Issue 3, p7
The article presents detailed information on mirror molecules.
- New developments in analytical ultracentrifugation and related macromolecular modelling techniques.
Byron, O.; Harding, Stephen E. // European Biophysics Journal; 1997, Vol. 25 Issue 5/6, p305
Focuses on the development of the analytical ultracentrifuge, a tool for the analysis of biomolecular systems in terms of molecular mass, molecular mass distribution, mass action phenomena and solution conformation. Developments in instrumentation; Applications of the analytical ultracentrifuge...
Byron, O.; Harding, Stephen E. // Taber's Cyclopedic Medical Dictionary (2009); 2009, Issue 21, p1453
A definition of the term "metabolite" is presented.
Byron, O.; Harding, Stephen E. // Taber's Cyclopedic Medical Dictionary (2009); 2009, Issue 21, p1453
A definition of the term "metabolomics, which refers to the collective metabolites in an organism, is presented.
- Modeling solvation contributions to conformational free energy changes of biomolecules using a potential of mean force expansion.
Pellegrini, Matteo; Doniach, Sebastian // Journal of Chemical Physics; 8/15/95, Vol. 103 Issue 7, p2696
The standard free energy perturbation (FEP) techniques for the calculation of conformational free energy changes of a solvated biomolecule involve long molecular dynamics (MD) simulations. We have developed a method for performing the same calculations many orders of magnitude faster. We model...
- Structural sensing using fluorescence nanotomography.
Rolinski, Olaf J.; Birch, David J. S. // Journal of Chemical Physics; 6/15/2002, Vol. 116 Issue 23, p10411
Fluorescence nanotomography is a newly developed experimental technique enabling determination of the molecular distributions with �ngstrom resolution in complex structures such as soft solids, porous materials, and biomacromolecules. In this approach to structural sensing, F�rster resonance...
- Intraspecific variation in the venom electrophoretic profile of saw-scaled viper, Echis carinatus of Central Punjab, Pakistan.
Feroze, A.; Malik, S. A.; Qureshi, J. A. // Internet Journal of Veterinary Medicine; 2009, Vol. 6 Issue 2, p1
The use of Polyacrylamide gel electrophoresis (PAGE) for basic proteins may be a useful auxiliary tool for the characterization of whole snake venoms and for the taxonomic classification of snakes. The electrophoretic characterization of the basic venom proteins has emerged as an efficient...
- Analytic solution of the stochastic-Liouville model of spin exchange.
Adrian, Frank J. // Journal of Chemical Physics; 3/1/88, Vol. 88 Issue 5, p3216
An analytic solution is obtained for the stochastic-Liouville model of spin exchange between a pair of radicals undergoing isotropic diffusion in solution and interacting via an exchange interaction that decays exponentialy with radical separation. The resulting spin exchange cross section is...
- Photo-induced dissociation of electrospray generated ions in an ion trap/time-of-flight mass...
Gabryelski, Wojciech; Liang Li // Review of Scientific Instruments; Nov99, Vol. 70 Issue 11, p4192
Describes an experimental setup for laser photo-induced dissociation (PID) studies of biomolecules by mass spectrometry. Use of an ion trap/time-of-flight mass spectrometer for the detection of PID products; Production of the intact molecular ions by electrospray ionization; Comparison of the...
- Attractive-mode force microscope for investigations of biomolecules under ambient conditions.
King, G. M.; Nunes, G. // Review of Scientific Instruments; Nov2001, Vol. 72 Issue 11, p4261
We report on the design and performance of a quartz tuning-fork-based dynamic mode atomic force microscope for the imaging of biological samples under ambient conditions. The instrument uses a stiff cantilever that maintains stable oscillations at low amplitudes even in the presence of capillary...
- Force-extension behavior of folding polymers.
Cocco, S.; Marko, J. F.; Monasson, R.; Sarkar, A.; Yan, J. // European Physical Journal E -- Soft Matter; Mar2003, Vol. 10 Issue 3, p249
: The elastic response of flexible polymers made of elements which can be either folded or unfolded, having different lengths in these two states, is discussed. These situations are common for biopolymers as a result of folding interactions intrinsic to the monomers, or as a result of binding of...
- A technique for microsecond heating and cooling of a thin (submicron) biological sample.
Steel, Bradley C.; Bilek, Marcela M.; McKenzie, David R.; dos Remedios, Cristobal G. // European Biophysics Journal; 2002, Vol. 31 Issue 5, p378
Temperature excursions of short duration are useful in exploring the effects of stress on biological systems. Stress will affect the conformation of biological molecules such as proteins, which will lead to an effect on their function. The feasibility of generating such temperature excursions is...
- Innovations of Membrane Chromatography.
Warner, Tim N.; Nochumson, Sam // Pharmaceutical Technology North America; Sep2002, Vol. 26 Issue 9, p36
Focuses on the importance of membrane chromatography for biomolecular purification in the biopharmaceutical industry. Limitations of chromatography; Comparison of various types of biopharmaceutical purification methods; Advantages of membrane chromatography.
- McMush lab.
Brown, Judy // American Biology Teacher; Nov/Dec94, Vol. 56 Issue 8, p492
Presents a laboratory activity designed to help students analyze four classes of biomolecules found in an ordinary fast-food lunch. Assigning of teams which will be responsible for testing for the presence of a specific organic compound; Materials needed for teacher demonstration.
- Lipids from Descurainia Sophia Seeds.
Bekker, N. P.; Ul'chenko, N. T.; Glushenkova, A. I. // Chemistry of Natural Compounds; May2005, Vol. 41 Issue 3, p346
Cites a study on lipids from Descurainia sophia seeds. Examination of the seeds of D. sophia collected in Tashkent; Separation of lipids by preparative TLC on silica-gel plates using benzine dieethylether; Analysis of the results of benzine separation of the extract of D. sophia seeds.
- Effect of friction on electron transfer in biomolecules.
Garg, Anupam; Onuchic, Jos� Nelson; Ambegaokar, Vinay // Journal of Chemical Physics; 11/1/85, Vol. 83 Issue 9, p4491
In biological and chemical electron transfer, a nuclear reaction coordinate is coupled to other nuclear and/or ��solvent�� coordinates. This coupling, or friction, if strong enough, may substantially slow down motion along the reaction coordinate, and thus vitiate the assumption of...
- Solvent-induced forces between solutes: A time- and space-resolved molecular dynamics study.
Brug�, F.; Fornili, S. L.; Palma-Vittorelli, M. B. // Journal of Chemical Physics; 8/1/94, Vol. 101 Issue 3, p2407
A molecular dynamics statistical mechanical simulation study of solvent-induced forces (SIFs) acting between two fixed model solutes in a bath of 727 water molecules is reported. Simulations were run up to 500 ps on a multiprocessor system, involving 60 T800-20 transputers. Results are discussed...
- Protein�trehalose�water structures in trehalose coated carboxy-myoglobin.
Cottone, Grazia; Ciccotti, Giovanni; Cordone, Lorenzo // Journal of Chemical Physics; 12/1/2002, Vol. 117 Issue 21, p9862
Some organisms can survive complete dehydration and/or high temperature in a state of suspended animation called anydrobiosis, in which all metabolic processes are "switched off' however, upon rehydration, their normal life cycle is restored, without formation of irreversible damages. A common...
- Calculating Probabilities of Carbon-Based Biomolecules.
Isaac, Randy // Perspectives on Science & Christian Faith; Mar2012, Vol. 64 Issue 1, p72
A letter to the editor about carbon-based biomolecules is presented.
- Demonstration of vacuum field emission from a self-assembling biomolecular microstructure composite.
Kirkpatrick, D.A.; Bergeron, G.L. // Applied Physics Letters; 3/30/1992, Vol. 60 Issue 13, p1556
Demonstrates a vacuum field emission from ungated field emitter array fabricated from self-assembling biomolecular microstructures. Use of diacetylenic lipid to form tubules for metal deposition; Enhancement of electric field by sharp edges of exposed metal tubules; Suitability of the surface...
- Autoantigen microarrays for multiplex characterization of autoantibody responses.
Robinson, William H.; DiGennaro, Carla; Hueber, Wolfgang; Haab, Brian B.; Kamachi, Makoto; Dean, Erik J.; Fournel, Sylvie; Fong, Derek; Genovese, Mark C.; de Vegvar, Henry E. Neuman; Skriner, Karl; Hirschberg, David L.; Morris, Robert I.; Muller, Sylviane; Pruijn, Ger J.; van Venrooij, Walther J.; Smolen, Josef S.; Brown, Patrick O.; Steinman, Lawrence // Nature Medicine; Mar2002, Vol. 8 Issue 3, p295
We constructed miniaturized autoantigen arrays to perform large-scale multiplex characterization of autoantibody responses directed against structurally diverse autoantigens, using submicroliter quantities of clinical samples. Autoantigen microarrays were produced by attaching hundreds of...
- Programmable and autonomous computing machine made of biomolecules.
Benenson, Yaakov; Paz-Elizur, Tamar; Adar, Rivka; Keinan, Ehud; Livneh, Zvi; Shapiro, Ehud // Nature; 11/22/2001, Vol. 414 Issue 6862, p430
Investigates the fabrication of programmable and autonomous computing machine made of biomolecules. Discussion on the automata technique; Mode of operation of the Turing machine; Similarity of the Turing machine to information-encoding biopolymers.
- Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules.
Han, Mingyong; Gao, Xiaohu; Su, Jack Z.; Nie, Shuming // Nature Biotechnology; Jul2001, Vol. 19 Issue 7, p631
Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots (zinc sulfide-capped cadmium selenide nanocrystals) into polymeric microbeads at precisely controlled ratios. Their novel optical properties (e.g., size-tunable emission and simultaneous...
- Born in a grain of dust.
Nielsen, Ilga // New Scientist; 9/1/2001, Vol. 171 Issue 2306, p17
Focuses on the origin of earliest life forms from space. Transformation of simple chemicals into complex biological molecules; Details on the bombardment of solar wind particles; Creation of a primary material for building complex organic molecules.
- The Baculovirus Expression System as a Tool for Generating Diversity by Viral Surface Display.
Grabherr, R.; Ernst, W. // Combinatorial Chemistry & High Throughput Screening; Apr2001, Vol. 4 Issue 2, p185
It has become a major goal of molecular biologists, biochemists, and immunologists to be able to modulate the structure of proteins, in order to increase their antigenicity, alter their biological properties and-or explore their function. Based on the concept of bacterial phage display, by which...
- Antitumour Metallocenes: Structure-Activity Studies and Interactions with Biomolecules.
Harding, Margaret M.; Mokdsi, George // Current Medicinal Chemistry; Dec2000, Vol. 7 Issue 12, p1289
The metallocene dihalides are a relatively new class of small, hydrophobic organometallic anticancer agents that exhibit antitumour properties against numerous cell lines including leukemias P388 and L1210, colon 38 and Lewis lung carcinomas, B16 melanoma, solid and fluid Ehrlich ascites tumours...
- Biomolecules Linked to Transition Metal Complexes - New Chances for Chemotherapy.
Paschkel, Reinhard; Paetz, Christian; Mueller, Thomas; Schmoll, Hans-Joachim; Mueller, Helmut; Sorkau, Eduard; Sinn, Ekkehard // Current Medicinal Chemistry; Oct2003, Vol. 10 Issue 19, p2033
From the synthetic point of view the fast developing fields of medicine and biology offer new opportunities for the design of very effective drugs with high selectivity. Especially in the field of anticancer therapy many efforts have been made to deliver drugs to specific tissues. Sugar...
- Brain Nitric Oxide and Its Dual Role in Neurodegeneration / Neuroprotection: Understanding Molecular Mechanisms to Devise Drug Approaches.
Contestabile, Antonio; Monti, Barbara; Contestabile, Andrea; Ciani, Elisabetta // Current Medicinal Chemistry; Oct2003, Vol. 10 Issue 20, p2147
Nitric oxide (NO) has been established as an important messenger molecule in various steps of brain physiology, from development to synaptic plasticity, learning and memory. However, NO has also been viewed as a major agent of neuropathology when, escaping controlled production it may directly...
- Understanding the Molecular Mechanism of Sigma-1 Receptors: Towards A Hypothesis that Sigma-1 Receptors are Intracellular Amplifiers for Signal Transduction.
Su, Tsung-Ping; Hayashi, Teruo // Current Medicinal Chemistry; Oct2003, Vol. 10 Issue 20, p2073
Although sigma receptors were discovered in 1982, the biochemical and physiological roles of sigma receptors have just begun to unveil. Sigma receptors are non-opioid, non-phencyclidine receptors that contain two subtypes: sigma-1 and sigma-2 receptors. The sigma-1 receptor has been cloned and...
- Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals.
Su, Tsung-Ping; Hayashi, Teruo // BioMetals; Feb2009, Vol. 22 Issue 1, p149
Abstract��Zinc(II) ions are essential for all forms of life. In humans, they have catalytic and structural functions in an estimated 3,000 zinc proteins. In addition, they interact with proteins transiently when they regulate proteins or when proteins regulate cellular zinc re-distribution....
- Di-iron proteins of the Ric family are involved in iron�sulfur cluster repair.
Marta Justino; Joana Baptista; L�gia Saraiva // BioMetals; Feb2009, Vol. 22 Issue 1, p99
Abstract��A key element in eukaryotic immune defenses against invading microbes is the production of reactive oxygen and nitrogen species. One of the main targets of these species are the iron�sulfur clusters, which are essential prosthetic groups that confer to proteins the ability to...