Citations with the tag: APOPTOSIS
Results 1 - 50
- Cells for suicide.
// Psychology Today; Jul/Aug95, Vol. 28 Issue 4, p22
Reports that apoptosis or programmed cell death happens when a brain artery gets blocked or ruptured. Risk of cell mutation after a stroke; Implications of preventing apoptosis; Occurrence of apoptosis in the prenatal brain.
- Does apoptosis have a role in arteriosclerosis?
P.F.C. // Cortlandt Forum; 04/25/97, Vol. 10 Issue 4, p98
Presents information on apoptosis in relation to the cardiovascular system. Apoptosis as the natural form of cellular death.
- You say tomato and I say tomahto: Getting a handle on pronouncing apoptosis.
Kuska, Bob // JNCI: Journal of the National Cancer Institute; 03/05/97, Vol. 89 Issue 5, p351
Comments on the proper pronunciation of the word apoptosis. Definition of apoptosis; Origin of the word.
- Making friends with death-wish genes.
Douglas, Kate // New Scientist; 7/30/94, Vol. 143 Issue 1936, p30
Focuses on the biological study of apoptosis, the cellular death wish. Implication of apoptosis in various disease including cancer; Process of apoptosis; Factors of life; Genes involved in decisions about cell growth and suicide; Biologists studying apoptosis. INSET: Genetic clocks..
- Bcl-2 associates with the ras-related protein R-ras p23.
Fernandez-Sarabia, Maria Jose; Bischoff, James R. // Nature; 11/18/1993, Vol. 366 Issue 6452, p274
Uses the yeast two-hybrid system to show that the human ras-related protein R-ras p23 binds to Bcl-2. Importance of apoptosis in cell regulation; Immunoprecipitates from human extracts; Evidence of a putative component of a signal transduction pathway involved in the regulation of apoptosis.
- Fascinating death factor.
Cory, Suzanne // Nature; 1/27/1994, Vol. 367 Issue 6461, p317
Reports on the cell-surface receptor Fas or Apo-1 which triggers apoptosis. Discovery of Fas/Apo-1; Tumor necrosis factor (TNF) receptors; Description of apoptosis; Studies on mice homologues of the gene; Control of the Fas/Apo-1 pathway.
- Death gets a brake.
Wylie, Andrew H. // Nature; 5/26/1994, Vol. 369 Issue 6478, p272
Discusses the process of apoptosis as initiated by cells. Genes that inhibit apoptosis; Gene interaction; Implications for developmental biology, cancer research, immunology and toxicology.
- Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.
Verheij, Marcel; Bose, Ron // Nature; 3/7/1996, Vol. 380 Issue 6569, p75
Reports that ceramide initiates the induction of programmed cell death, or apoptosis, through the SAPK cascade. Evidence for a signalling mechanism that integrates cytokine- and stress-activated apoptosis; The stress effects in U937 human monoblastic leukaemia and bovine aortic endothelial...
- Erratum / Erratum.
Cao, Jun; Arulanandam, Rozanne; Vultur, Adina; Anagnostopoulou, Aikaterini; Raptis, Leda // Biochemistry & Cell Biology; Jun2007, Vol. 85 Issue 3, p396
A correction to the article "Differential Effects of c-Ras Upon Transformation, Adipocytic Differentiation, and Apoptosis Mediated by the Simian Virus 40 large Tumor Antigen," by Jun Cao, Rozanne Arulanandam, Adina Vultur, Aikaterini Anagnostopoulou, and Leda Raptis.
- Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis.
Grzegorczyk, Janina; Kowalski, Marek L.; Pilat, Anna; Iwaszkiewicz, Jolanta // Mediators of Inflammation; Aug2002, Vol. 11 Issue 4, p225
Background: The goal of our study was to examine spontaneous and stimulated apoptosis of peripheral blood MNC from allergic patients, sensitized to Der p I antigen as compared to cells from non-atopic subjects. Furthermore we aimed to investigate which populations of mononuclear cells...
- Effect of BCL-2 on Harringtonine-induced apoptosis and intracellular Ca[sup 2+] mobilization in human leukemia HL-60 cells.
Zhang, Chunyang; Li, Yinping; Hui; Li, Suwen; Xue, Shaobai; Chen, Dieyan // Research on Chemical Intermediates; 2001, Vol. 27 Issue 9, p991
Harringtonine (HT), a kind of anticancer drug isolated from Chinese herb Cephalotaxus hainanensis Li, has been used in the clinical treatment of human glanulocytic leukemia and chromic myelocytic leukemia. In this study, we investigated the effect of Bcl-2 on HT-induced apoptosis and Ca[sup 2+]...
- Mechanisms of apoptotic cell death.
Rowan, S; Fisher, D E // Leukemia (08876924); Apr97, Vol. 11 Issue 4, p457
Apoptosis is the mechanism by which cells are programmed to die under a wide range of physiological and developmental stimuli. Several mediators of programmed cell death have been identified and signals of apoptosis have been found to utilize common pathways, some of which have been elucidated....
- Apoptosis and resistance to daunorubicin in human leukemic cells.
Efferth, T; Fabry, U; Osieka, R // Leukemia (08876924); Jul97, Vol. 11 Issue 7, p1180
We compared test methods based on specific mechanisms of daunorubicin (DNR) resistance to more global procedures. Assessment of P-glycoprotein (P-gp) expression and function by means of immunocytochemistry, DNR accumulation, and modulation of resistance and accumulation by the P-gp inhibitor...
- Natural resistance of acute myeloid leukemia cell lines to mitoxantrone is associated with lack of apoptosis.
Bailly, J-D; Skladanowski, A; Bettaieb, A; Mansat, V; Larsen, A K; Laurent, G // Leukemia (08876924); Sep97, Vol. 11 Issue 9, p1523
The purpose of this study was to characterize mitoxantrone-induced cytotoxicity in KG1a and TF-1, two P-glycoprotein expressing AML cell lines which display early differentiation phenotypes, compared to more mature HL-60 and U937 cells. KG1a and TF-1 cells were found to be 30-40-fold more...
- In vitro activation of low-grade non-Hodgkin�s lymphoma by murine fibroblasts, IL-4, anti-CD40 antibodies and the soluble CD40 ligand.
Buske, C; Twiling, A; Gogowski, G; Schreiber, K; Feuring-Buske, M; Wulf, G G; Hiddemann, W; W�rmann, B // Leukemia (08876924); Nov97, Vol. 11 Issue 11, p1862
The in vitro analysis of growth regulation in low-grade B non-Hodgkin's lymphoma (B-NHL) is hampered by the rapid apoptotic death of the malignant B cells ex vivo. A complex culture system, using murine CDw32 transfected fibroblasts (LTK[SUP-] cells), IL-4 and anti-CD40 mAb, has been established...
- Apoptosis of leukemia cells induced by valine-deficient medium.
Ohtawa, K; Ueno, T; Mitsui, K; Kodera, Y; Hiroto, M; Matsushima, A; Nishimura, H; Inada, Y // Leukemia (08876924); Oct98, Vol. 12 Issue 10, p1651
Focuses on the fragmentation of chromosomal DNA and activation of caspase-3 in murine and human leukemia cells treated with amino acid-deficient medium. Apoptosis of leukemia cells induced by valine-deficient medium.
- The clinical significance of Fas expression in leukemia: questions and controversies.
Findley, H W; Zhou, M // Leukemia (08876924); Feb99, Vol. 13 Issue 2, p147
Binding of agonistic anti-Fas (APO-1/CD95) antibodies or Fas ligand (Fas-L) induces apoptosis in some Fas1 leukemias, and anti-Fas antibody was originally investigated as a possible therapeutic reagent. More recently, a number of studies have examined a potential role for the Fas/Fas-L pathway...
- A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.
Niehues, T; Kapaun, P; Harms, D O; Burdach, S; Kramm, C; K�rholz, D; Janka-Schaub, G; G�bel, U // Leukemia (08876924); Apr99, Vol. 13 Issue 4, p614
During T cell selection in the thymic cortex more than 90% of the thymocytes are eliminated by apoptosis. Based on this biology, we propose to define blasts of T cell acute lymphoblastic leukemia (ALL) with the phenotype of cortical thymocytes (CD1[SUP+])and/or CD4[SUP+]8[SUP+]) as...
- Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds.
Tentori, L; Turriziani, M; Franco, D; Serafino, A; Levati, L; Roy, R; Bonmassar, E; Graziani, G // Leukemia (08876924); Jun99, Vol. 13 Issue 6, p901
Methylating triazenes have shown marked antileukemic effects, possibly through generation of a variety of DNA adducts. Cells tolerant to O[SUP6]-methylguanine due to a defect in the mismatch repair system (MRS), might become sensitive to other methyl adducts, by inhibiting the N-methylpurine...
- Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells.
Blagosklonny, M V; Chuman, Y; Bergan, R C; Fojo, T // Leukemia (08876924); Jul99, Vol. 13 Issue 7, p1028
Raf-1 activation and Bcl-2 hyperphosphorylation following treatment with paclitaxel (Taxol) or other microtubule-active drugs is associated with mitotic arrest. Here we show that microtubule-active drugs do not activate the mitogen-activated protein kinase (MAPK) pathway in leukemia cells....
- Quantitative analysis detects ubiquitous expression of apoptotic regulators in B cell non-Hodgkin�s lymphomas.
Xerri, L; Devilard, E; Bouabdallah, R; Hassoun, J; Chaperot, L; Birg, F; Plumas, J // Leukemia (08876924); Oct99, Vol. 13 Issue 10, p1548
To determine whether the expression levels of Bcl-2 family apoptotic regulators are correlated with the histopathological heterogeneity of B cell non-Hodgkin's lymphomas (NHL), we quantified their expression in malignant B cell populations isolated from 33 biopsy samples, including small...
- Apoptosis research is saving the reputation of chemotherapy.
Gieseler, F; Nuessler, V // Leukemia (08876924); Nov99, Vol. 13 Issue 11, p1853
Focuses on studies on association of apoptosis with chemotherapy. Factors affecting the apoptosis network; Difference in regulation of apoptosis network in lymphatic and myeloid cells; Effects of chemotherapy on apoptotic pathways.
- Modulation of cell apoptosis by AIR.
Turco, M. C.; Lamberti, A.; Bisogni, R.; Romano, M. F.; Petrella, A.; Ammirante, M.; Rosati, A.; Davenia, M.; Arra, C.; Spugnini, E.; Bonelli, P.; Venuta, S. // Leukemia (08876924); Jan2008, Vol. 22 Issue 1, p229
A correction to the article "Modulation of cell apoptosis by AIR" that was published in a previous issue is presented.
- Sex in the white matter.
Skoff, R.; Cerghet, M.; Swamydas, M.; Bessert, D. // Multiple Sclerosis (13524585); Mar2007, Vol. 13 Issue 2, p295
An abstract of the article "Sex in the white matter," by R. Skoff, M. Cerghet, M. Swamydas and D. Bessert is presented.
- Driving p53 Response to Bax Activation Greatly Enhances Sensitivity to Taxol by Inducing Massive Apoptosis.
De Feudis, Paola; Vignati, Sara; Rossi, Cosmo; Mincioni, Tatiana; Giavazzi, Raffaella; D'Incalci, Maurizio; Broggini, Massimo // Neoplasia; May2000, Vol. 2 Issue 3, p203
The proapoptotic gene bax is one of the downstream effectors of p53. The p53 binding site in the bax promoter is less responsive to p53 than the one in the growth arrest mediating gene p21. We introduced the bax gene under the control of 13 copies of a strong p53 responsive element into two...
- Effect of Insulin-Like Growth Factor II on Protecting Myoblast Cells Against Cisplatin-Induced Apoptosis Through p70 S6 Kinase Pathway.
Xiaolin Wan; Helman, Lee J. // Neoplasia; Sep/Oct2002, Vol. 4 Issue 5, p400
Deals with a study which investigated the role of insulin-like growth factor-II on cisplatin-induced apoptosis. Materials and methods; Results; Discussion.
- � cell expression of IGF-I leads to recovery from type 1 diabetes.
George, Monica; Ayuso, Eduard; Casellas, Alba; Costa, Cristina; Devedjian, Jean Christophe; Bosch, Fatima // Journal of Clinical Investigation; 5/1/2002, Vol. 109 Issue 9, p1153
Presents information on a study which identified patients with type 1 diabetes after the onset of the disease, when ? cell destruction is almost complete. Determination of ? cell replication; Detection of apoptosis; Hormone and metabolite assays; Results and discussion.
- Apoptosis and Histopathologic Changes in Diffuse Coronary Atherosclerosis.
Zorc, Marjeta; Zorc-Pleskovic, Ruda; Vraspir-Porenta, Olga; Legan, Mateja; Petrovic, Daniel // Angiology; Jan2003, Vol. 54 Issue 1, p81
The aims of the study were to investigate the histopathologic characteristics of atherosclerotic lesions and to evaluate the role of apoptosis or programmed cell death in diffuse coronary atherosclerosis. The study included 59 patients who underwent coronary artery bypass grafting coupled with...
- Variable Expression of Apoptotic Phenotype in Keratinocytes Treated with Ultraviolet Radiation, Ceramide, or Suspended in Semisolid Methylcellulose.
Gniadecki, Robert; Gajkowska, Barbara; Bartosik, Jacek; Hansen, Michael; Christian Wulf, Hans // Acta Dermato-Venereologica; 7/21/98, Vol. 78 Issue 4, p248
Apoptosis is a form of cellular suicide and is activated in various cells, including keratinocytes, in response to physiological and pathological stimuli. A current hypothesis holds that apoptotic cells in a concerted manner express characteristic phenotypic features comprising cytoplasmic...
- Protein may be treatment target in advanced PCa.
Tennant, Scott // Urology Times; Apr2002, Vol. 30 Issue 4, p1
Reports on the appearance of stress-related protein Clusterin to inhibit apoptosis associated with androgen withdrawal in Vancouver, British Columbia. Importance of the protein for men with advanced prostate cancer; Effects of the findings on the organization of a trial; Information on clusterin.
- 2-Chloro-2'-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4.
Nomura, Y; Inanami, O; Takahashi, K; Matsuda, A; Kuwabara, M // Leukemia (08876924); Feb2000, Vol. 14 Issue 2, p299
The mechanism of apoptosis induced by 2-chloro-2'-deoxyad-enosine (2CdA) in human leukemia cell line MOLT-4 was investigated. 2CdA induced increases of 3'-OH ends of genomic DNA, ladder-like DNA fragmentation and phosphatidylserine translocation to the outer membrane, which are apoptotic...
- Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis.
Gong, H; Z�lzer, F; von Recklinghausen, G; Havers, W; Schweigerer, L // Leukemia (08876924); May2000, Vol. 14 Issue 5, p826
L-Asparaginase is used for the treatment of acute leukemias, but is sometimes ineffective or associated with severe side-effects. We report here that the enzyme arginine deiminase is approximately 100-fold more potent than L-asparaginase in inhibiting the proliferation of cultured human...
- Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.
Blalock, W L; Moye, P W; Chang, F; Pearce, M; Steelman, L S; McMahon, M; McCubrey, J A // Leukemia (08876924); Jun2000, Vol. 14 Issue 6, p1080
The MEK1 oncoprotein plays a critical role in Ras/Raf/ MEK/MAPK-mediated transmission of mitogenic signals from cell surface receptors to the nucleus. In order to examine this pathway's role in leukemic transformation, a conditionally active (�-estradiol-inducible) form of the MEK1 protein was...
- Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.
Moye, P W; Blalock, W L; Hoyle, P E; Chang, F; Franklin, R A; Weinstein-Oppenheimer, C; Pearce, M; Steelman, L; McMahon, M; McCubrey, J A // Leukemia (08876924); Jun2000, Vol. 14 Issue 6, p1060
The Raf oncoprotein plays critical roles in the transmission of mitogenic signals from cytokine receptors to the nucleus. There are three Raf family members: A-Raf, B-Raf and Raf-1. Conditionally active forms of the Raf proteins were created by ligating N-terminal truncated activated forms to...
- Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo.
Prokop, A; Wieder, T; Sturm, I; E�mann, F; Seeger, K; Wuchter, C; Ludwig, W-D; Henze, G; D�rken, B; Daniel, P T // Leukemia (08876924); Sep2000, Vol. 14 Issue 9, p1606
Dysfunction of the p53/Bax/caspase-3 apoptosis signaling pathway has been shown to play a role in tumorigenesis and tumor progression, ie the development of acquired drug resistance. Low expression of the apoptosis inducer Bax correlates with poor response to therapy and shorter overall survival...
- C/EBPe -/- mice: increased rate of myeloid proliferation and apoptosis.
Verbeek, W; W�chter, M; Lekstrom-Himes, J; Koeffler, H P // Leukemia (08876924); Jan2001, Vol. 15 Issue 1, p103
CCAAT/enhancer binding protein epsilon (C/EBP?) is essential for terminal granulocytic differentiation. Its expression begins at the transition between the proliferative and non-proliferative compartments of myelopoiesis. We studied the effect of targeted disruption of the C/EBP? gene on murine...
- Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Cai, Z; Lin, M; Wuchter, C; Ruppert, V; D�rken, B; Ludwig, W-D; Karawajew, L // Leukemia (08876924); Apr2001, Vol. 15 Issue 4, p567
In the present study, we investigated the in vitro apoptotic response of leukemic cells to the cellular stress induced by homoharringtonine (HHT), a plant alkaloid with antileukemic activity which is currently being tested for treatment of acute and chronic leukemias. A comparison of leukemic...
- Granulocyte colony-stimulating factor inhibits Fas-triggered apoptosis in bone marrow cells isolated from patients with refractory anemia with ringed sideroblasts.
Schmidt-Mende, J; Tehranchi, R; Forsblom, A M; Joseph, B; Christensson, B; Fadeel, B; Zhivotovsky, B; Hellstr�m-Lindberg, E // Leukemia (08876924); May2001, Vol. 15 Issue 5, p742
Treatment with granulocyte colony-stimulating factor (G-CSF) plus erythropoietin may synergistically improve hemoglobin levels and reduce bone marrow apoptosis in patients with refractory anemia with ringed sideroblasts (RARS). Fas-induced caspase activity is increased in RARS bone marrow cells....
- Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage.
Shen, Y; Shen, Z-X; Yan, H; Chen, J; Zeng, X-Y; Li, J-M; Li, X-S; Wu, W; Xiong, S-M; Zhao, W-L; Tang, W; Wu, F; Liu, Y-F; Niu, C; Wang, Z-Y; Chen, S-J; Chen, Z // Leukemia (08876924); May2001, Vol. 15 Issue 5, p735
Twenty cases of patients with relapsed acute promyelocytic leukemia (APL) were entered into this study for evaluating the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide (As[SUB2]O[SUB3]). As[SUB2]O[SUB3] was given at a daily dose of 0.08 mg/kg intravenously for 28 days....
- Unwinding the loop of Bcl-2 phosphorylation.
Blagosklonny, M V // Leukemia (08876924); Jun2001, Vol. 15 Issue 6, p869
Recent evidence indicates that anti-apoptotic functions of Bcl-2 can be regulated by its phosphorylation. According to the 'mitotic arrest-induced' model, multi-site phosphorylation of the Bcl-2 loop domain is followed by cell death. In contrast, in cytokine-dependent cell lines, cytokines...
- A new matrix metalloproteinase inhibitor SI-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to TNF alpha-induced apoptosis.
Nakamura, Y; Sato, K; Wakimoto, N; Kimura, F; Okuyama, A; Motoyoshi, K // Leukemia (08876924); Aug2001, Vol. 15 Issue 8, p1217
MMP inhibitors are used clinically for the stabilization of tumor growth, thus prolonging survival in cancer patients. However, their role in the treatment of hematopoietic malignancies remains unclear. In the present study, we investigated the effects of a new MMP inhibitor, SI-27, in...
- Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells.
McCubrey, J A; Blalock, W L; Saleh, O; Pearce, M; Burrows, C; Steelman, L S; Lee, J T; Franklin, R A; Oberhaus, S M; Moye, P W; Doshi, P D; McKearn, J P // Leukemia (08876924); Aug2001, Vol. 15 Issue 8, p1203
Modified and chimeric cytokines have been developed to aid in the recovery of hematopoietic precursor cells after myeloablative chemotherapy. The interleukin-3 (IL-3) receptor agonist, daniplestim, binds to the IL-3 receptor-a subunit with 60-fold greater affinity and induces cell proliferation...
- Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts.
Wieder, T; Prokop, A; Bagci, B; Essmann, F; Bernicke, D; Schulze-Osthoff, K; D�rken, B; Schmalz, H-G; Daniel, P T; Henze, G // Leukemia (08876924); Nov2001, Vol. 15 Issue 11, p1735
The stilbene phytochemicals resveratrol and piceatannol have been reported to possess substantial antitumorigenic and anti-leukemic activities, respectively. Although recent experimental data revealed the proapoptotic potency of resveratrol, the molecular mechanisms underlying the antileukemic...
- No evidence for MUC 1-induced apoptosis.
Boussiotis, Vassiliki; Freeman, Gordon; Gribben, John; Hayes, Daniel; Nadler, Lee // Nature Medicine; Oct98, Vol. 4 Issue 10, p1093
Comments on a paper which examined whether MUC 1-induced apoptosis of T cells exists, previously published in the periodical 'Nature Medicine.' Evaluation of experiments on MUC 1-induced apoptosis.
- Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective.
Young, Deborah; Lawlor, Patricia A.; Leone, Paola; Dragunow, Michael; During, Matthew J. // Nature Medicine; Apr99, Vol. 5 Issue 4, p448
The mammalian brain has a high degree of plasticity, with dentate granule cell neurogenesis and glial proliferation stimulated by an enriched environment combining both complex inanimate and social stimulation. Moreover, rodents exposed to an enriched environment both before and after a cerebral...
- Apoptosis and cancer: When BAX is TRAILing away.
Roth, Wilfried; Reed, John C. // Nature Medicine; Mar2002, Vol. 8 Issue 3, p216
Provides insights into mechanisms of apoptosis resistance in tumor cells and suggest how this resistance might be overcome. Role of caspases in apoptotic cell-death; Details of pathways for achieving caspase activation; Occurrence of crosstalk between extrinsic and intrinsic pathways at...
- Apoptosis and the laws of thermodynamics.
Nicholls, David; Bernardi, Paolo; Brand, Martin; Halestrap, Andrew; Lemasters, John; Reynolds, Ian // Nature Cell Biology; Oct2000, Vol. 2 Issue 10, pE172
Comments on an article by Shigemi Matsuyama, Juan Llopi, Quinn L. Deveraux and Roger Tsien published in 'Nature Cell Biology' on Apoptosis. Increase in proton electrochemical gradient by Staurosporine through ATP-synthase reversal process; Factors on which the distribution of proton...
- Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.
Degterev, Alexei; Lugovskoy, Alexey; Cardone, Michael; Mulley, Bradley; Wagner, Gerhard; Mitchison, Timothy; Yuan, Junying // Nature Cell Biology; Feb2001, Vol. 3 Issue 2, p173
To study the role of the BH3 domain in mediating pro-apoptotic and anti-apoptotic activities of Bcl-2 family members, we identified a series of novel small molecules (BH3Is) that inhibit the binding of the Bak BH3 peptide to Bclx[sub L]. NMR analyses revealed that BH31s target the BH3-binding...
- Identification of XAF1 as an antagonist of XIAP anti-Caspase activity.
Liston, Peter; Fong, Wai Gin; Kelly, N. Lynn; Toji, Shingo; Miyazaki, Toshiaki; Conte, Damiano; Tamai, Katsuyuki; Craig, Constance G.; McBurney, Michael W.; Korneluk, Robert G. // Nature Cell Biology; Feb2001, Vol. 3 Issue 2, p128
The inhibitors of apoptosis (lAPs) suppress apoptosis through the inhibition of the caspase cascade and thus are key proteins in the control of cell death. Here we have isolated the protein XIAP-associated factor 1 (XAF1) on the basis of its ability to bind XIAP, a member of the lAP family. XIAP...
- Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1.
Hays, Rebecca; Wickline, Laura; Cagan, Ross // Nature Cell Biology; Jun2002, Vol. 4 Issue 6, p425
Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding and inhibition of caspases. We demonstrate that degradation of IAPs is an important mechanism for the initiation of apoptosis in vivo. Drosophila Morgue, a ubiquitin...