TITLE

Hemagglutination mediated by the spike protein of cell-adapted bovine torovirus

AUTHOR(S)
Shimabukuro, Kozue; Ujike, Makoto; Ito, Toshihiro; Tsunemitsu, Hiroshi; Oshitani, Hitoshi; Taguchi, Fumihiro
PUB. DATE
July 2013
SOURCE
Archives of Virology;Jul2013, Vol. 158 Issue 7, p1561
SOURCE TYPE
Academic Journal
DOC. TYPE
Report
ABSTRACT
Bovine torovirus (BToV)-Aichi, recently isolated in cultured cells, showed hemagglutination (HA) activity, although the virus has a truncated hemagglutinin-esterase (HE) protein, judging from its gene structure, indicating the existence of another viral protein with HA activity. We examined whether the spike (S) protein possesses HA activity. A BToV antiserum used in this study, reactive to S but not to HE, inhibited HA activity. Furthermore, cells infected with BToV and those expressing S showed hemadsorption (HAD) activity, which was inhibited by the anti-BToV serum; however, HAD activity by expressed HE was not blocked. These data indicate that the S protein of BToV-Aichi is responsible for its HA activity.
ACCESSION #
88428251

 

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