Ghrelin Level and Weight Loss After Laparoscopic Sleeve Gastrectomy and Gastric Mini-Bypass for Prader-Willi Syndrome in Chinese

Fong, Anthony; Wong, Simon; Lam, Candice; Ng, Enders
November 2012
Obesity Surgery;Nov2012, Vol. 22 Issue 11, p1742
Academic Journal
Prader-Willi syndrome (PWS) is a chromosomal disorder characterized by the presence of hyperghrelinemia, hyperphagia, and obesity. The optimal treatment for PWS patient remains controversial. Here, we present our experience of treating PWS with laparoscopic mini-gastric bypass (LMGBP) and laparoscopic sleeve gastrectomy (LSG). Three patients with genetic diagnosis of PWS and body mass index (BMI) greater than 40 kg/m were referred for bariatric surgery. All of them had completed 2-year postoperative follow-up. Body weight, BMI, and ghrelin levels were recorded before and after surgery. They were two females and one male. Their age ranged from 15 to 23 years old, and the mean BMI was 46.7 kg/m (range 44-50). Two patients underwent LSG and one patient underwent LMGBP. After a median follow-up of 33 months (range 24-36 months), mean weight loss and percentage of excessive weight loss at 2 years were 32.5 kg (24.9-38.3 kg) and 63.2 % (range 50.5-86.2 %), respectively. The mean fasting active ghrelin level decreased from 1,134.2 pg/ml preoperatively to 519.8 pg/ml 1 year after surgery. No major complication was observed. Iron deficiency anemia was observed in the patient who underwent LMGBP. Significant reduction of body weight and level of serum ghrelin can be achieved with minimal morbidity by LSG or LMGBP in patients with PWS.


Related Articles

  • Treatment of Adult Obesity with Bariatric Surgery. SCHROEDER, ROBIN; GARRISON JR., JORDAN M.; JOHNSON, MARK S. // American Family Physician;10/1/2011, Vol. 84 Issue 7, p805 

    Bariatric surgery procedures, including laparoscopic adjustable gastric banding, laparoscopic sleeve gastrectomy, and Roux-en-Y gastric bypass, result in an average weight loss of 50 percent of excess body weight. Remission of diabetes mellitus occurs in approximately 80 percent of patients...

  • Sleeve gastrectomy: radiologic patterns after surgery. Goitein, David; Goitein, Orly; Feigin, Anya; Zippel, Douglas; Papa, Moshe // Surgical Endoscopy;Jul2009, Vol. 23 Issue 7, p1559 

    Laparoscopic sleeve gastrectomy (LSG) is gaining popularity as an additional bariatric procedure, either as a first step for biliopancreatic diversion or gastric bypass or as a stand-alone option for selected patients. Early postoperative fluid tolerance varies between patients and influences...

  • Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Achieve Comparable Weight Loss at 1 Year. YAGHOUBIAN, AREZOU; TOLAN, AMY; STABILE, BRUCE E.; KAJI, AMY H.; BELZBERG, GARY; MUN, EDWARD; ZANE, ROBERT // American Surgeon;Dec2012, Vol. 78 Issue 12, p1325 

    Laparoscopic sleeve gastrectomy has gained popularity as a weight loss surgical option for morbidly obese patients. Although initial studies have shown weight loss and comorbidity resolution comparable to those after laparoscopic Roux-en-Y gastric bypass (RYGB), many of these studies are limited...

  • Differential Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on Appetite, Circulating Acyl-ghrelin, Peptide YY3-36 and Active GLP-1 Levels in Non-diabetic Humans. Yousseif, Ahmed; Emmanuel, Julian; Karra, Efthimia; Millet, Queensta; Elkalaawy, Mohamed; Jenkinson, Andrew; Hashemi, Majid; Adamo, Marco; Finer, Nicholas; Fiennes, Alberic; Withers, Dominic; Batterham, Rachel // Obesity Surgery;Feb2014, Vol. 24 Issue 2, p241 

    Laparoscopic Roux-en-Y gastric bypass (LRYGBP) reduces appetite and induces significant and sustainable weight loss. Circulating gut hormones changes engendered by LRYGBP are implicated in mediating these beneficial effects. Laparoscopic sleeve gastrectomy (LSG) is advocated as an alternative to...

  • Results of Teenaged Bariatric Patients Performed in an Adult Program. Madan, Atul K.; Dickson, Paxton V.; Ternovits, Craig A.; Tichansky, David S.; Lobe, Thom E. // Journal of Laparoendoscopic & Advanced Surgical Techniques;Aug2007, Vol. 17 Issue 4, p473 

    Background: Morbid obesity is a growing epidemic among adolescents. Bariatric surgery has proven to be the only long-term effective method in treating morbidly obese adults for over a decade. The laparoscopic approach has become a popular option. This study tested the hypothesis that...

  • Early Complications of 120 Laparoscopic Greater Curvature Plication. Andraos, Youssef; Ziade, Dany; Achcouty, Rana; Awad, Mariette // Bariatric Times;Sep2011, Vol. 8 Issue 9, p1 

    Reduction of gastric volume is traditionally the primary mechanism by which patients can lose weight safely. Weight loss is made possible by different procedures, including sleeve gastrectomy, vertical banding gastroplasty, and perigastric ring. Since the success rate of these procedures is...

  • Mid-term Results of Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass in Adolescent Patients. Cozacov, Yaniv; Roy, Mayank; Moon, Savannah; Marin, Pablo; Menzo, Emanuele; Szomstein, Samuel; Rosenthal, Raul // Obesity Surgery;May2014, Vol. 24 Issue 5, p747 

    The prevalence and severity of obesity in children and adolescents has been increasing in recent years at an unprecedented rate. Morbidly obese children will almost certainly develop severe comorbidities as they progress to adulthood, and bariatric surgery may provide the only alternative for...

  • Revisional surgery after failed laparoscopic adjustable gastric banding: a systematic review. Elnahas, Ahmad; Graybiel, Kerry; Farrokhyar, Forough; Gmora, Scott; Anvari, Mehran; Hong, Dennis // Surgical Endoscopy;Mar2013, Vol. 27 Issue 3, p740 

    Background: Laparoscopic adjustable gastric banding (LAGB) has emerged as one of the most commonly performed bariatric procedures worldwide. Unfortunately, revisional surgery is required in 20-30 % of cases. Several revisional strategies have been proposed, but there is no consensus regarding...

  • Gastric Histopathology in Laparoscopic Sleeve Gastrectomy: Pre- and Post-Operative Comparison. Onzi, Tiago; d'Acampora, Armando; Araújo, Fabricio; Baratieri, Ricardo; Kremer, Gilberto; Lyra, Humberto; Leitão, Joyce // Obesity Surgery;Mar2014, Vol. 24 Issue 3, p371 

    Background: Sleeve gastrectomy (SG) produces excellent results in weight reduction and resolution of comorbidities. The histology of the gastric mucosa can be affected by the surgical procedure, with alterations of inflammatory patterns. The objective of this study is to evaluate alterations of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics