Variant Angina Associated With Bitter Orange in a Dietary Supplement

Gange, Christopher A.; Madias, Christopher; Felix-Getzik, Erika M.; Weintraub, Andrew R.; Estes III, N. A. Mark
April 2006
Mayo Clinic Proceedings;Apr2006, Vol. 81 Issue 4, p545
Academic Journal
The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in adverse cardiovascular sequelae. To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement.


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