TITLE

Efficacy of TNF blockade in cyclophosphamide resistant neuro-Behçet disease

AUTHOR(S)
Ribi, C.; Sztajzel, R.; Delavelle, J.; Chizzolini, C.
PUB. DATE
December 2005
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Dec2005, Vol. 76 Issue 12, p1733
SOURCE TYPE
Academic Journal
DOC. TYPE
Report
ABSTRACT
Behçet disease is a chronic relapsing inflammatory condition, predominantly affecting young adults, characterised by recurrent bipolar aphtae and systemic manifestations for which tumour necrosis factor (TNF} α blockade has recently emerged as an effective treatment. We report the case of a patient presenting with mucocutaneous and ocular manifestations who in the course of his disease developed CNS parenchymal involvement. White being treated with pulsed cyclophosphamide and corticosteroids, he suffered a relapse of his CNS involvement that was efficaciously controlled by infliximab. No disease activity was observed during a full year of TNF blockade, associated with azathioprine, colchicine, and corticosteroids. However, 7 months after the last administration of infliximab and still under immunosuppressant agents, CNS lesions recurred. Infliximab was successfully reintroduced and since continued with no side effects. The sequence of events observed in this patient suggests that TNF blockade is efficacious in suppressing neuro-Behçet disease and once introduced should be maintained for a prolonged period of time.
ACCESSION #
19236648

 

Related Articles

  • What Alternative Therapies are there for Patients with spondyloarthritis Refractory to TNF-α Blockers? Kemta Lekpa, Fernando; Claudepierre, Pascal // Current Medical Literature: Rheumatology;2013, Vol. 32 Issue 4, p117 

    The article discusses the treatment options available to patients with spondyloarthritis (SpA) refractory to tumor necrosis factor (TNF)-alpha blockers. SpA is a family of inflammatory rheumatic diseases and the first-line treatment of these conditions is still based on the optimal use of...

  • New Drugs for Rheumatoid Arthritis. Olsen, Nancy J.; Stein, C. Michael // New England Journal of Medicine;5/20/2004, Vol. 350 Issue 21, p2167 

    Reviews the properties of new drugs developed to treat rheumatoid arthritis. Short-term efficacy and the toxic effects of drugs; Classification of the drugs as disease-modifying antirheumatic drugs; Description of leflunomide, an immunomodulatory drug, tumor necrosis factor antagonists and...

  • Agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ): a new compound with potent gastroprotective and ulcer healing properties. Brzozowski, Tomasz; Konturek, Peter C.; Pajdo, Robert; Kwiecień, Slawomir; Konturek, Stanislaw; Targosz, Aneta; Burnat, Grzegorz; Cieszkowski, Jakub; Pawlik, Wieslaw W.; Hahn, Eckhart G. // Inflammopharmacology;2005, Vol. 13 Issue 1-3, p317 

    Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-γ), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-α), but its role in the...

  • Other Future Targeting Therapy Beyond TNF-α Inhibitor in Patients with Spondyloarthropathy. Wen-Chan Tsai; Tsang-Teng Ou; Chen-Ching Wu // Current Rheumatology Reviews;2009, Vol. 5 Issue 3, p153 

    Spondyloarthropathy defines a group of diseases characterized by chronic inflammation of axial or peripheral joints with a variety of mucocutaneous, ophthalmic lesions. Evidence showed that these disorders are autoimmune in origin with T cells, B cells and monocytes/macrophages playing major...

  • Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study. Ruiz-Valdepeñas, Lourdes; Martínez-Orgado, José A; Benito, Cristina; Millán, África; Tolón, Rosa M; Romero, Julián // Journal of Neuroinflammation;2011, Vol. 8 Issue 1, p5 

    Background: The phytocannabinoid cannabidiol (CBD) exhibits antioxidant and antiinflammatory properties. The present study was designed to explore its effects in a mouse model of sepsis-related encephalitis by intravenous administration of lipopolysaccharide (LPS). Methods: Vascular responses of...

  • Role of IL-1β and prostaglandins in β2-microglobulin-induced bone mineral dissolution. Moe, Sharon M.; Hack, Bradley K.; Cummings, Shelly A.; Sprague, Stuart M. // Kidney International;Feb1995, Vol. 47 Issue 2, p587 

    β2-microglobulin (β2m) induces an osteoclast-mediated net calcium efflux from neonatal mouse calvariae which occurs only after 48 hours of incubation, suggesting that β2m acts via other growth factors. To further test this hypothesis, calvariae were incubated with and without β2m in...

  • Nonsteroidal Anti-Inflammatory Drugs for Wounds: Pain Relief or Excessive Scar Formation? Wen-Hsiang Su; Ming-Huei Cheng; Wen-Ling Lee; Tsung-Shan Tsou; Wen-Hsun Chang; Chien-Sheng Chen; Peng-Hui Wang // Mediators of Inflammation;2010, Vol. 2010, p1 

    The inflammatory process has direct effects on normal and abnormal wound healing. Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Two...

  • Infliximab in a case of early adult-onset Still’s disease. Olivieri, I.; de Stefano, G.; Padula, A.; La Gala, A.; de Stefano, C. // Clinical Rheumatology;Oct2003, Vol. 22 Issue 4/5, p369 

    The article presents information on infliximab in a case of early adult-onset. Tumour necrosis factor-alpha blockade has recently been suggested to be effective in long-standing adult onset Still's disease. The patient, a 38-year-old man, was admitted to the Department of Infectious Disease in...

  • Anti-Inflammatory Pharmacotherapy with Ketoprofen Ameliorates Experimental Lymphatic Vascular Insufficiency in Mice. Nakamura, Kenta; Radhakrishnan, Kavita; Yat Man Wong; Rockson, Stanley G. // PLoS ONE;2009, Vol. 4 Issue 12, p1 

    Background: Disruption of the lymphatic vasculature causes edema, inflammation, and end-tissue destruction. To assess the therapeutic efficacy of systemic anti-inflammatory therapy in this disease, we examined the impact of a nonsteroidal anti-inflammatory drug (NSAID), ketoprofen, and of a...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics