TITLE

Cognitive patterns and progression in multiple sclerosis: construction and validation of percentile curves

AUTHOR(S)
Achiron, A.; Polliack, M.; Roo, S. M.; Barak, Y.; Lavie, M.; Appelboim, N.; Harel, Y.; Rao, S M
PUB. DATE
May 2005
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;May2005, Vol. 76 Issue 5, p744
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background and Objectives: Rate and pattern of progression of cognitive decline in multiple sclerosis (MS) has not been clearly identified. The present study aimed to identify correlations between cognitive tests and disease duration, construct longitudinal cognitive curves, and assess pattern of change over time.Methods: The Neuropsychological Screening Battery for Multiple Sclerosis was administered in 150 consecutive MS patients, and tests that correlated with disease duration were identified. Percentile curves were constructed and the pattern of cognitive decline over time explored. The cognitive curves were validated in an additional group of 83 patients with MS.Results: Three of four measures of the spatial recall test (SPART 7/24), and the paced auditory serial addition task for two seconds (PASAT 2'), correlated with disease duration. These tests were used to construct cross-sectional curves identifying the pattern of cognitive decline over time in the MS population. On the basis of this cross-sectional analysis, the earliest cognitive decline occurred in the SPART 7/24 trials 1-5 between one and three years from onset, followed by decline in the SPART delayed recall between three and seven years, and then by decline in the PASAT 2' after seven years from onset.Conclusions: Verbal fluency and verbal memory appear to be affected earliest in MS. The pattern of cognitive decline is further characterised by a decrease in visuospatial learning, followed by delayed recall, and then by attention and information processing speed. Cognitive percentile curves can be used to evaluate the pattern of progression and identify patients at increased risk.
ACCESSION #
17052459

 

Related Articles

  • Multidisciplinary aspects of rehabilitation (RIMS).  // Multiple Sclerosis (13524585);Sep2004 Supplement 2, Vol. 10, p102 

    This article presents brief summary of articles, on aspects of rehabilitation of multiple sclerosis (MS), written by various researchers. Cognitive dysfunction, especially impaired memory and attention, is often found in MS patients that may only be apparent with careful assessment patients....

  • Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Nocentini, U.; Pasqualetti, P.; Bonavita, S.; Buccafusca, M.; de Caro, M. F.; Farina, D.; Girlanda, P.; Le Pira, F.; Lugaresi, A.; Quattrone, A.; Reggio, A.; Salemi, G.; Savettieri, G.; Tedeschi, G.; Trojano, M.; Valentino, P.; Caltagirone, C. // Multiple Sclerosis (13524585);Feb2006, Vol. 12 Issue 1, p77 

    Cognitive dysfunction is considered one of the clinical markers of multiple sclerosis (MS). However, in the literature there are inconsistent reports on the prevalence of cognitive dysfunction, and separate data for the relapsing-remitting (RR) type of the disease are not always presented. In...

  • Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study. Kheradvar, Arash; Tabassi, Abdol Reza; Nikbin, Behrouz; Khosravi, Farideh; Naroueynejad, Mehrnaz; Moradi, Batool; Amirzargar, Ali Akbar // Multiple Sclerosis (13524585);Oct2004, Vol. 10 Issue 5, p526 

    Background: Genetic predisposition in multiple sclerosis (MS) has always been a critical concern in aetiology and progress of the disease. The present study looks into the relations between human leukocyte antigen (HLA), optic neuritis (ON) and MS in the Iranian population. Methods: Patients...

  • Normal-appearing grey and white matter T1 abnormality in early relapsing remitting multiple sclerosis: a longitudinal study. Davies, G. R.; Hadjiprocopis, A.; Altmann, D. R.; Chard, D. T.; Griffin, C. M.; Rashid, W.; Parker, G. J.; Tofts, P. S.; Kapoor, R.; Thompson, A. J.; Miller, D. H. // Multiple Sclerosis (13524585);Mar2007, Vol. 13 Issue 2, p169 

    Objective To investigate the presence and evolution of T1 relaxation time abnormalities in normal-appearing white matter (NAWM) and grey matter (GM), early in the course of relapsing-remitting multiple sclerosis (MS). Methods Twenty-three patients with early relapsing-remitting MS and 14 healthy...

  • Latitudinal variation in the prevalence of multiple sclerosis in Ireland, an effect of genetic diversity. McGuigan C; McCarthy A; Quigley C; Bannan L; Hawkins S A; Hutchinson M; McGuigan, C; McCarthy, A; Quigley, C; Bannan, L; Hawkins, S A; Hutchinson, M // Journal of Neurology, Neurosurgery & Psychiatry;Apr2004, Vol. 75 Issue 4, p572 

    Background: Northern Ireland has a high and rising prevalence rate of multiple sclerosis (MS). The most recent survey in 1996 found a rate of 168.7/100 000. Recorded prevalence rates for the south of Ireland, including County Wexford, have been markedly lower and seemed to suggest...

  • About redefining my fight against MS. SHRANK, DIANE // Inside MS;Winter99, Vol. 17 Issue 1, p48 

    Discusses the strategies of the author in fighting multiple sclerosis (MS). Physiological effects of MS that the author had suffered; Importance of optimizing one's health; Lessons learned by the author.

  • Readers Write.  // Inside MS;Fall2001, Vol. 19 Issue 4, p16 

    Reveals experiences of some multiple sclerosis sufferers.

  • Fund created to aid poor in financing MRI and other MS diagnostic tests.  // Fairfield County Business Journal;8/21/95, Vol. 34 Issue 34, p10 

    Reports that the Multiple Sclerosis Association of America (MSAA) is sponsoring a program called MS Diagnostic Fund designed to help people suspected of having multiple sclerosis receive proper and accurate diagnosis. Payment for the expense of a magnetic resonance imaging (MRI) exam for the...

  • Cover page.  // Healing Muse;Fall2012, Vol. 12 Issue 1, preceding p1 

    A drawing of a multiple sclerosis patient is presented.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics