TITLE

Axonal sensorimotor neuropathy in patients with β-thalassaemia

AUTHOR(S)
Stamboulis, E.; Vlachou, N.; Drossou-Servou, M.; Tsaftaridis, P.; Koutsis, G.; Katsaros, N.; Economou-Petersen, E.; Loutradi-Anagnostou, A.
PUB. DATE
October 2004
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Oct2004, Vol. 75 Issue 10, p1483
SOURCE TYPE
Academic Journal
DOC. TYPE
Report
ABSTRACT
Objective: The purpose of this study was to investigate the prevalence of peripheral neuropathy in patients with Beta;- thalassaemia. Methods: Thirty six patients with a mean age of 29.2 ± 8.2 years and 17 healthy controls with a mean age of 27.6±9.1 were included in this study. Measurements included the neuropathy symptoms score (NSS), the neuropathy disability score (NDS) as well as nerve conduction studies of two motor (ulnar and peroneal) and two sensory (ulnar and swat) nerves of the right limbs. Results: A mainly sensory axonal polyneuropathy was present in 19 out of 36 patients (52.7%). Eight out of these 19 patients' also had abnormal'. NDS values. The neuropathy correlated significantly with the age of the patients and the hematocrit. However,. it did not correlate with the presence of antibodies against HCV, the ferritin levels, or with a history of transfusions, desferrioxamine treatment, or splenectomy. Conclusions: This study showed a high prevalence of a predominantly sensory neuropathy in patients with β- thalassoemia. The electrophysiological data. suggest that the underlying pathology `is an axonopathy. Chronic hypoxia of the nerves resulting from severe anaemia may contribute to the pathogenesis of this neuropathy.
ACCESSION #
14730187

 

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