Axonal sensorimotor neuropathy in patients with β-thalassaemia

Stamboulis, E.; Vlachou, N.; Drossou-Servou, M.; Tsaftaridis, P.; Koutsis, G.; Katsaros, N.; Economou-Petersen, E.; Loutradi-Anagnostou, A.
October 2004
Journal of Neurology, Neurosurgery & Psychiatry;Oct2004, Vol. 75 Issue 10, p1483
Academic Journal
Objective: The purpose of this study was to investigate the prevalence of peripheral neuropathy in patients with Beta;- thalassaemia. Methods: Thirty six patients with a mean age of 29.2 ± 8.2 years and 17 healthy controls with a mean age of 27.6±9.1 were included in this study. Measurements included the neuropathy symptoms score (NSS), the neuropathy disability score (NDS) as well as nerve conduction studies of two motor (ulnar and peroneal) and two sensory (ulnar and swat) nerves of the right limbs. Results: A mainly sensory axonal polyneuropathy was present in 19 out of 36 patients (52.7%). Eight out of these 19 patients' also had abnormal'. NDS values. The neuropathy correlated significantly with the age of the patients and the hematocrit. However,. it did not correlate with the presence of antibodies against HCV, the ferritin levels, or with a history of transfusions, desferrioxamine treatment, or splenectomy. Conclusions: This study showed a high prevalence of a predominantly sensory neuropathy in patients with β- thalassoemia. The electrophysiological data. suggest that the underlying pathology `is an axonopathy. Chronic hypoxia of the nerves resulting from severe anaemia may contribute to the pathogenesis of this neuropathy.


Related Articles

  • HYPERTENSION AND SUBCLINICAL PERIPHERAL NEUROPATHY. Chaco, Joshua; Viskoper, Ruben J. // Angiology;Oct1971, Vol. 22 Issue 9, p521 

    Motor nerve conduction velocity testing was used to detect subclinical peripheral neuropathy in hypertension. The right ulnar and left median nerves of thirty patients with essential hypertension, but without diabetes or uremia, were examined. Neurological examination in all patients was normal....

  • Neurectomy Outcomes in Patients With Morton Neuroma: Comparison of Plantar vs Dorsal Approaches. Habashy, Alexander; Treuting, Robert J.; Sumarriva, Gonzalo // Ochsner Journal;Winter2016, Vol. 16 Issue 4, p471 

    The presented research paper deals with the patients with the morton neuroma, a plantar digital nerve of neuropathy disease, whose advantages and disadvantages outcomes through assessment tools with the plantar vs dorsal approach is evaluated, for the patients satisfaction.

  • The clinical, electrophysiological and prognostic heterogeneity of ulnar neuropathy at the elbow. Dunselman, H. H. A. M.; Visser, L. H. // Journal of Neurology, Neurosurgery & Psychiatry;Dec2008, Vol. 79 Issue 12, p1364 

    Ulnar nerve neuropathy is one of the most common entrapment neuropathies and is often considered to be one entity in clinical and follow-up studies. The aim of this study was to determine whether there is a difference in the long term outcome of patients with a severe motor conduction block...

  • Guidelines for the prevention and treatment of foot problems in diabetes.  // Journal of Endocrinology, Metabolism & Diabetes of South Africa;Mar2012, Vol. 17 Issue 1, pS68 

    The article offers information on the epidemiology, risk factors, and treatment strategies of patients with neuropathy, nonulcerative pathology, and ulcerated feet. It focuses on the morbidity and mortality associated with distal peripheral sensory diabetic neuropathy and its sequelae, and also...

  • Posttraumatic neuropathy of the palmar cutaneous branch of the median nerve: four cases. Laceration or entrapment? Pardal-Fernández, Jose Manuel; Gracia-Rodríguez, Indalecio; Iniesta-López, Ivan; Rodríguez-Vázquez, María // Acta Neurochirurgica;Mar2011, Vol. 153 Issue 3, p617 

    The palmar cutaneous branch of the median nerve is highly exposed to trauma at the wrist; nevertheless, very few cases have been reported. We report four cases of this neuropathy, three being superficial while the fourth was deeper or more severe. The neuropathy was confirmed using...

  • IVIg dose increase in multifocal motor neuropathy. Baumann, Andreas; Hess, Christian W.; Sturzenegger, Matthias // Journal of Neurology;Apr2009, Vol. 256 Issue 4, p608 

    In this prospective, non-randomized 6-month observational study we evaluated the efficacy of intravenous immunoglobulin (IVIg) dose increase in patients with multifocal motor neuropathy (MMN). Diagnosis according to AAEM criteria, repetitive IVIg treatment for at least one year, persistent...

  • Exploring Current and Emerging Treatment Strategies for Optimal Patient Outcomes in Painful Diabetic Peripheral Neuropathy. Abrahamson, Martin J. // Clinical Diabetes;Summer2006, Vol. 24 Issue 3, p7 

    The article discusses treatment strategies for optimal patient outcomes in painful diabetic peripheral neuropathy (DPN). Approximately 10% of patients with DPN suffer from persistent pain or sensory distortion. Painful DPN can interfere with patients' quality of life by impairing their general...

  • The Adaptive ARMA Analysis of EMG Signals. Barişçi, Necaattin // Journal of Medical Systems;Feb2008, Vol. 32 Issue 1, p43 

    In this study, Adaptive auto regressive-moving average (A-ARMA) analysis of EMG signals recorded on the ulnar nerve region of the right hand in resting position was performed. A-ARMA method, especially in the calculation of the spectrums of stationary signals, is used for frequency analysis of...

  • Anti-Myelin Associated Glycoprotein Polyneuropathy in a Patient With Lymphoma and its Resolution After Chemotherapy. Ahmad, Nisar; Haider, Sajjad; Jameel, Muzaffar; Shahid, Zainab; Yared, Marwan; Usmani, Saad Z. // Journal of Medical Cases;2013, Vol. 4 Issue 8, p557 

    Anti-myelin associated glycoprotein (anti-MAG) antibody associated polyneuropathy is a chronic distal symmetric sensorimotor neuropathy. The rarity of this condition precludes establishment of a standard of care. It has been treated with steroids, intravenous immunoglobulin (IVIG) and Rituximab....


Read the Article


Sign out of this library

Other Topics