TITLE

Structural basis for selectivity and toxicity of ribosomal antibiotics

AUTHOR(S)
B�ttger, Erik C.; Springer, Burkhard; Prammananan, Therdsak; Kidan, Yishak; Sander, Peter
PUB. DATE
April 2001
SOURCE
EMBO Reports;Apr2001, Vol. 2 Issue 4, p318
SOURCE TYPE
Academic Journal
DOC. TYPE
Report
ABSTRACT
Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance mutations in bacteria allows the prediction of whether cytoplasmic or mitochondrial ribosomes in eukaryotic cells will be sensitive to the drug. This has important implications for drug specificity and toxicity. Together with recent data on the structure of ribosomal subunits these data provide the basis for development of new ribosomal antibiotics by rationale drug design.
ACCESSION #
12956762

 

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