Wasserman, Stephen I.
November 1976
Journal of Investigative Dermatology;Nov76, Vol. 67 Issue 5 Part 2, p620
Academic Journal
The primary chemical mediators of immediate type hypersensitivity include histamine, the eosinophil chemotactic factor of anaphylaxis, slow reacting substance of anaphhylaxis, and platelet activating factor. All four primary mediators have been associated with the human peripheral blood basophil and the human tissue mast cell. These mediators may be generated and released following the interaction of antigen and specific IgE antibody bound to receptors on the surface of the mast cell or basophils or following interaction of mast cells or basophils with antibody directed toward the IgE molecule itself.


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