Relapsing Polychondritis: Reversible Airway Obstruction Is Not Always Asthma

Segel, Michael J.; Godfrey, Simon; Berkman, Neville
March 2004
Mayo Clinic Proceedings;Mar2004, Vol. 79 Issue 3, p407
Academic Journal
Relapsing polychondritis (RP) is a rare disease characterized by recurrent inflammation of cartilaginous and other proteoglycan-rich tissues. Respiratory tract involvement is a common cause of morbidity and mortality in RP. We describe a patient whose clinical features at onset of disease were typical of asthma. Later, the patient developed symptoms and signs characteristic of RP. Tracheobronchomalacia necessitated airway support by stenting. The possibility that airway obstruction in the initial stages of RP is due to airway inflammation and that early, aggressive immunosuppressive treatment of RP may delay or prevent irreversible cartilaginous destruction and airway collapse are discussed.


Related Articles

  • Microbial Communities in the Upper Respiratory Tract of Patients with Asthma and Chronic Obstructive Pulmonary Disease. Park, HeeKuk; Shin, Jong Wook; Park, Sang-Gue; Kim, Wonyong // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Respiratory infections are well-known triggers of chronic respiratory diseases. Recently, culture-independent tools have indicated that lower airway microbiota may contribute to pathophysiologic processes associated with asthma and chronic obstructive pulmonary disease (COPD). However, the...

  • Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD. Eltom, Suffwan; Dale, Nicole; Raemdonck, Kristof R. G.; Stevenson, Christopher S.; Snelgrove, Robert J.; Sacitharan, Pradeep K.; Recchi, Chiara; Wavre-Shapton, Silene; McAuley, Daniel F.; O'Kane, Cecilia; Belvisi, Maria G.; Birrell, Mark A. // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    Background: Infection-related exacerbations of respiratory diseases are a major health concern; thus understanding the mechanisms driving them is of paramount importance. Despite distinct inflammatory profiles and pathological differences, asthma and COPD share a common clinical facet: raised...

  • Asthma: alternative anti-inflammatory agents needed for patient subgroup.  // PharmaWatch: Monthly Review;Mar2005, Vol. 4 Issue 3, p26 

    The article presents a study conducted by the European Network for Understanding Mechanisms of Severe Asthma, concerning the role of the neutrophil in the pathogenesis of asthma. It has suggested that severe asthma is a different disease to mild-moderate disease. The presence of neutrophilic...

  • Author's response: Airway anatomy in COPD: many dimensions to consider. Smith, Benjamin M.; Hoffman, Eric A.; Barr, R. Graham // Thorax;Jun2015, Vol. 70 Issue 6, p585 

    A response from the authors of the article related to multi-ethnic study of atherosclerosis (MESA) chronic obstructive pulmonary disease that was published in the 2014 issue of the periodical.

  • Altered fibroblast proteoglycan production in COPD. Hallgren, Oskar; Nihlberg, Kristian; Dahlbäck, Magnus; Bjermer, Leif; Eriksson, Leif T.; Erjefält, Jonas S.; Löfdahl, Claes- Göran; Westergren-Thorsson, Gunilla // Respiratory Research;2010, Vol. 11, p55 

    Background: Airway remodeling in COPD includes reorganization of the extracellular matrix. Proteoglycans play a crucial role in this process as regulators of the integrity of the extracellular matrix. Altered proteoglycan immunostaining has been demonstrated in COPD lungs and this has been...

  • Increase in prevalence of physician-diagnosed asthma in Helsinki during the Finnish Asthma Programme: improved recognition of asthma in primary care? A cross-sectional cohort study. Kainu, Annette; Pallasaho, Paula; Piirilä, Päivi; Lindqvist, Ari; Sovijärvi, Anssi; Pietinalho, Anne // Primary Care Respiratory Journal;Mar2013, Vol. 22 Issue 1, p64 

    Background: The continuing rise in asthma prevalence has been questioned, with recent reports suggesting a plateau. Aims: To assess a 10-year trend in the age-adjusted prevalence of physician-diagnosed asthma, respiratory and allergic symptoms, and use of asthma medication in the adult...

  • Pediatric Respiratory Infections. Wingrove, Brian R. // Clinician Reviews;Feb2009, Vol. 19 Issue 2, p20 

    The article examines the common pathologies of pediatric respiratory infection. A detailed discussion on bronchiolitis, the common cold, croup, influenza and pneumonia is presented. It explores the differential diagnosis of bronchitis in children. Particular focus is given on the association...

  • Mediastinal Emphysema in Children. Fanta, E.; Canello, J.; Hasbuń, J.; Burdach, R. // Clinical Pediatrics;Jul1969, Vol. 8 Issue 7, p418 

    The article discusses the symptoms of mediastinal emphysema in children. Mediastinal emphysema has been variously attributed to inflammatory disease of the lung or upper respiratory tract, bronchopneumonia, interstitial pneumonitis, obstructive laryngitis, measles, influenza, whooping cough and...

  • Effect of breastfeeding duration on lung function at age 10 years: a prospective birth cohort study. Ogbuanu, I. U.; Karmaus, W.; Arshad, S. H.; Kurukulaaratchy, R. J.; Ewart, S. // Thorax;Jan2009, Vol. 64 Issue 1, p62 

    Introduction: The protective effects of breastfeeding on early life respiratory infections are established, but there have been conflicting reports on protection from asthma in late childhood. The association of breastfeeding duration and lung function was assessed in 10-year-old children....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics