Acute Renal Failure on Immune Reconstitution in an HIV-Positive Patient with Miliary Tuberculosis

Jehle, Andreas W.; Khanna, Nina; Sigle, Jorg-Peter; Glatz-Krieger, Katharina; Battegay, Manuel; Steiger, Jurg; Dickenmann, Michael; Hirsch, Hans H.
February 2004
Clinical Infectious Diseases;2/15/2004, Vol. 38 Issue 4, pe32
Academic Journal
Immune reconstitution syndrome following HAART in human immunodeficiency virus (HIV)--infected patients is characterized by inflammatory worsening of organ functions despite improvement in HIV surrogate markers of HIV infection. We describe a patient with miliary tuberculosis and urinary shedding of acid fast bacilli who developed acute renal failure 8 weeks after initiation of antituberculosis therapy and 6 weeks after initiation of HAART. The diagnostic workup and further course of disease implicated immune reconstitution syndrome as the cause of acute renal failure.


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