Colistin for Klebsiella pneumoniae--Associated Sepsis

Karabinis, A.; Paramythiotou, E.; Mylona-Petropoulou, D.; Kalogeromitros, A.; Katsarelis, N.; Kontopidou, F.; Poularas, I.; Malamou-Lada, H.
January 2004
Clinical Infectious Diseases;1/1/2004, Vol. 38 Issue 1, pe7
Academic Journal
Klebsiella pneumoniae that was resistant to all available antibiotics (minimum inhibitory concentration of imipenem, 32 μg/mL), including carbapenems, was isolated from blood samples obtained from a 48-year-old patient in the intensive care unit. The patient developed septic shock, which was successfully treated with colistin, the only antibiotic with activity against this multidrug-resistant strain.


Related Articles

  • Emergence of KPC-producing Klebsiella pneumoniae in Italy. Fontana, Carla; Favaro, Marco; Sarmati, Loredana; Natoli, Silvia; Altieri, Anna; Bossa, Maria C.; Minelli, Silvia; Leonardis, Francesca; Favalli, Cartesio // BMC Research Notes;2010, Vol. 3, p40 

    Background: The emergence of KPC-producing K. pneumoniae has now become a global concern. KPC betalactamases are plasmid-borne and, like extended spectrum beta lactamases (ESBLs), can accumulate and transfer resistance determinants to other classes of antibiotics. Therefore, infection control...

  • Antibiotic trends of Klebsiella pneumoniae and Acinetobacter baumannii resistance indicators in an intensive care unit of Southern Italy, 2008-2013. Agodi, Antonella; Barchitta, Martina; Quattrocchi, Annalisa; Maugeri, Andrea; Aldisio, Eugenia; Marchese, Anna Elisa; Mattaliano, Anna Rita; Tsakris, Athanassios // Antimicrobial Resistance & Infection Control;11/3/2015, Vol. 4, p1 

    Background: The overuse of antimicrobials is one of the main factors responsible for the development and spread of antimicrobial resistance, together with other causes, such as intra- and inter-hospital spread of resistant microorganisms and infection control policies and practices. The...

  • String test of hypervirulent Klebsiella pneumonia. Kumabe, A.; Kenzaka, T. // QJM: An International Journal of Medicine;Dec2014, Vol. 107 Issue 12, p1053 

    No abstract available.

  • Carbapenem-Sparing Antibiotic Regimens for Infections Caused by Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae in Intensive Care Unit. Sbrana, Francesco; Malacarne, Paolo; Viaggi, Bruno; Costanzo, Sergio; Leonetti, Piero; Leonildi, Alessandro; Casini, Beatrice; Tascini, Carlo; Menichetti, Francesco // Clinical Infectious Diseases;Mar2013, Vol. 56 Issue 5, p697 

    A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase–producing K. pneumoniae infectious episodes in 22 polytrauma intensive care unit patients without comorbidities. The 30-day crude mortality...

  • Risk factors for bloodstream infection with Klebsiella pneumoniae producing VIM-1 metallo-β-lactamase. Daikos, George L.; Vryonis, Evangelos; Psichogiou, Mina; Tzouvelekis, Leonidas S.; Liatis, Stavros; Petrikkos, Panayiotis; Kosmidis, Chris; Tassios, Panayotis T.; Bamias, Giorgos; Skoutelis, Athanasios // Journal of Antimicrobial Chemotherapy (JAC);Apr2010, Vol. 65 Issue 4, p784 

    Objectives: To identify risk factors for bloodstream infections (BSIs) caused by VIM-1-producing Klebsiella pneumoniae (VPKP). Methods: Consecutive patients with K. pneumoniae BSIs were identified in three tertiary care hospitals between February 2004 and March 2006. Patients infected with VPKP...

  • Molecular analysis of population structure and antibiotic resistance of Klebsiella isolates from a three-year surveillance program in Florence hospitals, Italy. Donnarumma, F.; Indorato, C.; Mastromei, G.; Goti, E.; Nicoletti, P.; Pecile, P.; Fanci, R.; Bosi, A.; Casalone, E. // European Journal of Clinical Microbiology & Infectious Diseases;Mar2012, Vol. 31 Issue 3, p371 

    We report the results of a three-year surveillance program of Klebsiella spp. in six hospitals in Florence (Italy). A total of 172 Klebsiella isolates were identified and typed by AFLP: 122 were K. pneumoniae and 50 were K. oxytoca. Most K. pneumoniae (80%) and K. oxytoca (93%) showed unrelated...

  • Antibiotic Resistance Pattern of Extended-Spectrum Beta-Lactamases-Producing Klebsiella pneumoniae Clinical Isolates from Zahedan, Southeast Iran. Shahraki-Zahedani, Shahram; Moghadampour, Mehdi; Bokaeian, Mohammad; Ansari-Moghaddam, Alireza // Zahedan Journal of Research in Medical Sciences;Nov2016, Vol. 18 Issue 11, p1 

    Background: Resistance to various classes of antibiotics iscommonamong extended-spectrum beta-lactamases (ESBLs)-producing bacteria. Objectives: To determine the antibiotic resistance pattern of ESBLs-producing K. pneumoniae clinical isolates from Zahedan. Methods: In this sectional-descriptive...

  • Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain. Leavitt, Azita; Chmelnitsky, Inna; Ofek, Itzhak; Carmeli, Yehuda; Navon-Venezia, Shiri // Journal of Antimicrobial Chemotherapy (JAC);Feb2010, Vol. 65 Issue 2, p243 

    Objectives: An extremely drug-resistant (XDR) clone of KPC-3-producing Klebsiella pneumoniae emerged in Israel in 2006, causing a nationwide outbreak. We aimed to characterize the local KPC-3-encoding plasmid carried by these isolates and study its contribution to antibiotic resistance.

  • Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study. Tumbarello, Mario; Trecarichi, Enrico Maria; De Rosa, Francesco Giuseppe; Giannella, Maddalena; Giacobbe, Daniele Roberto; Bassetti, Matteo; Losito, Angela Raffaella; Bartoletti, Michele; Del Bono, Valerio; Corcione, Silvia; Maiuro, Giuseppe; Tedeschi, Sara; Celani, Luigi; Cardellino, Chiara Simona; Spanu, Teresa; Marchese, Anna; Ambretti, Simone; Cauda, Roberto; Viscoli, Claudio; Viale, Pierluigi // Journal of Antimicrobial Chemotherapy (JAC);Jul2015, Vol. 70 Issue 7, p2133 

    Objectives: Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics