TITLE

Autoantibodies to Interferon-γ in a Patient with Selective Susceptibility to Mycobacterial Infection and Organ-Specific Autoimmunity

AUTHOR(S)
Döffinger, Rainer; Helbert, Matthew R.; Barcenas-Morales, Gabriela; Kun Yang; Dupuis, Stephanie; Ceron-Gutierrez, Lourdes; Espitia-Pinzon, Clara; Barnes, Neil; Bothamley, Graham; Casanova, Jean-Laurent; Longhurst, Hilary J.; Kumararatne, Dinakantha S.
PUB. DATE
January 2004
SOURCE
Clinical Infectious Diseases;1/1/2004, Vol. 38 Issue 1, pe10
SOURCE TYPE
Academic Journal
DOC. TYPE
Report
ABSTRACT
We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-γ (IFN-γ) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-γ can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy.
ACCESSION #
11791287

 

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