TITLE

Tenofovir-Related Fanconi Syndrome with Nephrogenic Diabetes Insipidus in a Patient with Acquired Immunodeficiency Syndrome: The Role of Lopinavir-Ritonavir-Didanosine

AUTHOR(S)
Rollot, Florence; Nazal, Eve-Marie; Chauvelot-Moachon, Laurence; Kélaïdi, Charikleia; Daniel, Nathalie; Saba, Mona; Abad, Sebastien; Blanche, Philippe
PUB. DATE
December 2003
SOURCE
Clinical Infectious Diseases;12/15/2003, Vol. 37 Issue 12, p174
SOURCE TYPE
Academic Journal
DOC. TYPE
Report
ABSTRACT
Tenofovir-related tubular damage, like all other recently reported cases, occurred in patients receiving the protease inhibitor (PI) ritonavir, often with lopinavir. Increased plasma concentrations of didanosine were also observed after the addition of tenofovir. It was suspected that tenofovir with PIs interacted with renal organic anion transporters, leading to nephrotoxic tubular concentrations of tenofovir and systemic accumulation of didanosine. Until there is a better understanding of these interactions, close monitoring is recommended for patients receiving tenofovir, PIs, and didanosine.
ACCESSION #
11770298

 

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