activins
Tags: ACTIVIN; GROWTH factors; POLYPEPTIDES
Related Articles
- Inhibin-βA subunit immunolabeling as a prognostic factor in endometrioid adenocarcinomas: a matter of evaluation? Mylonas, Ioannis // Archives of Gynecology & Obstetrics;Aug2011, Vol. 284 Issue 2, p467
Introduction: Inhibins and activins are secreted polypeptides of the transforming growth factor-β superfamily that comprise a subfamily of dimeric, disulphide-linked proteins. Inhibins are composed of an alpha subunit and one of two possible beta subunits (βA or βB), while activins are...
- angiogenic growth factors. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p129
A definition of the term "angiogenic growth factors," which refers to a set of polypeptides capable of stimulating the development of new blood vessels, is presented.
- The pancreas and its heartless beginnings. Duncan, Stephen A // Nature Genetics;Apr2001, Vol. 27 Issue 4, p355
Studies the mechanisms controlling the development of the dorsal and ventral pancreas. Secretion of activin and fibroblast growth factor-2; Expression of a number of transcription factors; Spatio-temporal relationship of liver and pancreas specification; Role of cardiac mesoderm in diverting...
- Inhibitors of the TGF-� Superfamily and their Clinical Applications. Tsuchida, K.; Sunada, Y.; Noji, S.; Murakami, T.; Uezumi, A.; Nakatani, M. // Mini Reviews in Medicinal Chemistry;Nov2006, Vol. 6 Issue 11, p1255
The transforming growth factor-� (TGF-�) superfamily includes TGF-� s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-� family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural...
- Activin/TGF-� induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP. Valderrama-Carvajal, Hector; Cocolakis, Eftihia; Lacerte, Annie; Lee, Eun-Hye; Krystal, Gerald; Ali, Suhad; Lebrun, Jean-Jacques // Nature Cell Biology;Dec2002, Vol. 4 Issue 12, p963
Members of the transforming growth factor � (TGF-�) family regulate fundamental physiological processes, such as cell growth, differentiation and apoptosis, in almost all cell types. As a result, defects in TGF-� signalling pathways have been linked to uncontrolled cellular proliferation...
- A component of the ARC/Mediator complex required for TGFBeta;/Nodal signalling. Kato, Yoichi; Habas, Raymond; Katsuyama, Yu; Naar, Anders M.; He, Xi // Nature;8/8/2002, Vol. 418 Issue 6898, p641
Reports on a study which showed that ARC105, a component of the activator-recruited co-factor complex or the metazoan mediator complex, is essential for transforming growth factor Beta;/Activin/Nodal/Smad2/3 signal transduction. Identification of Smad-dependent signalling pathways; Contents of...
- Transforming Growth Factor-� Type I Receptor Inhibitor Induces Functional and Morphologic Recovery in a Rat Model of Erectile Dysfunction and Cavernous Fibrosis. Ji Kan Ryu; Seung Min Oh; Hai Rong Jin; Kang Moon Song; Mi Hye Kwon; Do Kyung Kim; Jun Kyu Suh // Korean Journal of Andrology;Apr2012, Vol. 30 Issue 1, p23
Purpose: To examine the effectiveness of small-molecule inhibitor of transforming growth factor-� (TGF-�) type I receptor, an activin receptor-like kinase 5 (ALK5), on erectile dysfunction (ED) in a rat model of cavernous fibrosis, in which fibrosis was induced by intracavernous injection of...
- TGF-β. // Encyclopedic Reference of Cancer;2001, p887
A definition of the term "TGF-β," the acronym for transforming growth factor β, is presented. It refers to a multifunctional dimeric 25 kD polypeptide growth factor. Activation renders the biologically latent TGF-β into its active form. The TGFβ superfamily contains at least 40 cytokines...
- The crystal structure of auracyanin A at 1.85 � resolution: the structures and functions of auracyanins A and B, two almost identical �blue� copper proteins, in the photosynthetic bacterium Chloroflexus aurantiacus. Lee, Mihwa; del Rosario, Melissa C.; Harris, Hugh H.; Blankenship, Robert E.; Guss, J. Mitchell; Freeman, Hans C. // Journal of Biological Inorganic Chemistry;Mar2009, Vol. 14 Issue 3, p329
Auracyanins A and B are two closely similar �blue� copper proteins produced by the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. Both proteins have a water-soluble 140-residue globular domain, which is preceded in the sequence by an N-terminal tail. The globular...
