January 2005
Taber's Cyclopedic Medical Dictionary;2005, p2245
Reference Entry
A definition of the term "tryptophanase" is presented. It refers to an enzyme that catalyzes the splitting of tryptophan into indole, pyruvic acid and ammonia.


Related Articles

  • Evolution of Vertebrate Indoleamine 2,3-Dioxygenases. Yuasa, Hajime Julie; Takubo, Miwa; Takahashi, Ayumi; Hasegawa, Tetsuo; Noma, Hiroshi; Suzuki, Tomohiko // Journal of Molecular Evolution;Dec2007, Vol. 65 Issue 6, p705 

    Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the same reaction, the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed among life-forms, being found not only in eukaryotes but also in...

  • Effect of cysteine desulfhydrase gene disruption on l-cysteine overproduction in Escherichia coli. Awano, N.; Wada, M.; Kohdoh, A.; Oikawa, T.; Takagi, H.; Nakamori, S. // Applied Microbiology & Biotechnology;Aug2003, Vol. 62 Issue 2/3, p239 

    In Escherichia coli, the enzyme called cysteine desulfhydrase (CD), which is responsible for l-cysteine degradation, was investigated by native-PAGE and CD activity staining of crude cell extracts. Analyses with gene-disrupted mutants showed that CD activity resulted from two enzymes:...

  • Cooperative Binding of l-Trp to Human Tryptophan 2,3-Dioxygenase: Resonance Raman Spectroscopic Analysis. Fukumura, Eiko; Hiroshi, Sugimoto; Misumi, Yuko; Ogura, Takashi; Shiro, Yoshitsugu // Journal of Biochemistry;Apr2009, Vol. 145 Issue 4, p505 

    Tryptophan 2,3-dioxygenase (TDO) is a tetrameric enzyme that catalyses the oxidative cleavage of l-tryptophan (l-Trp) to N-formylkynurenine by the addition of O2 across the 2,3-bond of the indole ring. This reaction is the first and rate-limiting step in the kynurenine pathway in mammals. In the...

  • Tryptophanase-Catalyzed L-Tryptophan Synthesis from D-Serine in the Presence of Diammonium Hydrogen Phosphate. Shimada, Akihiko; Ozaki, Haruka; Saito, Takeshi; Noriko, Fujii // International Journal of Molecular Sciences;Jun2009, Vol. 10 Issue 6, p2578 

    Tryptophanase, an enzyme with extreme absolute stereospecificity for optically active stereoisomers, catalyzes the synthesis of L-tryptophan from L-serine and indole through a β-substitution mechanism of the ping-pong type, and has no activity on D-serine. We previously reported that...

  • Synthesis of [3-14C]-L-tryptophan and 5′-hydroxy-[3-14C]-L-tryptophan. Winnicka, E.; Kańska, M. // Journal of Radioanalytical & Nuclear Chemistry;Apr2009, Vol. 280 Issue 1, p79 

    The synthesis of selectively labeled [3-14C]-L-tryptophan and its derivative 5′-hydroxy-[3-14C]-L-tryptophan using chemical and multienzymatic methods is reported. The key intermediate for this synthesis, [3-14C]-DL-alanine was obtained from 14CH3I as a result of its condensation with...

  • Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells. Sun, Ting; Chen, Xiang-Hua; Tang, Zheng-De; Cai, Jiong; Wang, Xiao-Yan; Wang, Shih-Chen; Li, Zhao-Long // Molecular & Cellular Biochemistry;Sep2010, Vol. 342 Issue 1/2, p29 

    Indoleamine 2,3-dioxygenase (IDO) is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer. We synthesized 1-alkyl-tryptophan targeted IDO...

  • On the non-redundant roles of TDO2 and IDO1. Puccetti, Paolo // Frontiers in Immunology;Oct2014, Vol. 5, p1 

    The author discuses the paper "AhR-mediated, non-genomic modulation of IDO1 function," by M. T. Pallotta and colleagues which explores the relationship between tryptophan catabolic enzymes and the aryl hydrocarbon receptor (AhR) in the transitional response. He explores the roles of tryptophan...

  • Isoform.  // Encyclopedic Reference of Cancer;2001, p468 

    A definition of the term "isoform" is presented. This term refers to a structurally and functionally related form of a protein. Isoforms are also referred to as isozymes and are enzyme molecules that catalyze the same reactions. However, the other properties of these enzyme molecules, such as...

  • tryptophanase.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2382 

    A definition of the medical term "tryptophanase," which refers to am enzyme that catalyzes the splitting of tryptophan into indole, is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics