Coughlin, Shaun
June 2014
Cardiology Today;Jun2014, Vol. 17 Issue 6, p30
The author discusses the health benefits of protease activated receptor-1 (PAR-1).


Related Articles

  • Targeting A549 lung adenocarcinoma cell growth and invasion with protease-activated receptor-1 siRNA. ZHUO WU; YANYAN ZENG; MINGKANG ZHONG; BIN WANG // Molecular Medicine Reports;2014, Vol. 9 Issue 5, p1787 

    Lung cancer is the major cause of cancer-associated mortality worldwide and the invasive and metastatic characteristics of lung tumor cells are responsible for their high malignancy. Protease-activated receptor 1 (PARI) is a G-protein-coupled receptor (GPCR) which is activated by a unique...

  • Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death. Burns, Kelly E.; Thèvenin, Damien // Biochemical Journal;12/15/2015, Vol. 472 Issue 3, p287 

    Even though abnormal expression of G protein-coupled receptors (GPCRs) and of their ligands is observed in many cancer cells of various origins, only a few anti-cancer compounds directly act on their signalling. One promising approach to modulate their activity consists of targeting the receptor...

  • P618 PAR2 expression differentially regulates immune response upon treatment with Poly(I:C) and LPS. Weithaeuser, A; Schultheiss, HP; Rauch, U // Cardiovascular Research;Jul2014, Vol. 103 Issue suppl_1, pS112 

    Introduction: The protease activated receptor 2 (PAR2) is a G-protein coupled receptor, that is activated by serine proteases such as trypsin, tryptase and the complex composed of tissue factor (TF)/ factor VII (FVII) and factor X (FX). PAR2 is also involved in modulating immune response after...

  • Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist. Cho, Nam-Chul; Seo, Seoung-Hwan; Kim, Dohee; Shin, Ji-Sun; Ju, Jeongmin; Seong, Jihye; Seo, Seon; Lee, Iiyoun; Lee, Kyung-Tae; Kim, Yun; No, Kyoung; Pae, Ae // Journal of Computer-Aided Molecular Design;Aug2016, Vol. 30 Issue 8, p625 

    Protease-activated receptor 2 (PAR) is a G protein-coupled receptor, mediating inflammation and pain signaling in neurons, thus it is considered to be a potential therapeutic target for inflammatory diseases. In this study, we performed a ligand-based virtual screening of 1.6 million compounds...

  • Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR2) through the Use of Lipid Tethering. Boitano, Scott; Hoffman, Justin; Tillu, Dipti V.; Asiedu, Marina N.; Zhang, Zhenyu; Sherwood, Cara L.; Wang, Yan; Dong, Xinzhong; Price, Theodore J.; Vagner, Josef // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR2 with in vitro physiological and Ca2+ signaling assays to...

  • Altered Protease–Activated Receptor-1 Expression and Signaling in a Malignant Pleural Mesothelioma Cell Line, NCI-H28, with Homozygous Deletion of the β-Catenin Gene. Fazzini, Alessandra; D’Antongiovanni, Vanessa; Giusti, Laura; Da Valle, Ylenia; Ciregia, Federica; Piano, Ilaria; Caputo, Antonella; D’Ursi, Anna Maria; Gargini, Claudia; Lucacchini, Antonio; Mazzoni, Maria Rosa // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    Protease activated receptors (PARs) are G-protein coupled receptors that are activated by an unique proteolytic mechanism. These receptors play crucial roles in hemostasis and thrombosis but also in inflammation and vascular development. PARs have also been implicated in tumor progression,...

  • Protease Activated Receptor-2 Contributes to Heart Failure. Antoniak, Silvio; Sparkenbaugh, Erica M.; Tencati, Michael; Rojas, Mauricio; Mackman, Nigel; Pawlinski, Rafal // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Heart failure is a major clinical problem worldwide. Previous studies have demonstrated an important role for G protein-coupled receptors, including protease-activated receptors (PARs), in the pathology of heart hypertrophy and failure. Activation of PAR-2 on cardiomyocytes has been shown to...

  • Increased Expression of Protease-Activated Receptor 4 and Trefoil Factor 2 in Human Colorectal Cancer. Yu, Guoyu; Jiang, Ping; Xiang, Yang; Zhang, Yong; Zhu, Zhu; Zhang, Chuanrao; Lee, Siman; Lee, Wenhui; Zhang, Yun // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Protease-activated receptor 4 (PAR4), a member of G-protein coupled receptors family, was recently reported to exhibit decreased expression in gastric cancer and esophageal squamous cancer, yet increased expression during the progression of prostate cancer. Trefoil factor 2 (TFF2), a small...

  • Biased Signaling of Protease-activated Receptors. Peishen Zhao; Matcalf, Matthew; Bunnett, Nigel W. // Frontiers in Endocrinology;Apr2014, Vol. 5, preceding p1 

    In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain and repair mechanisms. Certain proteases can signal to cells by cleaving...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics