How to define biomarkers of human T cell aging and immunocompetence?

Herndler-Brandstetter, Dietmar; Ishigame, Harumichi; Flavell, Richard A.
June 2013
Frontiers in Immunology;Jun2013, Vol. 4, p1
Academic Journal
In this article the authors discuss how aging affects the number, phenotype, and function of human T cells, and how to identify potential biomarkers of T cell aging. According to the authors, the decline in T cell number and function seems to be an important feature of human immune cell aging. The authors say that at the age of 50 years, 90 percent of functional tissue of thymus is lost; and this leads to a considerable shortage of T cells in the peripheral blood, lymph nodes, and bone marrow.


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