TITLE

Immune reconstitution inflammatory syndrome: the trouble with immunity when you had none

AUTHOR(S)
Barber, Daniel L.; Andrade, Bruno B.; Sereti, Irini; Sher, Alan
PUB. DATE
February 2012
SOURCE
Nature Reviews Microbiology;Feb2012, Vol. 10 Issue 2, p150
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
Some individuals who are infected with HIV rapidly deteriorate shortly after starting antiretroviral therapy, despite effective viral suppression. This reaction, referred to as immune reconstitution inflammatory syndrome (IRIS), is characterized by tissue-destructive inflammation and arises as CD4+ T cells re-emerge. It has been proposed that IRIS is caused by a dysregulation of the expanding population of CD4+ T cells specific for a co-infecting opportunistic pathogen. Here, we argue that IRIS instead results from hyper-responsiveness of the innate immune system to T cell help, a mechanism that may be shared by the many manifestations of IRIS that occur following the reversal of other types of immunosuppression in pathogen-infected hosts.
ACCESSION #
70360944

 

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