TITLE

Interfering With Tumor Pathways That Augment Viral Oncolysis

AUTHOR(S)
Bell, John C
PUB. DATE
December 2011
SOURCE
Molecular Therapy;Dec2011, Vol. 19 Issue 12, p2108
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
The author comments on a functional genomics approach that determines unexpected cancer-specific pathways which can augment oncolytic virus (OV) killing of tumor cells. He says that major breakthroughs in the understanding of the molecular biology of the cell has been led by studying viruses. According to him, OVs have shown promise in early clinical studies.
ACCESSION #
67652945

 

Related Articles

  • Sequence-based cancer genomics: progress, lessons and opportunities. Strausberg, Robert L.; Simpson, Andrew J. G.; Wooster, Richard // Nature Reviews Genetics;Jun2003, Vol. 4 Issue 6, p409 

    Technologies that provide a genome-wide view offer an unprecedented opportunity to scrutinize the molecular biology of the cancer cell. The information that is derived from these technologies is well suited to the development of public databases of alterations in the cancer genome and its...

  • The field of cancer research: an indicator of present transformations in biology. Morange, M. // Oncogene;12/6/2007, Vol. 26 Issue 55, p7607 

    ‘Biology and cancer research have developed together. Invariably, at each stage, the characteristics of the cancer cell have been ascribed to some defect in whatever branch of biology happens at the time to be fashionable and exciting; today, it is molecular genetics’. Tremendous...

  • Recent Patents on Melanoma with Focus on Genetic Strategies. Gramiccia, Talia; Saraceno, Rosita; Stefani, Alessandro D.; Chimenti, Sergio // Recent Patents on Anti-Infective Drug Discovery;Jun2008, Vol. 3 Issue 2, p136 

    Recent advances in molecular biology have enhanced the understanding of the pathology of melanocytic lesions. Several targetable pathways, responsible for survival and apoptosis resistance in melanoma cells, have been described and current research has focused on mechanism inactivating these...

  • Genomics and proteomics.  // Mayo Clinic Guide to Women's Cancers;2005, p31 

    The article focuses on genomics and proteomics, two important areas of cancer research. Genomics is the study of the human genome--the complete set of approximately 40,000 genes in a human being. The completion of the Human Genome Project was an enormous advance in genomics. Information about...

  • Comparative analysis of variable regions in the variola virus genome. Babkin, I. V.; Nepomnyashchikh, T. S.; Maksyutov, R. A.; Gutorov, V. V.; Babkina, I. N.; Shchelkunov, S. N. // Molecular Biology;Jul2008, Vol. 42 Issue 4, p543 

    Two segments of the variable terminal regions of the variola virus (VARV) genome were sequenced in 22 strains from the Russian collection, including about 13.5 kb of the left segment and about 10.5 kb of the right segment. The total length of the sequences was over 540 kb. Phylogenetic analysis...

  • Dual effects of sodium butyrate on hepatocellular carcinoma cells. Jiang, Wenjun; Guo, Qiya; Wu, Jun; Guo, Bin; Wang, Yingming; Zhao, Shenan; Lou, Huiling; Yu, Xin; Mei, Xinyu; Wu, Chaoqun; Qiao, Shouyi; Wu, Yanhua // Molecular Biology Reports;May2012, Vol. 39 Issue 5, p6235 

    Sodium butyrate (NaBu), a histone deacetylase inhibitor, has been shown to inhibit cell growth, induce cell differentiation and apoptosis in multiple cell lines. In present study, we revealed the dual effects of NaBu in regulating hepatocellular carcinoma (HCC) cells. In two different HCC cell...

  • Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors. Chan Joo Yeom; Yoko Goto; Yuxi Zhu; Hiraoka, Masahiro; Harada, Hiroshi // International Journal of Molecular Sciences;Nov2012, Vol. 13 Issue 11, p13949 

    Because of the accelerated proliferation of cancer cells and the limited distance that molecular oxygen can diffuse from functional tumor blood vessels, there appears to be a unique histology in malignant solid tumors, conglomerates of micro tumor cords. A functional blood vessel exists at the...

  • Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia. Kodiha, Mohamed; Hutter, Eliza; Boridy, Sebastien; Juhas, Michal; Maysinger, Dusica; Stochaj, Ursula // Cellular & Molecular Life Sciences;Nov2014, Vol. 71 Issue 21, p4259 

    Gold nanoparticles have emerged as promising tools for cancer research and therapy, where they can promote thermal killing. The molecular mechanisms underlying these events are not fully understood. The geometry and size of gold nanoparticles can determine the severity of cellular damage....

  • Mechanistic Evaluation of a Novel Small Molecule Targeting Mitochondria in Pancreatic Cancer Cells. Shabaik, Yumna H.; Millard, Melissa; Neamati, Nouri // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Background: Pancreatic cancer is one of the deadliest cancers with a 5-year survival rate of 6%. Therapeutic options are very limited and there is an unmet medical need for safe and efficacious treatments. Cancer cell metabolism and mitochondria provide unexplored targets for this disease. We...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics