TITLE

The next level of complexity: post-transcriptional regulation by microRNAs

AUTHOR(S)
Kramann, Rafael; Moeller, Marcus J
PUB. DATE
October 2011
SOURCE
Kidney International;Oct2011, Vol. 80 Issue 7, p692
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that regulate expression of about half of human genes. Canonical miRNA biosynthesis involves two RNase III-type proteins, Drosha and Dicer. A podocyte-specific knockout of Dicer resulted in foot process effacement. In this issue, Zhdanova et al. report on targeting Drosha in a podocyte-specific fashion. Their study demonstrates an essential role of canonical miRNAs in maintaining the fully differentiated podocyte phenotype.
ACCESSION #
65433575

 

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