Advances in the Diagnosis, Classification, Risk Stratification, and Management of Monoclonal Gammopathy of Undetermined Significance: Implications for Recategorizing Disease Entities in the Presence of Evolving Scientific Evidence

Rajkumar, S. Vincent; Kyle, Robert A.; Buadi, Francis K.
October 2010
Mayo Clinic Proceedings;Oct2010, Vol. 85 Issue 10, p945
Academic Journal
In this article, the authors discuss the process of malignant transformation and management strategies for dealing with monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma cell disorder. They emphasize that preventive therapy cannot be justified without safe treatment opinions and evidence of benefit from phase three clinical trials. They stress that high-risk MGUS patients require follow-up strategies, prevention trials and research on biomarkers.


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