Advances in the Diagnosis, Classification, Risk Stratification, and Management of Monoclonal Gammopathy of Undetermined Significance: Implications for Recategorizing Disease Entities in the Presence of Evolving Scientific Evidence

Rajkumar, S. Vincent; Kyle, Robert A.; Buadi, Francis K.
October 2010
Mayo Clinic Proceedings;Oct2010, Vol. 85 Issue 10, p945
Academic Journal
In this article, the authors discuss the process of malignant transformation and management strategies for dealing with monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma cell disorder. They emphasize that preventive therapy cannot be justified without safe treatment opinions and evidence of benefit from phase three clinical trials. They stress that high-risk MGUS patients require follow-up strategies, prevention trials and research on biomarkers.


Related Articles

  • Verification of serum reference intervals for free light chains in a local South African population. Zemlin, Annalise E.; Rensburg, Megan A.; Ipp, Hayley; Germishuys, Jurie J.; Erasmus, Rajiv T. // Journal of Clinical Pathology;Nov2013, Vol. 66 Issue 11, p992 

    Monoclonal serum free light chain measurements are used to follow up and manage patients with monoclonal gammopathies, and abnormal serum free light chain ratios are associated with risk of progression in certain diseases. We aimed to validate the reference intervals in our population. Reference...

  • Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis. Tang, An; Chen, Joshua; Le, Thuy-Anh; Changchien, Christopher; Hamilton, Gavin; Middleton, Michael; Loomba, Rohit; Sirlin, Claude // Abdominal Imaging;Jan2015, Vol. 40 Issue 1, p26 

    Purpose: To explore the cross-sectional and longitudinal relationships between fractional liver fat content, liver volume, and total liver fat burden. Methods: In 43 adults with non-alcoholic steatohepatitis participating in a clinical trial, liver volume was estimated by segmentation of...

  • Platform presentation—Late-breaking research—Multivariate Clinical Predictors of Huntington Disease (HD): Prospective Results from the PREDICT-HD Study Langbehn, D.; Paulsen, J. // Neurotherapeutics;Jan2010, Vol. 7 Issue 1, p137 

    Background: An original primary aim of PREDICT-HD was identification and quantification of clinical marker sets predictive of HD diagnosis. Such models would add substantial power and efficiency to eventual clinical trials to prevent or delay HD onset. Since the study''s inception, skepticism...

  • Is relative leg length a biomarker of childhood nutrition? Long-term follow-up of the Hyderabad Nutrition Trial. Kinra, Sanjay; Sarma, KV Rameshwar; Hards, Michelle; Smith, George Davey; Ben-Shlomo, Yoav // International Journal of Epidemiology;Aug2011, Vol. 40 Issue 4, p1022 

    Background Relative leg length is frequently used as a biomarker of childhood nutrition in epidemiological studies, but evidence is lacking. We examined the association between supplemental nutrition in pregnancy and childhood and relative proportions of components of height in...

  • Outcomes of discretionary laboratory requesting of serum protein electrophoresis. Hughes, Marie; Davidson, D. Fraser; McColl, Mark // Annals of Clinical Biochemistry;Sep2006, Vol. 43 Issue 5, p372 

    Background: Discretionary laboratory requesting of serum protein electrophoresis (SPE) is widespread throughout the UK despite limited evidence to support clinical usefulness. We aimed to examine the clinical usefulness of discretionary SPE requesting on serum samples with globulins > 45 g/L by...

  • MGUS preceded nearly all multiple myelomas.  // Hem/Onc Today;7/10/2009, Vol. 10 Issue 13, p30 

    The article deals with two studies which found that premalignant plasma cell disorder monoclonal gammopathy of undetermined significant almost always preceded the development of multiple myeloma.

  • Reply: Antral follicle count might be underestimated in the presence of an ovarian endometrioma. Muzii, Ludovico; Panici, Pierluigi Benedetti // Human Reproduction;Jan2015, Vol. 30 Issue 1, p251 

    No abstract available.

  • Monoclonal gammopathy and rheumatic diseases. Raposo, Ana; Peixoto, Daniela; Bogas, Mónica // Acta Reumatológica Portuguesa;jan-mar2014, Vol. 39 Issue 1, p12 

    It is common to find monoclonal gammopathy in the investigation workout for an unrelated disorder. There are studies relating rheumatic diseases and therapies which show an increased risk of monoclonal gammopathy. The specific mechanisms are not well understood but chronic antigen stimulation...

  • CORRECTIONS.  // Mayo Clinic Proceedings;Nov2006, Vol. 81 Issue 11, p1509 

    Two corrections to the articles "Monoclonal Gammopathy of Undetermined Significance, Waldenström Macroglobulinemia, AL Amyloidosis, and Related Plasma Cell Disorders: Diagnosis and Treatment," that was published in the May 2006 issue and "Oncologic Emergencies: Diagnosis and Treatment," that...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics