TITLE

Advances in the Diagnosis, Classification, Risk Stratification, and Management of Monoclonal Gammopathy of Undetermined Significance: Implications for Recategorizing Disease Entities in the Presence of Evolving Scientific Evidence

AUTHOR(S)
Rajkumar, S. Vincent; Kyle, Robert A.; Buadi, Francis K.
PUB. DATE
October 2010
SOURCE
Mayo Clinic Proceedings;Oct2010, Vol. 85 Issue 10, p945
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
In this article, the authors discuss the process of malignant transformation and management strategies for dealing with monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma cell disorder. They emphasize that preventive therapy cannot be justified without safe treatment opinions and evidence of benefit from phase three clinical trials. They stress that high-risk MGUS patients require follow-up strategies, prevention trials and research on biomarkers.
ACCESSION #
54592677

 

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