Navigating the road to personalized medicine: Can we believe?

Hirschfield, Gideon M.; Amos, Christopher I.; Siminovitch, Katherine A.
April 2010
CMAJ: Canadian Medical Association Journal;4/20/2010, Vol. 182 Issue 7, p651
Academic Journal
The article comments on an article related to the risk factors associated with Crohn disease, publsihed within the issue. It states that nucleotide binding oligomerization domain 2 (NOD2) and caspase recruitment domain 15 (CARD15) are variants to the risk for Crohn disease. It mentions that the genetic contribution to this disease is engendered by 30 gene variants. The study results reinforce the future of personalized medicine.


Related Articles

  • Association of CARD8 with inflammatory bowel disease in Koreans. Yang, Suk-Kyun; Kim, Hyeri; Hong, Myunghee; Lim, Jiyoung; Choi, Eunkyoung; Ye, Byong Duk; Park, Soo-Kyung; Song, Kyuyoung // Journal of Human Genetics;Mar2011, Vol. 56 Issue 3, p217 

    Caspase recruitment domain (CARD)-containing protein 8 (CARD8) is a potential candidate risk gene for inflammatory bowel disease (IBD) because of its role as a component of the NALP3 inflammasome and as an inhibitor of nuclear factor-kappa B. Previous studies examining the association of a CARD8...

  • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Barrett, Jeffrey C.; Hansoul, Sarah; Nicolae, Dan L.; Cho, Judy H.; Duerr, Richard H.; Rioux, John D.; Brant, Steven R.; Silverberg, Mark S.; Taylor, Kent D.; Barmada, M. Michael; Bitton, Alain; Dassopoulos, Themistocles; Datta, Lisa Wu; Green, Todd; Griffiths, Anne M.; Kistner, Emily O.; Murtha, Michael T.; Regueiro, Miguel D.; Rotter, Jerome I.; Schumm, L. Philip // Nature Genetics;Aug2008, Vol. 40 Issue 8, p955 

    Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases...

  • Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study). Chan, Simon S M; Luben, Robert; Olsen, Anja; Tjonneland, Anne; Kaaks, Rudolf; Teucher, Birgit; Lindgren, Stefan; Grip, Olof; Key, Timothy; Crowe, Francesca L; Bergmann, Manuela M; Boeing, Heiner; Hallmans, Göran; Karling, Pontus; Overvad, Kim; Palli, Domenico; Masala, Giovanna; Kennedy, Hugh; vanSchaik, Fiona; Bueno-de-Mesquita, Bas // American Journal of Gastroenterology;Apr2013, Vol. 108 Issue 4, p575 

    OBJECTIVES:Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between...

  • Adverse Events Associated With Common Therapy Regimens for Moderate-to-Severe Crohn's Disease. Marehbian, Josh; Arrighi, H Michael; Hass, Steve; Tian, Haijun; Sandborn, William J // American Journal of Gastroenterology;Oct2009, Vol. 104 Issue 10, p2524 

    OBJECTIVES:We sought to determine whether treatment with steroids, immunosuppressives (ISs), and anti-tumor necrosis factor (TNF) agents is associated with an increased risk of adverse events in patients with Crohn's disease (CD).METHODS:This study analyzed claims from patients with CD and...

  • What's Hot in the Red Journal This Month.  // American Journal of Gastroenterology;Nov2014, Vol. 109 Issue 11, p1695 

    A preview of articles from the November 2014 issue is presented, which include "Antibiotics Associated With Increased Risk of New-Onset Crohn's Disease But Not Ulcerative Colitis: A Meta-Analysis";"What Level of Bowel Prep Quality Requires Early Repeat Colonoscopy: Systematic Review and...

  • Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN Study. Høivik, M. L.; Solberg, Mourn B. // Inflammatory Bowel Disease Monitor;2012, Vol. 13 Issue 1, p18 

    This study uses data from the large, population-based, IBSEN (Inflammatory Bowel South-Eastern Norway) inception cohort of IBD patients to examine the rate of work disability in patients diagnosed with Crohn's disease. The authors of this study found that almost 20% of IBD patients had received...

  • Vitamin D and Inflammatory Bowel Disease. Ardesia, Marco; Ferlazzo, Guido; Fries, Walter // BioMed Research International;4/27/2015, Vol. 2015, p1 

    Vitamin D deficiency has been recognized as an environmental risk factor for Crohn’s disease since the early 80s. Initially, this finding was correlated with metabolic bone disease. Low serum 25-hydroxyvitamin D levels have been repeatedly reported in inflammatory bowel diseases together...

  • Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease. Schnitzler, Fabian; Brand, Stephan; Staudinger, Tanja; Pfennig, Simone; Hofbauer, Katrin; Seiderer, Julia; Tillack, Cornelia; Göke, Burkhard; Ochsenkühn, Thomas; Lohse, Peter // Immunogenetics;Mar2006, Vol. 58 Issue 2/3, p99 

    We performed a limited DNA sequence analysis of the CARD15 gene in 89 patients with Crohn’s disease (CD), 19 patients with ulcerative colitis (UC), and three patients with indeterminate colitis (IC), who were heterozygous carriers of one of the common CARD15 mutations [c.2104C>T...

  • IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance. Roberts, R. L.; Gearry, R. B.; Barclay, M. L.; Kennedy, M. A. // Pharmacogenomics Journal;2007, Vol. 7 Issue 5, p312 

    Around 9% of inflammatory bowel disease (IBD) patients are resistant to azathioprine. We hypothesized that these patients may carry mutations within inosine-5′-monophosphate dehydrogenase (IMPDH). To test this hypothesis, we screened 20 azathioprine-resistant patients for variations in the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics