To B or Not to B: Is Non-High-Density Lipoprotein Cholesterol an Adequate Surrogate for Apolipoprotein B?

Lavie, Carl J.; Milani, Richard V.; O'Keefe, James H.
May 2010
Mayo Clinic Proceedings;May2010, Vol. 85 Issue 5, p446
Academic Journal
In this article the authors discuss whether non-high-density lipoprotein (HDL) cholesterol can adequately replace for Apolipoprotein B (Apo B). The authors regard the relationship of the level of Apo B with the coronary heart disease risks. The authors show support for the routine assessment and treatment directed at levels of non-HDL-C as well as the value and goals in routine laboratory results.


Related Articles

  • Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease. McCaskie, Pamela A.; Beilby, John P.; Chapman, Caroline M.L.; Hung, Joseph; McQuillan, Brendan M.; Thompson, Peter L.; Palmer, Lyle J. // Human Genetics;Apr2007, Vol. 121 Issue 3/4, p401 

    High-density lipoprotein cholesterol (HDL-C) is a known inverse predictor of coronary heart disease (CHD) and is thus a potential therapeutic target. Cholesteryl ester transfer protein (CETP) is a key protein in HDL-C metabolism such that elevated CETP activity is associated with lower HDL-C....

  • High density lipoprotein cholesterol is not a major risk factor for ischaemic heart disease in British men. Pocock, S.J.; Shaper, A.G.; Phillips, A.N.; Walker, M.; Whitehead, T.P. // British Medical Journal (Clinical Research Edition);2/22/1986, Vol. 292 Issue 6519, p515 

    Examines the concentration of high density lipoprotein cholesterol (HDL cholesterol) in serum among middle aged men in Great Britain. Rate of HDL cholesterol concentration in men with ischemic heart disease; Reliability of HDL cholesterol as a predictor of heart disease risk; Influence of HDL...

  • HDL-cholesterol and triglycerides: an overlooked issue? Twomey, P. J.; Pledger, D. R. // Journal of Clinical Pathology;Sep2007, Vol. 60 Issue 9, p1065 

    The article presents a case study of the relationship between high-density lipoprotein-cholesterol (HDL-C) and triglyceride concentrations. According to the findings of several prospective clinical trials and epidemiological studies, a low concentration of HDL-C is an independent risk factor for...

  • Risk of CAD as measured by total cholesterol/HDL ratio.  // Geriatrics;May95, Vol. 50 Issue 5, p19 

    States that the ratio of total cholesterol (TC) to high density lipoproteins (HDL) is the best single indicator of risk for coronary artery disease. Calculation of the ratio.

  • Biological, clinical and population relevance of 95 loci for blood lipids. Teslovich, Tanya M.; Musunuru, Kiran; Smith, Albert V.; Edmondson, Andrew C.; Stylianou, Ioannis M.; Koseki, Masahiro; Pirruccello, James P.; Ripatti, Samuli; Chasman, Daniel I.; Willer, Cristen J.; Johansen, Christopher T.; Fouchier, Sigrid W.; Isaacs, Aaron; Peloso, Gina M.; Barbalic, Maja; Ricketts, Sally L.; Bis, Joshua C.; Aulchenko, Yurii S.; Thorleifsson, Gudmar; Feitosa, Mary F. // Nature;8/5/2010, Vol. 466 Issue 7307, p707 

    Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common...

  • Trends in Lipids and Lipoproteins in US Adults, 1988-2010. Carroll, Margaret D.; Kit, Brian K.; Lacher, David A.; Shero, Susan T.; Mussolino, Michael E. // JAMA: Journal of the American Medical Association;10/17/2012, Vol. 308 Issue 15, p1545 

    The article discusses a study that was conducted in the U.S. to examine the trends of serum lipids in adults from the year 1988 to 2010. It informs that the high concentrations of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) and low levels of high-density lipoprotein...

  • Effect of an intervention to improve the cardiovascular health of family members of patients with coronary artery disease: a randomized trial. Reid, Robert D.; McDonnell, Lisa A.; Riley, Dana L.; Mark, Amy E.; Mosca, Lori; Beaton, Louise; Papadakis, Sophia; Blanchard, Chris M.; Mochari-Greenberger, Heidi; O'Farrell, Patricia; Wells, George A.; Slovinec D'Angelo, Monika E.; Pipe, Andrew L. // CMAJ: Canadian Medical Association Journal;1/7/2014, Vol. 186 Issue 1, p23 

    Background: Family members of patients with coronary artery disease (CAD) have higher risk of vascular events. We conducted a trial to determine if a family heart-health intervention could reduce their risk of CAD. Methods: We assessed coronary risk factors and randomized 426 family members of...

  • LIPIDS.  // Monthly Prescribing Reference;Jan2011, Vol. 27 Issue 1, p52 

    The article focuses on lowering the amount of cholesterol contained in low-density lipoprotein (LDL-C). It notes that once the LDL-C lowering goal is reached, other lipid and non-lipid risk factors can be treated. It implies to do lipoprotein analysis if there is evidence of coronary heart...

  • LIPID MANAGEMENT.  // Monthly Prescribing Reference;May2015, Vol. 31 Issue 5, p18 

    The article offers information on various factors to consider during lipid and non-lipid risk factors treatment. Topics discussed include the importance of achieving low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) treatment goal, the effective use of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics