TITLE

The true culprit within the SPINK1 p.N34S-containing haplotype is still at large

AUTHOR(S)
Jian-Min Chen; Férec, Claude
PUB. DATE
April 2009
SOURCE
Gut;Apr2009, Vol. 58 Issue 4, p478
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
In this article, the authors discuss the serine protease inhibitor Kazal-type 1(SPINK1), commonly known as pancreatic secretory trypsin inhibitor (PSTI). They note that PSTI was considered as one of the defensive mechanisms against a prematurely activate trypsin-driven digestive zymogen activation cascade. They mention the analysis conducted with SPINK1 in 2000, wherein 14 variants exclusively found in chronic pancreatitis patients were reported.
ACCESSION #
45646916

 

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