Herpes Simplex Virus Type 1 DNA in Human Corneas: What Are the Virological and Clinical Implications?

Hill, James M.; Clement, Christian
July 2009
Journal of Infectious Diseases;7/1/2009, Vol. 200 Issue 1, p1
Academic Journal
The article presents the authors' perspective on a study about the prevalence of herpes simplex virus type 1 (HSV-1) DNA in human cornea tissues, published within the issue. They contend that the study provides additional knowledge about (HSV-1) DNA and offers important clinical information about consequences of HSV-1 DNA in the cornea. They also note that the study's result contributes to the understanding about herpetic keratitis (HK) and penetrating keratoplasty (PKP).


Related Articles

  • Detection of ICP0 protein in tear fluid of individuals with active herpetic epithelial keratitis. Morishige, Naoyuki; Yamada, Naoyuki; Morita, Yukiko; Nakamura, Yoshikuni; Nishida, Teruo; Sonoda, Koh-Hei // Japanese Journal of Ophthalmology;Nov2011, Vol. 55 Issue 6, p591 

    Purpose: Infected cell protein 0 (ICP0) has been detected in the tear fluid of rabbits with herpetic keratitis. Here, we investigated whether ICP0 of herpes simplex virus 1 is detectable in the tear fluid of patients with herpetic epithelial keratitis. Methods: Seven patients with herpetic...

  • The role of common viral ocular pathogens in Thygeson's superficial punctate keratitis. Connell, Paul P.; O'Reilly, James; Coughlan, Suzie; Collum, Louis M. T.; Power, William J. // British Journal of Ophthalmology;Aug2007, Vol. 91 Issue 8, p1038 

    Background/aims: The aetiology of Thygeson's superficial punctate keratitis (TSPK) remains elusive. A viral aetiology has been suggested by the absence of bacterial infection and clinical resemblance to other viral keratopathies. We report the results of polymerase chain reaction analysis for...

  • Pathogenesis and management of herpes simplex virus keratitis. Tullo, A. // Eye;Nov2003, Vol. 17 Issue 8, p919 

    Herpes simplex keratitis (HSK) remains a common cause of unilateral corneal disease. Despite intense research over three decades, the mainstay of therapy continues to be topical and, more recently, systemic acyclovir plus topical corticosteroid in some cases. There is increasing recognition that...

  • Prevalence and Clinical Consequences of Herpes Simplex Virus Type 1 DNA in Human Cornea Tissues. Remeijer, Lies; Rui Duan; van Dun, Jessica M.; Bettink, Mark A. Wefers; Osterhaus, Albert D. M. E.; and Georges M. G. M. Verjans // Journal of Infectious Diseases;7/1/2009, Vol. 200 Issue 1, p11 

    Background. We determined the prevalence and clinical consequences of herpes simplex virus (HSV) type 1 (HSV-1), HSV type 2 (HSV-2), and varicella-zoster virus (VZV) in cornea tissues obtained after penetrating keratoplasty (PKP) was performed. Methods. The excised corneas of 83 patients with a...

  • The outcome of deep anterior lamellar keratoplasty in herpes simplex virus-related corneal scarring, complications and graft survival. M A Awan // British Journal of Ophthalmology;Oct2010, Vol. 94 Issue 10, p1300 

    AIMS: To determine the visual outcome, graft survival and complications after deep anterior lamellar keratoplasty (DALK) in patients with herpes simplex virus (HSV)-related corneal scarring. METHODS: A retrospective analysis of the patients who had DALK for HSV-related corneal scarring between...

  • Infectious Keratitis in the Corneal Graft: Treatment With Partial Conjunctival Flaps. Geria, Roberto; Wainsztein, Ricardo D.; Brunzini, Mario; Brunzini, Ricardo; Geria, Marcos A. // Ophthalmic Surgery, Lasers & Imaging;Jul/Aug2005, Vol. 36 Issue 4, p298 

    BACKGROUND AND OBJECTIVE: The infection of the corneal graft is one of the most serious complications following keratoplasty. In many instances, it can be treated successfully with intensive topical and subconjunctival antibiotics. However, when this therapy is ineffective, a surgical approach...

  • The clinical characteristics of fungal keratitis in eyes after Descemet's stripping and automated endothelial keratoplasty. Kaoru Araki-Sasaki; Atsuko Fukumoto; Yasuhiro Osakabe; Hideya Kimura; Shinichiro Kuroda // Clinical Ophthalmology;2014, Vol. 8, p1757 

    The purpose of this study was to describe the clinical characteristics of fungal keratitis caused by Candida albicans in an eye after Descemet stripping automated endothelial keratoplasty (DSAEK). A 72-year-old male with a history of three trabeculectomies, cataract surgery, and two DSAEK...

  • Aspergillus keratitis following corneal foreign body. Fahad, B.; McKellar, M.; Armstrong, M.; Denning, D.; Tullo, A. // British Journal of Ophthalmology;Jun2004, Vol. 88 Issue 6, p847 

    Recognition, diagnosis, and management of fungal keratitis remain difficult despite significant advances in understanding of the disease. Most fungal keratitis is caused by filamentous fungi with the epidemiology varying throughout the world. It is believed to be rare in Great Britain,...

  • HERPES SIMPLEX VIRUS EPITHELIAL KERATITIS.  // Review of Optometry;4/15/2008 Supplement, Vol. 145, p22A 

    The article offers information about herpes simplex virus (HSV) epithelial keratitis, which occurs in children with bilateral involvement. The HSV infection involves a dendritic ulceration of the corneal epithelium accompanied by a stromal keratitis. This disease can be treated with 1% of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics