Pharmacoepidemiology of insulin initiation in diabetes care

Pogach, Leonard M.
June 2009
CMAJ: Canadian Medical Association Journal;6/23/2009, Vol. 180 Issue 13, p1287
Academic Journal
In this article the author discusses the significance of comprehensive measures to define the exact levels of glycemic control and the benefits and risks of insulin therapy in elderly patients. The author suggests that the use of advanced statistical methods such as total cost evaluation and appropriate clinical judgment presentation might help control biases in future studies. He notes that well-conducted analyses of data may allow simultaneous evaluation of outcomes and quality.


Related Articles

  • Effects of intensive insulin therapy upon pancreatic β cell function in patients newly diagnosed with type II diabetes. Defeng Wang; Li Sun; Guangyao Song; Shuchun Chen // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 1, p1391 

    Objective: This study was designed to evaluate the clinical efficacy of intensive insulin therapy for patients newly diagnosed with type 2 diabetes. Methods: A total of 219 patients newly diagnosed with type 2 diabetes were randomly assigned into insulin group (n = 55), gliclazide group (n =...

  • Adding Pioglitazone to Insulin Containing Regimens in Type 2 Diabetes: Systematic Review and Meta-Analysis. Clar, Christine; Royle, Pamela; Waugh, Norman // PLoS Clinical Trials;Jul2009, Vol. 6 Issue 7, Special section p1 

    Background: Type 2 diabetes is treated in a stepwise manner, progressing from diet and physical activity to oral antidiabetic agents and insulin. The oral agent pioglitazone is licensed for use with insulin when metformin is contraindicated or not tolerated. This systematic review and...

  • Hipoglicemiantes orales para el tratamiento de la diabetes mellitus gestacional. Revisión sistemática de la literatura. Milenko Pavlovic, B.; Jorge Carvajal, C. // Revista Chilena de Obstetricia y Ginecología;May2013, Vol. 78 Issue 3, p167 

    Background: Gestational diabetes mellitus (GDM) is associated to a higher maternal and perinatal risk. Usually GDM is controlled with diet, exercise and insulin. Oral hypoglycaemic agents (OHA) are an emergent therapy for the treatment of GDM. Objectives: Conduct a systematic review of all class...

  • Assessing Quality of Case Series Studies: Development and Validation of an Instrument by Herbal Medicine CAM Researchers. Angela Weihong Yang; Chun Guang Li; Da Costa, Cliff; Allan, Garry; Reece, John; Charlie Changli Xue // Journal of Alternative & Complementary Medicine;May2009, Vol. 15 Issue 5, p513 

    Objectives: When higher level of evidence is absent, findings of case series studies can be used to generate hypotheses for further research. However, to date, there has been no established instrument for determining their quality. This study was to develop and validate an instrument to assess...

  • Anti-Diabetic Medications and the Risk of Hepatocellular Cancer: A Systematic Review and Meta-Analysis. Singh, Siddharth; Singh, Preet Paul; Singh, Abha Goyal; Murad, Mohammad Hassan; Sanchez, William // American Journal of Gastroenterology;Jun2013, Vol. 108 Issue 6, p881 

    Several preclinical and observational studies have shown that anti-diabetic medications (ADMs) can modify the risk of hepatocellular cancer (HCC) in patients with diabetes mellitus (DM). We performed a systematic review and meta-analyses of studies evaluating the effect of metformin,...

  • Do clinicians understand the size of treatment effects? A randomized survey across 8 countries. Johnston, Bradley C.; Alonso-Coello, Pablo; Friedrich, Jan O.; Mustafa, Reem A.; Tikkinen, Kari A. O.; Neumann, Ignacio; Vandvik, Per O.; Akl, Elie A.; da Costa, Bruno R.; Adhikari, Neill K.; Dalmau, Gemma Mas; Kosunen, Elise; Mustonen, Jukka; Crawford, Mark W.; Thabane, Lehana; Guyatt, Gordon H. // CMAJ: Canadian Medical Association Journal;1/1/2016, Vol. 188 Issue 1, p25 

    Background: Meta-analyses of continuous outcomes typically provide enough information for decision-makers to evaluate the extent to which chance can explain apparent differences between interventions. The interpretation of the magnitude of these differences - from trivial to large -...

  • Rivermead Mobility Index: a brief review of research to date. Forlander, D.A.; Bohannon, R.W. // Clinical Rehabilitation;Apr99, Vol. 13 Issue 2, p97 

    Objective: To determine the extent of use of the Rivermead Mobility Index (RMI) in published research and document findings relevant to the RMI in that research. Design: Literature search and document analysis. Results: Eight research articles in which the RMI was used were found. The RMI was...

  • Intra-individual Variability of the Metabolic Effect of Inhaled Insulin Together With an Absorption Enhancer. Heinemann, Lutz; Klappoth, W.; Rave, K.; Hompesch, B.; Linkeschowa, R.; Heise, T. // Diabetes Care;Sep2000, Vol. 23 Issue 9, p1343 

    Discusses a study which investigated the effectiveness of insulin powder inhalation. Research design and methods; Results; Conclusions.

  • Canagliflozin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus. Plosker, Greg // Drugs;May2014, Vol. 74 Issue 7, p807 

    Canagliflozin (Invokanaâ„¢) is an orally administered sodium-glucose co-transporter-2 (SGLT2) inhibitor used in the treatment of patients with type 2 diabetes. By inhibiting the transporter protein SGLT2 in the kidneys, canagliflozin reduces renal glucose reabsorption, thereby increasing...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics