Personalized medicine: A transformative approach is needed
- Another locus, a new method. Singleton, Andrew B.; Gibbs, J. Raphael // Brain: A Journal of Neurology;Dec2010, Vol. 133 Issue 12, p3492
No abstract available.
- Mechanisms of trinucleotide repeat instability during human development. McMurray, Cynthia T. // Nature Reviews Genetics;Nov2010, Vol. 11 Issue 11, p786
Trinucleotide expansion underlies several human diseases. Expansion occurs during multiple stages of human development in different cell types, and is sensitive to the gender of the parent who transmits the repeats. Repair and replication models for expansions have been described, but we do not...
- Personalizing Prevention: The U.S. Surgeon General's Family History Initiative. Carmona, Richard H.; Wattendorf, Daniel J. // American Family Physician;1/1/2005, Vol. 71 Issue 1, p36
Focuses on the benefits that the Human Genome Project has made in identifying genetic variations that contribute to the risk for common diseases in the U.S. Steps that could prevent chronic diseases; Susceptibilities to diseases that many families share; Causes most often cited for common diseases.
- Diseases Are Due Mainly to Rare Variants, Study Hints. // Bioworld Week;4/18/2011, Vol. 19 Issue 16, p1
The article discusses the etiology of various diseases based on a study conducted by a team of researchers. It notes that the result of the study reveals that etiologies of these diseases are generally not from a common genetic makeup but from a rare genetic variants. These rare variants were...
- Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature. Zhenglun Pan; Trikalinos, Thomas A.; Kavvoura, Fotini K.; Lau, Joseph; Ioannidis, John P. A. // PLoS Medicine;Dec2005, Vol. 2 Issue 12, pe334
Background: Postulated epidemiological associations are subject to several biases. We evaluated whether the Chinese literature on human genome epidemiology may offer insights on the operation of selective reporting and language biases. Methods and Findings: We targeted 13 gene-disease...
- Translating Cancer Genomics into Clinical Oncology. Ramaswamy, Sridhar // New England Journal of Medicine;4/29/2004, Vol. 350 Issue 18, p1814
Presents a perspective on translating cancer genomics into clinical oncology. How medicine is changing due to the increased understanding of the human genome; Belief this change will transform clinical practice from population-based risk assessment to an empirical treatment of an individualized...
- Challenges for the Development of New Treatments for Severe Asthma: A Pharmaceutical Perspective. Knowles, Richard G. // Current Pharmaceutical Design;3/1/2011, Vol. 17 Issue 7, p699
No abstract available.
- Protein and non-protein biomarkers in melanoma: a critical update. Tandler, Nadine; Mosch, Birgit; Pietzsch, Jens // Amino Acids;Dec2012, Vol. 43 Issue 6, p2203
Melanoma is the most malignant type of all skin neoplasms. Its worldwide incidence has steadily increased during the past decades, suggesting a probable melanoma 'epidemic'. Although current clinical, morphologic, and histopathologic methods provide insights into disease behavior and outcome,...
- Distinct patterns and behaviour of urothelial carcinoma with respect to anatomical location: how molecular biomarkers can augment clinico-pathological predictors in upper urinary tract tumours. Yates, David; Catto, James // World Journal of Urology;Feb2013, Vol. 31 Issue 1, p21
Purpose: Upper urinary tract urothelial carcinoma (UTUC) shares many similarities with bladder-UC, but there is strong evidence on a clinical, aetiological, epidemiological and genetic level that key differences exist. In this review, we aim to highlight how UTUC differs from bladder-UC and...