Treatment of Methamphetamine Dependence
- Letter to the Editor: Sequence-specific 1H, 13C and 15N resonance assignments of human GABA receptor associated protein. Stangler, Thomas; Mayr, Lorenz M.; Dingley, Andrew J.; Luge, Cornelia; Willbold, Dieter // Journal of Biomolecular NMR;Oct2001, Vol. 21 Issue 2, p183
Presents a letter to the editor about a human GABA receptor associated protein.
- Independent evidence for the selective influence of GABAA receptors on one component of the bipolar disorder phenotype. Breuer, R.; Hamshere, M. L.; Strohmaier, J.; Mattheisen, M.; Degenhardt, F.; Meier, S.; Paul, T.; O'Donovan, M. C.; Mühleisen, T. W.; Schulze, T. G.; Nöthen, M. M.; Cichon, S.; Craddock, N.; Rietschel, M. // Molecular Psychiatry;Jun2011, Vol. 16 Issue 6, p587
A letter to the editor is presented which discusses the independent evidence of y-aminobutyric acid (GABA)A receptor genes in the component of the bipolar disorder (BD) phenotype which is schizophrenia-like psychotic symptoms.
- Expression cloning of GABAb receptors uncovers similarity to metabotropic glutamate receptors. Kaupmann, Klemens; Huggel, Katharina // Nature;3/20/1997, Vol. 386 Issue 6622, p239
Reports on the expression cloning of gamma-amino-butyric acid (GABA) type B receptor complementary DNA. The design of a high-affinity GABA type B receptor antagonist; GABA type B receptor-specific radioligands; Labelling of native GABA type B receptors; GABA type B receptors and metabotropic...
- GABA A receptor needs two homologous domains of the Beta-subunit for activation by GABA but not... Amin, Jahanshah; Weiss, David S. // Nature;12/9/1993, Vol. 366 Issue 6455, p565
Reports the identification of two separate and homologous domains of the beta-subunit, each of which contributes a tyrosine and threonine essential for activation by gamma-aminobutyric acid (GABA). Evidence which suggests that the two identified domains of the beta-subunit contribute a major...
- Validation of GABAA Receptor Subtypes as Potential Drug Targets by Using Genetically Modified Mice. Thomas W. Rosahl // Current Drug Targets - CNS & Neurological Disorders;Aug2003, Vol. 2 Issue 4, p207
A key issue for drug discovery in the post genomic era is target validation. This is particularly important when considering the CNS, where currently the majority of drug targets are neurotransmitter receptors that are known to exist as multi-gene families. The GABAergic system, which is the...
- GABAC Receptors as Drug Targets. Graham A.R. Johnston; Mary Chebib; Jane R. Hanrahan; Kenneth N. Mewett // Current Drug Targets - CNS & Neurological Disorders;Aug2003, Vol. 2 Issue 4, p260
GABAC receptors are the least studied of the three major classes of GABA receptors. The physiological roles of GABAC receptors are still being unravelled and the pharmacology of these receptors is being developed. A range of agents has been described that act on GABAC receptors with varying...
- Association Analysis of Exonic Variants of the GABA[sub B]-Receptor Gene and Alpha Electroencephalogram Voltage in Normal Subjects and Alcohol-Dependent Patients. Winterer, Georg; Mahlberg, Richard; Smolka, Michael N.; Samochowiec, Jerzy; Ziller, Mario; Rommelspacher, Hans-Peter; Herrmann, Werner M.; Schmidt, Lutz G.; Sander, Thomas // Behavior Genetics;
Based on pharmacologic evidence, it has been suggested that GABA[sub B] receptors may play a crucial role in the generation of alpha-electroencephalogram (EEG) oscillations. We tested whether three exonic variants of the gene encoding the human GABA[sub B] receptor (GABA[sub B]R1) modify...
- Identification of small aromatic ligands to GABA-A receptor associated protein GABARAP. Stangler, Thomas; Mohrl�der, Jeaninne; Hoffmann, Yvonne; Willbold, Dieter // BMC Neuroscience;2007 Supplement 1, Vol. 8, pP20
An abstract of the paper "Identification of Small Aromatic Ligands to GABA-A Receptor Associated Protein GABARAP," by Thomas Stangler, Yvonne Hoffmann, and colleagues is presented.
- Medicinal Chemistry and Molecular Pharmacology of GABA-C Receptors. Johnston, Graham A.R. // Current Topics in Medicinal Chemistry;Aug2002, Vol. 2 Issue 8, p903
GABA-C receptors belong to the nicotinicoid superfamily of ionotropic receptors that include nicotinic acetylcholine receptors, bicuculline-sensitive GABA-A receptors, strychnine-sensitive glycine receptors and 5HT3 serotonin receptors. The GABA-C receptor concept arose from medicinal chemical...