Glucocorticoid receptor isoform expression does not predict steroid treatment response in IBD
- EXPRESSION OF GLUCOCORTICOID RECEPTORS AND CYCLOOXYGENASE-2 IN NASAL POLYPS FROM NONALLERGENIC PATIENTS. Byung-heon Lee; Chang-bae Yun; Jang, Tae-jung // Annals of Otology, Rhinology & Laryngology;Jan2002, Vol. 111 Issue 1, p61
Examines the presence of glucocorticoid receptors (GRs) and cyclooxygenase-2 (COX-2) in the nasal polyps of nonallegic patients. Presence of COX-2 in the cytoplasm of surface mucosa; Association of GR labelling to the cytoplasm and nucleus of surface mucosa; Treatment suggested.
- High penetrance, overweight, and glucocorticoid receptor variant: case control study. Lin, Ruby C. Y.; Wang, William Y. S.; Morris, Brian J. // BMJ: British Medical Journal (International Edition);11/20/99, Vol. 319 Issue 7221, p1337
Provides information on a study on the possible link between the glucocorticoid receptor gene and overweight in families with morbid obesity. Method and results; Comment on the study.
- Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. T. Rein; J.C. Young; W.M.J. Obermann; A. Brychzy; K.F. Winklhofer; F.U. Hartl // EMBO Journal;7/15/2003, Vol. 22 Issue 14, p3613
In the eukaryotic cytosol, Hsp70 and Hsp90 cooperate with various co-chaperone proteins in the folding of a growing set of substrates, including the glucocorticoid receptor (GR). Here, we analyse the function of the co-chaperone Tpr2, which contains two chaperone-binding TPR domains and a DnaJ...
- In vivo analysis of the model tyrosine aminotransferase gene reveals multiple sequential steps in glucocorticoid receptor action. Grange, Thierry; Cappabianca, Lucia; Flavin, Michèle; Sassi, Habib; Thomassin, Hélène // Oncogene;5/28/2001 Review, Vol. 20 Issue 24, p3028
We are studying the mechanisms of transcriptional activation by nuclear receptors and we focus our studies on the glucocorticoid regulation of the model tyrosine aminotransferase gene. Rather than using in vitro biochemical approaches, we determine the actual events occurring in the cells. Our...
- Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. Cha, Hee-Jae; Park, Moon-Taek; Chung, Hae-Young; Kim, Nam Deuk; Sato, Hiroshi; Seiki, Motoharu; Kim, Kyu-Won // Oncogene;2/12/98, Vol. 16 Issue 6, p771
We have previously reported that ursolic acid, a pentacyclic triterpene acid, inhibited the invasion of HT1080 human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9. Since the chemical structure of ursolic acid is very similar to that of dexamethasone, a synthetic...
- Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus. Yan, Kunimasa; Kudo, Akihiko; Hirano, Hiroshi; Watanabe, Takashi; Tasaka, Tetsuya; Kataoka, Saeko; Nakajima, Noriko; Nishibori, Yukino; Shibata, Toru; Kohsaka, Takao; Higashihara, Eiji; Tanaka, Hirotoshi; Watanabe, Hidehiro; Nagasawa, Toshihiko; Awa, Shouichi // Kidney International;Jul1999, Vol. 56 Issue 1, p65
Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus. Background.The detailed mechanisms of glucocorticoid action in idiopathic nephrotic syndrome and progressive glomerulonephritides have not been clearly elucidated. The pharmacological actions of...
- Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Fryer, Christy J.; Archer, Trevor K. // Nature;5/7/1998, Vol. 393 Issue 6680, p88
Reports on research into the assembly of transcriptional DNA sequences into chromatin, which plays a fundamental role in modulating gene expression. How the promotor of the mouse mammary tumor virus (MMTV) is packaged into a regular array of nucleosomes;Findings; Results.
- Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans. Yuan Zhang, Tie; Labonté, Benoit; Lan Wen, Xiang; Turecki, Gustavo; Meaney, Michael J // Neuropsychopharmacology;May2013, Vol. 38 Issue 6, p1140
A correction to the article "Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans" by Tie Yuan Zhang, Gustavo Turecki and colleagues that was published in the September 12, 2012 issue is presented.
- The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Connell, Patrice; Ballinger, Carol A.; Jiang, Jihong; Wu, Yaxu; Thompson, Larry J.; Höhfeld, Jörg; Patterson, Cam // Nature Cell Biology;Jan2001, Vol. 3 Issue 1, p93
To maintain quality control in cells, mechanisms distinguish among improperly folded peptides, mature and functional proteins, and proteins to be targeted for degradation. The molecular chaperones, including heat-shock protein Hsp90, have the ability to recognize misfolded proteins and assist in...