TITLE

Bone Metastasis: Can osteoclasts be excluded? (Reply)

AUTHOR(S)
Jones, D. Holstead; Nakashima, Tomoki; Sanchez, Otto H.; Kozieradzki, Ivona; Komarova, Svetlana V.; Sarosi, Ildiko; Morony, Sean; Rubin, Evelyn; Sarao, Renu; Hojilla, Carlo V.; Komnenovic, Vukoslav; Young-Yun Kong; Schreiber, Martin; Dixon, S. Jeffrey; Sims, Stephen M.; Khokha, Rama; Wada, Teiji; Penninger, Josef M.
PUB. DATE
February 2007
SOURCE
Nature;2/22/2007, Vol. 445 Issue 7130, p19
SOURCE TYPE
Academic Journal
DOC. TYPE
Letter
ABSTRACT
Martin and Mundy emphasize the crucial role played by osteoclasts in the metastasis of many tumour types to bone. Our intention was not to question the importance of osteoclasts in bone metastases, but rather to show that RANK ligand (RANKL) exerts additional action on cancer cells beyond its effects on osteoclasts. We reported that epithelial tumour cells can express RANK, a finding that is supported by earlier work; that RANKL has chemotactic activity; and that in vivo inhibition of RANKL by osteoprotegerin reduces tumour burden in bone when assessed in a previously published experimental system.
ACCESSION #
24110165

 

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