TITLE

Tumor Necrosis Factor-γ Is Associated With Increased Protein C Activation in Nonobese Type 2 Diabetic Patients

AUTHOR(S)
Yano, Yutaka; Gabazza, Esteban C.; Kitagawa, Nagako; Bruno, Nelson E.; Matsumoto, Kazutaka; Nakatani, Kaname; Araki, Rika; Katsuki, Akira; Adachi, Yukihiko; Sumida, Yasuhiro
PUB. DATE
March 2004
SOURCE
Diabetes Care;Mar2004, Vol. 27 Issue 3, p844
SOURCE TYPE
Academic Journal
DOC. TYPE
Letter
ABSTRACT
Examines the association of the tumor necrosis factors on the increase of the activation of protein C in nonobese type 2 diabetic patients. Causes of vascular injury; Risks of inflammation; Level of survival.
ACCESSION #
12421143

 

Related Articles

  • Use of Thiazolidinediones and Risk of Heart Failure in People With Type 2 Diabetes: A Retrospective Cohort Study. Karter, Andrew J.; Ahmed, Ameena T.; Liu, Jennifer; Moffet, Howard O.; Parker, Melissa M.; Ferrara, Assiamira; Selby, Joe V. // Diabetes Care;Mar2004, Vol. 27 Issue 3, p850 

    Presents a comment on the study determining the effects of thiazolidinedione drugs on patients with type 2 diabetes. Increase on the risks of coronary heart disease; Factors influencing the rise on the level of mortality rate; Survival of the patients.

  • Anti-PD1 Pembrolizumab Can Induce Exceptional Fulminant Type 1 Diabetes. Gaudy, Caroline; Clévy, Céline; Monestier, Sandrine; Dubois, Noémie; Préau, Yanis; Mallet, Stéphanie; Richard, Marie-Aleth; Grob, Jean-Jacques; Valéro, René; Béliard, Sophie // Diabetes Care;Nov2015, Vol. 38 Issue 11, pe182 

    The article presents research which focused on the possibility that anti-PD1 pembrolizumab induces type 1 diabetes. Topics covered include the function of pembrolizumab as a monoclonal antibody that prevents PD1. Also mentioned is the importance of the antibody to enhance the survival of...

  • Feed-forward signaling of TNF-α and NF-κB via IKK-β pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice.  // Advances in Psoriasis & Inflammatory Skin Diseases;2010, Vol. 1 Issue 3, p112 

    A statistical association between insulin resistance, cardiovascular diseases, and psoriasis is now well established, but a causal relationship has not been clarified. In patients with psoriasis, the development of some of these associated diseases is thought to be caused by factors such as...

  • Increased Proinflammatory TNFα Converting Enzyme (TACE) in Skeletal Muscle Plays a Role in Insulin Resistance in Human Type 2 Diabetes Mellitus (T2DM). Monroy, Adriana; Federici, Massimo; Menghini, Rosella; Chavez-Velazquez, Alberto O.; Frolich, Victoria; Svrijiitamol, Apiradi; Barrentine, Andrea; Coletta, Dawn; Musi, Nicolas; Tripathy, Devjit; Defronzo, Ralph A.; Folli, Franco // Diabetes;Jun2007 Supplement 1, Vol. 56, pA396 

    Circulating tumor necrosis factor-α(TNFα) levels are increased in obesity, T2DM and insulin resistance (IR) states. In vivo the plasma TNFα concentration is regulated by the cleaving action of TACE on pro-TNFα, and the cleaving activity of TACE is inhibited by tissue inhibitor of...

  • The Acute Effects of Low-Dose TNF-α on Glucose Metabolism and β-Cell Function in Humans. Ibfelt, Tobias; Fischer, Christian P.; Plomgaard, Peter; van Hall, Gerrit; Pedersen, Bente Klarlund // Mediators of Inflammation;2014, Vol. 2014, p1 

    Type 2 diabetes is characterized by increased insulin resistance and impaired insulin secretion. Type 2 diabetes is also associated with low-grade inflammation and increased levels of pro inflammatory cytokines such as TNF-α. TNF-α has been shown to impair peripheral insulin signaling in...

  • Meta-Analysis of TNF 308 G/A Polymorphism and Type 2 Diabetes Mellitus. Ren-Nan Feng; Chen Zhao; Chang-Hao Sun; Ying Li // PLoS ONE;2011, Vol. 6 Issue 4, p1 

    Background and Objectives: Many investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this...

  • TNFR1 levels highly correlated with ESRD risk in T2D.  // Diabetes Digest;2012, Vol. 11 Issue 3, p159 

    The article discusses a study to evaluate the efficacy of circulating TNF receptors 1 and 2 to predict end-stage renal disease (ESRD) in people with type 2 diabetes (T2D), which found that a 12-year ESRD risk can be estimated from a single TNFR1 measurement.

  • Effect of Aerobic Exercise Training on MDA and TNF-α Levels in Patients with Type 2 Diabetes Mellitus. Arslan, Mihriban; Ipekci, Suleyman Hilmi; Kebapcilar, Levent; Dede, Nesrin Dogan; Kurban, Sevil; Erbay, Ekrem; Gonen, Mustafa Sait // ISRN Otolaryngology;2014, p1 

    Objective. Diabetes mellitus (DM) is associated with low-grade inflammation. The benefits of regular exercise for the DM are well established, whereas less is known about the impact of aerobic exercise on malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) in the DM. Methods. We...

  • Postprandial Increase in IL 6 and TNFα Is Reduced by a Basal + Prandial Insulin Regimen Compared With a Basal Insulin Regimen in Type 2 Diabetes (T2D) Patients. Tan, Meng H.; Brown, W. Virgil; Goldberg, Ronald B.; Ceriello, Antonio; Beisswenger, Paul J.; Le, Ngoc-Anh; Sarwat, Samiha; Jones, Cate A.; Milicevic, Zvonko; Robbins, David C. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA174 

    We compared the effects of basal+prandial insulin lispro mid mix (MM) (50% NPL, 50% lispro) ac tid with basal insulin glargine (G) hs, both plus metformin (Met), on postprandial (pp) blood glucose (BG), insulin, and inflammatory markers (IL 6 and TNFα) in T2D patients before and after 24 wks...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics