TITLE

Preexisting TP53 mutation in therapy-related acute myeloid leukemia

AUTHOR(S)
Schulz, Eduard; Kashofer, Karl; Heitzer, Ellen; Mhatre, Ketaki; Speicher, Michael; Hoefler, Gerald; Sill, Heinz
PUB. DATE
March 2015
SOURCE
Annals of Hematology;Mar2015, Vol. 94 Issue 3, p527
SOURCE TYPE
Academic Journal
DOC. TYPE
Letter
ABSTRACT
The article presents a case study of a 71 year-old male Caucasian patient suffering from Hodgkin lymphoma treated with chemotherapy and radiotherapy. According to classification of the World Health Organization (WHO) therapy-related myeloid neoplasms caused due to mutational events in hematopoietic stem and precursor cells induced by therapy-related treatment. The case also highlights that cytotoxic treatment does not induce leukemia specific mutation in TP53 protein.
ACCESSION #
100798995

 

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