RE: A Cancer Theory Kerfuffle Can Lead to New Lines of Research

Baker, Stuart G.
May 2015
JNCI: Journal of the National Cancer Institute;5/13/2015, Vol. 107 Issue 5, p1
Academic Journal
Letter to the Editor
A response from the author of the article "A Cancer Theory Kerfuffle Can Lead to New Lines of Research" in the 2015 issue is presented.


Related Articles

  • RE: A Cancer Theory Kerfuffle Can Lead to New Lines of Research. Kaye, Frederic J. // JNCI: Journal of the National Cancer Institute;5/13/2015, Vol. 107 Issue 5, p1 

    A letter to the editor is presented in response to the article "A Cancer Theory Kerfuffle Can Lead to New Lines of Research" by S. G. Baker in the 2015 issue.

  • The PIK3CA Gene as a Mutated Target for Cancer Therapy. Gustin, John P.; Cosgrove, David P.; Park, Ben Ho // Current Cancer Drug Targets;Dec2008, Vol. 8 Issue 8, p733 

    The development of targeted therapies with true specificity for cancer relies upon exploiting differences between cancerous and normal cells. Genetic and genomic alterations including somatic mutations, translocations, and amplifications have served as recent examples of how such differences can...

  • A comprehensive, sensitive and economical approach for the detection of mutations in the RB1 gene in retinoblastoma. PARSAM, VIDYA LATHA; KANNABIRAN, CHITRA; HONAVAR, SANTOSH; VEMUGANTI, GEETA K.; ALI, MOHAMMAD JAVED // Journal of Genetics;Dec2009, Vol. 88 Issue 4, p517 

    Retinoblastoma (Rb) is the most common primary intraocular malignancy in children. It is brought about by the mutational inactivation of both alleles of RB1 gene in the developing retina. To identify the RB1 mutations, we analysed 74 retinoblastoma patients by screening the exons and the...

  • BRAF mutations may lead to cetuximab, panitumumab resistance. Lawrence, Leah // Hem/Onc Today;11/25/2008, Vol. 9 Issue 21, p35 

    The article discusses research being done on metastatic colorectal cancer patients with a mutation in the BRAF gene. It references a study by Federica Di Nicolantonio and colleagues, presented at the 20th European Organization for Research and Treatment of Cancer (EORTC)-National Cancer...

  • Unwrapping the Implications of BRCA1 and BRCA2 Mutations in Ovarian Cancer. Hyman, David M.; Spriggs, David R. // JAMA: Journal of the American Medical Association;1/25/2012, Vol. 307 Issue 4, p408 

    The article looks at the implications of mutations in BRCA1 and BRCA2 genes for ovarian cancer. It references the study "Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer," by K. L. Bolton et al. published within the issue. The study...

  • Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes. Khokhar, Shama K.; Kommagani, Ramakrishna; Kadakia, Madhavi P. // Cell Research;Oct2008, Vol. 18 Issue 10, p1061 

    p63, known to play a role in development, has more recently also been implicated in cancer progression. Mutations in p63 have been shown to be responsible for several human developmental diseases. Differential splicing of the p63 gene gives rise to p63 isoforms, which can act either as tumor...

  • Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes and LATS1 LATS2 in Human Cancer. Tian Yu; Bachman, John; Zhi-Chun Lai // Genetics;Nov2013, Vol. 195 Issue 3, p1193 

    The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from...

  • A simple consensus approach improves somatic mutation prediction accuracy. Goode, David L.; Hunter, Sally M.; Doyle, Maria A.; Tao Ma; Rowley, Simone M.; Choong, David; Ryland, Georgina L.; Campbell, Ian G. // Genome Medicine;2013, Vol. 5 Issue 9, p90 

    Differentiating true somatic mutations from artifacts in massively parallel sequencing data is an immense challenge. To develop methods for optimal somatic mutation detection and to identify factors influencing somatic mutation prediction accuracy, we validated predictions from three somatic...

  • Analysis of the genome to personalize therapy for melanoma. Davies, M A; Samuels, Y // Oncogene;10/14/2010, Vol. 29 Issue 41, p5545 

    The treatment of cancer is being revolutionized by an improved understanding of the genetic events that occur in tumors. Advances in the understanding of the prevalence and patterns of mutations in melanoma have recently led to impressive results in trials of personalized, targeted therapies for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics