Biochemical and physiological mechanisms of female genital sexual arousal

Traish, Abdulmaged M.; Kim, Noel M.; Munarriz, Ricardo; Moreland, Robert; Goldstein, Irwin; Kim, Noel N
October 2002
Archives of Sexual Behavior;Oct2002, Vol. 31 Issue 5, p393
Academic Journal
journal article
Limited studies are available concerning physiological and biochemical mechanisms involved in female sexual function and dysfunction. The paucity of physiological and biochemical data pertaining to genital sexual arousal function is attributed, in part, to lack of reliable experimental models and tools for the investigation of female sexual arousal. This review summarizes research efforts from a number of laboratories in which several experimental models have been established. These include the development of in vivo animal models, organ bath studies, and the establishment of cell cultures. The availability of such experimental model systems have facilitated efforts aimed at defining the neurotransmitters responsible for vaginal smooth muscle relaxation, the role of sex steroid hormones and their receptors in modulating genital hemodynamics, smooth muscle contractility, and neurotransmitter receptor expression. A comprehensive and integral understanding of female sexual function requires detailed investigation of the vascular, neurological (central and peripheral), and structural components of this complex physiological process.


Related Articles

  • Positive Feelings for Private Parts.  // USA Today Magazine;Feb2010, Vol. 138 Issue 2777, p4 

    The article discusses a study by Debby Herbenick, associate director of the Center for Sexual Health Promotion in the School of Health, Physical Education and Recreation at Indiana Universty, Bloomington, which found that women who feel positively about the female genitalia experience more...

  • The physiology of sexual arousal in the human female: a recreational and procreational synthesis. Levin, Roy J. // Archives of Sexual Behavior;Oct2002, Vol. 31 Issue 5, p405 

    Changes induced by human sexual arousal serve reproductive and recreational functions. The current sexual phase model (desire, excitation, orgasm, and resolution) conveys little about this duarchy. Lack of spontaneous sexual desire in a third of nonclinic females indicates that the D phase needs...

  • Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women. Jason Yen-Ping Ho; Ming-Jer Chen; Wayne Huey-Herng Sheu; Yu-Chiao Yi; Andy Chi-Wei Tsai; Hwa-Fen Guu; Esther Shih-Chu Ho // Human Reproduction;Oct2006, Vol. 21 Issue 10, p2715 

    BACKGROUND: Recent studies have revealed that HRT may increase the risk for atherosclerotic vascular disease (ASVD). METHODS: We investigated the effects of HRT via different administration routes on the markers for ASVD and endothelial function in healthy postmenopausal women. The oral HRT...

  • Orgasms for All! Wexler, Sarah Z. // Women's Health;Nov2015, Vol. 12 Issue 9, p112 

    The article presents information on female orgasm parts that provides pleasure for most women. It is mentioned that urethal opening located a smidge under the clitoris possibly ejaculate for more of women who squirt during orgasm or 10% of women. It is noted that 8,000 supersensitive nerves are...


    Presents 25 facts about the female genitalia. Average depth of vagina; Number of orgasms that ancient Egyptian Cleopatra had every day; Percentage of women who are capable of multiple orgasm, according to Kinsey Report of 1953; Reason orgasm help relieve menstrual cramps.

  • Treatment of Labial Fusion with Topical Estrogen Therapy. Leung, Alexander K. C.; Robson, W. Lane M.; Kao, C. Pion; Liu, Edmond K. H.; Fong, Justine H. S. // Clinical Pediatrics;Apr2005, Vol. 44 Issue 3, p245 

    Twenty girls with labial fusion that covered at least 50% of the vaginal opening were treated with a topical estrogen cream. The cream was precisely applied to the fused area twice a day until the adhesions were totally lysed. After separation of the adhesions, a petroleum ointment...

  • Menopause: Understanding the Reproductive Cycle: What You Should Know Before Going to the Doctor. Kopel, Ann // Frontiers: A Journal of Women Studies;1998, Vol. 19 Issue 1, p1 

    The article focuses on menopause and how the reproductive cycle works during this period. Each month, during the reproductive years, estrogen levels vary from the beginning to the end of the cycle. It is low in the beginning. This triggers the hypothalamus to send a messenger hormone to the...

  • Development of the Mammalian Female Reproductive Tract. Yan Yin; Liang Ma // Journal of Biochemistry;Jun2005, Vol. 137 Issue 6, p677 

    The female reproductive tract (FRT), which includes the oviduct, uterus, cervix and vagina, is critical for mammalian reproduction. Recent research using knockout mice has contributed substantially to our understanding of the molecular mechanisms governing FRT development. Aside from satisfying...

  • A look at the causes of premenstrual dysphoric disorder.  // Patient Care for the Nurse Practitioner;Aug2003, Vol. 6 Issue 8, p12 

    The article examines the cases of premenstrual dysphoric disorder (PMDD). There is some evidence that gamma-aminobutyric acid, endogenous opiates, allopregnanolone, and various vitamins and minerals might play roles in severe premenstrual syndrome and PMDD. Women with PMDD may metabolize...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics