Epstein-Barr virus and human malignancy

Ziegler, John L.; Magrath, Ian T.; Gerber, Paul; Levine, Paul H.; Ziegler, J L; Magrath, I T; Gerber, P; Levine, P H
March 1977
Annals of Internal Medicine;Mar77, Vol. 86 Issue 3, p323
Academic Journal
journal article
The association of the Epstein-Barr virus and two human malignancies, Burkitt's lumphoma and nasopharyngeal carcinoma, is reviewed. Seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the Epstein-Barr virus in these tumors are presented. With our current state of knowledge we cannot conclude that the Ipstein-Barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its association with Burkitt's lymphoma and nasopharyngeal carcinoma.


Related Articles

  • Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma. Oduor, Cliff I.; Movassagh, Mercedeh; Kaymaz, Yasin; Chelimo, Kiprotich; Otieno, Juliana; Ong'echa, John M.; Moormann, Ann M.; Bailey, Jeffrey A. // Frontiers in Microbiology;3/28/2017, Vol. 8, p1 

    Endemic Burkitt lymphoma (eBL) is an aggressive B cell lymphoma and is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum malaria co-infections. Central to BL oncogenesis is the over-expression of the MYC proto-oncogene which is caused by a translocation of an Ig enhancer in...

  • Phenotypes of B Cells Differ in EBV-positive Burkitt's lymphoma Derived Cell Lines. Spaka, Irina; Birkenfelde, Rita; Kozireva, Svetlana; Osmjana, Jevgenija; Upmane, Madara; Kashuba, Elena; Kholodnyuk Holodnuka, Irina // World Academy of Science, Engineering & Technology;2012, Issue 72, p1569 

    Epstein-Barr virus (EBV) is implicated in the pathogenesis of the endemic Burkitt's lymphoma (BL). The EBVpositive BL-derived cell lines initially maintain the original tumor phenotype of EBV infection (latency I, LatI), but most of them drift toward a lymphoblast phenotype of EBV latency III...

  • Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders. Yoojin Kwun; Soo-Jong Hong; Jin Seong Lee; Da Hye Son; Jong Jin Seo // Korean Journal of Pediatrics;2014, Vol. 57 Issue 9, p420 

    The Epstein-Barr virus (EBV) is oncogenic and can transform B cells from a benign to a malignant phenotype. EBV infection is also associated with lymphoid interstitial pneumonia (LIP). Here, we report the case of a 14-year-old boy who was diagnosed with a latent EBV infection and underlying LIP,...

  • Difference of Epstein–Barr virus isolates from Japanese patients and African Burkitt’s lymphoma cell lines based on the sequence of latent membrane protein 1. Kyosuke Kanai; Yukio Satoh; Yuriko Saiki; Haruo Ohtani; Takeshi Sairenji // Virus Genes;Jan2007, Vol. 34 Issue 1, p55 

    Abstract??Sequence variations in the Epstein?Barr virus (EBV) latent membrane protein 1 (LMP1) gene have been described in many EBV-isolates. To characterize the genomic relationship between Japanese EBV and the EBV isolates of other countries, we analyzed the LMP1 nucleotide sequences in EBV...

  • Epstein-Barr virus and Burkitt lymphoma. Brady, G.; MacArthur, G. J.; Farell, P. J. // Journal of Clinical Pathology;Dec2007, Vol. 60 Issue 12, p1397 

    Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and...

  • Epstein–Barr virus–associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2. Kelly, Gemma; Bell, Andrew; Rickinson, Alan // Nature Medicine;Oct2002, Vol. 8 Issue 10, p1098 

    Epstein-Barr virus (EBV) is etiologically linked to endemic Burkitt lymphoma (BL), but its contribution to lymphomagenesis, versus that of the chromosomal translocation leading to c-myc gene deregulation, remains unclear. The virus's growth-transforming (Latency III) program of gene expression...

  • The AT-rich region between -54 to -66 is important for the promoter activity of interleukin-10 in Epstein–Barr virus positive Burkitt’s lymphoma cells. Kube, D; Laser, H; von Knethen, A; Tesch, H // Genes & Immunity;Nov99, Vol. 1 Issue 2, p105 

    IL-10 is an important regulatory cytokine. The recent characterization of the 5'-flanking region of IL-10 led to the identification of the promoter region. The infection of B cells with EBV induces IL-10 production which may contribute to EBV-induced transformation. In the present report, IL-10...

  • Epstein-Barr Virus. Manet, Evelyne // Encyclopedic Reference of Cancer;2001, p296 

    A definition of the term "Epstein-Barr Virus" is presented. It refers to the first virus isolated from a human tumor, the Burkitt lymphoma. It is described as a lymphotropic herpesvirus widely spread in the human population. 90 to 95 percent of adults possess antibodies against the virus. The...

  • Burkitt Lymphoma: Pathogenesis and Immune Evasion. God, Jason M.; Haque, Azizul // Journal of Oncology;2010, p1 

    B-cell lymphomas arise at distinct stages of cellular development andmaturation, potentially influencing antigen (Ag) presentation and T-cell recognition. Burkitt lymphoma (BL) is a highly malignant B-cell tumor associated with Epstein-Barr Virus (EBV) infection. Although BL can be effectively...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics