Mixture models for quantitative HIV RNA data

Moulton, Lawrence H; Curriero, Frank C; Barroso, Paulo F
August 2002
Statistical Methods in Medical Research;Aug2002, Vol. 11 Issue 4, p317
Academic Journal
journal article
Clinical investigators are increasing their use of quantitative determinations of HIV viral load in their study populations. The distributions of these measures may be highly skewed, left-censored, and with an extra spike below the detection limit of the assay. We recommended use of a mixture model in this situation, with two sets of explanatory covariates. We extend this model to incorporate multiple measures across time, and to employ shared parameters as a way of increasing model efficiency and parsimony. Data from a cohort of HIV-infected men are used to illustrate these features, and simulations are performed to assess the utility of shared parameters.


Related Articles

  • Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi. Kwiek, Jesse J.; Mwapasa, Victor; Milner, Danny A.; Alker, Alisa P.; Miller, William C.; Tadesse, Eyob; Molyneux, Malcolm E.; Rogerson, Stephen J.; Meshnick, Steven R.; Milner, Danny A Jr // PLoS Medicine;Jan2006, Vol. 3 Issue 1, pe10 

    Background: Between 25% and 35% of infants born to HIV-infected mothers become HIV-1 infected. One potential route of mother-to-child transmission (MTCT) could be through a breakdown in the placental barrier (i.e., maternal-fetal microtransfusions).Methods and Findings:...

  • High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals With or at Risk for HIV Infection. Beachler, Daniel C.; Yingshi Guo; Wiehong Xiao; Burk, Robert D.; Minkoff, Howard; Strickler, Howard D.; Cranston, Ross D.; Wiley, Dorothy J.; Jacobson, Lisa P.; Weber, Kathleen M.; Margolick, Joseph B.; Sugar, Elizabeth A.; Reddy, Susheel; Gillison, Maura L.; D'Souza, Gypsyamber; Guo, Yingshi; Xiao, Wiehong // Journal of Infectious Diseases;11/15/2015, Vol. 212 Issue 10, p1588 

    The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected...

  • Food insecurity is associated with incomplete HIV RNA suppression among homeless and marginally housed HIV-infected individuals in San Francisco. Weiser, Sheri D.; Frongillo, Edward A.; Ragland, Kathleen; Hogg, Robert S.; Riley, Elise D.; Bangsberg, David R. // JGIM: Journal of General Internal Medicine;Jan2009, Vol. 24 Issue 1, p14 

    Background and Objectives: There is growing international concern that food insecurity may negatively impact antiretroviral (ARV) treatment outcomes, but no studies have directly evaluated the effect of food insecurity on viral load suppression and antiretroviral adherence. We...

  • Dyslipidaemia in HIV-infected patients: association with adherence to potent antiretroviral therapy. Vergis, Emanuel N.; Paterson, David L.; Wagener, Marilyn M.; Swindells, Susan; Singh, Nina; Vergis, E N; Paterson, D L; Wagener, M M; Swindells, S; Singh, N // International Journal of STD & AIDS;Jul2001, Vol. 12 Issue 7, p463 

    Metabolic complications are being increasingly recognized among HIV-infected patients treated with potent combination antiretroviral therapies. We sought to assess the association of dyslipidaemia with adherence to protease inhibitor (PI) therapy and with the markers of clinical response to...

  • Food insecurity is associated with poor virologic response among HIV-infected patients receiving antiretroviral medications. Wang, Emily A.; McGinnis, Kathleen A.; Fiellin, David A.; Goulet, Joseph L.; Bryant, Kendall; Gibert, Cynthia L.; Leaf, David A.; Mattocks, Kristin; Sullivan, Lynn E.; Vogenthaler, Nicholas; Justice, Amy C.; VACS Project Team // JGIM: Journal of General Internal Medicine;Sep2011, Vol. 26 Issue 9, p1012 

    Background and Objective: Food insecurity negatively impacts HIV disease outcomes in international settings. No large scale U.S. studies have investigated the association between food insecurity and severity of HIV disease or the mechanism of this possible association. The objective...

  • Segmental modeling of changing viral load to assess drug resistance in HIV infection. Liang, H. // Statistical Methods in Medical Research;Aug2007, Vol. 16 Issue 4, p365 

    Studies of viral dynamics are important to our understanding of the pathogenesis of HIV-1 infection and in assessment of the potency of antiretroviral therapies. Although many different viral dynamic models and methods for estimating viral dynamic parameters have been proposed and used in...

  • Smoking cessation among women with and at risk for HIV: are they quitting? Goldberg, David; Weber, Kathleen; Orsi, Jennifer; Hessol, Nancy A.; D'Souza, Gypsyamber; Watts, D. Heather; Schwartz, Rebecca; Chenglong Liu; Glesby, Marshall; Burian, Pamela; Cohen, Mardge H.; Weber, Kathleen M; Liu, Chenglong // JGIM: Journal of General Internal Medicine;Jan2010, Vol. 25 Issue 1, p39 

    Background: Cigarette smoking is an important risk factor for adverse health events in HIV-infected populations. While recent US population-wide surveys report annual sustained smoking cessation rates of 3.4-8.5%, prospective data are lacking on cessation rates for HIV-infected...

  • Projected survival gains from revising state laws requiring written opt-in consent for HIV testing. April, Michael D.; Chiosi, John J.; Paltiel, A. David; Sax, Paul E.; Walensky, Rochelle P. // JGIM: Journal of General Internal Medicine;Jun2011, Vol. 26 Issue 6, p661 

    Background: Although the Centers for Disease Control and Prevention recommends HIV testing in all settings unless patients refuse (opt-out consent), many state laws require written opt-in consent.Objective: To quantify potential survival gains from passing state laws...

  • Understanding the slow depletion of memory CD4+ T cells in HIV infection. Yates, Andrew; Stark, Jaroslav; Klein, Nigel; Antia, Rustom; Callard, Robin // PLoS Medicine;May2007, Vol. 4 Issue 5, pe177 

    Background: The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood. One potential explanation is that the low average rate of homeostatic proliferation or immune activation dictates...

  • Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy. Rizzardi, G. Paolo; Harari, Alexandre; Capiluppi, Brunella; Tambussi, Giuseppe; Ellefsen, Kim; Ciuffreda, Donatella; Champagne, Patrick; Bart, Pierre-Alexandre; Chave, Jean-Philippe; Lazzarin, Adriano; Pantaleo, Giuseppe // Journal of Clinical Investigation;3/1/2002, Vol. 109 Issue 5, p681 

    Primary HIV-1 infection causes extensive immune activation, during which CD4(+) T cell activation supports massive HIV-1 production. We tested the safety and the immune-modulating effects of combining cyclosporin A (CsA) treatment with highly active antiretroviral therapy (HAART) during primary...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics